Treating neurological disorders

Abstract

Methods of treating neuronal disorders, such as mechanical neuronal traumas and neurodegenerative disorders, with TWEAK or a TWEAK receptor blocking agents are presented.

1 - 90 . (canceled) 
     
     
         91 . A method for treating a human subject having inflammation associated with a neuronal disorder comprising administering to the subject a therapeutically effective amount an agent that blocks a TWEAK/TWEAK-R interaction or activity, wherein the agent is an antibody or antigen-binding fragment thereof that binds to TWEAK and/or a TWEAK receptor, or a soluble form of a TWEAK receptor. 
     
     
         92 . The method of  claim 91 , wherein the agent reduces the ability of TWEAK to bind to Fn14. 
     
     
         93 . The method of  claim 91 , wherein the agent is an antibody or antigen-binding fragment thereof that binds to human TWEAK. 
     
     
         94 . The method of  claim 91 , wherein the antibody is a full-length IgG. 
     
     
         95 . The method of  91 , wherein the antibody consists of an antigen binding fragment of an IgG. 
     
     
         96 . The method of  claim 91 , wherein the antibody is a human or humanized antibody. 
     
     
         97 . The method of  claim 91 , wherein the agent is a soluble form of a TWEAK receptor. 
     
     
         98 . The method of  claim 91 , wherein the soluble form of the TWEAK receptor is fused with an antibody Fc region. 
     
     
         99 . The method of  claim 91 , wherein the agent is administered in an amount or for a time sufficient to reduce the amount of neuronal cell damage in the subject, relative to a similarly affected, but untreated subject. 
     
     
         100 . The method of  claim 91 , wherein the agent is administered in combination with another treatment for the neuronal disorder. 
     
     
         101 . A container comprising an agent that blocks a TWEAK/TWEAK-R interaction or activity, and a label with instructions for use of the agent in treating a neuronal disorder.