US2012190688A1PendingUtilityA1
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
Est. expiryMay 26, 2029(~2.9 yrs left)· nominal 20-yr term from priority
Inventors:Milan BrunckoHong DingGeorge A. DoherlySteven W. ElmoreLisa A. HasvoldLaura HexamerAaron R. KunzerXiaohong SongAndrew J. SouersGerard M. SullivanZhi-Fu TaoGary T. WangLe WangXilu WangMichael D. WendtRobert A. ManteiTodd M. Hansen
A61P 37/00A61P 43/00A61P 37/06A61P 35/00A61P 35/02A61P 35/04C07D 471/04C07D 209/82C07D 519/00C07D 401/14A61K 31/496A61K 31/437C07D 403/12C07D 401/12Y02A50/30
62
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Abstract
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
Claims
exact text as granted — not AI-modified1 .- 8 . (canceled)
9 . The compound 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide or a pharmaceutically acceptable salt thereof.
10 .- 32 . (canceled)
33 . A pharmaceutical composition comprising an excipient and a therapeutically effective amount of 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide or a pharmaceutically acceptable salt thereof.Cited by (0)
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