Vasculature and lymphatic system imaging and ablation

Abstract

Devices, methods, and systems related to imaging and ablation are disclosed.

1 .- 216 . (canceled) 
     
     
         217 . A method, comprising:
 eliciting image information responsive to first energy output from one or more first energy source of one or more untethered device disposed in or proximal to one or more blood vessel or lymph vessel;   locally capturing the image information associated with the one or more blood vessel or lymph vessel in a subject using the one or more untethered device;   analyzing the image information to at least partially identify one or more targets in real time;   selectively closing at least one valve to trap the one or more identified targets in an insert of the one or more untethered device responsive to the one or more identified targets being identified; and   locally providing second energy, from one or more second energy source of the one or more untethered device, to the one or more identified targets trapped in the insert in real time, the energy having a magnitude selected to at least partially ablate the one or more identified targets.   
     
     
         218 . The method of  claim 217 , wherein the image information includes spatial-temporal location information. 
     
     
         219 . The method of  claim 217 , wherein the image information includes velocity information. 
     
     
         220 . The method of  claim 217 , wherein analyzing the image information includes comparing the image information to one or more of reference image information or target image information. 
     
     
         221 . The method of  claim 220 , wherein comparing the image information to one or more of reference image information or target image information includes comparing one or more of cell shape or cell outline with one or more of reference cell shape or cell outline information or target cell shape or cell outline information. 
     
     
         222 . The method of  claim 220 , wherein comparing the image information to one or more of reference image information or target image information includes comparing one or more of intracellular shape or intracellular outline with one or more of reference intracellular shape or intracellular outline information or target intracellular shape or intracellular outline information. 
     
     
         223 . The method of  claim 217 , wherein analyzing the image information includes performing one or more of pattern recognition or shape recognition analysis. 
     
     
         224 . The method of  claim 217 , wherein analyzing the image information includes determining spatial-temporal information associated with the image information. 
     
     
         225 . The method of  claim 224 , wherein determining spatial-temporal information associated with the image information includes predicting future spatial-temporal locations associated with the image information. 
     
     
         226 . The method of  claim 224 , wherein determining spatial-temporal information associated with the image information includes determining velocity information associated with the image information. 
     
     
         227 . The method of  claim 217 , further comprising locally inhibiting fluid flow associated with the one or more blood vessel or lymph vessel. 
     
     
         228 . A method of treating, ameliorating, or preventing a disease or disorder in a subject, the method comprising:
 eliciting image information responsive to first energy output from one or more first energy source of an untethered device disposed in or proximal to one or more blood vessel or lymph vessel;   locally capturing the image information associated with the one or more blood vessel or lymph vessel in the subject using one or more sensors of the untethered device;   analyzing the image information to at least partially identify one or more targets in real time;   selectively closing at least one valve to trap the one or more identified targets in an insert of the untethered device responsive to the one or more identified targets being identified; and   with the one or more identified targets trapped in the insert, locally providing ablation energy, from one or more second energy sources, to the target area in real time, the ablation energy having characteristics appropriate to at least partially ablate the one or more identified targets;   wherein the one or more identified targets are associated with the disease or disorder.   
     
     
         229 . The method of  claim 228 , wherein the disease or disorder is an infection. 
     
     
         230 . The method of  claim 228 , wherein the disease or disorder is a neoplasm. 
     
     
         231 . The method of  claim 228 , wherein the image information includes spatial-temporal location information. 
     
     
         232 . The method of  claim 228 , wherein the image information includes velocity information. 
     
     
         233 . The method of  claim 228 , wherein analyzing the image information includes performing one or more of a pattern recognition or a shape recognition analysis. 
     
     
         234 . The method of  claim 228 , wherein analyzing the image information includes determining spatial-temporal information associated with the image information. 
     
     
         235 . The method of  claim 234 , wherein determining spatial-temporal information associated with the image information includes predicting future spatial-temporal locations associated with the image information. 
     
     
         236 . A method, comprising:
 eliciting image information responsive to first energy output from one or more first energy source of one or more untethered device disposed in or proximal to one or more blood vessel or lymph vessel;   locally capturing the image information associated with the one or more blood vessel or lymph vessel in a subject using one or more sensors of the one or more untethered device;   analyzing the image information using control circuitry that is coupled to the one or more sensors to at least partially identify one or more targets during an expected transit time of the one or more targets through a detection area in the lumen;   selectively closing at least one valve to trap the one or more identified targets in an insert of the one or more untethered device responsive to the one or more identified targets being identified by the control circuitry; and   locally providing second energy, from one or more second energy source of the one or more untethered device, to the one or more identified targets trapped in the insert in real time, the energy having a magnitude selected to at least partially ablate the one or more identified targets.