Geodate delivery vehicles

Abstract

The present invention provides geodate delivery vehicles and methods of manufacture and administration. A vehicle including a lipid monolayer disposed about a hydrophobic domain is disclosed, that can be part of an emulsion or other mixture, or further disposed in a lipid strata. A vehicle including a lipid strata disposed about a hydrophobic domain is also disclosed. The vehicle can be incorporated into a variety of medicinal, food preparations, and personal care products to deliver or stabilize a cargo moiety. Packaged delivery vehicles for to later addition of cargo moieties are also contemplated.

1 - 48 . (canceled) 
     
     
         49 . A geodate delivery vehicle for a cargo moiety comprising:
 a lipid monolayer comprising an anionic phospholipid, disposed about a hydrophobic domain; and   a lipid strata comprising alternating divalent metal cations and anionic phospholipids, wherein the lipid strata is disposed about the lipid monolayer; and   a cargo moiety associated with the hydrophobic domain.   
     
     
         50 . The geodate delivery vehicle of  claim 49 , wherein the geodate delivery vehicle is suspended in an aqueous environment. 
     
     
         51 . The geodate delivery vehicle of  claim 50 , wherein the geodate delivery vehicle is suspended in an emulsion. 
     
     
         52 . The geodate delivery vehicle of  claim 49 , wherein the geodate delivery vehicle is in powder form. 
     
     
         53 . The geodate delivery vehicle of  claim 49 , wherein the hydrophobic domain is the cargo moiety. 
     
     
         54 . The geodate delivery vehicle of  claim 49 , wherein the hydrophobic domain comprises a cargo moiety associated with an oil or fat. 
     
     
         55 . The geodate delivery vehicle of  claim 49 , wherein the lipid strata comprises at least about 50% negatively charged lipid. 
     
     
         56 . The geodate delivery vehicle of  claim 49 , wherein the lipid strata comprises at least about 75% negatively charged lipid. 
     
     
         57 . The geodate delivery vehicle of  claim 49 , wherein the cargo moiety is at least one member selected from the group consisting of a vitamin, a mineral, a nutrient, a toxin, a microbicide, a microbistat, a co-factor, an enzyme, a polypeptide, a polypeptide aggregate, a polynucleotide, a lipid, a carbohydrate, a nucleotide, a pigment, a fatty acid, a flavor substance, a flavored essential oil or extract, a hormone, a cytokine, a virus, an organelle, a steroid, a saccharide, a metal, a metabolic poison, an antigen, an imaging agent, a porphyrin, and a drug. 
     
     
         58 . The geodate delivery vehicle of  claim 57 , wherein the drug is at least one member selected from the group consisting of a protein, a small peptide, a bioactive polynucleotide, an anesthetic, an anti-infectious, an anticancer, an immunosuppressant, a steroidal anti-inflammatory, a non-steroidal anti-inflammatory, an antioxidant, an antidepressant which can be synthetic or naturally derived, an anticonvulsant, a non-nucleophilic reverse transcriptase inhibitor, a cytokine, a tranquilizer or a vasodilatory agent. 
     
     
         59 . The geodate delivery vehicle of  claim 57 , wherein the drug is at least one member selected from the group consisting of Amphotericin B, acyclovir, adriamycin, carbamazepine, ivermectin, melphalen, nifedipine, indomethacin, curcumin, ibuprofen, naproxen, steroids, phenyloin, ergotamines, cannabinoids, rapamycin, propanadid, propofol, alphadione, echinomycin, miconazole nitrate, teniposide, hexamethylmelamine, taxol, taxotere, piroxicam, diazepam, verapamil, vancomycin, tobramycin, geldanamycin, acetaminophen, aspirin, nystatin, rifampin, vitamin A acid, mesalamine, risedronate, nitrofurantoin, dantrolene, etidronate, caspofungin, nicotine, amitriptyline, clomipramine, citalopram, dothepin, doxepin, fluoxetine, imipramine, lofepramine, mirtazapine, nortriptyline, paroxetine, reboxitine, sertraline, trazodone, venlafaxine, dopamine, St. John's wort, phosphatidylserine, phosphatidic acid, amastatin, antipain, bestatin, benzamidine, chymostatin, 3,4-dichloroisocoumarin, elastatinal, leupeptin, pepstatin, 1,10-phenanthroline, phosphoramidon, ethosuximide, ethotoin, felbamate, fosphenyloin, lamotrigine, levitiracetam, mephenyloin, methsuximide, oxcarbazepine, phenobarbital, phensuximide, primidone, topirimate, trimethadione, zonisamide, saquinavir, ritonavir, indinavir, nelfinavir, or amprenavir. 
     
     
         60 . The geodate delivery vehicle of  claim 57 , wherein the polynucleotide is at least one member selected from the group consisting of a deoxyribonucletic acid (DNA) molecule, a ribonucleic acid (RNA) molecule, an siRNA, a ribozyme, an antisense molecule, a polynucleotide modified to have a morpholino backbone, and a plasmid. 
     
     
         61 . The geodate delivery vehicle of  claim 57 , wherein the polypeptide is at least one member selected from the group consisting of cyclosporin, angiotensin I, II, or III, enkephalins and their analogs, ACTH, anti-inflammatory peptides I, II, or III, bradykinin, calcitonin, beta-endorphin, dinorphin, leucokinin, leutinizing hormone releasing hormone (LHRH), insulin, neurokinins, somatostatin, substance P, thyroid releasing hormone (TRH), and vasopressin. 
     
     
         62 . The geodate delivery vehicle of  claim 57 , wherein the antigen is at least one member selected from the group consisting of a carbohydrate, envelope glycoproteins from viruses, an animal cell membrane protein, a plant cell membrane protein, a bacterial membrane protein and a parasitic membrane protein. 
     
     
         63 . The geodate delivery vehicle of  claim 57 , wherein the nutrient is at least one member selected from the group consisting of vitamins, minerals, fatty acids, amino acids, fish oils, fish oil extracts, resveratrol, biotin, choline, inositol, ginko, and saccharides. 
     
     
         64 . The geodate delivery vehicle of  claim 63 , wherein the nutrient is a phytochemical. 
     
     
         65 . The geodate delivery vehicle of  claim 57 , wherein the nutrient is at least one member selected from the group consisting of beta-carotene, lutein, zeaxanthine, quercetin, silibinin, perillyl alcohol, genistein, sulfurophane, lycopene, omega-3 and omega-6 fatty acids. 
     
     
         66 . The geodate delivery vehicle of  claim 57 , wherein the vitamin is at least-one member selected from the group consisting of vitamins A, B, B1, B2, B3, B12, B6, B-complex, C, D, E, and K, vitamin precursors, and carotenoids. 
     
     
         67 . The geodate delivery vehicle of  claim 57 , wherein the mineral is at least one member selected from the group consisting of boron, chromium, colloidal minerals, colloidal silver, copper, manganese, potassium, selenium, vanadium, vanadyl sulfate, calcium, magnesium, barium, iron and zinc. 
     
     
         68 . The geodate delivery vehicle of  claim 57 , wherein the fatty acid is at least one member selected from the group consisting of monounsaturated, polyunsaturated and saturated fatty acids. 
     
     
         69 . The geodate delivery vehicle of  claim 57 , wherein the saccharide or sweetener is at least one member selected from the group consisting of saccharine, isomalt, maltodextrine, aspartame, glucose, maltose, dextrose, fructose and sucrose. 
     
     
         70 . The geodate delivery vehicle of  claim 57 , wherein the flavor substance is at least one oil or extract selected from the group consisting of oils and extracts of cinnamon, vanilla, almond, peppermint, spearmint, chamomile, geranium, ginger, grapefruit, hyssop, jasmine, lavender, lemon, lemongrass, marjoram, lime, nutmeg, orange, rosemary, sage, rose, thyme, anise, basil, black pepper, tea or tea extracts, an herb, a citrus, a spice and a seed. 
     
     
         71 . The geodate delivery vehicle of  claim 49 , wherein the geodate delivery vehicle further comprises an aggregation inhibitor. 
     
     
         72 . The geodate delivery vehicle of  claim 71 , wherein the aggregation inhibitor comprises methylcellulose. 
     
     
         73 . A pharmaceutical composition comprising a geodate delivery vehicle of  claim 49  and a pharmaceutically acceptable carrier. 
     
     
         74 . The geodate delivery vehicle of  claim 57 , wherein the pigment comprises a tetrapyrrolic pigment. 
     
     
         75 . The geodate delivery vehicle of  claim 57 , wherein the nutrient is at least one nutrient selected from the group consisting of a micronutrient and an amino acid. 
     
     
         76 . The geodate delivery vehicle of  claim 58 , wherein the drug is at least one drug selected from the group consisting of an antibiotic and an antifungal. 
     
     
         77 . The geodate delivery vehicle of  claim 59 , wherein the steroid is at least one steroid selected from the group consisting of estrogens, testosterones, 18-hydroxydeoxycorticosterone, prednisolone, dexamethazone, cortisone and hydrocortisone. 
     
     
         78 . The geodate delivery vehicle of  claim 66 , wherein the carotenoid comprises beta-carotene. 
     
     
         79 . The geodate delivery vehicle of  claim 49 , wherein the cargo moiety is Amphotericin B. 
     
     
         80 . The geodate delivery vehicle of  claim 57 , wherein the drug is an antiviral. 
     
     
         81 . The geodate delivery vehicle of  claim 57 , wherein the drug is an HIV protease inhibitor.