Nucleic acid and corresponding protein entitled 193p1e1b useful in treatment and detection of cancer

Abstract

A novel gene 0193P1E1B (also designated 193P1E1B) and its encoded protein, and variants thereof, are described wherein 193P1E1B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 193P1E1B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 193P1E1B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 193P1E1B can be used in active or passive immunization.

1 . A method for detecting the presence of a 193P1E1B protein in a sample, comprising:
 contacting the sample with an antibody or fragment thereof that specifically binds to the 193P1E1B protein, wherein the 193P1E1B protein comprises an amino acid sequence selected from the group consisting of residues 1 to 412 of SEQ ID NOS: 9, 11 and 13; and,   detecting the formation and/or presence of a complex comprising the antibody or fragment thereof and the 193P1E1B protein.   
     
     
         2 . The method of  claim 1 , wherein the protein comprises the amino acid sequence of SEQ ID NOS:9, 11, or 13. 
     
     
         3 . The method of  claim 1 , wherein the protein comprises the amino acid sequence of SEQ ID NO:9. 
     
     
         4 . The method of  claim 1 , wherein the protein comprises the amino acid sequence of SEQ ID NO:11. 
     
     
         5 . The method of  claim 1 , wherein the protein comprises the amino acid sequence of SEQ ID NO:13. 
     
     
         6 . A method for detecting the presence of a 193P1E1B mRNA in a sample, comprising:
 contacting the sample with a nucleotide probe that specifically binds to the mRNA which encodes a protein comprises an amino acid sequence selected from the group consisting of residues 1 to 412 of SEQ ID NOS: 9, 11 and 13, and   detecting the formation and/or presence of a complex comprising the probe and the mRNA.   
     
     
         7 . The method of  claim 6 , wherein the protein comprises the amino acid sequence of SEQ ID NOS:9, 11, or 13. 
     
     
         8 . The method of  claim 6 , wherein the protein comprises the amino acid sequence of SEQ ID NO:9. 
     
     
         9 . The method of  claim 6 , wherein the protein comprises the amino acid sequence of SEQ ID NO:11. 
     
     
         10 . The method of  claim 6 , wherein the protein comprises the amino acid sequence of SEQ ID NO:13. 
     
     
         11 . The method of  claim 6 , further comprising:
 producing a cDNA from the sample by reverse transcription using at least one primer;   amplifying the cDNA so produced using 193P1E1B polynucleotides as sense and antisense primers, wherein the 193P1E1B polynucleotides used as the sense and antisense primers serve to amplify a 193P1E1B cDNA; and,   detecting the presence of the amplified 193P1E1B cDNA.