Therapeutic calcium phosphate particles in use for aesthetic of cosmetic medicine, and methods of manufacture and use

Abstract

Calcium phosphate (“CAP”) particles for use in cosmetic, nutraceutic or aesthetic medicine. The particles may be used as carriers for cosmetic, nutraceutic or a factors, as controlled release matrices for the material, and as fillers in cosmetic treatments. The particles may be applied topically or injected or by any other appropriate delivery method.

1 . A skin filler for treating one or more skin conditions, consisting essentially of:
 a calcium phosphate particle having a diameter of between about 200 nm to about 4000 nm.   
     
     
         2 . The skin filler of  claim 1 , wherein the skin filler is adapted to be delivered to a layer of skin via topical delivery or via injection. 
     
     
         3 . (canceled) 
     
     
         4 . The skin filler of  claim 1 , wherein the calcium phosphate particle is smooth without any surface irregularities larger than 100 nm. 
     
     
         5 . The skin filler of  claim 1 , wherein the calcium phosphate particle is spherical, round, or oval in shape. 
     
     
         6 . The skin filler of  claim 1 , wherein the calcium phosphate particle is coated or has at least a partial layer of a surface modifying agent covering the particle. 
     
     
         7 . The skin filler of  claim 6 , wherein the surface modifying agent is a basic sugar, a modified sugar, an oligonucleotide, a carbohydrate, cellobiose, or polyethylene glycol. 
     
     
         8 . The skin filler of  claim 1 , wherein the calcium phosphate particle is smooth or substantially smooth. 
     
     
         9 - 15 . (canceled) 
     
     
         16 . A chemical peel, consisting essentially of:
 a calcium phosphate particle having a diameter of between about 200 nm to about 4000 nm have an aesthetic factor comprising trichloro acetic acid or other chemical peel agent at least partially coating the particle or impregnating the particle or both.   
     
     
         17 . The chemical peel of  claim 16 , wherein the calcium phosphate particle is smooth without any surface irregularities larger than 100 nm. 
     
     
         18 . The chemical peel of  claim 16 , wherein the calcium phosphate particle is spherical, round, or oval in shape. 
     
     
         19 . The chemical peel of  claim 16 , wherein the calcium phosphate particle is smooth or substantially smooth. 
     
     
         20 . A microderm abrasion treatments, consisting essentially of a calcium phosphate particle having a diameter of between about 200 nm to about 4000 nm having an aesthetic factor comprising silica gel crystals, microcrystalling aluminum oxide, alumina crystals, magnesium oxide crystals, sodium bicarbonate crystals, anti-oxidants, or any other commonly used materials for microderm abrasion at least partially coating the particle or impregnating the particle or both. 
     
     
         21 . The microderm abrasion treatment of  claim 20 , wherein the calcium phosphate particle is smooth without any surface irregularities larger than 100 nm. 
     
     
         22 . The microderm abrasion treatment of  claim 20 , wherein the calcium phosphate particle is spherical, round, or oval in shape. 
     
     
         23 . The microderm abrasion treatment of  claim 20 , wherein the calcium phosphate particle is smooth or substantially smooth. 
     
     
         24 . The microderm abrasion treatment of  claim 20 , wherein the injection is intradermal.