Bioerodible matrix for tissue involvement

Abstract

Disclosed herein are polyurethane polymer matrices with a porosity of from about 20 microns to about 90 microns that are useful in promoting closure and protection of incision sites; supporting the lower pole position of breast implants; and providing a partial or complete covering of breast implants to provide a beneficial interface with host tissue and to reduce the potential for malpositioning or capsular contracture. The disclosed matrices can be seeded with mammalian cells.

1 . A method of augmenting or reconstructing a breast of a patient, the method comprising:
 implanting a matrix in a breast of a patient, the matrix comprising a biodegradable polymer material admixed with an active cell population formed from processed lipoaspirate.   
     
     
         2 . The method of  claim 1  wherein the polymer material is a hydrogel. 
     
     
         3 . The method of  claim 2  wherein the hydrogel is selected from the group of hydrogels consisting of alginate, coral, agarose, fibrin, collagen, cartilage, hydroxyapatite, calcium phosphate, polylactic acid (PLA), polyglycolic acid (PGA) polylacticglycolic acid (PLGA), chitosan, and polyethylene glycol-based polymers. 
     
     
         4 . The method of  claim 3  wherein the hydrogel is a polyethylene glycol-based polymer. 
     
     
         5 . The method of  claim 4  wherein the polyethylene glycol-based polymer is one of a polyethylene glycol diacrylate, polyethylene glycol dimethacrylate or a mixture thereof. 
     
     
         6 . The method of  claim 3  wherein the hydrogel comprises collagen. 
     
     
         7 . The method of  claim 1  wherein the active cell population comprises adipose tissue. 
     
     
         8 . The method of  claim 1  wherein the active cell population consists essentially of adipose tissue. 
     
     
         9 . The method of  claim 1  wherein the matrix is implanted so as to support a lower pole position of a breast implant. 
     
     
         10 . The method of  claim 1  wherein the matrix is structured to promote tissue ingrowth. 
     
     
         11 . An implantable composition useful for augmenting or reconstructing a breast of a patient, the composition comprising a matrix comprising a biodegradable polymer material admixed with an active cell population formed from processed lipoaspirate. 
     
     
         12 . The composition of  claim 11  wherein the polymer material is a hydrogel. 
     
     
         13 . The composition of  claim 12  wherein the hydrogel is selected from the group of hydrogels consisting of alginate, coral, agarose, fibrin, collagen, cartilage, hydroxyapatite, calcium phosphate, polylactic acid (PLA), polyglycolic acid (PGA) polylacticglycolic acid (PLGA), chitosan, and polyethylene glycol-based polymers. 
     
     
         14 . The composition of  claim 13  wherein the hydrogel is a polyethylene glycol-based polymer. 
     
     
         15 . The composition of  claim 14  wherein the polyethylene glycol-based polymer is one of a polyethylene glycol diacrylate, polyethylene glycol dimethacrylate or a mixture thereof. 
     
     
         16 . The composition of  claim 13  wherein the hydrogel comprises collagen. 
     
     
         17 . The composition of  claim 11  wherein the active cell population consists essentially of adipose tissue. 
     
     
         18 . The composition of  claim 11  wherein the matrix is structured to support a lower pole position of a breast implant. 
     
     
         19 . The composition of  claim 11  wherein the matrix is structured to promote tissue ingrowth.