Compositions and methods relating to novel compounds and targets thereof

Abstract

The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and related compounds and methods of using benzodiazepine derivatives and related compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like.

1 - 13 . (canceled) 
     
     
         14 . A compound represented by the following formula: 
       
         
           
           
               
               
           
         
         including salts and both R and S enantiomeric forms and racemic mixtures thereof; wherein 
         A 1  is H or Cl; 
         R 1  is H or CH 3 ; 
         R 2  is 
       
       
         
           
           
               
               
           
         
         R 3  is H or Br; and 
         provided that at least one of A 1  and R 3  is not H. 
       
     
     
         15 . The compound of  claim 14 , wherein A 1  is H, and R 3  is Br. 
     
     
         16 - 19 . (canceled) 
     
     
         20 . A pharmaceutical composition comprising (a) a compound of  claim 14  and (b) a pharmaceutically acceptable carrier. 
     
     
         21 . A method of treating a disorder selected from the group consisting of an immune disorder, a hyperproliferative disorder, and a chronic inflammatory condition, comprising administering an effective amount of a compound  claim 14  to a subject in need thereof suffering from said immune disorder, said hyperproliferative disorder, or said chronic inflammatory condition, 
     
     
         22 . The method of  claim 21 , wherein said disorder is an immune disorder selected from the group consisting of a graft versus host disease, rheumatoid arthritis, and systemic lupus erythematosus. 
     
     
         23 . The method of  claim 21 , wherein the hyperproliferative disorder is a cancer. 
     
     
         24 . The method of  claim 23 , wherein the cancer is a tumor, neoplasm, lymphoma, myeloma or leukemia. 
     
     
         25 . The method of  claim 21 , wherein the disorder is a chronic inflammatory condition selected from the group consisting of asthma and psoriasis. 
     
     
         26 . The method of  claim 22 , further comprising administering an additional agent for treating said immune disorder. 
     
     
         27 . The method of  claim 23 , further comprising administering an additional agent for treating said cancer. 
     
     
         28 . The method of  claim 25 , further comprising administering an additional agent for treating said chronic inflammatory condition. 
     
     
         29 . A compound selected from the group consisting of: 
       
         
           
           
               
               
           
         
       
       and pharmaceutically acceptable salts thereof. 
     
     
         30 . A method of treating a disorder selected from the group consisting of an immune disorder, a hyperproliferative disorder, and a chronic inflammatory condition, comprising administering an effective amount of a compound  claim 29  to a subject in need thereof suffering from said immune disorder, said hyperproliferative disorder, or said chronic inflammatory condition, 
     
     
         31 . The method of  claim 30 , wherein said disorder is an immune disorder selected from the group consisting of a graft versus host disease, rheumatoid arthritis, and systemic lupus erythematosus. 
     
     
         32 . The method of  claim 30 , wherein the hyperproliferative disorder is a cancer. 
     
     
         33 . The method of  claim 32 , wherein the cancer is a tumor, neoplasm, lymphoma, myeloma or leukemia. 
     
     
         34 . The method of  claim 30 , wherein the disorder is a chronic inflammatory condition selected from the group consisting of asthma and psoriasis.