Therapeutic Compositions Comprising Monoterpenes

Abstract

This invention provides a compositions for transport of a therapeutic agent. The compositions contain a therapeutic agent and a monoterpene or an analog thereof. In one aspect, the monoterpene is perillyl alcohol (POH) or an analog thereof. In one aspect, the therapeutic agent is provided in an amount effective to treat the disease or subject of choice.

1 . A composition for administration by one or more of inhalation, intranasally or ocularly, comprising:
 a therapeutic agent;   at least about 0.03% (v/v) of perillyl alcohol or an analog thereof;   at least about 1.3% glycerol (v/v); and   at least about 1.3% ethanol, (v/v; 96% ethanol),   wherein the components equal 100% (v/v) of the composition.   
     
     
         2 .- 7 . (canceled) 
     
     
         8 . A method for treating a disease affecting the central nervous system, comprising administering to a subject in need of such treatment by administration by one or more of inhalation, intranasally or ocularly, an effective amount of the composition of  claim 1 , thereby treating the disease. 
     
     
         9 . The method of  claim 8 , wherein the composition comprises:
 a therapeutic agent;   from about 0.0001% to about 0.01% (v/v) of perillyl alcohol, perillaldehyde or a carboxylic acid ester of perillyl alcohol;   at least about 1.3% glycerol (v/v); and   at least about 1.3% ethanol, (v/v),   wherein the components equal 100% (v/v) of the composition, thereby treating the disease.   
     
     
         10 . The method of  claim 9 , wherein the disease is a primary central nervous system (CNS) tumor or a CNS metastasis from a systemic cancer. 
     
     
         11 . The method of  claim 9 , wherein the systemic cancer is one or more of lung cancer, prostate cancer, breast cancer, hematopoietic cancer or ovarian cancer. 
     
     
         12 . A kit comprising the composition of  claim 1 , a device for administering the composition by inhalation and instruction for use. 
     
     
         13 . The method of  claim 8  or  9 , wherein the composition comprises perillyl alcohol. 
     
     
         14 . The method of  claim 8  or  9 , wherein the perillyl alcohol, perillaldehyde or a carboxylic acid ester of perillyl alcohol is present in an amount from about 0.001% to about 0.01% (v/v). 
     
     
         15 . The composition of  claim 8  or  9 , wherein the perillyl alcohol, perillaldehyde or a carboxylic acid ester of perillyl alcohol is present in an amount of about 0.01% (v/v). 
     
     
         16 . The method of  claim 8  or  9 , wherein the therapeutic agent is a chemotherapeutic agent or a therapeutic antibody. 
     
     
         17 . The method of  claim 8  or  9 , wherein the therapeutic agent is temozolomide or dimethylcelecoxib. 
     
     
         18 . The method of  claim 8  or  9 , wherein the subject is a pediatric patient.