Use of a corn peptidi hydrolyzate as an active agent stimulating hair growth

Abstract

The invention relates to the use of a composition comprising at least one corn ( Zea mays L. ) peptidic hydrolyzate, as an active agent to stimulate and/or restore hair growth, or prevent hair loss. The invention is also relative to the use of this novel active agent to produce a dermato-pharmaceutical composition, intended to stimulate and restore hair growth or limit hair loss. The invention further applies to a cosmetic treatment method intended to prevent or combat the manifestations of hair aging.

1 . A cosmetic composition comprising at least one corn ( Zea mays L. ) peptidic hydrolyzate, as an active agent to stimulate and/or restore hair growth, or prevent hair loss. 
     
     
         2 . The cosmetic composition according to  claim 1 , wherein the peptidic hydrolyzate predominantly comprises peptidic nature compounds having a molecular weight of less than 5 kDa. 
     
     
         3 . The cosmetic composition according to  claim 1 , wherein the peptidic hydrolyzate is solubilized in one or more physiologically acceptable solvents, such as water, glycerol, ethanol, propylene glycol, butylene glycol, dipropylene glycol, ethoxylated diethylene glycol or propoxylated diethylene glycol, cyclic polyols, or any mixture of these solvents. 
     
     
         4 . The use cosmetic composition according to  claim 1 , wherein the peptidic hydrolyzate contains between 1 and 5 g/1 and preferentially between 1.5 and 3.0 g/1 of peptidic nature compounds. 
     
     
         5 . The cosmetic composition according to  claim 1 , wherein the peptidic hydrolyzate is used in a quantity representing from 0.001% to 5% of the total weight of the composition. 
     
     
         6 . The cosmetic composition according to  claim 1 , wherein the composition is present in a form suitable for topical application comprising a physiologically acceptable medium. 
     
     
         7 . The cosmetic composition according to  claim 1 , further comprising at least one other active agent protecting or improving hair growth and/or health, intended to encourage and supplement the action of said active agent. 
     
     
         8 . The cosmetic composition according to  claim 1 , wherein the cosmetic composition combats alopecia. 
     
     
         9 . The cosmetic composition of  claim 1 , wherein the peptidic hydrolyzate stimulates the hair follicle. 
     
     
         10 . The cosmetic composition according to  claim 9 , wherein the peptidic hydrolyzate increases the expression of laminin-5, and/or beta integrin 1, and/or fibronectin. 
     
     
         11 . The cosmetic composition according to  claim 9 , wherein the peptidic hydrolyzate increases the expression of protein p63, marker Ki67 and the phosphorylation of histone 3 in cells of the outer root sheath of the hair follicle. 
     
     
         12 . The cosmetic composition according to  claim 9 , wherein the peptidic hydrolyzate increases hair elongation. 
     
     
         13 . (canceled) 
     
     
         14 . A cosmetic treatment method for stimulation of the growth of eyelashes, or combating eyelash loss, the method comprising:
 providing a cosmetic composition comprising at least one corn ( Zea mays L. ) peptidic hydrolyzate, as an active agent to stimulate and/or restore hair growth, or prevent hair loss; and   applying the cosmetic composition topically to the area to be treated.   
     
     
         15 . The cosmetic composition of  claim 1 , wherein the composition is a dermato-pharmaceutical composition that stimulates and/or restores hair growth or limits hair loss connected to a pathological condition. 
     
     
         16 . The cosmetic composition according to  claim 15 , wherein the pathological conditions are alopecia areata, the side effects of drug treatments, certain infections or inflammations of the scalp. 
     
     
         17 . The cosmetic composition according to  claim 7 , wherein the other active agent is a plant peptidic extract. 
     
     
         18 . The cosmetic composition of  claim 5 , wherein the peptidic hydrolyzate is used in a quantity representing from 0.01% to 1% of the total weight of the composition.