Compositions, methods, and devices for treating liver disease

Abstract

Described are compositions and methods for treating liver disease, e.g., acute liver disease, using bone marrow-derived stem cells and bone marrow-derived stem cell conditioned media.

1 .- 31 . (canceled) 
     
     
         32 . A method comprising
 preparing a multipotent stromal cell (MSC) lysate, and   formulating the MSC lysate with a pharmaceutically acceptable carrier.   
     
     
         33 . The method of  claim 32 , wherein the MSC lysate is prepared by sonicating MSC. 
     
     
         34 . The method of  claim 32 , wherein the MSC lysate is formulated for parenteral administration. 
     
     
         35 . A pharmaceutical composition comprising
 a multipotent stromal cell (MSC) lysate, and   a pharmaceutically acceptable carrier.   
     
     
         36 . A method comprising
 administering an effective amount of a multipotent stromal cell (MSC) lysate to a subject in need thereof.   
     
     
         37 . The method of  claim 36 , wherein the subject is a human subject. 
     
     
         38 . The method of  claim 36 , wherein the subject has an autoimmune disease. 
     
     
         39 . The method of  claim 36 , wherein the subject has liver disease. 
     
     
         40 . The method of  claim 36 , wherein the subject has acute liver failure. 
     
     
         41 . The method of  claim 36 , wherein the MSC lysate is xenogeneic to the subject. 
     
     
         42 . The method of  claim 36 , wherein the subject is a farm animal, a sport animal, a primate, a horse, a dog, a cat, a rat, or a mouse.