Hydroxytyrosol combinations for enhancing mitochondrial function and energy production

Abstract

Hydroxytyrosol or olive juice containing hydroxytyrosol in combination with at least one of the compounds selected from the group consisting of: creatine, coenzyme Q10, resveratrol, caffeine, carnitine, B vitamins (B1, B2, B3, B5, B6, and/or B12) and ginseng (preferably: root) extract can be used to maintain or increase mitochondrial biogenesis in cardiac muscle, skeletal muscles, and liver tissue.

1 . A composition comprising hydroxytyrosol in combination with at least one of the compounds selected from the group consisting of: creatine, coenzyme Q10, resveratrol, caffeine, carnitine, B vitamins (B1 or thiamine; B2 or riboflavin; B3 or niacin or niacinamide; B5 or pantothenic acid; B6 or pyridoxine, pyridoxal, pyridoxamine, or pyridoxine hydrochloride; B7 or biotin; B9 or folic acid; or B12 or various cobalamins, such as cyanocobalamin), quercetin, alpha-lipoic acid, epigallocatechin (EGCG) and ginseng extract. 
     
     
         2 . A composition wherein the hydroxytyrosol is present in an olive extract. 
     
     
         3 . A composition according to  claim 1  wherein the composition is a nutraceutical or food composition. 
     
     
         4 . A composition according to  claim 1  wherein the composition is a veternary composition. 
     
     
         5 . Use of hydroxytyrosol in combination with at least one of the compounds selected from the group consisting of: creatine, coenzyme Q10, resveratrol, caffeine, carnitine, B vitamins (B1 or thiamine; B2 or riboflavin; B3 or niacin or niacinamide; B5 or pantothenic acid; B6 or pyridoxine, pyridoxal, pyridoxamine, or pyridoxine hydrochloride; B7 or biotin; B9 or folic acid; or B12 or various cobalamins, such as cyanocobalamin), quercetin, alpha-lipoic acid, epigallocatechin (EGCG) and ginseng extract to increase mitochondia biogenesis. 
     
     
         6 . Use according to  claim 5  wherein the hydroxytyrosol is present in an olive extract. 
     
     
         7 . Use according to  claim 5  as a nutraceutical or food composition. 
     
     
         8 . Use according to  claim 5  which is a veternary use. 
     
     
         9 . Use wherein effects of increased mitochondrial function and/or mitochondrial biogenesis include observations that the combination of this invention:
 helps reduce muscle fatigue; helps reduce muscle soreness; complements the immediate short term effect of caffeine with a sustained effect on energy generation; helps promote energy generation from fat; helps lower plasma lactate during exercise; helps maintain muscle force in conditions of oxidative stress; helps protect against exercise-induced oxidative stress; helps the body to find more energy without getting too much caffeine; gives long-lasting energy; helps boost body's own energy production; helps maintain more even energy levels throughout the day; provide for immediate and sustained energy; helps the body to adapt to exercise; helps prepare the body for exercise goals; helps revamp the body's shape; facilitates the restart of an exercise program; helps one to get going again; helps one feel more energetic; helps one feel more active; supports one's zest for action; helps one cope with a busy lifestyle; increased muscle work capacity; improved aerobic capacity; enhanced physical performance; enhanced exercise performance; improved running endurance; improved running distance and/or improved running time; or stimulates energy formation from nutrients.   
     
     
         10 . A method of increasing mitochondia biogenesis comprising:
 administering an effective amount of hydroxytyrosol in combination with at least one of the compounds selected from the group consisting of: creatine, coenzyme Q10, resveratrol, caffeine, carnitine, B vitamins (B1 or thiamine; B2 or riboflavin; B3 or niacin or niacinamide; B5 or pantothenic acid; B6 or pyridoxine, pyridoxal, pyridoxamine, or pyridoxine hydrochloride; B7 or biotin; B9 or folic acid; or B12 or various cobalamins, such as cyanocobalamin), quercetin, alpha-lipoic acid, epigallocatechin (EGCG) and ginseng extract; and observing a mitochondria biogenesis effect.   
     
     
         11 . A method according to  claim 10  wherein the hydroxytyrosol is from an olive extract. 
     
     
         12 . A method according to  claim 10  wherein the mitochondria biogenesis effect comprisies observations that the combination of this invention:
 helps reduce muscle fatigue; helps reduce muscle soreness; complements the immediate short term effect of caffeine with a sustained effect on energy generation; helps promote energy generation from fat; helps lower plasma lactate during exercise; helps maintain muscle force in conditions of oxidative stress; helps protect against exercise-induced oxidative stress; helps the body to find more energy without getting too much caffeine; gives long-lasting energy; helps boost body's own energy production; helps maintain more even energy levels throughout the day; provide for immediate and sustained energy; helps the body to adapt to exercise; helps prepare the body for exercise goals; helps revamp the body's shape; facilitates the restart of an exercise program; helps one to get going again; helps one feel more energetic; helps one feel more active; supports one's zest for action; helps one cope with a busy lifestyle; increased muscle work capacity; improved aerobic capacity; enhanced physical performance; enhanced exercise performance; improved running endurance; improved running distance and/or improved running time; or stimulates energy formation from nutrients.