Compounds and compositions as inhibitors of cannabinoid receptor 1 activity

Abstract

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).

1 . A compound selected from Formula Ia, Ib, Ic, Id, Ie, If, Ig, Ih, Ii, Ij and Ik: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         in which: 
         Y is selected from O, NR 7  and S; wherein R 7  is selected from hydrogen, hydroxy and C 1-6  alkyl; 
         R 1  is selected from C 5-10  heteroaryl, C 3-12 cyclolalkyl, phenyl and benzyl; wherein said heteroaryl, cycloalkyl, phenyl and benzyl of R 1  is optionally substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted C 1-6 alkyl, halo-substituted C 1-6  alkoxy, —NR 8 R 9 , —S(O) 0-2 R 8 , —C(O)OR 8  and R 10 ; 
         R 2  is selected from C 3-8 heterocycloalkyl, C 5-10 heteroaryl, phenyl and phenoxy; wherein said heterocycloalkyl, heteroaryl, phenyl or phenoxy of R 2  is optionally substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted C 1-6 alkyl, C 1-6 alkenyl, halo-substituted C 1-6 alkoxy, —XNR 8 R 9 , —XOR 8 , —XC(O)R 8 , —XS(O) 0-2 R 8 , —XC(O)NR 8 R 9 , —XC(O)OR 8 , —XOR 10 , —XNR 8 XR 10  and —XR 10 ; wherein each X is independently selected from a bond, C 1-4 alkylene and C 2-4 alkenylene; 
         R 3  is selected from hydrogen, halo, hydroxy, cyano, cyano-C 1-6 alkyl, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted C 1-6 alkoxy, —XNR 8 R 9 , —XR 10 , —XS(O) 0-2 R 9 , —XC(O)R 10 , —XC(O)NR 8 R 9 , —XC(O)NR 8 R 10  and —XC(O)OR 8 ; 
         R 4  is selected from C 1-6 alkyl, halo-substituted C 1-6 alkyl, C 6-10 aryl-C 0-4 alkyl, C 5-10 heteroaryl, C 3-12 cycloalkyl, C 3-8 heterocycloalkyl and C(O)R 11 ; wherein R 11  is selected from C 3-8 heterocycloalkyl and C 3-8 heteroaryl; wherein any alkyl of R 4  can optionally have a methylene replaced with O, S(O) 0-2  and NR 8 ; wherein any cycloalkyl, heterocycloalkyl, aryl or heteroaryl of R 4  can optionally be substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, —XOR 8 , —XR 10 , —XC(O)R 10 , —XS(O) 0-2 R 8 , —XNR 8 R 9 , —XC(O)NR 8 R 9 , —XC(O)NR 8 R 10 , —XC(O)NR 8 XNR 8 R 9 , —XC(O)NR 8 XOR 9  and —XC(O)OR 8 ; 
         R 5  is selected from hydrogen, halo, hydroxy, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, hydroxy-substituted-C 1-6 alkyl, hydroxy-substituted-C 1-6 alkoxy, —NR 8 R 9 , —OXOR 8 , —OXR 10 , —NR 8 XOR 9 , —OXNR 8 R 9  and —C(O)OR 8 ; wherein X is independently selected from a bond, C 1-4 alkylene and C 2-4 alkenylene; 
         R 6  is selected from hydrogen, halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted C 1-6 alkyl, halo-substituted C 1-6 alkoxy, —XNR 8 R 9 , —XNR 8 XOR 9 , —XNR 8 NR 8 R 9 , —XOXNR 8 R 9 , —XNR 8 S(O) 2 R 9 , —XS(O) 2 R 9 , and —XC(O)OR 8 ; 
         R 8  and R 9  are independently selected from hydrogen, C 1-6 alkyl and C 2-6 alkenyl; or R 8  and R 9  together with the nitrogen atom to which both are attached form C 3-8 heterocycloalkyl or C 5-10 heteroaryl; and R 10  is selected from C 5-10 heteroaryl, C 3-8 heterocycloalkyl, C 3-12 cycloalkyl and phenyl; wherein said heteroaryl or heterocycloalkyl of R 10  or the combination of R 8  and R 9  and additionally the cycloalkyl or phenyl of R 10  is optionally substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, cyano-C 1-6  alkyl, nitro, C 1-6  alkyl, C 1-6  alkoxy, halo-substituted-C 1-6  alkyl, halo-substituted-C 1-6 alkoxy, hydroxy-substituted-C 1-6 alkyl, hydroxy-substituted-C 1-6  alkoxy, phenyl, —NR 8 R 8 , —S(O) 0-2 R 8  and —C(O)OR 8 ; wherein each R 8  is independently selected from hydrogen, C 1-6 alkyl and C 2-6 alkenyl; 
         and the pharmaceutically acceptable salts, hydrates, solvates and isomers thereof; with the proviso that compounds of Formula Ia do not include compounds of Formula II. 
       
     
     
         2 . The compound of  claim 1  in which:
 R 1  is selected from phenyl and cyclohexyl; wherein said phenyl and cyclohexyl are optionally substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, —NR 8 R 9 , —S(O) 2 R 8 , —C(O)OR 8  and R 10 ; wherein R 8  and R 9  are independently selected from hydrogen, C 1-6 alkyl and C 2-6 alkenyl; or R 8  and R 9  together with the nitrogen atom to which both are attached form C 3-8 heterocycloalkyl or C 5-10 heteroaryl; and R 10  is selected from C 5-10 heteroaryl, C 3-8 heterocycloalkyl, C 3-12 cycloalkyl and phenyl; wherein said phenyl of R 1  and heteroaryl or heterocycloalkyl of R 10  or the combination of R 8  and R 9  and additionally the cycloalkyl or phenyl of R 10  is optionally substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6  alkoxy, phenyl, —NR 8 R 8  and —C(O)OR 8 ; wherein each R 8  is independently selected from hydrogen, C 1-6 alkyl and C 2-6 alkenyl. 
 
     
     
         3 . The compound of  claim 2  in which:
 R 2  is selected from piperazinyl, morpholino, benzthiazolyl, pyridinyl, pyrazolyl, phenyl and phenoxy; wherein said piperazinyl, morpholino, benzthiazolyl, pyridinyl, pyrazolyl, phenyl or phenoxy is optionally substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted C 1-6 alkyl, halo-substituted C 1-6  alkoxy, —XNR 8 R 9 , —XOR 8 , —XC(O)R 8 , —XS(O) 0-2 R 8 , —XC(O)NR 8 R 9 , —XC(O)OR 8 , —XOR 10 , —XNR 8 R 10  and XR 10 ; wherein each X is independently selected from a bond, C 1-4 alkylene and C 2-4 alkenylene; and R 8  and R 9  are independently selected from hydrogen, C 1-6 alkyl and C 2-6 alkenyl; or R 8  and R 9  together with the nitrogen atom to which both are attached form C 3-8 heterocycloalkyl or C 5-10 heteroaryl; and R 10  is selected from C 5-10 heteroaryl, C 3-8 heterocycloalkyl, C 3-12 cycloalkyl and phenyl; wherein said heteroaryl or heterocycloalkyl of R 10  or the combination of R 8  and R 9  and additionally the cycloalkyl or phenyl of R 10  is optionally substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, cyano-C 1-6 alkyl, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, phenyl, —NR 8 R 8  and —C(O)OR 8 ; wherein each R 8  is independently selected from hydrogen, C 1-6 alkyl and C 2-6 alkenyl. 
 
     
     
         4 . The compound of  claim 3  in which:
 R 4  is selected from C 1-6 alkyl, phenyl, C 5-10 heteroaryl, C 3-8 heterocycloalkyl, C 3-8 heterocycloalkyl-carbonyl and C 3-12 cycloalkyl; wherein any phenyl, cycloalkyl, heteroaryl or heterocycloalkyl of R 4  can optionally be substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted C 1-6 alkyl, halo-substituted C 1-6 alkoxy, —XS(O) 0-2 R 8 , —XNR 8 R 9 , —XC(O)NR 8 R 9 , —XC(O)NR 8 R 10 , —XC(O)NR 8 XNR 8 R 9 , —XC(O)NR 8 XOR 9 , —XOR 8 , —XC(O)R 10  and —XC(O)OR 8 ; wherein each X is independently selected from a bond, C 1-4 alkylene and C 2-4 alkenylene; each R 8  is independently selected from hydrogen, C 1-6 alkyl and C 2-6 alkenyl; and R 10  is selected from C 5-10 heteroaryl, C 3-8 heterocycloalkyl, C 3-12 cycloalkyl and phenyl; wherein said heteroaryl or heterocycloalkyl of R 10  or the combination of R 8  and R 9  and additionally the cycloalkyl or phenyl of R 10  is optionally substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, cyano-C 1-6 alkyl, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, phenyl, —NR 8 R 8  and —C(O)OR 8 ; wherein each R 8  is independently selected from hydrogen, C 1-6 alkyl and C 2-6 alkenyl; and 
 R 5  is selected from ethoxy, chloro, hydroxy, dimethyl-amino, morpholino-ethoxy, methoxy, amino, hydroxy-ethoxy, dimethyl-amino-ethoxy, hydroxy-ethyl-amino, morpholino-propoxy and methyl-piperazinyl-ethoxy. 
 
     
     
         5 . The compound of  claim 4  of Formula Ia: 
       
         
           
           
               
               
           
         
         in which: 
         Y is O; and 
         R 3  is selected from hydrogen, cyano, halo, halo-substituted-C 1-6 alkyl, cyano-C 1-6 alkyl, C 1-6 alkyl, —XS(O) 0-2 R 9a , —XC(O)NR 8a R 9a , —XC(O)OR 8a , —XR 10  and —XC(O)R 10 ; wherein each R 8a  and R 9a  are independently selected from hydrogen and C 1-6 alkyl; or R 8a  and R 9a  together with the nitrogen atom to which both are attached form C 3-8 heterocycloalkyl or C 5-10 heteroaryl; and R 10  is selected from C 5-10 heteroaryl, C 3-8 heterocycloalkyl, C 3-12 cycloalkyl and phenyl; wherein said heteroaryl or heterocycloalkyl of R 10  or the combination of R 8a  and R 9a  and additionally the cycloalkyl or phenyl of R 10  is optionally substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, cyano-C 1-6 alkyl, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, phenyl, —NR 8a R 8a  and —C(O)OR 8a ; wherein each R 8a  is independently selected from hydrogen and C 1-6 alkyl. 
       
     
     
         6 . The compound of  claim 5  in which R 1  is selected from phenyl and cyclohexyl; wherein said phenyl and cyclohexyl is optionally substituted with 1 to 2 radicals independently selected from chloro, bromo, fluoro, methyl, cyano, methyl-sulfanyl, t-butyl, methoxy-carbonyl, butoxy, trifluoromethoxy, trifluoromethyl, methoxy, isopropyl, piperidinyl and phenyl optionally substituted with halo. 
     
     
         7 . The compound of  claim 6  in which R 2  is selected from piperazinyl, morpholino, pyridinyl, pyrazolyl, benzthiazolyl, phenyl and phenoxy; wherein said piperazinyl, morpholino, pyridinyl, pyrazolyl, benzthiazolyl, phenyl or phenoxy is optionally substituted with 1 to 2 radicals independently selected from: bromo; chloro; fluoro; iodo; hydroxy; isopropyl; methyl; cyclohexyl; oxazolyl; isoxazolyl optionally substituted with 1 to 2 methyl radicals; pyrazolidinyl; methyl-carbonyl; amino-carbonyl; morpholino; thienyl; furanyl; cyclohexyl-amino optionally substituted with an amino radical; methyl-sulfonyl; trichloromethyl; methoxy-carbonyl; chloro-methyl; butoxy-ethenyl; butoxy-ethyl; trifluoromethyl; trifluoromethoxy; ethoxy-carbonyl; t-butyl; amino-carbonyl; ethyl; propyl; methoxy; methoxy-methyl; carboxy; piperidinyl; piperidinyl-methyl; morpholino-methyl; diethyl-amino-methyl; isobutyl-amino-methyl; cyclopropyl-methyl-amino-methyl; isopropoxy-methyl; ethenyl; cyclopropyl; butoxy; [1,2,4]oxadiazol-5-yl optionally substituted with methyl; piperazinyl optionally substituted with 1 to 2 radicals independently selected from methyl, isopropyl and methyl-sulfonyl; 2-oxo-piperidin-1-yl; 2-oxo-pyrrolidin-1-yl; 2H-[1,2,4]triazol-3-yl; 1-methyl-1H-[1,2,4]triazol-3-yl; pyrazolyl optionally substituted with methyl; pyridazinyl; pyrazinyl optionally substituted with 1 to 2 radicals independently selected from cyano and methyl; pyridinyl optionally substituted with 1 to 2 radicals independently selected from halo, methyl and amino; pyridinyl-N-oxide optionally substituted with methyl; pyrimidinyl optionally substituted with 1 to 2 radicals independently selected from halo, methyl and amino; phenyl optionally substituted with 1 to 2 radicals independently selected from halo, methyl and trifluoromethyl; imidazolyl optionally substituted with 1 to 2 radicals independently selected from methyl, ethyl and cyano-methyl; and 6-oxo-1,6-dihydro-pyridin-3-yl. 
     
     
         8 . The compound of  claim 7  in which R 3  is selected from hydrogen, methyl, methyl-sulfonyl, t-butoxy-carbonyl-methyl, amino-carbonyl-methyl, methyl-[1,2,4]oxadiazolyl, cyano-methyl, carboxy, ethoxy-carbonyl, methyl-amino-carbonyl, dimethyl-amino-carbonyl, benzyl, furanyl, pyridinyl, indolyl, morpholino-carbonyl, piperidinyl-amino-carbonyl, piperidinyl-carbonyl, isopropoxy-carbonyl, amino-carbonyl, methyl-sulfanyl, methyl-amino-carbonyl, cyano, methyl-sulfonyl, methyl-piperazinyl, benzyl and phenyl optionally substituted with 1 to 2 radicals independently selected from methyl, methoxy, fluoro, chloro, bromo, iodo, cyano, nitro, hydroxy-methyl, ethoxy-carbonyl, methyl-sulfonyl, dimethyl-amino, methyl-amino, cyclopropyl-aminocarbonyl, isopropoxy, trifluoromethyl and trifluoromethoxy. 
     
     
         9 . The compound of  claim 8  in which R 4  is methyl, hydroxy-ethyl, t-butyl, phenyl, benzyl, cyclohexyl, cyclopropyl, pyridinyl, furanyl, morpholino-carbonyl, tetrahydro-thiopyranyl, tetrahydro-thiopyranyl 1,1-dioxide and quinolinyl; wherein said phenyl, benzyl, cyclohexyl, cyclopropyl, pyridinyl, furanyl, morpholino-carbonyl, tetrahydro-thiopyranyl, tetrahydro-thiopyranyl 1,1-dioxide and quinolinyl of R 4  is optionally substituted with 1 to 2 radicals independently selected from methyl, cyano, carboxy, aminocarbonyl, methoxy, trifluoromethyl, isopropoxy, methyl-sulfanyl, dimethyl-amino, ethoxy-carbonyl, trifluoromethoxy, cyclopropyl-aminocarbonyl, pyridinyl-aminocarbonyl, cyclohexyl-aminocarbonyl, isoxazolyl-aminocarbonyl, dimethylamino-ethyl-aminocarbonyl, methoxy-ethyl-aminocarbonyl, nitro, amino, fluoro, chloro, bromo, hydroxymethyl, methyl-piperazinyl-carbonyl, morpholino-carbonyl and piperidinyl-carbonyl. 
     
     
         10 . The compound of  claim 4  of Formula Ic: 
       
         
           
           
               
               
           
         
         in which: 
         Y is O; and R 6  is selected from hydrogen, halo, cyano, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted C 1-6 alkyl, —XNR 8 R 9 , —XNR 8 S(O) 2 R 9 , —XR 10 , —XOXNR 8 R 9  and —XNR 8 NR 8 R 9 ; wherein each X is independently selected from a bond, C 1-4 alkylene and C 2-4 alkenylene; each R 8  is independently selected from hydrogen, C 1-6 alkyl and C 2-6 alkenyl; and R 10  is selected from C 5-10 heteroaryl, C 3-8 heterocycloalkyl, C 3-12 cycloalkyl and phenyl; wherein said heteroaryl or heterocycloalkyl of R 10  or the combination of R 8  and R 9  and additionally the cycloalkyl or phenyl of R 10  is optionally substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, cyano-C 1-6 alkyl, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, phenyl, —NR 8 R 8  and —C(O)OR 8 ; wherein each R 8  is independently selected from hydrogen, C 1-6 alkyl and C 2-6 alkenyl. 
       
     
     
         11 . The compound of  claim 10  in which R 1  is selected from phenyl and cyclohexyl; wherein said phenyl and cyclohexyl is optionally substituted with 1 to 2 radicals independently selected from chloro, bromo, fluoro, methyl, cyano, methyl-sulfanyl, t-butyl, methoxy-carbonyl, butoxy, trifluoromethoxy, trifluoromethyl, methoxy, isopropyl, piperidinyl and phenyl optionally substituted with halo. 
     
     
         12 . The compound of  claim 11  in which R 2  is selected from piperazinyl, morpholino, pyridinyl, pyrazolyl, benzthiazolyl, phenyl and phenoxy; wherein said piperazinyl, morpholino, pyridinyl, pyrazolyl, benzthiazolyl, phenyl or phenoxy is optionally substituted with 1 to 2 radicals independently selected from: bromo; chloro; fluoro; iodo; hydroxy; isopropyl; methyl; cyclohexyl; oxazolyl; isoxazolyl optionally substituted with 1 to 2 methyl radicals; pyrazolidinyl; methyl-carbonyl; amino-carbonyl; morpholino; thienyl; furanyl; cyclohexyl-amino optionally substituted with an amino radical; methyl-sulfonyl; trichloromethyl; methoxy-carbonyl; chloro-methyl; butoxy-ethenyl; butoxy-ethyl; trifluoromethyl; trifluoromethoxy; ethoxy-carbonyl; t-butyl; amino-carbonyl; ethyl; propyl; methoxy; methoxy-methyl; carboxy; piperidinyl; piperidinyl-methyl; morpholino-methyl; diethyl-amino-methyl; isobutyl-amino-methyl; cyclopropyl-methyl-amino-methyl; isopropoxy-methyl; ethenyl; cyclopropyl; butoxy; [1,2,4]oxadiazol-5-yl optionally substituted with methyl; piperazinyl optionally substituted with 1 to 2 radicals independently selected from methyl, isopropyl and methyl-sulfonyl; 2-oxo-piperidin-1-yl; 2-oxo-pyrrolidin-1-yl; 2H-[1,2,4]triazol-3-yl; 1-methyl-1H-[1,2,4]triazol-3-yl; pyrazolyl optionally substituted with methyl; pyridazinyl; pyrazinyl optionally substituted with 1 to 2 radicals independently selected from cyano and methyl; pyridinyl optionally substituted with 1 to 2 radicals independently selected from halo, methyl and amino; pyridinyl-N-oxide optionally substituted with methyl; pyrimidinyl optionally substituted with 1 to 2 radicals independently selected from halo, methyl and amino; phenyl optionally substituted with 1 to 2 radicals independently selected from halo, methyl and trifluoromethyl; imidazolyl optionally substituted with 1 to 2 radicals independently selected from methyl, ethyl and cyano-methyl; and 6-oxo-1,6-dihydro-pyridin-3-yl. 
     
     
         13 . The compound of  claim 12  in which R 4  is methyl, hydroxy-ethyl, t-butyl, phenyl, benzyl, cyclohexyl, cyclopropyl, pyridinyl, furanyl, morpholino-carbonyl, tetrahydro-thiopyranyl, tetrahydro-thiopyranyl 1,1-dioxide and quinolinyl; wherein said phenyl, benzyl, cyclohexyl, cyclopropyl, pyridinyl, furanyl, morpholino-carbonyl, tetrahydro-thiopyranyl, tetrahydro-thiopyranyl 1,1-dioxide and quinolinyl of R 4  is optionally substituted with 1 to 2 radicals independently selected from methyl, cyano, carboxy, aminocarbonyl, methoxy, trifluoromethyl, isopropoxy, methyl-sulfanyl, dimethyl-amino, ethoxy-carbonyl, trifluoromethoxy, cyclopropyl-aminocarbonyl, pyridinyl-aminocarbonyl, cyclohexyl-aminocarbonyl, isoxazolyl-aminocarbonyl, dimethylamino-ethyl-aminocarbonyl, methoxy-ethyl-aminocarbonyl, nitro, amino, fluoro, chloro, bromo, hydroxymethyl, methyl-piperazinyl-carbonyl, morpholino-carbonyl and piperidinyl-carbonyl. 
     
     
         14 . The compound of  claim 13  in which R 6  is selected from methyl-sulfonyl-aminomethyl, bromomethyl, methyl-sulfonyl-methyl, ethyl(methyl)amino, dimethylamino, methyl, ethyl, cyano, bromo, chloro, fluoro, morpholino, methyl-piperazinyl, dimethyl-amino-ethoxy, methyl-amino-amino and hydroxyethyl(methyl)amino and methoxy. 
     
     
         15 . The compound of  claim 4  selected from Formula Ie, Ig and Ih: 
       
         
           
           
               
               
           
         
         in which: Y is O; and R 6  is selected from hydrogen, halo, cyano, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted C 1-6 alkyl, —XNR 8 R 9 , —XNR 8 S(O) 2 R 9 , —XR 10 , —XOXNR 8 R 9  and —XNR 8 NR 8 R 9 ; wherein each X is independently selected from a bond and C 1-4 alkylene; each R 8  and R 9  are independently selected from hydrogen, C 1-6 alkyl and C 2-6 alkenyl; and R 10  is selected from C 5-10 heteroaryl, C 3-8 heterocycloalkyl, C 3-12 cycloalkyl and phenyl; wherein said heteroaryl or heterocycloalkyl of R 10  or the combination of R 8  and R 9  and additionally the cycloalkyl or phenyl of R 10  is optionally substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, cyano-C 1-6 alkyl, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, phenyl, —NR 8 R 8  and —C(O)OR 8 ; wherein each R 8  is independently selected from hydrogen, C 1-6 alkyl and C 2-6 alkenyl. 
       
     
     
         16 . The compound of  claim 15  in which R 1  is selected from phenyl and cyclohexyl; wherein said phenyl and cyclohexyl is optionally substituted with 1 to 2 radicals independently selected from chloro, bromo, fluoro, methyl, cyano, methyl-sulfanyl, t-butyl, methoxy-carbonyl, butoxy, trifluoromethoxy, trifluoromethyl, methoxy, isopropyl, piperidinyl and phenyl optionally substituted with halo. 
     
     
         17 . The compound of  claim 16  in which R 2  is selected from piperazinyl, morpholino, pyridinyl, pyrazolyl, benzthiazolyl, phenyl and phenoxy; wherein said piperazinyl, morpholino, pyridinyl, pyrazolyl, benzthiazolyl, phenyl or phenoxy is optionally substituted with 1 to 2 radicals independently selected from: bromo; chloro; fluoro; iodo; hydroxy; isopropyl; methyl; cyclohexyl; oxazolyl; isoxazolyl optionally substituted with 1 to 2 methyl radicals; pyrazolidinyl; methyl-carbonyl; amino-carbonyl; morpholino; thienyl; furanyl; cyclohexyl-amino optionally substituted with an amino radical; methyl-sulfonyl; trichloromethyl; methoxy-carbonyl; chloro-methyl; butoxy-ethenyl; butoxy-ethyl; trifluoromethyl; trifluoromethoxy; ethoxy-carbonyl; t-butyl; amino-carbonyl; ethyl; propyl; methoxy; methoxy-methyl; carboxy; piperidinyl; piperidinyl-methyl; morpholino-methyl; diethyl-amino-methyl; isobutyl-amino-methyl; cyclopropyl-methyl-amino-methyl; isopropoxy-methyl; ethenyl; cyclopropyl; butoxy; [1,2,4]oxadiazol-5-yl optionally substituted with methyl; piperazinyl optionally substituted with 1 to 2 radicals independently selected from methyl, isopropyl and methyl-sulfonyl; 2-oxo-piperidin-1-yl; 2-oxo-pyrrolidin-1-yl; 2H-[1,2,4]triazol-3-yl; 1-methyl-1H-[1,2,4]triazol-3-yl; pyrazolyl optionally substituted with methyl; pyridazinyl; pyrazinyl optionally substituted with 1 to 2 radicals independently selected from cyano and methyl; pyridinyl optionally substituted with 1 to 2 radicals independently selected from halo, methyl and amino; pyridinyl-N-oxide optionally substituted with methyl; pyrimidinyl optionally substituted with 1 to 2 radicals independently selected from halo, methyl and amino; phenyl optionally substituted with 1 to 2 radicals independently selected from halo, methyl and trifluoromethyl; imidazolyl optionally substituted with 1 to 2 radicals independently selected from methyl, ethyl and cyano-methyl; and 6-oxo-1,6-dihydro-pyridin-3-yl. 
     
     
         18 . The compound of  claim 17  in which R 3  is selected from hydrogen, methyl, methyl-sulfonyl, t-butoxy-carbonyl-methyl, amino-carbonyl-methyl, methyl-[1,2,4]oxadiazolyl, cyano-methyl, carboxy, ethoxy-carbonyl, methyl-amino-carbonyl, dimethyl-amino-carbonyl, benzyl, furanyl, pyridinyl, indolyl, morpholino-carbonyl, piperidinyl-amino-carbonyl, piperidinyl-carbonyl, isopropoxy-carbonyl, amino-carbonyl, methyl-sulfanyl, methyl-amino-carbonyl, cyano, methyl-sulfonyl, methyl-piperazinyl, benzyl and phenyl optionally substituted with 1 to 2 radicals independently selected from methyl, methoxy, fluoro, chloro, bromo, iodo, cyano, nitro, hydroxy-methyl, ethoxy-carbonyl, methyl-sulfonyl, dimethyl-amino, methyl-amino, cyclopropyl-aminocarbonyl, isopropoxy, trifluoromethyl and trifluoromethoxy. 
     
     
         19 . The compound of  claim 18  in which R 4  is methyl, hydroxy-ethyl, t-butyl, phenyl, benzyl, cyclohexyl, cyclopropyl, pyridinyl, furanyl, morpholino-carbonyl, tetrahydro-thiopyranyl, tetrahydro-thiopyranyl 1,1-dioxide and quinolinyl; wherein said phenyl, benzyl, cyclohexyl, cyclopropyl, pyridinyl, furanyl, morpholino-carbonyl, tetrahydro-thiopyranyl, tetrahydro-thiopyranyl 1,1-dioxide and quinolinyl of R 4  is optionally substituted with 1 to 2 radicals independently selected from methyl, cyano, carboxy, aminocarbonyl, methoxy, trifluoromethyl, isopropoxy, methyl-sulfanyl, dimethyl-amino, ethoxy-carbonyl, trifluoromethoxy, cyclopropyl-aminocarbonyl, pyridinyl-aminocarbonyl, cyclohexyl-aminocarbonyl, isoxazolyl-aminocarbonyl, dimethylamino-ethyl-aminocarbonyl, methoxy-ethyl-aminocarbonyl, nitro, amino, fluoro, chloro, bromo, hydroxymethyl, methyl-piperazinyl-carbonyl, morpholino-carbonyl and piperidinyl-carbonyl. 
     
     
         20 . The compound of  claim 19  in which R 6  is selected from methyl-sulfonyl-aminomethyl, bromomethyl, methyl-sulfonyl-methyl, ethyl(methyl)amino, dimethylamino, methyl, ethyl, cyano, bromo, chloro, fluoro, morpholino, methyl-piperazinyl, dimethyl-amino-ethoxy, methyl-amino-amino and hydroxyethyl(methyl)amino and methoxy. 
     
     
         21 . The compound of  claim 1  selected from: 5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-bromo-phenyl)-1-phenyl-6-p-tolyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-chloro-phenyl)-6-(2,4-dichloro-phenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridin-4-ylamine; 5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine; 5-(4-chloro-phenyl)-6-(2,4-dichloro-phenyl)-4-ethoxy-1-phenyl-1H-pyrazolo[3,4-b]pyridine; 5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-1-(4-nitro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-1-(2-nitro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 1-(4-Amino-phenyl)-5-(4-chloro-phenyl)-6-(2,4-dichloro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Bromo-phenyl)-6-(2-fluoro-phenyl)-1-quinolin-2-yl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-bromo-phenyl)-6-(4-fluoro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Bromo-phenyl)-1-pyridin-2-yl-6-o-tolyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Bromo-phenyl)-6-(2-fluoro-phenyl)-1-(2-hydroxy-ethyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(2,4-Dichloro-phenyl)-6-(2-fluoro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Bromo-phenyl)-6-(2,4-dichloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-(2,4-Dichloro-phenyl)-5-(4-fluoro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-(4-Chloro-phenyl)-5-(2,4-dichloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-2-fluoro-phenyl)-6-(4-chloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-(4-Chloro-phenyl)-5-(2,4-difluoro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-bromo-phenyl)-6-(2-chloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-bromo-phenyl)-6-(3-chloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-bromo-phenyl)-6-(2-bromo-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-bromo-phenyl)-6-(2,4-difluoro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-biphenyl-4-yl-5-(4-bromo-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-bromo-phenyl)-6-(3,4-dichloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-(4-Chloro-phenyl)-1,5-diphenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-bromo-phenyl)-6-(2-fluoro-phenyl)-1-pyridin-2-yl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-bromo-phenyl)-1-phenyl-6-o-tolyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-bromo-phenyl)-6-(3-fluoro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-bromo-phenyl)-1-cyclohexyl-6-(2-fluoro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Bromo-phenyl)-1-tert-butyl-6-(2-fluoro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Bromo-phenyl)-6-(2-fluoro-phenyl)-1-(4-methoxy-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-4-methoxy-1-phenyl-1H-pyrazolo[3,4-b]pyridine; 5-(4-Bromo-phenyl)-1-(3-fluoro-phenyl)-6-(2-fluoro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 4-[5-(4-Bromo-phenyl)-6-(2-fluoro-phenyl)-4-oxo-4,5-dihydro-pyrazolo[3,4-d]pyrimidin-1-yl]-benzonitrile; 5-(4-Bromo-phenyl)-6-(2-fluoro-phenyl)-1-m-tolyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Bromo-phenyl)-6-(2-fluoro-phenyl)-1-(4-trifluoromethyl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-bromo-phenyl)-6-(4-methoxy-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-bromo-phenyl)-1-phenyl-6-(4-trifluoromethoxy-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-bromo-phenyl)-6-(4-tert-butyl-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-bromo-phenyl)-1-phenyl-6-(2-trifluoromethyl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-bromo-phenyl)-6-(2,6-difluoro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-bromo-phenyl)-6-(2,6-dichloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-bromo-phenyl)-1-phenyl-6-(2,4,6-trifluoro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-bromo-phenyl)-6-(2-methoxy-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-bromo-phenyl)-1-phenyl-6-(4-trifluoromethyl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-biphenyl-4-yl-5-(4-chloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 1-(4-Bromo-phenyl)-2-(2-fluoro-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 4-[6-(2-Fluoro-phenyl)-4-oxo-1-phenyl-1,4-dihydro-pyrazolo[3,4-d]pyrimidin-5-yl]-benzonitrile; 6-(2-Fluoro-phenyl)-5-(4-methylsulfanyl-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-tert-Butyl-phenyl)-6-(2-fluoro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 4-[6-(2-Fluoro-phenyl)-4-oxo-1-phenyl-1,4-dihydro-pyrazolo[3,4-d]pyrimidin-5-yl]-benzoic acid methyl ester; 5-(4-Butoxy-phenyl)-6-(2-fluoro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-Biphenyl-4-yl-6-(2-fluoro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-(2-Fluoro-phenyl)-1-phenyl-5-(4-trifluoromethoxy-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-(2-Fluoro-phenyl)-1-phenyl-5-(4-trifluoromethyl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-Benzyl-6-(2-fluoro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-Cyclohexyl-6-(2-fluoro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Bromo-phenyl)-6-(2-fluoro-phenyl)-1-methyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 4-Chloro-5-(4-chloro-phenyl)-6-(2,4-dichloro-phenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine; 5,6-Bis-(4-chloro-phenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridin-4-ol; 5,6-Bis-(4-chloro-phenyl)-4-methoxy-1-phenyl-1H-pyrazolo[3,4-b]pyridine; 6-(4-Chloro-phenyl)-5-(2,4-dichloro-phenyl)-3-phenyl-3H-imidazol-4,5-b]pyridin-7-ylamine; 1-(4-Bromo-phenyl)-2-(2,4-dichloro-phenyl)-9-p-tolyl-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-2-(2,4-dichloro-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-2-(4-chloro-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-2-(3,4-dichloro-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-9-phenyl-2-p-tolyl-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-9-phenyl-2-(4-trifluoromethyl-phenyl)-1,9-dihydro-purin-6-one; 5-(4-bromo-phenyl)-6-(2-fluoro-phenyl)-1-(morpholine-4-carbonyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5,6-Bis-(4-chloro-phenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyrazine; 2-[5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yloxy]-ethanol; 5-(4-Bromo-phenyl)-6-(2-fluoro-phenyl)-1-(tetrahydro-thiopyran-4-yl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; [5,6-Bis-(4-chloro-phenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl]-dimethyl-amine; 5-(4-Bromo-phenyl)-1-(1,1-dioxo-hexahydro-1λ 6 -thiopyran-4-yl)-6-(2-fluoro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-[4-(3-methyl-[1,2,4]oxadiazol-5-yl)-phenyl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(4-isoxazol-5-yl-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-1-phenyl-6-[4-(2H-pyrazol-3-yl)-phenyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-(4-Acetyl-phenyl)-5-(4-chloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 4-[5-(4-Chloro-phenyl)-4-oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-benzamide; 6-[4-(2-Amino-pyrimidin-4-yl)-phenyl]-5-(4-chloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-1-phenyl-6-(4-pyrimidin-4-yl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-[4-(2-methyl-pyrimidin-4-yl)-phenyl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-1-phenyl-6-[4-(2H-[1,2,4]triazol-3-yl)-phenyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(4-[1,2,4]oxadiazol-5-yl-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-Biphenyl-4-yl-5-(4-chloro-phenyl)-4-oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine-3-carboxylic acid amide; 6-Biphenyl-4-yl-5-(4-chloro-phenyl)-4-oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine-3-carboxylic acid ethyl ester; 5-(4-chloro-phenyl)-6-(3′-fluoro-biphenyl-4-yl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-chloro-phenyl)-6-(4-morpholin-4-yl-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-chloro-phenyl)-6-(4-imidazol-1-yl-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-chloro-phenyl)-1-phenyl-6-(4-pyridin-2-yl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-chloro-phenyl)-1-phenyl-6-(4-phenyl-piperazin-1-yl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-benzothiazol-2-yl-5-(4-chloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-chloro-phenyl)-1-phenyl-6-p-tolyloxy-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-(4-bromo-phenyl)-3-phenyl-5-p-tolyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one; 1-(4-Chloro-phenyl)-2-(4-isopropyl-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(4-methoxymethyl-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 5-(4-Bromo-phenyl)-1-phenyl-6-pyridin-3-yl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-(2-Fluoro-phenyl)-1-phenyl-5-pyridin-3-yl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Bromo-phenyl)-6-(2-fluoro-phenyl)-1-(tetrahydro-pyran-4-yl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(4-iodo-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(4′-fluoro-biphenyl-4-yl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(2′-fluoro-biphenyl-4-yl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-(2-Fluoro-phenyl)-1-phenyl-5-(4-piperidin-1-yl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-1-phenyl-6-(4′-trifluoromethyl-biphenyl-4-yl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-1-phenyl-6-(4-thiophen-3-yl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-[4-(4-methyl-piperazin-1-yl)-phenyl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; {2-[5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yloxy]-ethyl}-dimethyl-amine; 2-[5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridin-4-ylamino]-ethanol; 5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-4-(3-morpholin-4-yl-propoxy)-1-phenyl-1H-pyrazolo[3,4-b]pyridine; 5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-4-[2-(4-methyl-piperazin-1-yl)-ethoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine; 5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-4-(2-morpholin-4-yl-ethoxy)-1-phenyl-1H-pyrazolo[3,4-b]pyridine; 1-(4-Chloro-phenyl)-9-phenyl-2-(4-pyridin-2-yl-phenyl)-1,9-dihydro-purin-6-one; 5-(4-Chloro-phenyl)-1-phenyl-6-(4-piperidin-1-yl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-(4-Bromo-phenyl)-5-(4-chloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(4-phenoxy-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Bromo-phenyl)-1-phenyl-6-(4-phenyl-piperazin-1-yl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Bromo-phenyl)-6-[4-(4-fluoro-phenyl)-piperazin-1-yl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-(4-Bromo-2-fluoro-phenyl)-5-(4-chloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-(4-Bromo-2-chloro-phenyl)-5-(4-chloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(2-fluoro-4-morpholin-4-yl-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-(2-Chloro-4-morpholin-4-yl-phenyl)-5-(4-chloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(3-fluoro-biphenyl-4-yl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-(3-Chloro-biphenyl-4-yl)-5-(4-chloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(4-furan-3-yl-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-1-phenyl-6-(4-pyridin-3-yl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-1-phenyl-6-(4-pyridin-4-yl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-[4-(3,5-dimethyl-isoxazol-4-yl)-phenyl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-Biphenyl-4-yl-5 (4-chloro-phenyl)-1-(tetrahydro-pyran-4-yl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-[1-(3-fluoro-phenyl)-1H-pyrazol-4-yl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 4-[5-(4-Chloro-phenyl)-4-oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-benzoic acid methyl ester; 5-(4-Bromo-phenyl)-6-morpholin-4-yl-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Bromo-phenyl)-6-(4-isopropyl-piperazin-1-yl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-1-phenyl-6-(4-pyrazol-1-yl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-[4-(2-amino-cyclohexylamino)-phenyl]-5-(4-chloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-(4-Bromo-3-fluoro-phenyl)-5-(4-chloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 4-[5-(4-Chloro-phenyl)-4-oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-benzoic acid ethyl ester; 5-(4-Chloro-phenyl)-6-(2-fluoro-biphenyl-4-yl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(3-fluoro-4-morpholin-4-yl-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-[3-fluoro-4-(4-methyl-piperazin-1-yl)-phenyl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-[3-fluoro-4-(4-isopropyl-piperazin-1-yl)-phenyl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(2′-methyl-biphenyl-4-yl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(3′-methyl-biphenyl-4-yl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(4′-methyl-biphenyl-4-yl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-[2-fluoro-4-(4-methyl-piperazin-1-yl)-phenyl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-[2-fluoro-4-(4-isopropyl-piperazin-1-yl)-phenyl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-[2-Chloro-4-(4-methyl-piperazin-1-yl)-phenyl]-5-(4-chloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-[2-Chloro-4-(4-isopropyl-piperazin-1-yl)-phenyl]-5-(4-chloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-1-phenyl-6-o-tolyloxy-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-1-phenyl-6-m-tolyloxy-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-1-phenyl-6-p-tolyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-1-phenyl-6-(4-trifluoromethyl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(4-methanesulfonyl-piperazin-1-yl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 7-Benzyl-1-(4-chloro-phenyl)-2-(2,4-dichloro-phenyl)-1,7-dihydro-purin-6-one; 9-Benzyl-1-(4-chloro-phenyl)-2-(2,4-dichloro-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-2-(2,4-dichloro-phenyl)-7-phenyl-1,7-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-9-cyclopropyl-2-(2,4-dichloro-phenyl)-1,9-dihydro-purin-6-one; 3-[1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-6-oxo-1,6-dihydro-purin-7-yl]-benzonitrile; 1-(4-Chloro-phenyl)-9-phenyl-2-(4-thiophen-3-yl-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-2-(2,4-dichloro-phenyl)-8-methyl-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-8-ethyl-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-9-phenyl-2-(4-pyridin-4-yl-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-2-(2-fluoro-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-Biphenyl-4-yl-2-(4-chloro-phenyl)-7-phenyl-1,7-dihydro-purin-6-one; 1,2-Bis-(4-chloro-phenyl)-7-phenyl-1,7-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-2-(2,4-dichloro-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 2-Biphenyl-4-yl-1-(4-chloro-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 4-[1-(4-Bromo-phenyl)-2-(2,4-dichloro-phenyl)-6-oxo-1,6-dihydro-purin-9-yl]-benzonitrile; 1-(4-Bromo-phenyl)-9-phenyl-2-(2-trifluoromethyl-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-9-phenyl-2-m-tolyl-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-9-phenyl-2-o-tolyl-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-2-(4-methoxy-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-2-(2,3-difluoro-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-2-(4-fluoro-3-methyl-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-7-(3-nitro-phenyl)-1,7-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-7-furan-3-yl-1,7-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-9-(2-trifluoromethyl-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-9-(3,5-difluoro-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-9-(2-isopropoxy-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-7-(3-trifluoromethoxy-phenyl)-1,7-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-7-(3,5-dimethyl-phenyl)-1,7-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-9-(3-trifluoromethoxy-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-9-(3,5-dimethyl-phenyl)-1,9-dihydro-purin-6-one; 2-(4-Bromo-phenyl)-1-(2,4-dichloro-phenyl)-7-phenyl-1,7-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-9-(3-nitro-phenyl)-1,9-dihydro-purin-6-one; 3-[1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-6-oxo-1,6-dihydro-purin-9-yl]-benzonitrile; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-9-furan-3-yl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-7-(3,5-difluoro-phenyl)-1,7-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-9-(2-methoxy-5-methyl-phenyl)-1,9-dihydro-purin-6-one; 2-(4-Chloro-phenyl)-1-(2-fluoro-phenyl)-7-phenyl-1,7-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-7-(5-fluoro-2-methoxy-phenyl)-1,7-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-7-(2-trifluoromethyl-phenyl)-1,7-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-2-(4-tert-butyl-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-2-(3-fluoro-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(4-iodo-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(3′,5′-difluoro-biphenyl-4-yl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2′-fluoro-biphenyl-4-yl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(3′-fluoro-biphenyl-4-yl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(4′-fluoro-biphenyl-4-yl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-7-pyridin-3-yl-1,7-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-9-pyridin-3-yl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-7-pyridin-4-yl-1,7-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-7-(2-fluoro-phenyl)-1,7-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-9-(2-fluoro-phenyl)-1,9-dihydro-purin-6-one; 2-[1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-6-oxo-1,6-dihydro-purin-7-yl]-indole-1-carboxylic acid tert-butyl ester; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-7-(4-hydroxymethyl-phenyl)-1,7-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-9-(4-hydroxymethyl-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-7-(2,5-difluoro-phenyl)-1,7-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-9-(2,5-difluoro-phenyl)-1,9-dihydro-purin-6-one; 7-(5-Chloro-2-methyl-phenyl)-1-(4-chloro-phenyl)-2-(2,4-dichloro-phenyl)-1,7-dihydro-purin-6-one; 9-(5-Chloro-2-methyl-phenyl)-1-(4-chloro-phenyl)-2-(2,4-dichloro-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-7-(2,5-dichloro-phenyl)-1,7-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-9-(2,5-dichloro-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-7-(2-nitro-phenyl)-1,7-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-9-(2-nitro-phenyl)-1,9-dihydro-purin-6-one; 3-[1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-6-oxo-1,6-dihydro-purin-7-yl]-benzoic acid ethyl ester; 3-[1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-6-oxo-1,6-dihydro-purin-9-yl]-benzoic acid ethyl ester; 4-[1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-6-oxo-1,6-dihydro-purin-7-yl]-N-cyclopropyl-benzamide; 4-[1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-6-oxo-1,6-dihydro-purin-9-yl]-N-cyclopropyl-benzamide; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-7-(4-fluoro-2-methyl-phenyl)-1,7-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-9-(5-fluoro-2-methyl-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-7-(3-methoxy-phenyl)-1,7-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-9-(3-methoxy-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-7-(4-methanesulfonyl-phenyl)-1,7-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-9-(4-methanesulfonyl-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-7-(4-dimethylamino-phenyl)-1,7-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-9-(4-dimethylamino-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-7-(2-chloro-phenyl)-2-(2,4-dichloro-phenyl)-1,7-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-7-(2,5-dimethyl-phenyl)-1,7-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-9-(2,5-dimethyl-phenyl)-1,9-dihydro-purin-6-one; 4-[1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-6-oxo-1,6-dihydro-purin-7-yl]-benzoic acid ethyl ester; 4-[1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-6-oxo-1,6-dihydro-purin-9-yl]-benzoic acid ethyl ester; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-7-(4-methylamino-phenyl)-1,7-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-8-methyl-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-2-(3-fluoro-4-trifluoromethyl-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-2-(4-ethyl-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-2-(2,4-dichloro-phenyl)-8-ethyl-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-9-phenyl-2-(4-propyl-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-2-(2,4-dichloro-phenyl)-9-(3-trifluoromethoxy-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-9-(2-methoxy-5-methyl-phenyl)-2-p-tolyl-1,9-dihydro-purin-6-one; 3-[1-(4-Bromo-phenyl)-6-oxo-2-p-tolyl-1,6-dihydro-purin-9-yl]-benzonitrile; 3-[1-(4-Bromo-phenyl)-2-(2,4-dichloro-phenyl)-6-oxo-1,6-dihydro-purin-9-yl]-benzonitrile; 1-(4-Bromo-phenyl)-8-ethyl-9-phenyl-2-(4-propyl-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-8-ethyl-2-(4-ethyl-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-8-ethyl-9-phenyl-2-(4-trifluoromethyl-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-2-(2,4-dichloro-phenyl)-9-(2-methoxy-5-methyl-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-8-ethyl-9-phenyl-2-p-tolyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2-fluoro-4-methyl-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2-fluoro-4-trifluoromethyl-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dimethyl-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 2-(4-Chloro-2-fluoro-phenyl)-1-(4-chloro-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-9-phenyl-2-(4-trifluoromethyl-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-9-phenyl-2-p-tolyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-9-phenyl-2-(4-propyl-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(4-ethyl-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 4-[1-(4-Chloro-phenyl)-6-oxo-9-phenyl-6,9-dihydro-1H-purin-2-yl]-benzoic acid methyl ester; 2-Biphenyl-4-yl-1-(4-chloro-phenyl)-8-ethyl-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(4-isobutyl-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-9-phenyl-2-(4-pyridin-3-yl-phenyl)-1,9-dihydro-purin-6-one; 5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-1-(2-nitro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 1-(4-Amino-phenyl)-5-(4-chloro-phenyl)-6-(2,4-dichloro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5,6-Bis-(4-chloro-phenyl)-1-(4-nitro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5,6-Bis-(4-chloro-phenyl)-1-(2-nitro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 1-(4-Amino-phenyl)-5,6-bis-(4-chloro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-1-(4-fluoro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-3-(4-methyl-piperazin-1-yl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Bromo-phenyl)-6-(2,4-dichloro-phenyl)-3-methylsulfanyl-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Bromo-phenyl)-6-(2,4-dichloro-phenyl)-3-methanesulfonyl-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 4-[5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-4-oxo-4,5-dihydro-pyrazolo[3,4-d]pyrimidin-1-yl]-benzoic acid; 5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-1-(4-hydroxymethyl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-1-[4-(morpholine-4-carbonyl)-phenyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-1-[4-(piperidine-1-carbonyl)-phenyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-1-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-3-methylsulfanyl-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-3-methanesulfonyl-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 1-(4-Chloro-phenyl)-8-(ethyl-methyl-amino)-9-phenyl-2-(4-trifluoromethyl-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-8-dimethylamino-9-phenyl-2-(4-trifluoromethyl-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-6-oxo-9-phenyl-2-(4-trifluoromethyl-phenyl)-6,9-dihydro-1H-purine-8-carbonitrile; 8-Bromo-1-(4-chloro-phenyl)-2-(2,4-dichloro-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-8-(ethyl-methyl-amino)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-8-morpholin-4-yl-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-8-(4-methyl-piperazin-1-yl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-8-(2-dimethylamino-ethoxy)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-8-(N′-methyl-hydrazino)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-8-[(2-hydroxy-ethyl)-methyl-amino]-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-8-methoxy-9-phenyl-1,9-dihydro-purin-6-one; 8-Bromo-2-(4-bromo-phenyl)-1-(4-chloro-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 5-(4-chloro-phenyl)-1-phenyl-6-(4-pyridin-2-yl-piperazin-1-yl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-chloro-phenyl)-1-phenyl-6-(4-pyridin-4-yl-piperazin-1-yl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-biphenyl-4-yl-6-(4-chloro-phenyl)-3-phenyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one; 6-(4-chloro-phenyl)-5-(4-isopropyl-phenyl)-3-phenyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one; 6-(4-bromo-phenyl)-2-methyl-3-phenyl-5-p-tolyl-2,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one; 6-(4-bromo-phenyl)-1-methyl-3-phenyl-5-p-tolyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one; 6-(4-chloro-phenyl)-5-(4-isopropyl-phenyl)-1-methanesulfonyl-3-phenyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one; 6-(4-chloro-phenyl)-5-(4-isopropyl-phenyl)-7-oxo-3-phenyl-6,7-dihydro-pyrazolo[4,3-d]pyrimidine-1-carboxylic acid dimethylamide; 6-(4-chloro-phenyl)-5-(4-isopropyl-phenyl)-2-methyl-3-phenyl-2,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one; 6-(4-chloro-phenyl)-5-(4-isopropyl-phenyl)-1-methyl-3-phenyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one; [6-(4-chloro-phenyl)-5-(4-isopropyl-phenyl)-7-oxo-3-phenyl-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-2-yl]-acetic acid tert-butyl ester; [6-(4-chloro-phenyl)-5-(4-isopropyl-phenyl)-7-oxo-3-phenyl-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl]-acetic acid tert-butyl ester; 5-(4-chloro-phenyl)-6-[4-(1-oxy-pyridin-4-yl)-phenyl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-bromo-phenyl)-6-(4-chloro-phenyl)-3-phenyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one; 5-(4-bromo-phenyl)-6-(4-chloro-phenyl)-1-methanesulfonyl-3-phenyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one; 6-(4-chloro-phenyl)-5-(4-isopropyl-phenyl)-3-phenyl-6H-isoxazolo[4,3-d]pyrimidin-7-one; 5-(4-chloro-phenyl)-6-[4-(2-methyl-imidazol-1-yl)-phenyl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-chloro-phenyl)-6-[4-(4-methyl-imidazol-1-yl)-phenyl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-biphenyl-4-yl-6-(4-chloro-phenyl)-3-phenyl-6H-isoxazolo[4,3-d]pyrimidin-7-one; 2-[6-(4-chloro-phenyl)-5-(4-isopropyl-phenyl)-7-oxo-3-phenyl-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl]-acetamide; 5-(4-chloro-phenyl)-3-(3-methyl-[1,2,4]oxadiazol-5-yl)-1-phenyl-6-(4-pyridin-2-yl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; [6-(4-chloro-phenyl)-5-(4-isopropyl-phenyl)-7-oxo-3-phenyl-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl]-acetonitrile; (1-{4-[5-(4-chloro-phenyl)-4-oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-phenyl}-1H-imidazol-4-yl)-acetonitrile; 5-(4-chloro-phenyl)-6-[4-(1-oxy-pyridin-2-yl)-phenyl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-chloro-phenyl)-6-[4-(2-ethyl-imidazol-1-yl)-phenyl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-chloro-phenyl)-6-[4-(2,4-dimethyl-imidazol-1-yl)-phenyl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-chloro-phenyl)-6-[4-(4-fluoro-phenyl)-piperazin-1-yl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-bromo-phenyl)-6-(4-chloro-phenyl)-1-methyl-3-phenyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one; 6-(4-chloro-phenyl)-5-(4-isopropyl-phenyl)-3-phenyl-6H-isoxazolo[4,5-d]pyrimidin-7-one; 6-(4-chloro-phenyl)-1-methyl-3-phenyl-5-(4-pyridin-2-yl-phenyl)-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one; 6-(4-chloro-phenyl)-2-methyl-3-phenyl-5-(4-pyridin-2-yl-phenyl)-2,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one; 6-[4-(6-amino-pyridin-3-yl)-phenyl]-5-(4-chloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-chloro-phenyl)-6-[4-(1-oxy-pyridin-3-yl)-phenyl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-chloro-phenyl)-6-[4-(1H-imidazol-2-yl)-phenyl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-chloro-phenyl)-3-methanesulfonyl-1-phenyl-6-(4-pyridin-4-yl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-chloro-phenyl)-6-[4-(2-methyl-1-oxy-pyridin-4-yl)-phenyl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-chloro-phenyl)-6-[4-(3-methyl-1-oxy-pyridin-4-yl)-phenyl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-chloro-phenyl)-3-methanesulfonyl-6-[4-(1-oxy-pyridin-4-yl)-phenyl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-chloro-phenyl)-6-[4-(6-oxo-1,6-dihydro-pyridin-3-yl)-phenyl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-[4-(4-amino-pyridin-2-yl)-phenyl]-5-(4-chloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-[4-(6-amino-pyridin-2-yl)-phenyl]-5-(4-chloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-(4-Bromo-phenyl)-5-(4-chloro-phenyl)-4-oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine-3-carboxylic acid; 6-(4-Bromo-phenyl)-5-(4-chloro-phenyl)-4-oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine-3-carboxylic acid ethyl ester; 6-(4-Bromo-phenyl)-5-(4-chloro-phenyl)-4-oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine-3-carboxylic acid methylamide; 6-(4-Bromo-phenyl)-5-(4-chloro-phenyl)-4-oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine-3-carboxylic acid dimethylamide; 6-(4-Bromo-phenyl)-5-(4-chloro-phenyl)-3-(morpholine-4-carbonyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-(4-Bromo-phenyl)-5-(4-chloro-phenyl)-4-oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine-3-carboxylic acid piperidin-1-ylamide; 6-(4-Bromo-phenyl)-5-(4-chloro-phenyl)-1-phenyl-3-(piperidine-1-carbonyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-(4-Bromo-phenyl)-5-(4-chloro-phenyl)-4-oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine-3-carboxylic acid isopropyl ester; 6-(4-Bromo-phenyl)-5-(4-chloro-phenyl)-4-oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine-3-carboxylic acid tert-butyl ester; 5-(4-Chloro-phenyl)-6-(4-isopropyl-phenyl)-4-oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine-3-carboxylic acid amide; 5-(4-Chloro-phenyl)-6-(4-isopropyl-phenyl)-4-oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine-3-carboxylic acid ethyl ester; 5-(4-Chloro-phenyl)-6-(4-isopropyl-phenyl)-3-(3-methyl-[1,2,4]oxadiazol-5-yl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-[4-(2-chloro-pyrimidin-4-yl)-phenyl]-3-methylsulfanyl-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-[4-(2-Amino-pyrimidin-4-yl)-phenyl]-5-(4-chloro-phenyl)-3-methylsulfanyl-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(4-isopropyl-phenyl)-4-oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine-3-carboxylic acid methylamide; 5-(4-Chloro-phenyl)-6-(4-isopropyl-phenyl)-4-oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine-3-carbonitrile; 5-(4-Chloro-phenyl)-6-[4-(2-chloro-pyrimidin-4-yl)-phenyl]-3-methanesulfonyl-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-[4-(2-Amino-pyrimidin-4-yl)-phenyl]-5-(4-chloro-phenyl)-3-methanesulfonyl-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-(4-Bromo-phenyl)-5-(4-chloro-phenyl)-3-(3-methyl-[1,2,4]oxadiazol-5-yl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-[4-(2-Amino-pyrimidin-4-yl)-phenyl]-5-(4-chloro-phenyl)-4-oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine-3-carboxylic acid amide; 6-[4-(2-Butoxy-vinyl)-phenyl]-5-(4-chloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-[4-(2-Butoxy-ethyl)-phenyl]-5-(4-chloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-[4-(1-methyl-1H-pyrazol-3-yl)-phenyl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-1-phenyl-6-(4-pyridazin-3-yl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-[4-(2-methyl-2H-pyrazol-3-yl)-phenyl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-1-phenyl-6-(4-pyrimidin-2-yl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-[4-(6-Amino-pyrazin-2-yl)-phenyl]-5-(4-chloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 3-{4-[5-(4-Chloro-phenyl)-4-oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-phenyl}-pyrazine-2-carbonitrile; 5-(4-Chloro-phenyl)-6-[4-(3,6-dimethyl-pyrazin-2-yl)-phenyl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-(4-isoxazol-4-yl-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-6-[4-(1-methyl-1H-imidazol-2-yl)-phenyl]-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-phenyl)-1-phenyl-6-(4-pyrazin-2-yl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-(4-Isopropyl-phenyl)-1-phenyl-5-m-tolyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-(4-Isopropyl-phenyl)-1-phenyl-5-(3-trifluoromethyl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Chloro-3-methyl-phenyl)-6-(4-isopropyl-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(3,5-Difluoro-phenyl)-6-(4-isopropyl-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(3,4-Dichloro-phenyl)-6-(4-isopropyl-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(4-Bromo-phenyl)-6-(4-chloro-phenyl)-3-phenyl-3,6-dihydro-[1,2,3]triazolo[4,5-d]pyrimidin-7-one; 5-(3-Fluoro-phenyl)-6-(4-isopropyl-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 5-(3-Chloro-phenyl)-6-(4-isopropyl-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 543-Bromo-phenyl)-6-(4-isopropyl-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; 6-(4-Chloro-phenyl)-5-(4-isopropyl-phenyl)-3-phenyl-3,6-dihydro-[1,2,3]triazolo[4,5-d]pyrimidin-7-one; 3-[2-Biphenyl-4-yl-1-(4-chloro-phenyl)-6-oxo-1,6-dihydro-purin-9-yl]-benzoic acid; 3-[2-Biphenyl-4-yl-1-(4-chloro-phenyl)-6-oxo-1,6-dihydro-purin-9-yl]-benzamide; N-[2-Biphenyl-4-yl-1-(4-chloro-phenyl)-6-oxo-9-phenyl-6,9-dihydro-1H-purin-8-ylmethyl]-methanesulfonamide; 3-[2-Biphenyl-4-yl-1-(4-chloro-phenyl)-6-oxo-1,6-dihydro-purin-9-yl]-benzoic acid ethyl ester; 2-Biphenyl-4-yl-1-(4-chloro-phenyl)-8-methanesulfonylmethyl-9-phenyl-1,9-dihydro-purin-6-one; 2-Biphenyl-4-yl-8-bromomethyl-1-(4-chloro-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 3-[2-Biphenyl-4-yl-1-(4-chloro-phenyl)-6-oxo-1,6-dihydro-purin-9-yl]-N-cyclopropyl-benzamide; 3-[2-Biphenyl-4-yl-1-(4-chloro-phenyl)-6-oxo-1,6-dihydro-purin-9-yl]-N-pyridin-3-yl-benzamide; 3-[2-Biphenyl-4-yl-1-(4-chloro-phenyl)-6-oxo-1,6-dihydro-purin-9-yl]-N-cyclohexyl-benzamide; 3-[2-Biphenyl-4-yl-1-(4-chloro-phenyl)-6-oxo-1,6-dihydro-purin-9-yl]-N-isoxazol-3-yl-benzamide; 3-[2-Biphenyl-4-yl-1-(4-chloro-phenyl)-6-oxo-1,6-dihydro-purin-9-yl]-N-(2-dimethylamino-ethyl)-benzamide; 3-[2-Biphenyl-4-yl-1-(4-chloro-phenyl)-6-oxo-1,6-dihydro-purin-9-yl]-N-(2-methoxy-ethyl)-benzamide; 1-(4-Bromo-phenyl)-2-(4-methoxy-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(4-methoxymethyl-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 4-[1-(4-Chloro-phenyl)-6-oxo-9-phenyl-6,9-dihydro-1H-purin-2-yl]-benzoic acid; 2-(4-Bromo-phenyl)-1-(4-chloro-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-9-phenyl-2-(4-pyrazol-1-yl-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(4-imidazol-1-yl-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2,9-diphenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(4-[1,2,4]oxadiazol-5-yl-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(4-methoxy-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-[4-(2-oxo-piperidin-1-yl)-phenyl]-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-[4-(2-oxo-pyrrolidin-1-yl)-phenyl]-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-9-phenyl-2-[4-(2H-[1,2,4]triazol-3-yl)-phenyl]-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-[4-(2-methyl-2H-[1,2,4]triazol-3-yl)-phenyl]-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-[4-(1-methyl-1H-[1,2,4]triazol-3-yl)-phenyl]-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(4-hydroxy-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 2-(4-Chloromethyl-phenyl)-1-(4-chloro-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-9-phenyl-2-(4-piperidin-1-ylmethyl-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(4-morpholin-4-ylmethyl-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(4-diethylaminomethyl-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-[4-(isobutylamino-methyl)-phenyl]-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-{4-[(cyclopropylmethyl-amino)-methyl]-phenyl}-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(4-isopropoxymethyl-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-9-phenyl-2-(4-vinyl-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(4-cyclopropyl-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 2-(4-Butoxy-phenyl)-1-(4-chloro-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-8-ethyl-9-phenyl-2-(4-trifluoromethyl-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-[4-(2-chloro-pyrimidin-4-yl)-phenyl]-9-phenyl-1,9-dihydro-purin-6-one; 2-Biphenyl-4-yl-1-(4-chloro-phenyl)-8-methyl-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-8-methyl-9-phenyl-2-(4-trifluoromethyl-phenyl)-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(4-cyclohexyl-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-(4-oxazol-5-yl-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 2-(4-Chloro-phenyl)-7-phenyl-1-p-tolyl-1,7-dihydro-purin-6-one; 2-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-7-phenyl-1,7-dihydro-purin-6-one; 2-(4-Chloro-phenyl)-1-(4-isopropyl-phenyl)-7-phenyl-1,7-dihydro-purin-6-one; 8-Bromo-1-(4-bromo-phenyl)-9-phenyl-2-p-tolyl-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-8-methoxy-9-phenyl-2-p-tolyl-1,9-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-6-oxo-9-phenyl-2-p-tolyl-6,9-dihydro-1H-purine-8-carbonitrile; 1-(4-Bromo-phenyl)-2-(4-chloro-phenyl)-7-phenyl-1,7-dihydro-purin-6-one; 7-Benzyl-2-biphenyl-4-yl-1-(4-chloro-phenyl)-1,7-dihydro-purin-6-one; 3-[2-Biphenyl-4-yl-1-(4-chloro-phenyl)-6-oxo-1,6-dihydro-purin-9-yl]-benzonitrile; 4-[2-Biphenyl-4-yl-1-(4-chloro-phenyl)-6-oxo-1,6-dihydro-purin-9-yl]-benzonitrile; 2-Biphenyl-4-yl-1-(4-chloro-phenyl)-9-(3-trifluoromethoxy-phenyl)-1,9-dihydro-purin-6-one; 2-Biphenyl-4-yl-1-(4-chloro-phenyl)-9-p-tolyl-1,9-dihydro-purin-6-one; 2-Biphenyl-4-yl-1-(4-chloro-phenyl)-9-(2-methoxy-5-methyl-phenyl)-1,9-dihydro-purin-6-one; 2-Biphenyl-4-yl-1-(4-chloro-phenyl)-9-cyclopropyl-1,9-dihydro-purin-6-one; 7-Benzyl-1-biphenyl-4-yl-2-(4-chloro-phenyl)-1,7-dihydro-purin-6-one; 2-(4-Chloro-phenyl)-1-(4′-fluoro-biphenyl-4-yl)-7-phenyl-1,7-dihydro-purin-6-one; 2-(4-Chloro-phenyl)-1-(3′-fluoro-biphenyl-4-yl)-7-phenyl-1,7-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-[4-(1-oxy-pyridin-4-yl)-phenyl]-9-phenyl-1,9-dihydro-purin-6-one; 2-(4-Chloro-phenyl)-1-(2′-fluoro-biphenyl-4-yl)-7-phenyl-1,7-dihydro-purin-6-one; 1-(4-Bromo-phenyl)-8-ethyl-9-phenyl-2-(4-trichloromethyl-phenyl)-1,9-dihydro-purin-6-one; 4-[1-(4-Bromo-phenyl)-8-ethyl-6-oxo-9-phenyl-6,9-dihydro-1H-purin-2-yl]-benzoic acid methyl ester; 2-[4-(6-Amino-pyridin-3-yl)-phenyl]-1-(4-chloro-phenyl)-9-phenyl-1,9-dihydro-purin-6-one; 1-(4-Chloro-phenyl)-2-[4-(6-oxo-1,6-dihydro-pyridin-3-yl)-phenyl]-9-phenyl-1,9-dihydro-purin-6-one; and 1-(4-Chloro-phenyl)-2-(4-methanesulfonyl-phenyl)-9-phenyl-1,9-dihydro-purin-6-one. 
     
     
         22 . A method of treating a disease mediated by the Cannabinoid-1 receptor comprising administration of to a patient in need of such treatment of a therapeutically effective amount of a compound selected from Formula Ia, Ib, Ic, Id, Ie, If, Ig, Ih, Ii, Ij and Ik: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         in which: 
         Y is selected from O, NR 7  and S; wherein R 7  is selected from hydrogen, hydroxy and C 1-6  alkyl; 
         R 1  is selected from C 5-10 heteroaryl, C 3-12 cyclolalkyl, phenyl and benzyl; wherein said heteroaryl, cycloalkyl, phenyl and benzyl of R 1  is optionally substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted C 1-6 alkyl, halo-substituted C 1-6  alkoxy, —NR 8 R 9 , —S(O) 0-2 R 8 , —C(O)OR 8  and R 10 ; 
         R 2  is selected from C 3-8 heterocycloalkyl, C 5-10 heteroaryl, phenyl and phenoxy; wherein said heterocycloalkyl, heteroaryl, phenyl or phenoxy of R 2  is optionally substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted C 1-6 alkyl, C 1-6 alkenyl, halo-substituted C 1-6 alkoxy, —XNR 8 R 9 , —XOR 8 , —XC(O)R 8 , —XS(O) 0-2 R 8 , —XC(O)NR 8 R 9 , —XC(O)OR 8 , —XOR 10 , —XNR 8 XR 10  and —XR 10 ; wherein each X is independently selected from a bond, C 1-4 alkylene and C 2-4 alkenylene; 
         R 3  is selected from hydrogen, halo, hydroxy, cyano, cyano-C 1-6 alkyl, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted C 1-6 alkoxy, —XNR 8 R 9 , —XR 10 , —XS(O) 0-2 R 9 , —XC(O)R 10 , —XC(O)NR 8 R 9 , —XC(O)NR 8 R 10  and —XC(O)OR 8 ; 
         R 4  is selected from C 1-6 alkyl, halo-substituted C 1-6 alkyl, C 6-10 aryl-C 0-4 alkyl, C 5-10 heteroaryl, C 3-12 cycloalkyl, C 3-8 heterocycloalkyl and C(O)R 11 ; wherein R 11  is selected from C 3-8 heterocycloalkyl and C 3-8 heteroaryl; wherein any alkyl of R 4  can optionally have a methylene replaced with O, S(O) 0-2  and NR 8 ; wherein any cycloalkyl, heterocycloalkyl, aryl or heteroaryl of R 4  can optionally be substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, —XOR 8 , —XR 10 , —XC(O)R 10 , —XS(O) 0-2 R 8 , —XNR 8 R 9 , —XC(O)NR 8 R 9 , —XC(O)NR 8 R 10 , —XC(O)NR 8 XNR 8 R 9 , —XC(O)NR 8 XOR 9  and —XC(O)OR 8 ; 
         R 5  is selected from hydrogen, halo, hydroxy, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, hydroxy-substituted-C 1-6 alkyl, hydroxy-substituted-C 1-6 alkoxy, —NR 8 R 9 , —OXOR 8 , —OXR 10 , —NR 8 XOR 9 , —OXNR 8 R 9  and —C(O)OR 8 ; wherein X is independently selected from a bond, C 1-4 alkylene and C 2-4 alkenylene; 
         R 6  is selected from hydrogen, halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted C 1-6 alkyl, halo-substituted C 1-6 alkoxy, —XNR 8 R 9 , —XNR 8 XOR 9 , —XNR 8 NR 8 R 9 , —XOXNR 8 R 9 , —XNR 8 S(O) 2 R 9 , —XS(O) 2 R 9 , and —XC(O)OR 8 ; 
         R 8  and R 9  are independently selected from hydrogen, C 1-6 alkyl and C 2-6 alkenyl; or R 8  and R 9  together with the nitrogen atom to which both are attached form C 3-8 heterocycloalkyl or C 5-10 heteroaryl; and R 10  is selected from C 5-10 heteroaryl, C 3-8 heterocycloalkyl, C 3-12 cycloalkyl and phenyl; wherein said heteroaryl or heterocycloalkyl of R 10  or the combination of R 8  and R 9  and additionally the cycloalkyl or phenyl of R 10  is optionally substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, cyano-C 1-6 alkyl, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, hydroxy-substituted-C 1-6 alkyl, hydroxy-substituted-C 1-6 alkoxy, phenyl, —NR 8 R 8 , —S(O) 0-2 R 8  and —C(O)OR 8 ; wherein each R 8  is independently selected from hydrogen, C 1-6 alkyl and C 2-6 alkenyl; and the pharmaceutically acceptable salts, hydrates, solvates and isomers thereof. 
       
     
     
         23 . The method according to  claim 22  wherein the disease mediated by the Cannabinoid-1 receptor is an eating disorder associated with excessive food intake. 
     
     
         24 . The method according to  claim 23  wherein the eating disorder associated with excessive food intake is selected from obesity, bulimia nervosa, and compulsive eating disorders. 
     
     
         25 . The method according to  claim 24  wherein the eating disorder associated with excessive food intake is obesity. 
     
     
         26 . A method of preventing obesity in a person at risk for obesity comprising administration to said person of about 0.001 mg to about 100 mg per kg of a compound selected from Formula Ia, Ib, Ic, Id, Ie, If, Ig, Ih, Ii, Ij and Ik: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         in which: 
         Y is selected from O, NR 7  and S; wherein R 7  is selected from hydrogen, hydroxy and C 1-6 alkyl; 
         R 1  is selected from C 5-10 heteroaryl, C 3-12 cyclolalkyl, phenyl and benzyl; wherein said heteroaryl, cycloalkyl, phenyl and benzyl of R 1  is optionally substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted C 1-6 alkyl, halo-substituted C 1-6 alkoxy, —NR 8 R 9 , —S(O) 0-2 R 8 , —C(O)OR 8  and R 10 ; 
         R 2  is selected from C 3-8 heterocycloalkyl, C 5-10 heteroaryl, phenyl and phenoxy; wherein said heterocycloalkyl, heteroaryl, phenyl or phenoxy of R 2  is optionally substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted C 1-6 alkyl, C 1-6 alkenyl, halo-substituted C 1-6 alkoxy, —XNR 8 R 9 , —XOR 8 , —XC(O)R 8 , —XS(O) 0-2 R 8 , —XC(O)NR 8 R 9 , —XC(O)OR 8 , —XOR 10 , —XNR 8 XR 10  and —XR 10 ; wherein each X is independently selected from a bond, C 1  alkylene and C 2-4 alkenylene; 
         R 3  is selected from hydrogen, halo, hydroxy, cyano, cyano-C 1-6 alkyl, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted C 1-6 alkoxy, —XNR 8 R 9 , —XR 10 , —XS(O) 0-2 R 9 , —XC(O)R 10 , —XC(O)NR 8 R 9 , —XC(O)NR 8 R 10  and —XC(O)OR 8 ; 
         R 4  is selected from C 1-6 alkyl, halo-substituted C 1-6 alkyl, C 6-10 aryl-C 0-4 alkyl, C 5-10 heteroaryl, C 3-12 cycloalkyl, C 3-8 heterocycloalkyl and C(O)R 11 ; wherein R 11  is selected from C 3-8 heterocycloalkyl and C 3-8 heteroaryl; wherein any alkyl of R 4  can optionally have a methylene replaced with O, S(O) 0-2  and NR 8 ; wherein any cycloalkyl, heterocycloalkyl, aryl or heteroaryl of R 4  can optionally be substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, —XOR 8 , —XR 10 , —XC(O)R 10 , —XS(O) 0-2 R 8 , —XNR 8 R 9 , —XC(O)NR 8 R 9 , —XC(O)NR 8 R 10 , —XC(O)NR 8 XNR 8 R 9 , —XC(O)NR 8 XOR 9  and —XC(O)OR 8 ; 
         R 5  is selected from hydrogen, halo, hydroxy, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, hydroxy-substituted-C 1-6 alkyl, hydroxy-substituted-C 1-6 alkoxy, —NR 8 R 9 , —OXOR 8 , —OXR 10 , —NR 8 XOR 9 , —OXNR 8 R 9  and —C(O)OR 8 ; wherein X is independently selected from a bond, C 1-4 alkylene and C 2-4 alkenylene; 
         R 6  is selected from hydrogen, halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted C 1-6 alkyl, halo-substituted C 1-6 alkoxy, —XNR 8 R 9 , —XNR 8 XOR 9 , —XNR 8 NR 8 R 9 , —XOXNR 8 R 9 , —XNR 8 S(O) 2 R 9 , —XS(O) 2 R 9 , and —XC(O)OR 8 ; 
         R 8  and R 9  are independently selected from hydrogen, C 1-6 alkyl and C 2-6 alkenyl; or R 8  and R 9  together with the nitrogen atom to which both are attached form C 3-8 heterocycloalkyl or C 5-10 heteroaryl; and R 10  is selected from C 5-10 heteroaryl, C 3-8 heterocycloalkyl, C 3-12 cycloalkyl and phenyl; wherein said heteroaryl or heterocycloalkyl of R 10  or the combination of R 8  and R 9  and additionally the cycloalkyl or phenyl of R 10  is optionally substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, cyano-C 1-6 alkyl, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, hydroxy-substituted-C 1-6 alkyl, hydroxy-substituted-C 1-6 alkoxy, phenyl, —NR 8 R 8 , —S(O) 0-2 R 8  and —C(O)OR 8 ; wherein each R 8  is independently selected from hydrogen, C 1-6 alkyl and C 2-6 alkenyl; and the pharmaceutically acceptable salts, hydrates, solvates and isomers thereof. 
       
     
     
         27 . A composition comprising a pharmaceutically acceptable carrier and a compound selected from Formula Ia, Ib, Ic, Id, Ie, If, Ig, Ih, Ii, Ij and Ik: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         in which: 
         Y is selected from O, NR 7  and S; wherein R 7  is selected from hydrogen, hydroxy and C 1-6 alkyl; 
         R 1  is selected from C 5-10 heteroaryl, C 3-12 cyclolalkyl, phenyl and benzyl; wherein said heteroaryl, cycloalkyl, phenyl and benzyl of R 1  is optionally substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted C 1-6 alkyl, halo-substituted C 1-6 alkoxy, —NR 8 R 9 , —S(O) 0-2 R 8 , —C(O)OR 8  and R 10 ; 
         R 2  is selected from C 3-8 heterocycloalkyl, C 5-10 heteroaryl, phenyl and phenoxy; wherein said heterocycloalkyl, heteroaryl, phenyl or phenoxy of R 2  is optionally substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted C 1-6 alkyl, C 1-6 alkenyl, halo-substituted C 1-6 alkoxy, —XNR 8 R 9 , —XOR 8 , —XC(O)R 8 , —XS(O) 0-2 R 8 , —XC(O)NR 8 R 9 , —XC(O)OR 8 , —XOR 10 , —XNR 8 XR 10  and —XR 10 ; wherein each X is independently selected from a bond, C 1  alkylene and C 2-4 alkenylene; 
         R 3  is selected from hydrogen, halo, hydroxy, cyano, cyano-C 1-6 alkyl, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted C 1-6 alkoxy, —XNR 8 R 9 , —XR 10 , —XS(O) 0-2 R 9 , —XC(O)R 10 , —XC(O)NR 8 R 9 , —XC(O)NR 8 R 10  and —XC(O)OR 8 ; 
         R 4  is selected from C 1-6 alkyl, halo-substituted C 1-6 alkyl, C 6-10 aryl-C 0-4 alkyl, C 5-10 heteroaryl, C 3-12 cycloalkyl, C 3-8 heterocycloalkyl and C(O)R 11 ; wherein R 11  is selected from C 3-8 heterocycloalkyl and C 3-8 heteroaryl; wherein any alkyl of R 4  can optionally have a methylene replaced with O, S(O) 0-2  and NR 8 ; wherein any cycloalkyl, heterocycloalkyl, aryl or heteroaryl of R 4  can optionally be substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, —XOR 8 , —XR 10 , —XC(O)R 10 , —XS(O) 0-2 R 8 , —XNR 8 R 9 , —XC(O)NR 8 R 9 , —XC(O)NR 8 R 10 , —XC(O)NR 8 XNR 8 R 9 , —XC(O)NR 8 XOR 9  and —XC(O)OR 8 ; 
         R 5  is selected from hydrogen, halo, hydroxy, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, hydroxy-substituted-C 1-6 alkyl, hydroxy-substituted-C 1-6 alkoxy, —NR 8 R 9 , —OXOR 8 , —OXR 10 , —NR 8 XOR 9 , —OXNR 8 R 9  and —C(O)OR 8 ; wherein X is independently selected from a bond, C 1-4 alkylene and C 2-4 alkenylene; 
         R 6  is selected from hydrogen, halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted C 1-6 alkyl, halo-substituted C 1-6 alkoxy, —XNR 8 R 9 , —XNR 8 XOR 9 , —XNR 8 NR 8 R 9 , —XOXNR 8 R 9 , —XNR 8 S(O) 2 R 9 , —XS(O) 2 R 9 , and —XC(O)OR 8 ; 
         R 8  and R 9  are independently selected from hydrogen, C 1-6 alkyl and C 2-6 alkenyl; or R 8  and R 9  together with the nitrogen atom to which both are attached form C 3-8 heterocycloalkyl or C 5-10 heteroaryl; and R 10  is selected from C 5-10 heteroaryl, C 3-8 heterocycloalkyl, C 3-12 cycloalkyl and phenyl; wherein said heteroaryl or heterocycloalkyl of R 10  or the combination of R 8  and R 9  and additionally the cycloalkyl or phenyl of R 10  is optionally substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, cyano-C 1-6  alkyl, nitro, C 1-6  alkyl, C 1-6  alkoxy, halo-substituted-C 1-6  alkyl, halo-substituted-C 1-6 alkoxy, hydroxy-substituted-C 1-6 alkyl, hydroxy-substituted-C 1-6  alkoxy, phenyl, —NR 8 R 8 , —S(O) 0-2 R 8  and —C(O)OR 8 ; wherein each R 8  is independently selected from hydrogen, C 1-6 alkyl and C 2-6 alkenyl; and the pharmaceutically acceptable salts, hydrates, solvates and isomers thereof. 
       
     
     
         28 . The use of a compound for the manufacture of a medicament useful for the treatment of a disease mediated by the Cannabinoid-1 receptor in a human patient in need of such treatment, said compound being selected from Formula Ia, Ib, Ic, Id, Ie, If, Ig, Ih, Ii, Ij and 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         in which: 
         Y is selected from O, NR 7  and S; wherein R 7  is selected from hydrogen, hydroxy and C 1-6 alkyl; 
         R 1  is selected from C 5-10 heteroaryl, C 3-12 cyclolalkyl, phenyl and benzyl; wherein said heteroaryl, cycloalkyl, phenyl and benzyl of R 1  is optionally substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted C 1-6 alkyl, halo-substituted C 1-6 alkoxy, —NR 8 R 9 , —S(O) 0-2 R 8 , —C(O)OR 8  and R 10 ; 
         R 2  is selected from C 3-8 heterocycloalkyl, C 5-10 heteroaryl, phenyl and phenoxy; wherein said heterocycloalkyl, heteroaryl, phenyl or phenoxy of R 2  is optionally substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted C 1-6 alkyl, C 1-6 alkenyl, halo-substituted C 1-6 alkoxy, —XNR 8 R 9 , —XOR 8 , —XC(O)R 8 , —XS(O) 0-2 R 8 , —XC(O)NR 8 R 9 , —XC(O)OR 8 , —XOR 10 , —XNR 8 XR 10  and —XR 10 ; wherein each X is independently selected from a bond, C 1  alkylene and C 2-4 alkenylene; 
         R 3  is selected from hydrogen, halo, hydroxy, cyano, cyano-C 1-6 alkyl, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted C 1-6 alkoxy, —XNR 8 R 9 , —XR 10 , —XS(O) 0-2 R 9 , —XC(O)R 10 , —XC(O)NR 8 R 9 , —XC(O)NR 8 R 10  and —XC(O)OR 8 ; 
         R 4  is selected from C 1-6 alkyl, halo-substituted C 1-6 alkyl, C 6-10 aryl-C 0-4 alkyl, C 5-10 heteroaryl, C 3-12 cycloalkyl, C 3-8 heterocycloalkyl and C(O)R 11 ; wherein R 11  is selected from C 3-8 heterocycloalkyl and C 3-8 heteroaryl; wherein any alkyl of R 4  can optionally have a methylene replaced with O, S(O) 0-2  and NR 8 ; wherein any cycloalkyl, heterocycloalkyl, aryl or heteroaryl of R 4  can optionally be substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, —XOR 8 , —XR 10 , —XC(O)R 10 , —XS(O) 0-2 R 8 , —XNR 8 R 9 , —XC(O)NR 8 R 9 , —XC(O)NR 8 R 10 , —XC(O)NR 8 XNR 8 R 9 , —XC(O)NR 8 XOR 9  and —XC(O)OR 8 ; 
         R 5  is selected from hydrogen, halo, hydroxy, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, hydroxy-substituted-C 1-6 alkyl, hydroxy-substituted-C 1-6 alkoxy, —NR 8 R 9 , —OXOR 8 , —OXR 10 , —NR 8 XOR 9 , —OXNR 8 R 9  and —C(O)OR 8 ; wherein X is independently selected from a bond, C 1-4 alkylene and C 2-4 alkenylene; 
         R 6  is selected from hydrogen, halo, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted C 1-6 alkyl, halo-substituted C 1-6 alkoxy, —XNR 8 R 9 , —XNR 8 XOR 9 , —XNR 8 NR 8 R 9 , —XOXNR 8 R 9 , —XNR 8 S(O) 2 R 9 , —XS(O) 2 R 9 , and —XC(O)OR 8 ; 
         R 8  and R 9  are independently selected from hydrogen, C 1-6 alkyl and C 2-6 alkenyl; or R 8  and R 9  together with the nitrogen atom to which both are attached form C 3-8 heterocycloalkyl or C 5-10 heteroaryl; and R 10  is selected from C 5-10 heteroaryl, C 3-8 heterocycloalkyl, C 3-12 cycloalkyl and phenyl; wherein said heteroaryl or heterocycloalkyl of R 10  or the combination of R 8  and R 9  and additionally the cycloalkyl or phenyl of R 10  is optionally substituted with 1 to 3 radicals independently selected from halo, hydroxy, cyano, cyano-C 1-6 alkyl, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted-C 1-6 alkoxy, hydroxy-substituted-C 1-6 alkyl, hydroxy-substituted-C 1-6 alkoxy, phenyl, —NR 8 R 8 , —S(O) 0-2 R 8  and —C(O)OR 8 ; wherein each R 8  is independently selected from hydrogen, C 1-6 alkyl and C 2-6 alkenyl; and the pharmaceutically acceptable salts, hydrates, solvates and isomers thereof. 
       
     
     
         29 . The use according to  claim 28  wherein the disease mediated by the Cannabinoid-1 receptor is selected from: metabolic disorders as well as conditions associated with metabolic disorders including obesity, bulimia nervosa, compulsive eating disorders, diabetes, arteriosclerosis, hypertension, polycystic ovary disease, cardiovascular disease, osteoarthritis, dermatological disorders, hypertension, insulin resistance, hypercholesterolemia, hypertriglyceridemia, cholelithiasis and sleep disorders, and hyperlipidemic conditions; or psychiatric disorders such as substance abuse, psychosis, depression, anxiety, stress, epilepsy, mania and schizophrenia; or cognitive disorders such as dementia including Alzheimer's disease, memory deficits, short term memory loss and attention deficit disorders; or neurodegenerative disorders such as Parkinson's Disease, cerebral apoplexy and craniocerebral trauma, hypotension, catabolism in connection with pulmonary dysfunction and ventilator dependency; or cardiac dysfunction including valvular disease, myocardial infarction, cardiac hypertrophy and congestive heart failure); or the overall pulmonary dysfunction, transplant rejection, rheumatoid arthritis, migraine, neuropathy, multiple sclerosis, Guillain-Barre syndrome, the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, inflammatory bowel disease, lupus, graft vs. host disease, T-cell mediated hypersensitivity disease, psoriasis, asthma, Hashimoto's thyroiditis, Guillain-Barre syndrome, cancer, contact dermatitis, allergic rhinitis, ischemic or reperfusion injury, head trauma and movement disorders. 
     
     
         30 . The use according to  claim 29  wherein the disease mediated by the Cannabinoid-1 receptor is an eating disorder associated with excessive food intake. 
     
     
         31 . The use according to  claim 30 , wherein the eating disorder associated with excessive food intake is selected from obesity, bulimia nervosa, and compulsive eating disorders. 
     
     
         32 . The use according to  claim 31  wherein the eating disorder associated with excessive food intake is obesity. 
     
     
         33 . The use of a compound according to  claim 1  for the manufacture of a medicament for the prevention of obesity in a person at risk therefor.