Compositions and methods for treatment of pain

Abstract

The present invention provides compositions and methods for treatment or prevention of pain resulting from infection, infection related pain, and non-infectious pain as well as treatment or prevention of infections or adverse health consequences associated with infections.

1 . A method for treatment or prevention of pain comprising administering a probiotic composition to a subject having pelvic pain. 
     
     
         2 . The method of  claim 1 , wherein said pain is due to an active or inactive urinary tract infection. 
     
     
         3 . The method of  claim 1 , wherein said subject has previously been diagnosed with a urinary tract infection. 
     
     
         4 . The method of  claim 1 , wherein said probiotic compositions comprise probiotic bacteria. 
     
     
         5 . The method of  claim 1 , wherein said probiotic compositions comprise compositions derived from probiotic bacteria. 
     
     
         6 . The method of  claim 1 , wherein probiotic compositions comprise LPS. 
     
     
         7 . The method of  claim 4 , wherein said probiotic composition an asymptomatic  E. coli  strain isolated from the human urinary tract. 
     
     
         8 . The method of  claim 7 , wherein said probiotic composition comprises a strain of  E. coli  selected from the group consisting of NUA2, NUA1, 2-21, 2-37, 2-35, 2-32, 2-13, 2-29, 2-42, 2-44, 2-8, 2-43, NUA3, 83972, 2-33 and 2-12. 
     
     
         9 . The method of  claim 8 , wherein said probiotic bacteria comprises  E. coli  strain 83972 or a bacteria or strain that produces a functionally equivalent reduction in pain. 
     
     
         10 . The method of  claim 8 , wherein said probiotic bacteria comprises  E. coli  strain 2-12 or a bacteria or strain that produces a functionally equivalent reduction in pain. 
     
     
         11 . The method of  claim 1 , wherein said probiotic composition treats or prevents infection and/or inflammation in addition to pain. 
     
     
         12 . The method of  claim 1 , wherein said probiotic composition treats or prevents pain without treating or preventing infection and/or inflammation. 
     
     
         13 . The method of  claim 1 , wherein said probiotic composition is administered as a tablet, capsule, pill, injection, cream, ointment, lotion, slave, balm, suppository, solution, elixir, syrup, suspension, cream, lozenge, paste or spray. 
     
     
         14 . The method of  claim 1 , wherein said probiotic composition is administered systemically. 
     
     
         15 . The method of  claim 1 , wherein said probiotic composition is administered locally to the region of infection and/or pain. 
     
     
         16 . The method of  claim 13 , wherein said probiotic composition is administered vaginally. 
     
     
         17 . The method of  claim 1 , wherein said probiotic composition is administered such that pain in the affected region of infection and/or pain is treated via organ crosstalk or via corresponding dermatomes. 
     
     
         18 . The method of  claim 1 , wherein said pain is non-infectious pain. 
     
     
         19 . The method of  claim 18 , wherein said non-infectious pain is acute non-infectious pain or chronic non-infectious pain. 
     
     
         20 . The method of  claim 3 , wherein said probiotic composition treats symptoms of a urinary tract infection. 
     
     
         21 . A composition comprising a probiotic composition formulated for treating pelvic pain.