Process for the Preparation of (-)-(4-Chloro-Phenyl)-(3-Trifluoromethyl-Phenoxy)-Acetic Acid 2-Acetylamino-Ethyl Ester

Abstract

The present invention is directed to a novel process for the preparation of (4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester, useful in the treatment of metabolic disorders and further to a process for the preparation of (4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid, a synthesis intermediate.

1 - 57 . (canceled) 
     
     
         58 . A compound that is (−)-4-chloro-phenyl-(R)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester having an enantiomeric excess of 99.7% to 99.9%. 
     
     
         59 . A compound that is (−)-4-chloro-phenyl-(R)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester having a chemical purity of 99.1% to 99.6%. 
     
     
         60 . The compound of  claim 58  having a chemical purity of 99.1% to 99.6%. 
     
     
         61 . A compound that is (−)-4-chloro-phenyl-(R)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester having an enantiomeric excess of greater than 99.9%. 
     
     
         62 . A compound that is (−)-4-chloro-phenyl-(R)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester having a chemical purity of 99.9%. 
     
     
         63 . The compound of  claim 62 , wherein the compound is recrystallized. 
     
     
         64 . The compound of  claim 63 , wherein the compound is recrystallized from a single solvent. 
     
     
         65 . The compound of  claim 63 , wherein the single solvent is diisopropylether. 
     
     
         66 . The compound of  claim 61  having a chemical purity of 99.9%. 
     
     
         67 . A compound that is (−)-(4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid having an enantiomeric excess of 97.5% to 99.5%. 
     
     
         68 . A compound that is (−)-(4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid having a chemical purity of 97.5% to 99.5%. 
     
     
         69 . The compound of  claim 67  having a chemical purity of 97.5% to 99.5%.