US2012232435A1PendingUtilityA1

Ultrasound catheter and methods for making and using same

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Assignee: NITA HENRYPriority: Jan 14, 2003Filed: Apr 6, 2012Published: Sep 13, 2012
Est. expiryJan 14, 2023(expired)· nominal 20-yr term from priority
Inventors:Henry NitaJeff SargeSimon Nguyen
A61B 2017/00154A61B 2017/22014A61B 2017/22011A61M 25/001A61B 2017/00331A61B 2017/003A61B 2017/00292A61M 25/0009A61B 2017/00141A61B 2017/00526A61B 17/22012A61B 2017/320072A61B 2017/22015A61M 25/0041
54
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Claims

Abstract

Ultrasound catheter devices and methods provide enhanced disruption of blood vessel obstructions. Generally, ultrasound catheters include an elongate flexible catheter body with one or more lumens, an ultrasound transmission member extending longitudinally through the catheter body lumen and, in some embodiments, a guidewire tube extending through the lumen. A distal head for disrupting occlusions is coupled with the distal end of the ultrasound transmission member and is positioned adjacent the distal end of the catheter body. Some embodiments include improved features such as a bend in the catheter body for enhancing positioning and/or advancement of the catheter.

Claims

exact text as granted — not AI-modified
1 . A method for treating stenosis or inhibiting restenosis at a treatment location in an artery, comprising:
 enhancing permeability of the vessel wall via the delivery of ultrasound energy to the treatment location; and   delivering a therapeutic agent intravenously into the human body.   
     
     
         2 . The method of  claim 1 , wherein ultrasound energy is delivered to the treatment area using transcutaneous methods. 
     
     
         3 . The method of  claim 1 , wherein ultrasound energy is delivered to the treatment area using endovascular catheter methods. 
     
     
         4 . The method of  claim 1 , wherein the therapeutic agent is delivered to the human body according to one method selected from the group consisting of: before ultrasound energy delivery, during ultrasound energy delivery, or after ultrasound energy delivery. 
     
     
         5 . The method of  claim 1 , wherein ultrasonic energy is delivered in one method selected from group consisting of: continuous, pulse, modulated. 
     
     
         6 . The method of  claim 1 , wherein treating stenosis and inhibiting restenosis includes treating vulnerable plaque in an artery. 
     
     
         7 . A method for treating stenosis or inhibiting restenosis at a treatment location in an artery, comprising:
 enhancing permeability of the vessel wall via the delivery of ultrasound energy to the treatment location, and   delivering a therapeutic agent together with a contrast agent into the artery to the treatment location.   
     
     
         8 . The method of  claim 7  wherein ultrasound energy is delivered to the treatment area using transcutaneous methods. 
     
     
         9 . The method of  claim 7 , wherein ultrasound energy is delivered to the treatment area using endovascular catheter methods. 
     
     
         10 . The method of  claim 7 , wherein the therapeutic agent is delivered to the vessel wall according to one method selected from the group consisting of: before ultrasound energy delivery, during ultrasound energy delivery, after ultrasound energy delivery. 
     
     
         11 . The method of  claim 7 , wherein treating stenosis and inhibiting restenosis includes treating vulnerable plaque in an artery. 
     
     
         12 . The method of  claim 7 , wherein treating stenosis or inhibit re-stenosis in the artery includes ablating or removing plaque or thrombotic material. 
     
     
         13 . The method of  claim 7 , wherein treating stenosis or inhibiting restenosis includes treating a totally occluded artery. 
     
     
         14 . The method of  claim 7 , wherein treating stenosis and inhibiting restenosis includes treating vulnerable plaque in an artery. 
     
     
         15 . The method of  claim 7 , wherein a therapeutic agent and a contrast agent are further diluted with saline. 
     
     
         16 . A method for treating an occlusion in a vessel, comprising:
 enhancing permeability of a wall of the vessel via the delivery of ultrasound energy to a treatment location; and   delivering a medicament intravenously into the vessel at the treatment location.   
     
     
         17 . The method of  claim 16 , wherein ultrasound energy is delivered to the treatment area using transcutaneous methods. 
     
     
         18 . The method of  claim 16 , wherein ultrasound energy is delivered to the treatment location using endovascular catheter methods. 
     
     
         19 . The method of  claim 16 , wherein the medicament is delivered to the vessel according to one method selected from the group consisting of: before ultrasound energy delivery, during ultrasound energy delivery, or after ultrasound energy delivery. 
     
     
         20 . The method of  claim 16 , wherein the frequency of the ultrasonic energy is about 20 kHz. 
     
     
         21 . The method of  claim 16 , wherein ultrasonic energy is delivered in one method selected from group consisting of: continuous, pulse, modulated. 
     
     
         22 . The method of  claim 16 , wherein the medicament is selected from the group consisting of: liquid, powder, particle, and combinations thereof. 
     
     
         23 . The method of  claim 16 , further comprising positioning a device within the treatment area of the artery. 
     
     
         24 . The method of  claim 16 , wherein treating the occlusion includes treating plaque in an artery. 
     
     
         25 . A method for treating an occluded artery, comprising:
 enhancing permeability of a wall of the artery via the delivery of ultrasound energy to a treatment location, and   delivering a medicament together with a dye into the artery at the treatment location.   
     
     
         26 . The method of  claim 25  wherein ultrasound energy is delivered to the treatment area using transcutaneous methods. 
     
     
         27 . The method of  claim 25 , wherein ultrasound energy is delivered to the treatment area using endovascular catheter methods. 
     
     
         28 . The method of  claim 25 , wherein the medicament is delivered to the artery wall according to one method selected from the group consisting of: before ultrasound energy delivery, during ultrasound energy delivery, after ultrasound energy delivery. 
     
     
         29 . The method of  claim 25 , wherein treating the occlusion includes treating plaque in an artery. 
     
     
         30 . The method of  claim 25 , wherein treating the occlusion includes ablating or removing plaque or thrombotic material. 
     
     
         31 . The method of  claim 25 , wherein treating the occlusion includes treating a totally occluded artery. 
     
     
         32 . The method of  claim 25 , further comprising positioning a device within the artery to prevent the medicament from a quick washout by the blood. 
     
     
         33 . The method of  claim 25 , wherein treating the occlusion includes treating plaque in an artery. 
     
     
         34 . The method of  claim 25 , wherein a medicament and dye are further diluted with saline. 
     
     
         35 . A method for treating an occluded artery, comprising:
 enhancing permeability of a wall of the artery via the delivery of ultrasound energy to a treatment location within the artery; and   delivering a medicament to the treatment location using a catheter having a plurality of lumens.

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