Pyrithione biocides enhanced by silver, copper, or zinc ions

Abstract

The present invention is directed to an antimicrobial composition, comprising pyrithione or a pyrithione complex; and a zinc or copper or silver source selected from the group consisting of zinc or copper or silver salts, oxides, hydroxides, sulfates, chlorides, metals, and combinations thereof; wherein the weight ratio of the zinc or copper or silver source to the pyrithione or the pyrithione complex is in the range from about 1:300 to about 50:1, and wherein the antimicrobial composition has an enhanced biocidal effect against a variety of free-living microorganisms or biofilms. Also disclosed is a method of inhibiting the growth of free-living microorganisms or biofilm utilizing the above antimicrobial composition, as well as use of such antimicrobial compositions in various products including fuels, fluids, lubricants, coatings, adhesives, sealants, elastomers, soaps, cosmetics, plastic or woven or non-woven fibers, pharmaceuticals, and as preservatives for the above products.

1 . A coated substrate comprising:
 a substrate together with a coating on said substrate, said coating being produced by:   (a) contacting said substrate with a coating composition comprising pyrithione or a pyrithione complex; and a zinc or copper or silver source selected from the group consisting of zinc or copper or silver salts, zinc or copper or silver oxides, zinc or copper or silver hydroxides, zinc or copper or silver sulfates, zinc or copper or silver chlorides, zinc or copper or silver metals, zinc or copper or silver complexes, and combinations thereof; wherein the weight ratio of said zinc or copper or silver source to said pyrithione or said pyrithione complex is in the range from about 1:300 to about 50:1, and wherein said antimicrobial composition has an enhanced biocidal effect against microorganisms selected from the group consisting of free-living microorganisms, parasitic microorganisms, adherent microorganisms, biofilms, and combinations thereof; and   (b) drying said coating composition on said substrate to produce said coated substrate.   
     
     
         2 . The coated substrate of  claim 1 , wherein said weight ratio of said zinc or copper or silver source to said pyrithione or said pyrithione complex is in the range of from about 1:100 to about 1:1. 
     
     
         3 . A coating composition, comprising:
 (a) a base medium comprising water or a solvent resin system selected from the group consisting of vinyl, alkyl, epoxy, acrylic, polyurethane and polyester resins, and combinations thereof; and   (b) a biocide comprising an antimicrobial composition consisting essentially of pyrithione or a pyrithione complex, and a zinc or copper or solver source selected from the group consisting of zinc or copper or silver salts, zinc or copper or silver oxides, zinc or copper or silver hydroxides, zinc or copper or silver sulfates, zinc or copper or silver chlorides, zinc or copper or silver metals, zinc or copper or silver complexes, and combinations thereof; wherein the weight ratio of said zinc or copper or silver source to said pyrithione or said pyrithione complex is in the range from about 1:300 to about 50:1, and wherein said antimicrobial composition has an enhanced biocidal effect against microorganisms selected from the group consisting of free-living microorganisms, parasitic microorganisms, adherent microorganisms, biofilms, and combinations thereof.   
     
     
         4 . The coating composition of  claim 3 , wherein said weight ratio of said zinc or copper or silver source to said pyrithione or said pyrithione complex is in the range of from about 1:100 to about 10:1. 
     
     
         5 . A composition comprising an antimicrobial composition consisting essentially of pyrithione or a pyrithione complex; and a zinc or copper or silver source selected from the group consisting of zinc or copper or silver salts, zinc or copper or silver oxides, zinc or copper or silver hydroxides, zinc or copper or silver sulfates, zinc or copper or silver chlorides, zinc or copper or silver metals, zinc or copper or silver complexes, and combinations thereof; wherein the weight ratio of said zinc or copper or silver source to said pyrithione or said pyrithione complex is in the range from about 1:300 to about 50:1, and wherein said antimicrobial composition has an enhanced biocidal effect against microorganisms selected from the group consisting of free-living microorganisms, parasitic microorganisms, adherent microorganisms, biofilms, and combinations thereof. 
     
     
         6 . The composition of  claim 5 , further comprising at least one of: a plastic, a woven fiber, a nonwoven fiber, or a combination thereof. 
     
     
         7 . The composition of  claim 5 , further comprising: an adhesive base medium; wherein the composition is an adhesive composition. 
     
     
         8 . The composition of  claim 5 , further comprising: an elastomeric base medium; wherein the composition is an elastomer composition. 
     
     
         9 . The composition of  claim 5 , further comprising: an adhesive base medium; wherein the composition is a sealant composition. 
     
     
         10 . The composition of  claim 5 , further comprising: a skin care base; wherein the composition is a skin care composition. 
     
     
         11 . A method of preserving cellulose-based material, comprising the steps of:
 contacting a cellulose-based material with the composition of  claim 5 .   
     
     
         12 . The method of  claim 11 , wherein said cellulose-based material is selected from the group consisting of wood, paper, cardboard, and combinations thereof. 
     
     
         13 . The composition of  claim 5 , further comprising a metal ion source. 
     
     
         14 . The composition of  claim 13 , wherein the metal ion source is selected from the group consisting of titanium, cobalt, cadmium, chromium, manganese, platinum, palladium, and vanadium. 
     
     
         15 . The composition of  claim 5 , further comprising a carrier. 
     
     
         16 . The composition of  claim 15 , wherein the carrier is an aqueous media or an aqueous media in combination with at least one organic solvent(s). 
     
     
         17 . The coating composition of  claim 3  wherein the biocide is between about 0.01% and about 10% by weight based upon the weight of the base medium.