US2012259426A1PendingUtilityA1

Plga/hydroxyapatite composite biomaterial and method of making the same

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Assignee: KIM BYUNG-SOOPriority: Mar 6, 2006Filed: May 14, 2012Published: Oct 11, 2012
Est. expiryMar 6, 2026(expired)· nominal 20-yr term from priority
Inventors:Byung Soo Kim
A61L 27/44A61L 27/46A61L 2400/12A61L 27/56A61K 8/72A61L 2430/02C08L 67/04
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Claims

Abstract

The present invention is a new composite bone graft material made from biocompatible poly(D,L-lactic-co-glycolic acid) (PLGA) and nano-sized hydroxyapatite particles exposed on its surface using a gas foaming particle leaching (GF/PL) method. A further embodiment of this invention involves coating this PLGA/hydroxyapatite biomaterial with an adherent, fast, uniform coating of a mineral such as apatite. The PLGA polymer portion of the composite provides sufficient mechanical strength to replace bone and is degradable over time to allow new bone tissue ingrowth. The incorporated hydroxyapatite particles increase the composite material's osteogenic properties by providing sites for tissue attachment and propagation. Finally, a uniform coating of mineral apatite on the surface of this novel biomaterial composite further enhances its osteogenic qualities.

Claims

exact text as granted — not AI-modified
1 . A bone graft biomaterial comprised of a biocompatible polymer and hydroxyapatite composite wherein the hydroxyapatite particles are less than 1.0 μm in diameter. 
     
     
         2 . The bone graft material of  claim 1  wherein the scaffolds are made via a solvent casting particulate leaching or gas foaming particulate leaching process. 
     
     
         3 . The bone graft biomaterial of  claim 1  wherein the biomaterial contains pores sized 200 μm or less. 
     
     
         4 . A bone graft biomaterial of PLGA/hydroxyapatte as in  claim 1  further comprising an adherent, uniform coating of apatite on the surface of the biomaterial. 
     
     
         5 . A bone graft biomaterial of PLGA/hydroxyapatite as in  claim 1  further comprising an adherent, uniform coating of apatite on the surface of the biomaterial. 
     
     
         6 . The bone graft material of  claim 1  wherein the ratio of biocompatible polymer to hydroxyapatite is from about 1:2 to about 2:1. 
     
     
         7 . The bone graft material of  claim 1  wherein the ratio of biocompatible polymer to hydroxyapatite is about 1:1 
     
     
         8 . The bone graft material of  claim 1  wherein the ratio of biocompatible polymer to NaCl ranges from 1:4 to 1:18. 
     
     
         9 . The bone graft material of  claim 1  wherein the ratio of biocompatible polymer to NaCl is about 1:9. 
     
     
         10 . The bone graft material of  claim 3  wherein the pores are created by washing out a salt. 
     
     
         11 . The bone graft material of  claim 3  wherein the pores are from approximately 100 μm to 200 μm in diameter. 
     
     
         12 . The bone graft material of  claim 1  wherein the biocompatible polymer is comprised of at least one of the following: poly glycolic acid, poly lactic acid, poly lactic co glycolic acid. 
     
     
         13 . The bone graft material of  claim 1  wherein the biocompatible polymer is poly lactic co glycolic acid. 
     
     
         14 . A bone graft biomaterial comprised of a polylactic co glycolic polymer and hydroxyapatite composite wherein the hydroxyapatite particles are less than 1.0 μm in diameter. 
     
     
         15 . The bone graft material of  claim 1  wherein the scaffolds are made via a solvent casting particulate leaching or gas foaming particulate leaching process. 
     
     
         16 . The bone graft biomaterial of  claim 1  wherein the biomaterial contains pores sized 200 μm or less. 
     
     
         17 . A bone graft biomaterial as in  claim 1  further comprising an adherent, uniform coating of apatite on the surface of the biomaterial. 
     
     
         18 . A bone graft biomaterial as in  claim 1  further comprising an adherent, uniform coating of apatite on the surface of the biomaterial. 
     
     
         19 . The bone graft material of  claim 1  wherein the ratio of biocompatible polymer to hydroxyapatite is about 1:1. 
     
     
         20 . The bone graft material of  claim 3  wherein the pores are created by washing out a salt. 
     
     
         21 . The bone graft material of  claim 3  wherein the pores are from approximately 100 μm to 200 μm in diameter. 
     
     
         22 . The bone graft material of  claim 1  wherein the biocompatible polymer is comprised of at least one of the following: poly glycolic acid, poly lactic acid, poly lactic co glycolic acid. 
     
     
         23 . The bone graft material of  claim 1  wherein the biocompatible polymer is poly lactic co glycolic acid.

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