US2012270458A1PendingUtilityA1

Medical nonwoven fabric, and preparation method thereof

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Assignee: IM JUNG NAMPriority: Dec 24, 2009Filed: Apr 1, 2010Published: Oct 25, 2012
Est. expiryDec 24, 2029(~3.5 yrs left)· nominal 20-yr term from priority
Inventors:Jung Nam ImDae Young LimGuk-Hwan AnYoon-Jin Kim
D21H 17/53D21H 15/02D21H 17/375D21H 11/00D21H 21/28A61F 2013/15495D21H 21/52Y10T442/669Y10T156/10A61L 15/60D21H 13/04A61F 2013/00217D04H 1/407A61F 13/44Y10T442/668D21H 17/24A61L 15/56D21H 25/04D21H 21/18A61L 15/28A61L 15/26D21H 21/14A61L 31/042A61F 2013/15869A61L 31/129A61F 13/36A61F 2013/15951A61L 31/146A61L 31/048D21H 17/36D21H 27/30D21H 5/1281D21H 17/25D21H 5/14A61F 13/02D21H 19/36A61L 27/50
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Claims

Abstract

The present invention relates to a medical nonwoven fabric comprising gelable cellulose derivative short-cut fibers as prepared by the paper making process, a preparation method thereof, and an adhesion prevention barrier using the same. The present invention provides a single phase of medical nonwoven fabric comprising gelable cellulose derivative short-cut fibers, to induce capillary action of micropores formed between the fibers and thereby control the gelation time, and provides a composite nonwoven fabric formed by laminating a nonwoven fabric layer comprising a different kind of biodegradable polymer material not susceptible to gelation on the single-phase of medical nonwoven fabric comprising gelable cellulose derivative short-cut fibers, thereby improving dimensional stability and convenience of surgical procedure. The present invention further provides a dyed medical nonwoven fabric to improve visibility, allowing easiness of recognizing the placement or location of the medical nonwoven fabric. Further, the single-phase nonwoven fabric or the composite nonwoven fabric, which makes it possible to efficiently control the gelation time by way of capillary action of the micropores formed between the fiber in the nonwoven fabric, can also be used as an adhesion prevention barrier with improved convenience of surgical procedure and post-surgical adhesion, in contrast to the conventional knit or film type adhesion prevention barrier.

Claims

exact text as granted — not AI-modified
1 . A medical nonwoven fabric provided in the form of a wet-laid nonwoven fabric comprising gelable cellulose derivative short-cut fibers. 
     
     
         2 . The medical nonwoven fabric as claimed in  claim 1 , wherein the wet-laid nonwoven fabric comprising short-cut fibers is a porous thin nonwoven fabric having micropores of 1 to 500 μm. 
     
     
         3 . The medical nonwoven fabric as claimed in  claim 1 , wherein the wet-laid nonwoven fabric comprising short-cut fibers is dyed with a biocompatible dye or pigment. 
     
     
         4 . A medical nonwoven fabric comprising a laminate of
 a first nonwoven fabric layer in the form of a wet-laid nonwoven fabric comprising gelable cellulose derivative short-cut fibers; and   a second nonwoven fabric layer comprising a different kind of biodegradable polymer material not susceptible to gelation.   
     
     
         5 . The medical nonwoven fabric as claimed in  claim 4 , further comprising:
 a dyed layer formed on the second nonwoven fabric layer and dyed with a biocompatible dye or pigment.   
     
     
         6 . The medical nonwoven fabric as claimed in  claim 4 , wherein the wet-laid nonwoven fabric comprising short-cut fibers has micropores 1 to 500 μm in diameter. 
     
     
         7 . The medical nonwoven fabric as claimed in  claim 4 , wherein the first and second nonwoven fabric layers are of a structure fully laminated or partly bonded by ultrasound bonding. 
     
     
         8 . The medical nonwoven fabric as claimed in  claim 4 , wherein the biocompatible polymer material is a homopolymer or a copolymer synthesized from monomers selected from the group consisting of glycolide, glycolic acid, lactide, lactic acid, caprolactone, dioxanone, trimethylene carbonate, and ethylene glycol. 
     
     
         9 . The medical nonwoven fabric as claimed in  claim 4 , wherein the second nonwoven fabric layer comprises a homopolymer or a copolymer prepared from glycolide or glycolic acid. 
     
     
         10 . The medical nonwoven fabric as claimed in  claim 1 , wherein the medical nonwoven fabric is applied to any one medical application selected from an adhesion prevention barrier, an air shielding, a hemostat, a cell culturing scaffold, or a supporting material for wound closure. 
     
     
         11 . A method for preparing a medical nonwoven fabric, comprising:
 mixing and dispersing, with respect to 100 parts by weight of a cellulose fiber, 0 to 50 parts by weight of a binder material and 0 to 10 parts by weight of a biocompatible dispersing agent as suspended in an aqueous medium under agitation;   removing the aqueous medium by filtration and compressing the mixture to obtain a nonwoven fabric of short-cut fibers; and   subjecting the nonwoven fabric to chemical treatment to form a wet-laid nonwoven fabric comprising getable cellulose derivative short-cut fibers.   
     
     
         12 . The method as claimed in  claim 11 , wherein the binder material is a polymer with a hydroxyl group selected from polyvinyl alcohol or chitosan; or any one polymer selected from the group consisting of homopolymers or copolymers prepared from glycolide, lactide, caprolactone, dioxanone, or trimethylene carbonate. 
     
     
         13 . The method as claimed in  claim 12 , wherein the binder material is provided in the form of powder or fiber. 
     
     
         14 . The method as claimed in  claim 11 , wherein the biocompatible dispersing agent is any one selected from the group consisting of a poly(ethylene oxide)-(propylene oxide)-based nonionic surfactant, a Tween-series polysorbate surfactant, and polyacrylamide. 
     
     
         15 . A method for preparing a medical composite nonwoven fabric, comprising:
 positioning a second nonwoven fabric layer comprising a biodegradable polymer material not susceptible to gelation on a first nonwoven fabric layer provided in the form of the wet-laid nonwoven fabric comprising getable cellulose derivative short-cut fibers according to  claim 11 ; and   bonding the first and second nonwoven fabrics together for full lamination by calendering.   
     
     
         16 . A method for preparing a medical composite nonwoven fabric, comprising:
 positioning a second nonwoven fabric layer comprising a biodegradable polymer material not susceptible to gelation on a first nonwoven fabric layer provided in the form of the wet-laid nonwoven fabric comprising gelable cellulose derivative short-cut fibers according to  claim 11 ; and   bonding the first and second nonwoven fabrics together for partial bonding by ultrasound bonding.   
     
     
         17 . The method as claimed in  claim 15 , further comprising:
 conducting a dyeing process on the first nonwoven fabric with a solution containing a biocompatible dye or pigment.   
     
     
         18 . The method as claimed in  claim 15 , further comprising:
 applying gamma radiations after preparation of the second nonwoven fabric layer or the composite nonwoven fabric.   
     
     
         19 . An adhesion prevention barrier using the medical nonwoven fabric as claimed in  claim 1 . 
     
     
         20 . The method as claimed in  claim 16 , further comprising:
 conducting a dyeing process on the first nonwoven fabric with a solution containing a biocompatible dye or pigment.   
     
     
         21 . The method as claimed in  claim 16 , further comprising:
 applying gamma radiations after preparation of the second nonwoven fabric layer or the composite nonwoven fabric.

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