Human transmembrane proteins

Abstract

The invention provides human transmembrane proteins (HTMPN) and polynucleotides which identify and encode HTMPN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HTMPN.

1 .- 20 . (canceled) 
     
     
         21 . An isolated polypeptide comprising an amino acid sequence having at least about 90% sequence identity to SEQ ID NO: 74. 
     
     
         22 . An isolated polypeptide comprising an amino acid sequence having at least about 95% sequence identity to SEQ ID NO: 74. 
     
     
         23 . The isolated polypeptide of  claim 21  comprising SEQ ID NO: 74. 
     
     
         24 . The isolated peptide of  claim 21  which has been modified by one or more of acetylation, carboxylation, glycosylation, phosphorylation, lipidation, or acylation. 
     
     
         25 . The isolated peptide of  claim 21  which is ligated to a heterologous amino acid sequence. 
     
     
         26 . A composition comprising the polypeptide of  claim 21  and at least one pharmaceutically acceptable excipient. 
     
     
         27 . A method of screening a compound for effectiveness as an agonist of the polypeptide of  claim 21 , the method comprising:
 (a) exposing a sample comprising the polypeptide of  claim 21  to the compound, and   (b) detecting agonist activity in the sample.   
     
     
         28 . A method of screening a compound for effectiveness as an antagonist of the polypeptide of  claim 21 , the method comprising:
 (a) exposing a sample comprising the polypeptide of  claim 21  to the compound, and   (b) detecting antagonist activity in the sample.   
     
     
         29 . A method of screening for a compound that specifically binds to the polypeptide of  claim 21 , the method comprising:
 (a) combining the polypeptide of  claim 21  with at least one test compound under suitable conditions, and   (b) detecting binding of the polypeptide of  claim 21  to the test compound, thereby identifying a compound that specifically binds to the polypeptide of  claim 21 .   
     
     
         30 . An antibody that specifically binds to a polypeptide comprising SEQ ID NO: 74. 
     
     
         31 . The antibody of  claim 28  which is labeled. 
     
     
         32 . The antibody of  claim 29 , wherein the label is selected from the group consisting of radionuclides, enzymes, fluorescent, chemiluminescent, and chromogenic agents. 
     
     
         33 . The antibody of  claim 30  which is monoclonal.