N-substituted benzene sulfonamides

Abstract

The invention provides N-substituted benzenesulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. Compounds of particular interest are defined by Formula (I), wherein R 1 , R 2 , R 3 , R 4 , and R 3′ , are as described in the specification. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders, including Alzheimer's disease using compounds of Formula (I).

1 . A compound of the formula: 
       
         
           
           
               
               
           
         
       
       or pharmaceutically acceptable salts thereof, wherein
 R 1  is C 2 -C 6  alkynyl, C 2 -C 6  alkenyl, or C 1 -C 8  alkyl wherein each is optionally substituted with 1, 2, or 3 groups that are independently C 1 -C 6  alkoxy, OH, halogen, CN, C 1 -C 6  thioalkoxy, phenyl, naphthyl, C 3 -C 8  cycloalkyl, NH 2 , NH(C 1 -C 6 )alkyl, N(C 1 -C 6 )alkyl(C 1 -C 6  alkyl), —C(O)NH 2 , —C(O)NH(C 1 -C 6 )alkyl, —C(O)N(C 1 -C 6 )alkyl(C 1 -C 6 )alkyl, —C(O) phenyl, or C 1 -C 6  alkoxycarbonyl,
 wherein each of the cyclic groups is optionally substituted with 1, 2, 3, or 4 groups that are independently halogen, C 1 -C 4  alkyl, C 1 -C 4  alkoxy, NH 2 , NH(C 1 -C 6 )alkyl, N(C 1 -C 6 )alkyl(C 1 -C 6  alkyl), —SO 2 —(C 1 -C 6 )alkyl, or OH; or 
 
 R 1  is C 3 -C 8  cycloalkyl optionally substituted with 1 or 2 groups that are independently C 1 -C 4  alkyl, C 1 -C 4  hydroxyalkyl, or OH; or 
 R 1  is heterocycloalkyl or heterocycloalkyl(C 1 -C 4 )alkyl wherein the heterocycloalkyl group is piperidinyl, pyrrolidinyl, tetrahydrofuranyl, pyrazolyl, or morpholinyl, wherein the heterocycloalkyl groups are optionally substituted with 1 or 2 groups that are independently C 1 -C 4  alkyl, C 1 -C 4  alkoxy, phenyl, phenyl(C 1 -C 4 )alkyl, OH, halogen, CO 2 H, C 1 -C 4  alkoxycarbonyl, —C(O)NH 2 , —C(O)NH(C 1 -C 4 )alkyl, —C(O)N(C 1 -C 4 )alkyl(C 1 -C 4 )alkyl, or C 1 -C 4  alkoxycarbonyl; or 
 R 1  is heteroaryl(C 1 -C 4 )alkyl, wherein the heteroaryl group is pyridyl, pyrimidyl, furanyl, or thienyl and the heteroaryl group is optionally substituted with 1, 2, or 3 groups that are independently halogen, CO 2 H, C 1 -C 4  alkoxycarbonyl, —C(O)NH 2 , —C(O)NH(C 2 -C 4 )alkyl, —C(O)N(C 2 -C 4 )alkyl(C 1 -C 4 )alkyl, C 1 -C 4  alkyl, C 1 -C 4  alkoxy or OH; 
 R 2  is C 1 -C 8  alkyl, C 1 -C 6  hydroxyalkyl, or C 2 -C 8  alkenyl, each of which is optionally substituted with 1, 2, or 3 groups that are independently 2H-chromenyl, 1,2,3,4-tetrahydronaphthalenyl, indolyl, 3,4-dihydronaphthalenyl, phenyl, naphthyl, C 3 -C 8  cycloalkyl, benzofuranyl, indolyl, 1,4-benzodioxanyl, 1,3-benzodioxolyl, pyridyl, pyrimidyl, C 1 -C 4  alkyl, halogen, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, NO 2 , thiadiazolyl, furanyl, triazolyl, or CN,
 wherein the cyclic portions of each of the above are optionally substituted with 1, 2, or 3 groups that are independently halogen, CO 2 H, C 1 -C 6  alkoxycarbonyl, —C(O)NH 2 , —C(O)NH(C 1 -C 6 )alkyl, —C(O)N(C 1 -C 6 )alkyl(C 1 -C 6 )alkyl, C 1 -C 4  alkoxy optionally substituted with pyridyl, thiazolyl, or methyl thiazol-5-yl, NO 2 , C 1 -C 4  alkyl, —S(O) x —R 25 , —(C 1 -C 4  alkyl)-S(O) x —R 25 , or OH; wherein
 x is 0, 1, or 2; 
 R 25  is C 1 -C 6  alkyl, OH, NR 26 R 27 ; 
 R 26  and R 27  are independently H, C 1 -C 6  alkyl, phenyl(C 1 -C 4  alkyl), phenyl, or pyridyl; or 
 
 
 R 26 , R 27  and the nitrogen to which they are attached represent pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, or imidazolidinyl; 
 R 3  is H, halogen, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkyl, or CN, 
 R 4  is H, halogen, C 1 -C 6  alkyl optionally substituted with —CO 2 —(C 1 -C 6  alkyl), C 1 -C 6  alkoxy, C 1 -C 6  haloalkyl, C 1 -C 6  haloalkoxy, CN, aryloxy, isocyanato, —SO 2 —(C 1 -C 6  alkyl), —NHR′, —NR′R″, C 1 -C 6  alkanoyl, pyridyl, or phenyl; or 
 R 3  and R 4  and the carbons to which they are attached form a heterocycloalkyl ring which is optionally substituted with 1, 2, or 3 groups that are independently C 1 -C 4  alkyl, C 1 -C 4  alkoxy, halogen, or C 1 -C 4  alkanoyl wherein the alkanoyl group is optionally substituted with up to 3 halogen atoms; 
 R 3′  is H, —SO 2 —NR′R″, halogen, or 
 R 4  and R 3′  and the carbons to which they are attached form a phenyl ring; or 
 R 4  and R 3′  and the carbons to which they are attached form a 1-oxa-2,3-diazacyclopentyl ring;
 R′ is H, C 1 -C 6  alkyl, phenyl(C 1 -C 4 )alkyl, C 1 -C 6  alkanoyl, phenyl(C 1 -C 6 )alkanoyl, pyridyl(C 1 -C 4 )alkyl, pyrimidyl(C 1 -C 4 )alkyl, pyridazyl(C 1 -C 4 )alkyl, pyrazinyl(C 1 -C 4 )alkyl, thienyl(C 1 -C 4 )alkyl, oxazolyl(C 1 -C 4 )alkyl, thiazolyl(C 1 -C 4 )alkyl, furanyl(C 1 -C 4 )alkyl, —SO 2 -alkyl, —SO 2 -phenyl, —SO 2 -pyridyl, —SO 2 -pyrimidyl, —SO 2 -pyridazyl, —SO 2 -pyrazinyl, —SO 2 -thienyl, —SO 2 -oxazolyl, —SO 2 -thiazolyl, —SO 2 -furanyl, pyridyl(C 1 -C 6 )alkanoyl, pyrimidyl(C 1 -C 6 )alkanoyl, pyridazyl(C 1 -C 6 )alkanoyl, pyrazinyl(C 1 -C 6 )alkanoyl, thienyl(C 1 -C 6 )alkanoyl, oxazolyl(C 1 -C 6 )alkanoyl, thiazolyl(C 1 -C 6 )alkanoyl, or furanyl(C 1 -C 6 )alkanoyl, wherein the alkyl portion of the alkyl and alkanoyl groups are optionally substituted with halogen or C 1 -C 6  alkoxy, wherein the aryl, and heteroaryl groups are optionally substituted with alkyl, alkoxy, halogen, haloalkyl, haloalkoxy, 
 R″ is H, or C 1 -C 6  alkyl, wherein the alkyl group is optionally substituted with halogen. 
 
 
     
     
         2 . A compound according to  claim 1 , wherein
 R 1  is C 1 -C 8  alkyl which is optionally substituted with 1, 2, or 3 groups that are independently C 1 -C 6  alkoxy, OH, halogen, CN, C 1 -C 6  thioalkoxy, phenyl, naphthyl, C 3 -C 8  cycloalkyl, NH 2 , NH(C 1 -C 6 )alkyl, N(C 1 -C 6 )alkyl(C 1 -C 6  alkyl), —C(O)NH 2 , —C(O)NH(C 1 -C 6 )alkyl, —C(O)N(C 1 -C 6 )alkyl(C 1 -C 6 )alkyl, —C(O)phenyl, or C 1 -C 6  alkoxycarbonyl,
 wherein each of the cyclic groups is optionally substituted with 1, 2, 3, or 4 groups that are independently halogen, C 1 -C 4  alkyl, C 1 -C 4  alkoxy, NH 2 , NH(C 1 -C 6 )alkyl, N(C 1 -C 6 )alkyl(C 1 -C 6  alkyl), —SO 2 —(C 1 -C 6 )alkyl, or OH. 
   
     
     
         3 . A compound according to  claim 2 , wherein
 R 3  is H, halogen, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkyl, CN;   R 4  is H, halogen, C 1 -C 6  alkyl optionally substituted with —CO 2 —(C 1 -C 6  alkyl), C 1 -C 6  alkoxy, C 1 -C 4  haloalkyl, C 1 -C 6  haloalkoxy, CN, aryloxy, isocyanato, —SO 2 —(C 1 -C 6  alkyl), —NHR′, —NR′R″, C 1 -C 6  alkanoyl, oxazolyl, pyrazolyl, thiazolyl, pyridyl, furanyl or thienyl, phenyl; and   R 3′  is H, or halogen.   
     
     
         4 . A compound according to  claim 3 , wherein
 R 2  is C 1 -C 8  alkyl, or C 2 -C 8  alkenyl, each of which is optionally substituted with 1, 2, or 3 groups that are independently, 2H-chromenyl, 1,2,3,4-tetrahydronaphthalenyl, indolyl, 3,4-dihydronaphthalenyl, phenyl, naphthyl, C 3 -C 8  cycloalkyl, benzofuranyl, indolyl, 1,4-benzodioxanyl, 1,3-benzodioxolyl, pyridyl, pyrimidyl, C 1 -C 4  alkyl, halogen, —CO 2 —(C 1 -C 6  alkyl), pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, thiadiazolyl, triazolyl, or CN,
 wherein the cyclic portions of each of the above are optionally substituted with 1, 2, or 3 groups that are independently halogen, CO 2 H, C 1 -C 6  alkoxycarbonyl, —C(O)NH 2 , —C(O)NH(C 1 -C 6 )alkyl, —C(O)N(C 1 -C 6 )alkyl(C 1 -C 6 )alkyl, C 1 -C 4  alkoxy optionally substituted with pyridyl, thiazolyl, or methyl thiazol-5-yl, C 1 -C 4  alkyl, —S(O) x —R 25 , —(C 1 -C 4  alkyl)-S(O) x —R 25 , or OH; wherein
 x is 0, 1, or 2; 
 R 25  is C 1 -C 6  alkyl, OH, NR 26 R 27 ; 
 R 26  and R 27  are independently H, C 1 -C 6  alkyl, phenyl(C 1 -C 4  alkyl), phenyl, or pyridyl; or 
 R 26 , R 27  and the nitrogen to which they are attached represent pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, or imidazolidinyl. 
 
   
     
     
         5 . A compound according to  claim 4 , wherein
 R 1  is C 1 -C 8  alkyl which is optionally substituted with OH.   
     
     
         6 . A compound according to  claim 5 , wherein
 R 3  is H, halogen, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, CF 3 , CN;   R 4  is H, halogen, C 1 -C 6  alkoxy, C 1 -C 6  alkyl, CF 3 , OCF 3 , CN, phenyloxy, —SO 2 —(C 1 -C 6  alkyl), —NHR′, —NR′R″, C 1 -C 4  alkanoyl, pyridyl, furanyl or thienyl, phenyl, or C 1 -C 6  alkyl optionally substituted with —CO 2 —(C 1 -C 6  alkyl);   R 3′  is H, or halogen;
 R′ is H, C 1 -C 6  alkyl, phenyl(C 1 -C 4 )alkyl, C 1 -C 6  alkanoyl, phenyl(C 1 -C 4 )alkanoyl, pyridyl(C 1 -C 4 )alkyl, —SO 2 -alkyl, —SO 2 -phenyl, —SO 2 -pyridyl, pyridyl(C 1 -C 6 )alkanoyl, wherein the alkyl portion of the alkyl and alkanoyl groups are optionally substituted with halogen or C 1 -C 4  alkoxy,
 wherein the phenyl and pyridyl groups are optionally substituted with C 1 -C 4  alkyl, C 1 -C 4  alkoxy, halogen, CF 3 , OCF 3 ; 
 
 R″ is H or C 1 -C 6  alkyl, wherein the alkyl group is optionally substituted with halogen. 
   
     
     
         7 . A compound according to  claim 6 , wherein
 R 2  is C 1 -C 8  alkyl which is optionally substituted with 1 or 2 phenyl groups, 2H-chromenyl, 1,2,3,4-tetrahydronaphthalenyl, indolyl, 3,4-dihydronaphthalenyl, phenyl, naphthyl, C 3 -C 8  cycloalkyl, benzofuranyl, indolyl, 1,4-benzodioxanyl, 1,3-benzodioxolyl, pyridyl, pyrimidyl, triazolyl, or CN,
 wherein the cyclic portions of each of the above are optionally substituted with 1, 2, or 3 groups that are independently halogen, CO 2 H, C 1 -C 6  alkoxycarbonyl, —C(O)NH 2 , —C(O)NH(C 1 -C 6 )alkyl, —C(O)N(C 1 -C 6 )alkyl(C 1 -C 6 )alkyl, C 1 -C 4  alkoxy optionally substituted with pyridyl, thiazolyl, or methyl thiazol-5-yl, C 1 -C 4  alkyl, —S(O) x —R 25 , —(C 1 -C 4  alkyl)-S(O) x —R 25 , or OH; wherein
 x is 0, 1, or 2; 
 R 25  is C 1 -C 6  alkyl, OH, NR 26 R 27 ; 
 R 26  and R 27  are independently H, C 1 -C 6  alkyl, phenyl(C 1 -C 4  alkyl), phenyl, or pyridyl; or 
 R 26 , R 27  and the nitrogen to which they are attached represent pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, or imidazolidinyl. 
 
   
     
     
         8 . A compound according to  claim 7 , wherein
 R 2  is C 1 -C 8  alkyl which is optionally substituted with phenyl, benzofuranyl, 1,4-benzodioxanyl, or 1,3-benzodioxolyl,
 wherein the cyclic portions of each of the above are optionally substituted with 1, 2, or 3 groups that are independently halogen, CO 2 H, C 1 -C 6  alkoxycarbonyl, —C(O)NH 2 , —C(O)NH(C 1 -C 6 )alkyl, —C(O)N(C 8 -C 6 )alkyl(C 1 -C 6 )alkyl, C 1 -C 4  alkoxy optionally substituted with pyridyl, thiazolyl, or methyl thiazol-5-yl, C 1 -C 4  alkyl, —S(O) x —R 25 , —(C 1 -C 4  alkyl)-S(O) x —R 25 , or OH; wherein
 x is 0, 1, or 2; 
 R 25  is C 1 -C 6  alkyl, OH, NR 26 R 27 ; 
 R 26  and R 27  are independently H, C 1 -C 6  alkyl, phenyl(C 1 -C 4  alkyl), phenyl, or pyridyl; or 
 R 26 , R 27  and the nitrogen to which they are attached represent pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, or imidazolidinyl. 
 
   
     
     
         9 . A compound according to  claim 8 , wherein
 R 2  is C 1 -C 8  alkyl substituted with phenyl, wherein the phenyl is optionally substituted with 1, 2, or 3 groups that are independently halogen, CO 2 H, C 1 -C 6  alkoxycarbonyl, —C(O)NH 2 , —C(O)NH(C 1 -C 6 )alkyl, —C(O)N(C 1 -C 6 )alkyl(C 1 -C 6 )alkyl, C 1 -C 4  alkoxy optionally substituted with pyridyl, thiazolyl, or methyl thiazol-5-yl, C 1 -C 4  alkyl, —S(O) x —R 25 , —(C 1 -C 4  alkyl)-S(O) x —R 25 , or OH; wherein
 x is 0, 1, or 2; 
 R 25  is C 1 -C 6  alkyl, OH, NR 26 R 27 ; 
 R 26  and R 27  are independently H, C 1 -C 6  alkyl, phenyl(C 1 -C 4  alkyl), phenyl, or pyridyl; or 
 R 26 , R 27  and the nitrogen to which they are attached represent pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, or imidazolidinyl. 
   
     
     
         10 . A compound according to  claim 9 , wherein
 R 1  is C 1 -C 8  hydroxyalkyl;   R 3  is H, halogen, C 1 -C 4  alkyl, C 1 -C 4  alkoxy, CF 3 , CN;   R 4  is H, halogen, C 1 -C 4  alkoxy, CF 3 , OCF 3 , CN, phenyloxy, —SO 2 —(C 1 -C 6  alkyl), —NHR′, —NR′R″, C 1 -C 4  alkanoyl, pyridyl, furanyl or thienyl, phenyl, or C 1 -C 6  alkyl optionally substituted with —CO 2 —(C 1 -C 6  alkyl);   R 3′  is H, or halogen;
 R′ is H, C 1 -C 4  alkyl, benzyl, C 1 -C 6  alkanoyl, phenyl(C 1 -C 4 )alkanoyl, pyridyl(C 1 -C 4 )alkyl, —SO 2 -alkyl, —SO 2 -phenyl, —SO 2 -pyridyl, pyridyl(C 1 -C 6 )alkanoyl, wherein the alkyl portion of the alkyl and alkanoyl groups are optionally substituted with halogen or C 1 -C 4  alkoxy,
 wherein the phenyl and pyridyl groups are optionally substituted with C 1 -C 4  alkyl, C 1 -C 4  alkoxy, halogen, CF 3 , OCF 3 ; 
 
 R″ is H or C 1 -C 6  alkyl, wherein the alkyl group is optionally substituted with halogen. 
   
     
     
         11 . A compound according to  claim 10 , wherein
 R 1  is   
       
         
           
           
               
               
           
         
         R 3  is H, halogen, methyl, methoxy, CF 3 , or CN; 
         R 4  is H, halogen, methyl, methoxy, CF 3 , OCF 3 , CN, —NHR′, or —NR′R″; 
         R 3′  is H, or halogen;
 R′ is H, or C 1 -C 4  alkyl; and 
 R″ is H or C 1 -C 6  alkyl, wherein the alkyl group is optionally substituted with halogen. 
 
       
     
     
         12 . A compound according to  claim 5 , wherein
 R 1  is C 1 -C 8  alkyl;   R 2  is C 1 -C 8  alkyl substituted with a phenyl group, benzofuranyl, 1,4-benzodioxanyl, or 1,3-benzodioxolyl, wherein the phenyl group is optionally substituted with 1, 2, or 3 groups that are independently halogen, CO 2 H, C 1 -C 6  alkoxycarbonyl, —C(O)NH 2 , —C(O)NH(C 1 -C 6 )alkyl, —C(O)N(C 1 -C 6 )alkyl(C 1 -C 6 )alkyl, C 1 -C 4  alkoxy optionally substituted with pyridyl, thiazolyl, or methyl thiazol-5-yl, C 1 -C 4  alkyl, —S(O) x —R 25 , —(C 1 -C 4  alkyl)-S(O) x —R 25 , or OH; wherein
 x is 0, 1, or 2; 
 R 25  is C 1 -C 6  alkyl, OH, NR 26 R 27 ; 
 R 26  and R 27  are independently H, C 1 -C 6  alkyl, phenyl(C 1 -C 4  alkyl), phenyl, or pyridyl; or 
 R 26 , R 27  and the nitrogen to which they are attached represent pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, or imidazolidinyl; 
   R 3  is H, halogen, C 1 -C 4  alkyl, C 1 -C 4  alkoxy, CF 3 , CN;   R 4  is H, halogen, C 1 -C 4  alkoxy, CF 3 , OCF 3 , CN, phenyloxy, —SO 2 —(C 1 -C 6  alkyl), —NHR′, —NR′R″, C 1 -C 4  alkanoyl, pyridyl, furanyl or thienyl, phenyl, or C 1 -C 4  alkyl optionally substituted with —CO 2 —(C 1 -C 6  alkyl);   R 3′  is H, or halogen;
 R′ is H, C 1 -C 4  alkyl, benzyl, C 1 -C 6  alkanoyl, phenyl(C 1 -C 4 )alkanoyl, pyridyl(C 1 -C 4 )alkyl, —SO 2 -alkyl, —SO 2 -phenyl, —SO 2 -pyridyl, pyridyl(C 1 -C 6 )alkanoyl, wherein the alkyl portion of the alkyl and alkanoyl groups are optionally substituted with halogen or C 1 -C 4  alkoxy,
 wherein the phenyl and pyridyl groups are optionally substituted with C 1 -C 4  alkyl, C 1 -C 4  alkoxy, halogen, CF 3 , OCF 3 ; 
 
 R″ is H or C 1 -C 6  alkyl, wherein the alkyl group is optionally substituted with halogen. 
   
     
     
         13 . A compound according to  claim 12 , wherein
 R 1  is C 2 -C 6  alkyl;   R 3  is H, halogen, methyl, methoxy, CF 3 , or CN;   R 4  is halogen, methyl, methoxy, CF 3 , OCF 3 , CN, —NHR′, or —NR′R″;   R 3′  is H, or halogen;
 R′ is H, or C 1 -C 4  alkyl; and 
 R″ is H or C 1 -C 6  alkyl, wherein the alkyl group is optionally substituted with halogen. 
   
     
     
         14 . A compound according to  claim 6 , wherein
 R 2  is C 3 -C 8  alkenyl, optionally substituted with 1 or 2 groups that are independently phenyl, halogen, 2H-chromenyl, 1,2,3,4-tetrahydronaphthalenyl, indolyl, 3,4-dihydronaphthalenyl, naphthyl, C 3 -C 8  cycloalkyl, benzofuranyl, indolyl, 1,4-benzodioxanyl, 1,3-benzodioxolyl, pyridyl, C 1 -C 4  alkyl, halogen, —CO 2 —(C 1 -C 4  alkyl), pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, thiadiazolyl, triazolyl, or pyrimidyl;
 wherein the cyclic portions of each of the above are optionally substituted with 1, 2, or 3 groups that are independently halogen, CO 2 H, C 1 -C 4  alkoxycarbonyl, —C(O)NH 2 , —C(O)NH(C 1 -C 4 )alkyl, —C(O)N(C 1 -C 4 )alkyl(C 1 -C 4 )alkyl, C 1 -C 4  alkoxy optionally substituted with pyridyl, thiazolyl, or methyl thiazol-5-yl, C 1 -C 4  alkyl, —S(O) x —R 25 , —(C 1 -C 4  alkyl)-S(O) x —R 25 , or OH; wherein 
 x is 0, 1, or 2; 
 R 25  is C 1 -C 6  alkyl, OH, NR 26 R 27 ; 
 R 26  and R 27  are independently H, C 1 -C 6  alkyl, phenyl(C 1 -C 4  alkyl), phenyl, or pyridyl; or 
 R 26 , R 27  and the nitrogen to which they are attached represent pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, or imidazolidinyl. 
   
     
     
         15 . A compound according to  claim 14 , wherein
 R 2  is C 3 -C 6  alkenyl, optionally substituted with 1 or 2 groups that are phenyl, halogen, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, thiadiazolyl, or pyrimidyl; wherein the phenyl group is optionally substituted with 1, 2, or 3 groups that are independently halogen, CO 2 H, C 1 -C 4  alkoxycarbonyl, —C(O)NH 2 , —C(O)NH(C 1 -C 4 )alkyl, —C(O)N(C 1 -C 4 )alkyl(C 1 -C 4 )alkyl, C 1 -C 4  alkoxy optionally substituted with pyridyl, thiazolyl, or methyl thiazol-5-yl, C 1 -C 4  alkyl, —S(O) x —R 25 , —(C 1 -C 4  alkyl)-S(O) x —R 25 , or OH; wherein
 x is 0, 1, or 2; 
 R 25  is C 1 -C 6  alkyl, OH, NR 26 R 27 ; 
 R 26  and R 27  are independently H, C 1 -C 6  alkyl, phenyl(C 1 -C 4  alkyl), phenyl, or pyridyl; or 
 R 26 , R 27  and the nitrogen to which they are attached represent pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, or imidazolidinyl. 
   
     
     
         16 . A compound according to  claim 1 , wherein
 R 1  is C 3 -C 8  cycloalkyl optionally substituted with 1 or 2 groups that are independently C 1 -C 4  alkyl, C 1 -C 4  hydroxyalkyl, or OH; or   R 1  is heterocycloalkyl or heterocycloalkyl(C 1 -C 4 )alkyl wherein the heterocycloalkyl group is piperidinyl, pyrrolidinyl, tetrahydrofuranyl, pyrazolyl, or morpholinyl, wherein the heterocycloalkyl groups are optionally substituted with 1 or 2 groups that are independently C 1 -C 4  alkyl, C 1 -C 4  alkoxy, phenyl, phenyl(C 1 -C 4 )alkyl, OH, halogen, CO 2 H, C 1 -C 4  alkoxycarbonyl, —C(O)NH 2 , —C(O)NH(C 1 -C 4 )alkyl, —C(O)N(C 1 -C 4 )alkyl(C 1 -C 4 )alkyl, or C 1 -C 4  alkoxycarbonyl; or   R 1  is heteroaryl(C 1 -C 4 )alkyl, wherein the heteroaryl group is pyridyl, pyrimidyl, furanyl, or thienyl and the heteroaryl group is optionally substituted with 1, 2, or 3 groups that are independently halogen, CO 2 H, C 1 -C 4  alkoxycarbonyl, —C(O)NH 2 , —C(O)NH(C 1 -C 4 )alkyl, —C(O)N(C 1 -C 4 )alkyl(C 1 -C 4 )alkyl, C 1 -C 4  alkyl, C 1 -C 4  alkoxy or OH.   
     
     
         17 . A compound according to  claim 16 , wherein
 R 2  is C 1 -C 8  alkyl, or C 2 -C 8  alkenyl, each of which is optionally substituted with 1 or 2 groups that are independently, 2H-chromenyl, 1,2,3,4-tetrahydronaphthalenyl, indolyl, 3,4-dihydronaphthalenyl, phenyl, naphthyl, C 3 -C 8  cycloalkyl, benzofuranyl, indolyl, 1,4-benzodioxanyl, 1,3-benzodioxolyl, pyridyl, pyrimidyl, C 1 -C 4  alkyl, halogen, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, thiadiazolyl, furanyl, triazolyl, or CN,
 wherein the cyclic portions of each of the above are optionally substituted with 1, 2, or 3 groups that are independently halogen, CO 2 H, C 1 -C 4  alkoxycarbonyl, —C(O)NH 2 , —C(O)NH(C 1 -C 4 )alkyl, —C(O)N(C 1 -C 4 )alkyl(C 1 -C 4 )alkyl, C 1 -C 4  alkoxy, C 1 -C 4  alkoxy optionally substituted with pyridyl, thiazolyl, or methyl thiazol-5-yl, NO 2 , C 1 -C 4  alkyl, —S(O) x —R 25 , —(C 1 -C 4  alkyl)-S(O) x —R 25 , or OH; wherein 
 x is 0, 1, or 2; 
 R 25  is C 1 -C 6  alkyl, OH, NR 26 R 27 ; 
 R 26  and R 27  are independently H, C 1 -C 6  alkyl, phenyl(C 1 -C 4  alkyl), phenyl, or pyridyl; or 
 R 26 , R 27  and the nitrogen to which they are attached represent pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, or imidazolidinyl. 
   
     
     
         18 . A pharmaceutical composition comprising a compound of  claim 1  and at least one pharmaceutically acceptable carrier, solvent, adjuvant or excipient, or a combination thereof. 
     
     
         19 . A method of treating a patient who has, or in preventing a patient from getting, a disease or condition selected from the group consisting of Alzheimer's disease, for helping prevent or delay the onset of Alzheimer's disease, for treating patients with mild cognitive impairment (MCI) and preventing or delaying the onset of Alzheimer's disease in those who would progress from MCI to AD, for treating Down's syndrome, for treating humans who have Hereditary Cerebral Hemorrhage with Amyloidosis of the Dutch-Type, for treating cerebral amyloid angiopathy and preventing its potential consequences, i.e. single and recurrent lobar hemorrhages, for treating other degenerative dementias, including dementias of mixed vascular and degenerative origin, dementia associated with Parkinson's disease, dementia associated with progressive supranuclear palsy, dementia associated with cortical basal degeneration, age related macular degeneration, or diffuse Lewy body type of Alzheimer's disease and who is in need of such treatment which comprises administration of a therapeutically effective amount of a compound of  claim 1 . 
     
     
         20 . A compound according to  claim 1  that is
 (S)-4-chloro-N-cinnamyl-N-(1-hydroxy-4-methylpentan-2-yl)benzenesulfonamide; 
 [(4-Chloro-benzenesulfonyl)-methyl-amino]-acetic acid ethyl ester; 
 [2-(4-Chloro-benzenesulfonylimino)-imidazolidin-1-yl]-acetic acid; 
 2-(4-Chloro-benzenesulfonylamino)-N-methyl-propionamide; 
 2-[(4-Chloro-benzenesulfonyl)-(3,4-dimethoxy-benzyl)-amino]-3-phenyl-propionamide; 
 2-[(4-Chloro-benzenesulfonyl)-(3-phenyl-propyl)-amino]-3-hydroxy-N-methyl-butyramide; 
 3-[(4-Chloro-benzenesulfonyl)-(3,4-dimethoxy-benzyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester; 
 4-Chloro-N-(1,2-dimethyl-propyl)-N-(3-phenyl-allyl)-benzenesulfonamide; 
 4-Chloro-N-(1,2-dimethyl-propyl)-N-(3-phenyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-(1,3-dimethyl-butyl)-N-(3-phenyl-allyl)-benzenesulfonamide; 
 4-Chloro-N-(1,3-dimethyl-butyl)-N-(3-phenyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-(1-chloro-3,4-dihydro-naphthalen-2-ylmethyl)-N-(1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N-(1-ethyl-propyl)-N-(3-phenyl-allyl)-benzenesulfonamide; 
 4-Chloro-N-(1-ethyl-propyl)-N-(3-phenyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-(1-hydroxymethyl-3-methyl-butyl)-N-(1,2,3,4-tetrahydro-naphthalen-2-yl)-benzenesulfonamide; 
 4-Chloro-N-(1-hydroxymethyl-3-methyl-butyl)-N-(1-methyl-1H-indol-2-ylmethyl)-benzenesulfonamide; 
 4-Chloro-N-(1-hydroxymethyl-3-methyl-butyl)-N-(1-methyl-3-phenyl-allyl)-benzenesulfonamide; 
 4-Chloro-N-(1-hydroxymethyl-3-methyl-butyl)-N-(1-methyl-3-phenyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-(1-hydroxymethyl-3-methyl-butyl)-N-(2-methyl-3-phenyl-allyl)-benzenesulfonamide; 
 4-Chloro-N-(1-hydroxymethyl-3-methyl-butyl)-N-(2-pentyl-3-phenyl-allyl)-benzenesulfonamide; 
 4-Chloro-N-(1-hydroxymethyl-3-methyl-butyl)-N-(3-phenyl-butyl)-benzenesulfonamide; 
 4-Chloro-N-(1-hydroxymethyl-3-methyl-butyl)-N-(3-phenyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-(1-hydroxymethyl-3-methyl-butyl)-N-(4-methoxy-benzyl)-benzenesulfonamide; 
 4-Chloro-N-(1-hydroxymethyl-3-methyl-butyl)-N-[3-(2-methoxy-phenyl)-allyl]-benzenesulfonamide; 
 4-Chloro-N-(1-hydroxymethyl-3-methyl-butyl)-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-benzenesulfonamide; 
 4-Chloro-N-(1-hydroxymethyl-3-methyl-butyl)-N-methyl-benzenesulfonamide; 
 4-Chloro-N-(1-hydroxymethyl-3-methyl-butyl)-N-propyl-benzenesulfonamide; 
 4-Chloro-N-(1-hydroxymethyl-pentyl)-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-benzenesulfonamide; 
 4-Chloro-N-(1-hydroxymethyl-pentyl)-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-benzenesulfonamide; 
 4-Chloro-N-(1-hydroxymethyl-propyl)-N-(3-phenyl-allyl)-benzenesulfonamide; 
 4-Chloro-N-(1-hydroxymethyl-propyl)-N-(3-phenyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-(1-methyl-butyl)-N-(3-phenyl-allyl)-benzenesulfonamide; 
 4-Chloro-N-(1-methyl-butyl)-N-(3-phenyl-propyl)-benzenesulfonamide; 
 4-chloro-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N-[(1S)-1-(hydroxymethyl)-3-methylbutyl]benzenesulfonamide; 
 4-Chloro-N-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-N-(1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N-(2,3-dihydroxy-propyl)-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-benzenesulfonamide; 
 4-Chloro-N-(2,3-dihydroxy-propyl)-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-benzenesulfonamide; 
 4-Chloro-N-(2,4-dichloro-benzyl)-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-benzenesulfonamide; 
 4-Chloro-N-(2,4-dichloro-benzyl)-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-benzenesulfonamide; 
 4-Chloro-N-(2,4-difluoro-benzyl)-N-(1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-chloro-N-(2,4-difluorobenzyl)-N-[(1R)-1-(hydroxymethyl)-3-methylbutyl]benzenesulfonamide; 
 4-Chloro-N-(2-cyano-ethyl)-N-cyclopropyl-benzenesulfonamide; 
 4-Chloro-N-(2-cyano-ethyl)-N-cyclopropyl-benzenesulfonamide; 
 4-Chloro-N-(2-cyano-ethyl)-N-ethyl-benzenesulfonamide; 
 4-Chloro-N-(2-cyano-ethyl)-N-ethyl-benzenesulfonamide; 
 4-Chloro-N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-benzenesulfonamide; 
 4-Chloro-N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-benzenesulfonamide; 
 4-Chloro-N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-benzenesulfonamide; 
 4-Chloro-N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-benzenesulfonamide; 
 4-Chloro-N-(2-hydroxy-cyclohexylmethyl)-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-benzenesulfonamide; 
 4-Chloro-N-(2-hydroxy-propyl)-N-(3-phenyl-allyl)-benzenesulfonamide; 
 4-Chloro-N-(2-hydroxy-propyl)-N-(3-phenyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-(2-hydroxy-propyl)-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-benzenesulfonamide; 
 4-Chloro-N-(2-hydroxy-propyl)-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-benzenesulfonamide; 
 4-Chloro-N-(2-methoxy-1-methyl-ethyl)-N-(3-phenyl-allyl)-benzenesulfonamide; 
 4-Chloro-N-(2-methoxy-1-methyl-ethyl)-N-(3-phenyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-(2-methyl-cyclohexyl)-N-(3-phenyl-allyl)-benzenesulfonamide; 
 4-Chloro-N-(2-methyl-cyclohexyl)-N-(3-phenyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(1-hydroxymethyl-2-methyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(1-hydroxymethyl-2-methyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(1-hydroxymethyl-2-phenyl-ethyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(1-hydroxymethyl-2-phenyl-ethyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(1-hydroxymethyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(1-naphthalen-1-yl-ethyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(1-naphthalen-1-yl-ethyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(1-phenyl-ethyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(1-phenyl-ethyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(2,3-dimethyl-cyclohexyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(2,3-dimethyl-cyclohexyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(2-hydroxy-1-hydroxymethyl-2-phenyl-ethyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(2-hydroxy-1-phenyl-ethyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(2-methyl-cyclohexyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(3-hydroxy-2,2-dimethyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(3-hydroxymethyl-bicyclo[2.2.1]hept-2-yl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(4-methyl-cyclohexyl)-benzenesulfonamide; 
 4-chloro-N-(3,4-dimethoxybenzyl)-N-[(1R,2S)-2-hydroxy-1-(hydroxymethyl)-2-phenylethyl]benzenesulfonamide; 
 4-chloro-N-(3,4-dimethoxybenzyl)-N-[(1S)-1-(hydroxymethyl)-3-methylbutyl]benzenesulfonamide; 
 4-chloro-N-(3,4-dimethoxybenzyl)-N-[(1S)-1-(hydroxymethyl)propyl]benzenesulfonamide; 
 4-chloro-N-(3,4-dimethoxybenzyl)-N-[(1S)-2-hydroxy-1-phenylethyl]benzenesulfonamide; 
 4-chloro-N-(3,4-dimethoxybenzyl)-N-[(1S,2R)-2-hydroxy-1-methyl-2-phenylethyl]benzenesulfonamide; 
 4-chloro-N-(3,4-dimethoxybenzyl)-N-[(1S,3R,4R)-3-(hydroxymethyl)bicyclo[2.2.1]hept-2-yl]benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-[1-(4-methanesulfonyl-phenyl)-ethyl]-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-[1-(4-methanesulfonyl-phenyl)-ethyl]-benzenesulfonamide; 
 4-Chloro-N-(3-fluoro-4-methoxy-benzyl)-N-(1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-chloro-N-(3-fluoro-4-methoxybenzyl)-N-[(1S)-1-(hydroxymethyl)-3-methylbutyl]benzenesulfonamide; 
 4-Chloro-N-(3-hydroxy-butyl)-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-benzenesulfonamide; 
 4-Chloro-N-(4-chloro-6-fluoro-2H-chromen-3-ylmethyl)-N-(1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N-(4-chloro-benzyl)-N-(1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-chloro-N-(4-chlorobenzyl)-N-[(1R)-1-(hydroxymethyl)-3-methylbutyl]benzenesulfonamide; 
 4-Chloro-N-(4-diethylamino-1-methyl-butyl)-N-(3,4-dimethoxy-benzyl)-benzenesulfonamide; 
 4-Chloro-N,N-dicyclohexyl-benzenesulfonamide; 
 4-Chloro-N,N-diisopropyl-benzenesulfonamide; 
 4-Chloro-N,N-divinyl-benzenesulfonamide; 
 4-chloro-N-[(1R)-1-(hydroxymethyl)-3-methylbutyl]-N-(3-phenylpropyl)benzenesulfonamide; 
 4-chloro-N-[(1R)-1-(hydroxymethyl)-3-methylbutyl]-N-(4-methoxybenzyl)benzenesulfonamide; 
 4-chloro-N-[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylbenzenesulfonamide; 
 4-chloro-N-[(1S)-1-(hydroxymethyl)-3-methylbutyl]-N-[(2E)-2-methyl-3-phenylprop-2-en-1-yl]benzenesulfonamide; 
 4-chloro-N-[(1S)-1-(hydroxymethyl)-3-methylbutyl]-N-[(2E)-3-phenylprop-2-en-1-yl]benzenesulfonamide; 
 4-chloro-N-[(1S)-1-(hydroxymethyl)-3-methylbutyl]-N-{3-methoxy-4-[2-(4-methyl-1,3-thiazol-5-yl)ethoxy]benzyl}benzenesulfonamide; 
 4-chloro-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylbenzenesulfonamide; 
 4-Chloro-N-[2-(3,4-dihydroxy-phenyl)-2-oxo-ethyl]-N-methyl-benzenesulfonamide; 
 4-chloro-N-{[(1R,2S)-2-hydroxycyclohexyl]methyl}-N-{3-methoxy-4-[2-(4-methyl-1,3-thiazol-5-yl)ethoxy]benzyl}benzenesulfonamide; 
 4-Chloro-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-N-(2-methyl-cyclohexyl)-benzenesulfonamide; 
 4-Chloro-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-N-(2-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-N-(3-methylsulfanyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-N-(4-methyl-cyclohexyl)-benzenesulfonamide; 
 4-Chloro-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-N-pyridin-2-ylmethyl-benzenesulfonamide; 
 4-Chloro-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-N-prop-2-ynyl-benzenesulfonamide; 
 4-Chloro-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-N-(3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-N-(tetrahydro-furan-2-ylmethyl)-benzenesulfonamide; 
 4-Chloro-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-N-(3-methoxy-propyl)-benzenesulfonamide; 
 4-Chloro-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-N-(1-phenyl-ethyl)-benzenesulfonamide; 
 4-Chloro-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-N-(2-methyl-allyl)-benzenesulfonamide; 
 4-Chloro-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-N-(2-methyl-cyclohexyl)-benzenesulfonamide; 
 4-Chloro-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-N-(2-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-N-(3-methylsulfanyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-N-(4-methyl-cyclohexyl)-benzenesulfonamide; 
 4-Chloro-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-N-pyridin-2-ylmethyl-benzenesulfonamide; 
 4-Chloro-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-N-prop-2-ynyl-benzenesulfonamide; 
 4-Chloro-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-N-(3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-N-(tetrahydro-furan-2-ylmethyl)-benzenesulfonamide; 
 4-Chloro-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-N-(3-methoxy-propyl)-benzenesulfonamide; 
 4-Chloro-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-N-(1-phenyl-ethyl)-benzenesulfonamide; 
 4-Chloro-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-N-(2-methyl-allyl)-benzenesulfonamide; 
 4-Chloro-N-cyanomethyl-N-methyl-benzenesulfonamide; 
 4-Chloro-N-cyclohexyl-N-(2-hydroxy-ethyl)-benzenesulfonamide; 
 4-Chloro-N-cyclohexyl-N-(2-hydroxy-ethyl)-benzenesulfonamide; 
 4-Chloro-N-cyclohexyl-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-benzenesulfonamide; 
 4-Chloro-N-cyclohexyl-N-isopropyl-benzenesulfonamide; 
 4-Chloro-N-cyclooctyl-N-(3,4-dimethoxy-benzyl)-benzenesulfonamide; 
 4-Chloro-N-cyclopentyl-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-benzenesulfonamide; 
 4-Chloro-N-cyclopentyl-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-benzenesulfonamide; 
 4-Chloro-N-cyclopropylmethyl-N-(1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N-cyclopropylmethyl-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-benzenesulfonamide; 
 4-Chloro-N-cyclopropylmethyl-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-benzenesulfonamide; 
 4-Chloro-N-ethyl-N-(2-pyridin-2-yl-ethyl)-benzenesulfonamide; 
 4-Chloro-N-ethyl-N-[2-hydroxy-2-(3-hydroxy-phenyl)-ethyl]-benzenesulfonamide; 
 4-Chloro-N-ethyl-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-benzenesulfonamide; 
 4-Chloro-N-isopropyl-N-(2-pyridin-4-yl-ethyl)-benzenesulfonamide; 
 4-Chloro-N-methyl-N-(1-methyl-piperidin-4-yl)-benzenesulfonamide; 
 4-Chloro-N-methyl-N-(1-methyl-piperidin-4-yl)-benzenesulfonamide; 
 4-Chloro-N-methyl-N-(2-pyridin-4-yl-ethyl)-benzenesulfonamide; 
 4-Chloro-N-pyrrolidin-3-yl-benzenesulfonamide; 
 N-(1,3-benzodioxol-5-ylmethyl)-4-chloro-N-[(1S)-1-(hydroxymethyl)-3-methylbutyl]benzenesulfonamide; 
 N-(1-Benzyl-pyrrolidin-3-yl)-4-chloro-N-ethyl-benzenesulfonamide; 
 N-(2-Amino-benzyl)-4-chloro-N-{3-methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzyl}-benzenesulfonamide; 
 N-(2-Benzyl-cyclohexyl)-4-chloro-N-(1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 N-(4-Bromo-benzyl)-4-chloro-N-(1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 N-(4-bromobenzyl)-4-chloro-N-[(1R)-1-(hydroxymethyl)-3-methylbutyl]benzenesulfonamide; 
 N,N-Di-sec-butyl-4-chloro-benzenesulfonamide; 
 N-[(1R)-1-benzyl-2-hydroxyethyl]-4-chloro-N-(3,4-dimethoxybenzyl)benzenesulfonamide; 
 N-[(1S)-1-benzyl-2-hydroxyethyl]-4-chloro-N-(3,4-dimethoxybenzyl)benzenesulfonamide; 
 N-[(4-chlorophenyl)sulfonyl]-N-(3,4-dimethoxybenzyl)-L-phenylalaninamide; 
 N-[3-(4-tert-Butyl-phenyl)-2-methyl-propyl]-4-chloro-N-(1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 N2-[(4-chlorophenyl)sulfonyl]-N-1-methyl-L-alaninamide; 
 N-Allyl-4-chloro-N-cyclohexyl-benzenesulfonamide; 
 N-Benzo[1,3]dioxol-5-ylmethyl-4-chloro-N-(1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 N-Benzofuran-2-ylmethyl-4-chloro-N-(1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 N-Benzofuran-2-ylmethyl-N-sec-butyl-4-chloro-benzenesulfonamide; 
 N-Benzyl-4-chloro-N-(1-hydroxymethyl-propyl)-benzenesulfonamide; 
 N-Benzyl-4-chloro-N-(2-hydroxy-cyclohexyl)-benzenesulfonamide; 
 N-Benzyl-4-chloro-N-(2-hydroxymethyl-cyclohexyl)-benzenesulfonamide; 
 N-benzyl-4-chloro-N-[(1R)-1-(hydroxymethyl)propyl]benzenesulfonamide; 
 N-benzyl-4-chloro-N-[(1S,2R)-2-(hydroxymethyl)cyclohexyl]benzenesulfonamide; 
 N-benzyl-4-chloro-N-[(1S,2S)-2-hydroxycyclohexyl]benzenesulfonamide; 
 N-Benzyl-N-sec-butyl-4-chloro-benzenesulfonamide; 
 N-sec-Butyl-4-chloro-N-(1-chloro-3,4-dihydro-naphthalen-2-ylmethyl)-benzenesulfonamide; 
 N-sec-Butyl-4-chloro-N-(1-methyl-1H-indol-2-ylmethyl)-benzenesulfonamide; 
 N-sec-Butyl-4-chloro-N-(1-methyl-3-phenyl-allyl)-benzenesulfonamide; 
 N-sec-Butyl-4-chloro-N-(1-methyl-3-phenyl-propyl)-benzenesulfonamide; 
 N-sec-Butyl-4-chloro-N-(2-pentyl-3-phenyl-allyl)-benzenesulfonamide; 
 N-sec-Butyl-4-chloro-N-(3,3-diphenyl-allyl)-benzenesulfonamide; 
 N-sec-Butyl-4-chloro-N-(3-phenyl-allyl)-benzenesulfonamide; 
 N-sec-Butyl-4-chloro-N-(3-phenyl-butyl)-benzenesulfonamide; 
 N-sec-Butyl-4-chloro-N-(3-phenyl-propyl)-benzenesulfonamide; 
 N-sec-Butyl-4-chloro-N-(4,6-dichloro-2H-chromen-3-ylmethyl)-benzenesulfonamide; 
 N-sec-Butyl-4-chloro-N-(4-chloro-6-fluoro-2H-chromen-3-ylmethyl)-benzenesulfonamide; 
 N-sec-Butyl-4-chloro-N-[3-(2-methoxy-phenyl)-allyl]-benzenesulfonamide; 
 N-tert-Butyl-2-(4-chloro-benzenesulfonylamino)-3-methyl-butyramide; or pharmaceutically acceptable salts thereof. 
 
     
     
         21 . A compound according to  claim 1  that is
 4-Chloro-N-cyclooctyl-N-(3,4-dimethoxy-benzyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(2,3-dimethyl-cyclohexyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(4-methyl-cyclohexyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(1-phenyl-ethyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(1-hydroxymethyl-2-methyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(3-hydroxy-2,2-dimethyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-[1-(4-methanesulfonyl-phenyl)-ethyl]-benzenesulfonamide; 
 3-[(4-Chloro-benzenesulfonyl)-(3,4-dimethoxy-benzyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(3-hydroxymethyl-bicyclo[2.2.1]hept-2-yl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N—(R-2-hydroxy-1-phenyl-ethyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N—(R-1-hydroxymethyl-2-phenyl-ethyl)-benzenesulfonamide; 
 N-Benzyl-4-chloro-N-(1S,2S-2-hydroxy-cyclohexyl)-benzenesulfonamide; 
 4-Chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-N-(3-phenyl-allyl)-benzenesulfonamide; 
 4-Chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-N-(2-methyl-3-phenyl-allyl)-benzenesulfonamide; 
 N-Benzo[1,3]dioxol-5-ylmethyl-4-chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N-(3-fluoro-4-methoxy-benzyl)-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-N-(4-methoxy-benzyl)-benzenesulfonamide; 
 4-Chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-N-(3-phenyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-(4-chloro-benzyl)-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 N-(4-Bromo-benzyl)-4-chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N-(2,4-difluoro-benzyl)-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 R—N-sec-Butyl-4-chloro-N-(3-phenyl-allyl)-benzenesulfonamide; 
 4-Chloro-N—(R-1,2-dimethyl-propyl)-N-(3-phenyl-allyl)-benzenesulfonamide; 
 4-Chloro-N-(1-ethyl-propyl)-N-(3-phenyl-allyl)-benzenesulfonamide; 
 4-Chloro-N-(1-hydroxymethyl-propyl)-N-(3-phenyl-allyl)-benzenesulfonamide; 
 4-Chloro-N-(2-hydroxy-propyl)-N-(3-phenyl-allyl)-benzenesulfonamide; 
 4-Chloro-N-(1,3-dimethyl-butyl)-N-(3-phenyl-allyl)-benzenesulfonamide; 
 4-Chloro-N-(1-methyl-butyl)-N-(3-phenyl-allyl)-benzenesulfonamide; 
 4-Chloro-N-(2-methoxy-1-methyl-ethyl)-N-(3-phenyl-allyl)-benzenesulfonamide; 
 4-Chloro-N-(2-methyl-cyclohexyl)-N-(3-phenyl-allyl)-benzenesulfonamide; 
 3-[(4-Chloro-benzenesulfonyl)-(3-phenyl-allyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester; 
 4-[(4-Chloro-benzenesulfonyl)-(3-phenyl-allyl)-amino]-piperidine-1-carboxylic acid ethyl ester; 
 R—N-sec-Butyl-4-chloro-N-(3-phenyl-propyl)-benzenesulfonamide; 
 4-Chloro-N—(R-1,2-dimethyl-propyl)-N-(3-phenyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-(1-ethyl-propyl)-N-(3-phenyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-(1-hydroxymethyl-propyl)-N-(3-phenyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-(2-hydroxy-propyl)-N-(3-phenyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-(1,3-dimethyl-butyl)-N-(3-phenyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-(1-methyl-butyl)-N-(3-phenyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-(2-methoxy-1-methyl-ethyl)-N-(3-phenyl-propyl)-benzenesulfonamide; 
 2S,3R-2-[(4-Chloro-benzenesulfonyl)-(3-phenyl-propyl)-amino]-3-hydroxy-N-methyl-butyramide; 
 4-Chloro-N-(1S,2S-2-hydroxy-cyclopentyl)-N-(3-phenyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-(2-methyl-cyclohexyl)-N-(3-phenyl-propyl)-benzenesulfonamide; 
 4-[(4-Chloro-benzenesulfonyl)-(3-phenyl-propyl)-amino]-piperidine-1-carboxylic acid ethyl ester; 
 N-[3-(4-tert-Butyl-phenyl)-2-methyl-propyl]-4-chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N-(4-chloro-6-fluoro-2H-chromen-3-ylmethyl)-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-N-(2-pentyl-3-phenyl-allyl)-benzenesulfonamide; 
 4-Chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-N-[3-(2-methoxy-phenyl)-allyl]-benzenesulfonamide; 
 N-Benzofuran-2-ylmethyl-4-chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-N-(3-phenyl-butyl)-benzenesulfonamide; 
 4-Chloro-N-cyclopropylmethyl-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 R—N-sec-Butyl-4-chloro-N-(1-methyl-3-phenyl-allyl)-benzenesulfonamide; 
 R—N-sec-Butyl-4-chloro-N-[3-(2-methoxy-phenyl)-allyl]-benzenesulfonamide; 
 R—N-Benzofuran-2-ylmethyl-N-sec-butyl-4-chloro-benzenesulfonamide; 
 R—N-sec-Butyl-4-chloro-N-(1-methyl-1H-indol-2-ylmethyl)-benzenesulfonamide; 
 R—N-sec-Butyl-4-chloro-N-(1-methyl-3-phenyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-(2,5-dimethyl-cyclohexyl)-N-(3-fluoro-4-methoxy-benzyl)-benzenesulfonamide; 
 4-Chloro-N-(2,4-difluoro-benzyl)-N-(2,5-dimethyl-cyclohexyl)-benzenesulfonamide; 
 4-Chloro-N-(2,5-dimethyl-cyclohexyl)-N-(3-phenyl-allyl)-benzenesulfonamide; 
 4-Chloro-N-(2,5-dimethyl-cyclohexyl)-N-(4-methoxy-benzyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(2,5-dimethyl-cyclohexyl)-benzenesulfonamide; 
 N-(4-Bromo-benzyl)-4-chloro-N-(2,5-dimethyl-cyclohexyl)-benzenesulfonamide; 
 4-Chloro-N-(2,5-dimethyl-cyclohexyl)-N-(3-phenyl-propyl)-benzenesulfonamide; 
 4-Chloro-N-(2,5-dimethyl-cyclohexyl)-N-(2-methyl-3-phenyl-allyl)-benzenesulfonamide; 
 4-Chloro-N-(3,4-dimethoxy-benzyl)-N-(1R,2S,5R-2-isopropyl-5-methyl-cyclohexyl)-benzenesulfonamide; 
 4-Chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-N-(1-methyl-3-phenyl-allyl)-benzenesulfonamide; 
 N-(2-Benzyl-cyclohexyl)-4-chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-N-(1,2,3,4-tetrahydro-naphthalen-2-yl)-benzenesulfonamide; 
 4-Chloro-N-(4,6-dichloro-2H-chromen-3-ylmethyl)-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-N-(1-methyl-1H-indol-2-ylmethyl)-benzenesulfonamide; 
 4-Chloro-N-(1-chloro-3,4-dihydro-naphthalen-2-ylmethyl)-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-N-(1-methyl-3-phenyl-propyl)-benzenesulfonamide; 
 4-Chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-N-propyl-benzenesulfonamide; 
 4-Chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-N-methyl-benzenesulfonamide; 
 R—N-sec-Butyl-4-chloro-N-(1-chloro-3,4-dihydro-naphthalen-2-ylmethyl)-benzenesulfonamide; 
 4-Chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N—(R-1,2-dimethyl-propyl)-benzenesulfonamide; 
 4-Chloro-N—(S-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-[(4-Chloro-benzenesulfonyl)-(R-1-hydroxymethyl-3-methyl-butyl)-amino]-3-methyl-but-2-enoic acid ethyl ester; 
 4-Chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-N-naphthalen-2-ylmethyl-benzenesulfonamide; 
 4-Chloro-N-furan-2-ylmethyl-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N-furan-3-ylmethyl-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N—(S-1-hydroxymethyl-3-methyl-butyl)-N-(3-phenyl-allyl)-benzenesulfonamide; 
 4-Chloro-N—(S-1,2-dimethyl-propyl)-N-(3-phenyl-allyl)-benzenesulfonamide; 
 N-(2-Bromo-3-phenyl-allyl)-4-chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 N-But-2-enyl-4-chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-N-pentyl-benzenesulfonamide; 
 4-Chloro-N-(3-furan-2-yl-2-methyl-allyl)-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N-(3-furan-2-yl-allyl)-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-N-(2-methyl-pentyl)-benzenesulfonamide; 
 4-Chloro-N-(2-ethyl-allyl)-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-N-(3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N-(2-ethyl-butyl)-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-N-(3-methyl-but-2-enyl)-benzenesulfonamide; 
 4-Chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-N-(3-pyridin-3-yl-allyl)-benzenesulfonamide; 
 4-Chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-N-[3-(2-nitro-phenyl)-allyl]-benzenesulfonamide; 
 4-[(4-Chloro-benzenesulfonyl)-(R-1-hydroxymethyl-3-methyl-butyl)-amino]-but-2-enoic acid ethyl ester; 
 4-Chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-N-(2-methyl-4-phenyl-pentyl)-benzenesulfonamide; 
 4-Chloro-N-cyclohexylmethyl-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N-(2-chloro-3-phenyl-allyl)-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N-[3-(3-chloro-phenyl)-allyl]-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-N-(3-p-tolyl-allyl)-benzenesulfonamide; 
 4-Chloro-N-[3-(4-dimethylamino-phenyl)-allyl]-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N-[3-(4-fluoro-phenyl)-allyl]-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-N-(3-m-tolyl-allyl)-benzenesulfonamide; 
 4-Chloro-N-[3-(3-fluoro-phenyl)-allyl]-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N—(R-1-hydroxymethyl-3-methyl-butyl)-N-(3-o-tolyl-allyl)-benzenesulfonamide; 
 4-Chloro-N-[3-(4-chloro-phenyl)-allyl]-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N-[3-(2-fluoro-phenyl)-allyl]-N—(R-1-hydroxymethyl-3-methyl-butyl)-benzenesulfonamide; 
 4-Chloro-N-(6-methoxy-pyridin-3-ylmethyl)-N-(2-methyl-cyclohexyl)-benzenesulfonamide; 
 4-Chloro-N-(6-chloro-pyridin-3-ylmethyl)-N-(2-methyl-cyclohexyl)-benzenesulfonamide; 
 N-(6-Bromo-pyridin-3-ylmethyl)-4-chloro-N-(2-methyl-cyclohexyl)-benzenesulfonamide; and 
 4-Chloro-N-(2-methyl-cyclohexyl)-N-(3-pyridin-3-yl-allyl)-benzenesulfonamide.