Certain chemical entities, compositions, and methods

Abstract

Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.

1 - 46 . (canceled) 
     
     
         47 . A method of treating a solid tumor in a subject, the method comprising administering to the subject a therapeutically effective amount of N-(2-(2-dimethylamino-acetylamino)-1-{4-[8-(1-hydroxy-ethyl)-imidazo[1,2-a]pyridin-2-yl]-benzyl}-ethyl)-3-chloro-4-isopropoxy-benzamide, or a pharmaceutically acceptable salt thereof. 
     
     
         48 . The method of  claim 47 , comprising administering to the subject a compound having the formula: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         49 . The method of  claim 47 , wherein the N-(2-(2-dimethylamino-acetylamino)-1-{4-[8-(1-hydroxy-ethyl)-imidazo[1,2-a]pyridin-2-yl]-benzyl}-ethyl)-3-chloro-4-isopropoxy-benzamide, or a pharmaceutically acceptable salt thereof, is formulated into a pharmaceutical composition comprising at least one pharmaceutical excipient. 
     
     
         50 . The method of  claim 49 , wherein the pharmaceutical composition is formulated for oral administration. 
     
     
         51 . The method of  claim 49 , wherein the pharmaceutical composition is formulated for intravenous administration. 
     
     
         52 . The method of  claim 47 , wherein the solid tumor is a cancerous tumor, wherein the cancerous tumor is selected from colon cancer, breast cancer, ovarian cancer, prostate cancer, lung cancer, neuroblastoma, Ewing sarcoma, and rhabdomyosarcoma.