Compounds

Abstract

The present invention includes novel compounds useful in the treatment of various disorders in particular infectious diseases, cancer, and allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, and as vaccine adjuvants.

1 . A process for the preparation of a compound of formula (I): 
       
         
           
           
               
               
           
         
         wherein;
 R 1  is C 1-8 alkylamino, C 1-8 alkoxy, C 3-7 cycloalkylC 1-6 alkylamino, C 3-7 cycloalkylC 1-6 alkoxy, C 1-3 alkoxyC 2-3 alkoxy, or Het b -C 1-3 alkoxy; 
 Het b  is a 5- or 6-membered saturated aliphatic heterocyle containing one oxygen atom; 
 R 2  is —(CH 2 ) n -Het; 
 n is an integer having a value of 1 to 4; 
 Het is a 5- or 6-membered saturated aliphatic heterocycle containing one oxygen heteroatom, which heterocycle may be substituted by one or two C 1-4 alkyl groups; 
 
         or a salts or a solvates thereof, comprising the deprotection of a compound of formula (IIA): 
       
       
         
           
           
               
               
           
         
         wherein R 1  and R 2  are as hereinbefore defined for a compound of formula (I) and R 3  is C 1-6 alkyl. 
       
     
     
         2 . A process for the preparation of a compound of formula (I): 
       
         
           
           
               
               
           
         
         wherein;
 R 1  is C 1-8 alkylamino, C 1-8 alkoxy, C 3-7 cycloalkylC 1-6 alkylamino, C 3-7 cycloalkylC 1-6 alkoxy, C 1-3 alkoxyC 2-3 alkoxy, or Het b -C 1-3 alkoxy; 
 Het b  is a 5- or 6-membered saturated aliphatic heterocyle containing one oxygen atom; 
 R 2  is —(CH 2 ) n —Het; 
 n is an integer having a value of 1 to 4; 
 Het is a 5- or 6-membered saturated aliphatic heterocycle containing one oxygen heteroatom, which heterocycle may be substituted by one or two C 1-4 alkyl groups; 
 
         or a salt or a solvate thereof, comprising the hydrolysis of a compound of formula (XXI): 
       
       
         
           
           
               
               
           
         
         wherein R 1  and R 2  are as hereinbefore defined for a compound of formula (I) and X is a halogen atom. 
       
     
     
         3 . A process for the preparation of a compound of formula (I): 
       
         
           
           
               
               
           
         
         wherein;
 R 1  is C 1-8 alkylamino, C 1-8 alkoxy, C 3-7 cycloalkylC 1-6 alkylamino, C 3-7 cycloalkylC 1-6 alkoxy, C 1-3 alkoxyC 2-3 alkoxy, or Het b -C 1-3 alkoxy; 
 Het b  is a 5- or 6-membered saturated aliphatic heterocyle containing one oxygen atom; 
 R 2  is —(CH 2 ) n -Het; 
 n is an integer having a value of 1 to 4; 
 Het is a 5- or 6-membered saturated aliphatic heterocycle containing one oxygen heteroatom, which heterocycle may be substituted by one or two C 1-4 alkyl groups; 
 
         or a salt or a solvate thereof, comprising the reaction of a compound of formula (XXIII): 
       
       
         
           
           
               
               
           
         
         wherein Y is a halogen atom, R 2  is as hereinbefore defined for a compound of formula (I), and R 3  is C 1-6 alkyl, with a compound of formula (VIB)
   R 1 —H  (VIB)
 
 
         wherein R 1  is C 1-8 alkylamino or C 3-7 cycloalkylC 1-6 alkylamino. 
       
     
     
         4 . A process according to  claim 1  further comprising the steps of at least one of:
 (i). converting a compound of formula (I) to a further compound of formula (I), and; 
 (ii). preparing a salt or solvate of the resulting compound. 
 
     
     
         5 . A process according to  claim 2  further comprising the steps of at least one of:
 (i). converting a compound of formula (I) to a further compound of formula (I), and; 
 (ii). preparing a salt or solvate of the resulting compound. 
 
     
     
         6 . A process according to  claim 3  further comprising the steps of at least one of:
 (i). converting a compound of formula (I) to a further compound of formula (I), and; 
 (ii). preparing a salt or solvate of the resulting compound.