Bone cement and a method for producing same

Abstract

The invention relates to a bone cement composed of a hydrophilic component and a hydrophobic component, wherein biodegradable material is deposited in pores of the bone cement via the hydrophilic component.

1 . A bone cement, comprising:
 at least one polymerizable hydrophobic component:   at least one hydrophilic component; and   biodegradable particles,   wherein said hydrophilic and said hydrophobic components are immiscible, and   wherein said biodegradable particles are contained at least partially in the hydrophilic component.   
     
     
         2 . The bone cement of  claim 1 , wherein at least 50% of the biodegradable particles are contained in said hydrophilic component. 
     
     
         3 . The bone cement of  claim 1 , wherein said hydrophobic component comprises an acrylate monomer. 
     
     
         4 . The bone cement of  claim 1 , wherein said hydrophilic component comprises water and at least one of calcium carbonate, calcium sulfate, and calcium phosphate. 
     
     
         5 . The bone cement of  claim 4 , wherein said hydrophilic component comprises hydroxyapatite. 
     
     
         6 . The bone cement of  claim 1 , wherein said biodegradable material is present in nanoparticulate form. 
     
     
         7 . The bone cement of  claim 1 , wherein said hydrophilic component comprises a system that starts a polymerization of the hydrophobic component. 
     
     
         8 . The bone cement of  claim 1 , wherein said hydrophobic component comprises polymer particles. 
     
     
         9 . The bone cement of  claim 8 , wherein said hydrophobic component further comprises a monomer, and said polymer particles are not completely soluble in said monomer. 
     
     
         10 . The bone cement of  claim 1 , further comprising an x-ray contrast agent. 
     
     
         11 . The bone cement of  claim 1 , further comprising a pharmaceutically active substance. 
     
     
         12 . The bone cement of  claim 1 , wherein the bone cement comprises between 10% and 50% of said biodegradable particles, between 10% and 85% of said polymerizable hydrophobic component, and between 2 and 30% of said hydrophilic component. 
     
     
         13 . The bone cement of  claim 1 , further comprising a polymer component and a liquid that is immiscible with the polymer component, wherein said biodegradable particles are in said liquid. 
     
     
         14 . The bone cement of  claim 1 , further comprising:
 10% to 50% of polymeric bone cement powder;   10% to 85% of a polar liquid;   a monomer;   an initiator; and   10% to 70% of said biodegradable particles.   
     
     
         15 . A cured bone cement comprising the bone cement of  claim 1 , and further comprising a polymer backbone having open pores that are filled at least partially with biodegradable material. 
     
     
         16 . The cured bone cement of  claim 15 , wherein said polymer backbone comprises an acrylate. 
     
     
         17 . The cured bone cement of  claim 15 , wherein the cured bone cement has an E-modulus of less than 4500 MPa. 
     
     
         18 . The cured bone cement of  claim 15 , wherein the cured bone cement has a porosity of between 5% and 90%. 
     
     
         19 . The cured bone cement of  claim 15 , wherein the cured bone cement has an average pore size of between 5 μm and 5 mm. 
     
     
         20 . The cured bone cement of  claim 15 , wherein said polymer backbone at least partially comprises a cross-linked polymer. 
     
     
         21 . The cured bone cement of  claim 15 , wherein the cured bone cement is open-pore porous, and said biodegradable particles are in said open-pores. 
     
     
         22 . A method for producing the bone cement of  claim 1 , comprising the step of mixing said polymerizable hydrophobic component with said hydrophilic component and said biodegradable material, so that said hydrophilic component forms at least partially open-pore regions, which are first filled with the hydrophilic component. 
     
     
         23 . The method of  claim 22 , further comprising the steps of adding and mixing said biodegradable material and hydrophilic component as a suspension. 
     
     
         24 . The method of  claim 22 , further comprising the step of adding said biodegradable material in the form of a nanoparticulate suspension and/or a suspension containing a dispersant. 
     
     
         25 . The method of  claim 22 , further comprising the steps of adding and mixing at least one of calcium carbonate, calcium sulfate, and calcium phosphate as said biodegradable particles. 
     
     
         26 . The method of  claim 22 , wherein during said mixing step, at least two pastes are used, and wherein said at least two pastes comprise a first paste containing said polymerizable hydrophobic component, and a second paste containing the biodegradable material and an initiator. 
     
     
         27 . The method of  claim 26 , wherein said first paste comprises an accelerator. 
     
     
         28 . The method of  claim 26 , wherein said first paste comprises polymer particles. 
     
     
         29 . The method of  claim 22 , further comprising the step of producing said hydrophobic component with an acrylate. 
     
     
         30 . The method of  claim 29 , further comprising the steps of precipitating said acrylate with (meth)acrylic acid, and producing said hydrophobic component with a powder that forms during said precipitating step. 
     
     
         31 . The method of  claim 29 , wherein said acrylate is a metal acrylic salt. 
     
     
         32 . (canceled)