Methods, Devices, Kits and Systems for Defunctionalizing the Cystic Duct

Abstract

The application discloses devices, systems, kits and methods for treating biliary disease. Devices comprise, for example, a component configurable for deployment between within a cystic duct of a patient which has a proximal end and a distal end. In some embodiments, a lumen may also extend therethrough.

1 . A device for treating biliary disease comprising:
 a component configurable for placement within a cystic duct of a biliary system of a patient, the component further comprising a proximal end and a distal end, an exterior surface, one or more external configurations adapted and configured to secure the component within the cystic duct, and a diameter sized to fit within the cystic duct,   wherein the device is adapted and configured to be implanted within the cystic duct to defunctionalize the duct and to at least one of control and prevent fluid communication between a gallbladder and a common bile duct.   
     
     
         2 . The device of  claim 1  further comprising a delivery mechanism for delivering a substance. 
     
     
         3 . The device of  claim 1  wherein the device is formed from at least one of a bioresorbable material or an activatable material. 
     
     
         4 . The device of  claim 1  wherein the device is at least one of removable and expandable. 
     
     
         5 . The device of  claim 1  further comprising one or more configurations selected from a deployment configuration, a delivery configuration and a final configuration. 
     
     
         6 . The device of  claim 5  further comprising a variable profile. 
     
     
         7 . The device of  claim 1  wherein a cross-sectional area of the device is variable along a length. 
     
     
         8 . The device of  claim 1  wherein the device is configurable for deployment by at least one of an endoscope and guidance element. 
     
     
         9 . The device of  claim 1  further comprising a lumen extending therethrough wherein the lumen is configurable to provide restrictable fluid flow. 
     
     
         10 . The device of  claim 9  further comprising one or more fluid control components. 
     
     
         11 . The device of  claim 1  further comprising a valve. 
     
     
         12 . The device of  claim 11  wherein the valve is at least one of a flow-restrictor or one-way valve. 
     
     
         13 . The device of  claim 1  wherein the device is flexible. 
     
     
         14 . The device of  claim 1  wherein the external configuration is one or more of threads, ridges and steps. 
     
     
         15 . A biliary disease treatment device comprising:
 an implant configurable for placement within a cystic duct of a biliary system of a patient, the implant further comprising a proximal end and a distal end, an exterior surface, and a diameter sized to fit within the cystic duct wherein the implant is adapted to be delivered by an endoscopic guidance element to the cystic duct.   
     
     
         16 . A method of delivering a device to treat biliary disease comprising:
 a. using an endoscope to place a guidance element between an access lumen and a gallbladder;   b. inserting a delivery catheter over the guidance element and into the gallbladder;   c. delivering a cystic duct defunctionalizing device comprising a proximal end and a distal end, an exterior surface, and a diameter sized to fit within the cystic duct, to the cystic duct via the guidance element; and   d. positioning the cystic duct defunctionalizing device within the cystic duct.   
     
     
         17 . A kit for treating biliary disease comprising:
 a. a device comprising a proximal end and a distal end, an exterior surface, and a diameter sized to fit within the cystic duct wherein the device is configurable to be positioned within a cystic duct; and optionally   b. a compound for delivery to a tissue.   
     
     
         18 . A method of treating biliary disease comprising:
 a. accessing a natural lumen associated with a gallbladder;   b. defunctionalizing a cystic duct.   
     
     
         19 . A device for treating biliary disease comprising a plug adapted and configured to be positioned within a lumen of a cystic duct of a patient wherein the device has a proximal end, a distal end and a diameter less sized to fit within the cystic duct and is configurable either internally or externally to seat within the lumen after deployment.