US2012295854A1PendingUtilityA1
Methods of Inducing Tissue Regeneration
Est. expiryNov 18, 2029(~3.4 yrs left)· nominal 20-yr term from priority
A61P 3/10A61P 9/00A61P 25/00A61P 25/16A61P 25/28C12N 2501/405A61P 1/16C12N 2506/1323A61P 21/00A61P 19/00G01N 33/502C12N 5/0658A61P 21/02A61P 1/18C12N 2501/40C12N 2501/00A61K 35/34A61P 17/00A61K 31/713A61P 11/02G01N 33/5061C12N 15/113
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Abstract
Methods are provided for producing cells within a lineage (lineage restricted cells) from post-mitotic differentiated cells of the same lineage ex vivo and in vivo, and for treating a subject in need of tissue regeneration therapy by employing these lineage-restricted cells. In addition, the production of lineage restricted cells from postmitotic tissues derived from patients with diseases allows for a characterization of pathways that have gone awry in these diseases and for screening of drugs that will ameliorate or correct the defects as a means of novel drug discovery. Also provided are kits for performing these methods.
Claims
exact text as granted — not AI-modified1 - 35 . (canceled)
36 . A kit for use in transiently inducing post-mitotic differentiated cells to transiently divide, comprising an agent that transiently inhibits the activity of a pocket protein and an agent that transiently inhibits the activity of ARF.Cited by (0)
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