Gemcitabine combination therapy

Abstract

The present invention provides compositions and methods for the treatment of cell proliferative disorders using at least one DAC inhibitor and gemcitabine.

1 . A method comprising steps of:
 administering to a subject suffering from or susceptible to a cell proliferative disorder, combination therapy of a DAC inhibitor and gemcitabine.   
     
     
         2 . The method of  claim 1  wherein the cell proliferative disorder involves a tumor. 
     
     
         3 . The method of  claim 2 , wherein the tumor is a Ras-expressing tumor. 
     
     
         4 . The method of  claim 2 , wherein the tumor is a pancreatic tumor. 
     
     
         5 . The method of  claim 1 , wherein the DAC inhibitor is romidepsin. 
     
     
         6 . The method of  claim 1  further comprising administering electrolyte supplementation. 
     
     
         7 . The method of  claim 1 , wherein the cell proliferative disorder is cutaneous T-cell lymphoma. 
     
     
         8 . The method of  claim 1 , wherein the cell proliferative disorder is peripheral T-cell lymphoma. 
     
     
         9 . The method of  claim 1 , wherein the cell proliferative disorder is a hematological malignancy.