Methods of Preventing and Reducing the Severity of Stress-Associated Conditions

Abstract

The present invention provides a method of preventing or reducing the severity of a stress-associated condition in a subject by systemically administering to the subject an effective amount of brimonidine or a pharmaceutically acceptable salt, ester, amide, sterioisomer or racemic mixture thereof. Stress-associated conditions that can be treated according to a method of the invention include, but are not limited to, dyspepsia, tachycardias other than tachycardia associated with myocardial ischemia, panic attack, non-inflammatory dermatogical conditions, disorders of muscle contraction, sensory hypersensitivity associated with migraine, and behavioral disorders.

1 - 22 . (canceled) 
     
     
         23 . A method of reducing the severity of one or more symptoms of an inflammatory dermatological condition in a subject, the method comprising topically administering to the skin of a subject in need of such reduction an effective amount of brimonidine or a pharmaceutically acceptable salt, ester, amide, stereoisomer or racemic mixture thereof. 
     
     
         24 . The method of claim  1 , wherein the method comprises topically administering brimonidine tartrate.