Guided bone regeneration membrane and manufacturing method thereof

Abstract

A guided bone regeneration material is disclosed. The guided bone regeneration material includes biodegradable fibers produced by an electro spinning method. The biodegradable fibers produced by the method include a silicon-releasing calcium carbonate and a biodegradable polymer. The silicon-releasing calcium carbonate is a composite of siloxane and calcium carbonate of vaterite phase. The biodegradable fibers may be coated with apatite. When the guided bone regeneration material is immersed in a neutral aqueous solution, silicon species ions are eluted from the calcium carbonate. The guided bone regeneration material excels in bone reconstruction ability.

1 . A guided bone regeneration material comprising biodegradable fibers produced by an electrospinning method, the biodegradable fibers comprising:
 a silicon-releasing calcium carbonate; and   a biodegradable polymer.   
     
     
         2 . The guided bone regeneration material according to  claim 1 , wherein the silicon-releasing calcium carbonate comprises a composite of siloxane and calcium carbonate of vaterite phase. 
     
     
         3 . The guided bone regeneration material according to  claim 1 , wherein when immersed in a neutral aqueous solution, silicon species ion is eluted from the silicon-releasing calcium carbonate. 
     
     
         4 . The guided bone regeneration membrane according to  claim 1 , wherein the biodegradable polymer comprises poly(lactic acid). 
     
     
         5 . The guided bone regeneration material according to  claim 1 , wherein the silicon-releasing calcium carbonate is produced by a carbonation process in which carbon dioxide is blown into a suspension prepared by mixing methanol, slaked lime and an organic silicon compound, and stirring to cause gelation of the suspension. 
     
     
         6 . The guided bone regeneration material according to  claim 1 , wherein the silicon-releasing calcium carbonate comprises powders of spherical particles. 
     
     
         7 . The guided bone regeneration material according to  claim 1 , wherein the biodegradable fibers are coated with an apatite. 
     
     
         8 . A biodegradable fiber of a guided bone regeneration material produced by an electrospinning process, the biodegradable fiber comprising:
 a silicon-releasing calcium carbonate; and   a biodegradable polymer.   
     
     
         9 . The biodegradable fiber according to  claim 8 , wherein the silicon-releasing calcium carbonate comprises a composite of siloxane and calcium carbonate of vaterite phase. 
     
     
         10 . The biodegradable fiber according to  claim 8 , wherein the biodegradable polymer comprises polylactic acid). 
     
     
         11 . The biodegradable fiber according to  claim 8 , wherein the silicon-releasing calcium carbonate is produced by a carbonation process in which carbon dioxide is blown into a suspension prepared by mixing methanol, slaked lime and an organic silicon compound, and stirring to cause a gelation of the suspension. 
     
     
         12 . The biodegradable fiber of a guided bone regeneration material according to  claim 8 , wherein the silicon-releasing calcium carbonate comprises powders of spherical particles. 
     
     
         13 . The biodegradable fiber of a guided bone regeneration material according to  claim 8 , wherein upon immersing in a neutral aqueous solution, silicon species ion is eluted from the silicon-releasing calcium carbonate. 
     
     
         14 . A method for manufacturing a guided bone regeneration material, the method comprising the steps of:
 mixing a silicon-releasing calcium carbonate with a solution of biodegradable polymer to produce a spinning solution;   producing biodegradable fibers from the spinning solution by electrospinning.   
     
     
         15 . The method according to  claim 14 , wherein the biodegradable polymer comprises poly(lactic acid). 
     
     
         16 . The method according to  claim 14 , wherein the silicon-releasing calcium carbonate is prepared by a carbonation process.