combination for the treatment of osteoarthritis

Abstract

The present invention relates to the use of a combination of glycine, proline, and optionally a natural or synthetic viscosity-controlling polymer, and/or lysine and/or leucine, to prepare a composition for the treatment of osteoarthritis.

1 . An intra-articular formulation for the treatment of osteoarthritis comprising:
 a) glycine,   b) proline,   and optionally   c) a natural or synthetic viscosity-controlling polymer, and/or   d) lysine, and/or   e) leucine.   
     
     
         2 . The formulation as claimed in  claim 1 , wherein osteoarthritis is patellofemoral or femorotibial knee osteoarthritis, hip osteoarthritis and shoulder osteoarthritis. 
     
     
         3 . The formulation as claimed in  claim 1 , wherein the natural or synthetic viscosity-controlling polymer is selected from hyaluronic acid or a salt thereof, polyvinylpyrrolidone and cellulose derivatives. 
     
     
         4 . The formulation as claimed in  claim 3 , wherein the natural or synthetic viscosity-controlling polymer is hyaluronic acid or a salt thereof. 
     
     
         5 . The formulation as claimed in  claim 1 , wherein the amino acids are in L form. 
     
     
         6 . The formulation as claimed in  claim 1 , wherein the various components of the combination are present in the following ranges by weight:
 a) 25 to 500 mg of glycine,   b) 40 to 300 mg of proline,   and optionally   c) 5 to 50 mg of hyaluronic acid or a salt thereof, and/or   d) 5 to 100 mg of lysine, and/or   e) 5 to 50 mg of leucine.   
     
     
         7 . The formulation as claimed in  claim 1 , in the form of powders for reconstitution or viscous solutions in biocompatible solvents.