US2012322737A1PendingUtilityA1
Modified recombinant factor viii and von willebrand factor and methods of use
Est. expiryNov 9, 2027(~1.3 yrs left)· nominal 20-yr term from priority
C07K 14/755C08L 2203/02A61K 47/549C08G 65/329C08H 1/00C08L 63/00A61K 47/60A61K 47/61A61P 7/04A61K 38/37A61P 7/00
55
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Claims
Abstract
The present invention provides novel methods of increasing the survival of a coagulation protein by inhibiting the interaction with a clearance receptor. The invention also provides methods of preparing compositions that inhibit coagulation protein clearance receptors. Conjugated coagulation proteins, including compositions and formulations thereof, are also provided by the present invention.
Claims
exact text as granted — not AI-modified1 . A method of increasing the survival of a coagulation protein by inhibiting the interaction with a clearance receptor, the method comprising the steps of:
(a) modifying a coagulation protein with a water soluble polymer, and (b) administering to a mammal in need thereof a therapeutically effective amount of a composition comprising the modified coagulation factor; wherein the modification increases the survival of the protein in the Hood circulation of a mammal.
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