Coatings for Medical Devices Comprising a Therapeutic Agent and a Metallic Material

Abstract

The invention relates generally to an implantable medical device for delivering a therapeutic agent to the body tissue of a patient, and a method for making such a medical device. In particular, the invention pertains to an implantable medical device, such as an intravascular stent, having a coating comprising a first coating composition comprising a therapeutic agent and, optionally, a polymer; and a second coating composition comprising a metallic material.

1 .- 30 . (canceled) 
     
     
         31 . An implantable intravascular stent comprising:
 (a) a stent sidewall structure defining a surface; and   (b) a coating comprising   (i) a first coating composition formed of a material selected from the group consisting of a one or more therapeutic agents and one or more polymers, the first coating composition contacting at least a portion of the surface of the stent sidewall structure; and   (ii) a second coating composition comprising a material different from the first coating composition, the second coating composition comprising a metallic material and being substantially free of any polymer, the second coating contacting at least a portion of the surface of the stent sidewall structure, at least a portion of the second coating composition being disposed adjacent to the first coating composition on the surface of the stent sidewall structure.   
     
     
         32 . The stent of  claim 31 , wherein the second coating composition is disposed upon less than all of the outer surface of the first coating composition. 
     
     
         33 . The stent of  claim 31 , wherein the surface of the stent sidewall structure is an abluminal surface. 
     
     
         34 . The stent of  claim 31 , wherein the one or more therapeutic agents comprise an agent that inhibits smooth muscle cell proliferation. 
     
     
         35 . The stent of  claim 31 , wherein the one or more therapeutic agents comprise an antithrombogenic agent, anti-angiogenesis agent, anti-proliferative agent, antibiotic, antirestenosis agent, growth factor, immunosuppressant or radiochemical. 
     
     
         36 . The stent of  claim 31 , wherein the one or more therapeutic agents comprise an antirestenosis agent. 
     
     
         37 . The stent of  claim 31 , wherein the one or more therapeutic agents comprise paclitaxel. 
     
     
         38 . The stent of  claim 31 , wherein the one or more therapeutic agents comprise sirolimus, tacrolimus, pimecrolimus, everolimus or zotarolimus. 
     
     
         39 . The stent of  claim 31 , wherein the metallic material is selected from the group consisting of stainless steel, nickel, titanium, chromium and alloys thereof. 
     
     
         40 . The stent of  claim 31 , wherein the one or more polymers are selected from the group consisting of styrene-isobutylene copolymer, polylactic acid, poly(methylmethacrylatebutylacrylate-methylmethacrylate). 
     
     
         41 . The stent of  claim 31 , wherein the first coating comprises at least one therapeutic agent and at least one polymer. 
     
     
         42 . The stent of  claim 31 , wherein the stent sidewall structure comprises a plurality of struts and openings and the surface of the stent sidewall structure is the abluminal surface of the stent. 
     
     
         43 . The stent of  claim 42 , wherein the first coating composition and the second coating composition are disposed upon at least a portion of the adluminal surface. 
     
     
         44 . The stent of  claim 42 , wherein the surface of the stent sidewall structure is the abluminal surface of at least one of the struts. 
     
     
         45 . The stent of  claim 44 , wherein the first coating composition and the second coating composition are disposed upon at least a portion of the adluminal surface of at least one of the struts. 
     
     
         46 . The implantable intravascular stent of  claim 31 , wherein:
 the first coating composition has a first thickness measured from the surface of the stent sidewall structure;   the second coating composition has a second thickness measured from the surface of the stent sidewall structure; and   the second thickness of the second coating composition is the same as or greater than the first thickness of the first coating composition.   
     
     
         47 . The stent of  claim 46 , wherein the first thickness of the first coating composition is equal to the second thickness of the second coating composition. 
     
     
         48 . The stent of  claim 46 , wherein the second thickness of the second coating composition is greater than the first thickness of the first coating composition. 
     
     
         49 . The stent of  claim 48 , wherein the second coating composition is exposed for contact with a wall of a lumen when the stent is delivered into the lumen, and the first coating composition has an outer surface substantially restricted from contact with the wall of the lumen when the stent is delivered into the lumen. 
     
     
         50 . The stent of  claim 49 , wherein the second coating composition is disposed upon at least a portion of the outer surface of the first coating composition.