Microparticle dispersion liquid manufacturing method and microparticle dispersion liquid manufacturing apparatus

Abstract

In a dissolving step, a poorly soluble drug and a dispersion stabilizer are dissolved in a volatile organic solvent. In a fixing step, the organic solvent, contained in a solution obtained in the dissolving step, is removed by evaporation, pellet-form residues are obtained by the organic solvent removal, and the residues are fixed on respective bottom surfaces of a plurality of locations of a container. In a water injecting step, water is injected into each of a plurality of recesses of the container. In an irradiating step, laser light L, emitted from a light irradiating unit, is irradiated simultaneously or successively on the residues fixed on the respective bottom surfaces of the recesses of the container, and the residues are thereby pulverized and made into microparticles and a microparticle dispersion liquid, constituted of the microparticles being dispersed in the water, is manufactured.

1 - 9 . (canceled) 
     
     
         10 . A microparticle dispersion liquid manufacturing apparatus comprising:
 a container, in which a poorly soluble drug and a dispersion stabilizer are dissolved in a volatile organic solvent, a residue, obtained by removal by evaporation of the organic solvent contained in the solution, is fixed on each of a plurality of locations of an inner wall, and water is injected into an interior; and   a light irradiating unit, irradiating light on the residues fixed on the respective locations of the inner wall of the container; and   wherein a liquid, having microparticles, containing the poorly soluble drug and the dispersion stabilizer, dispersed in water, is manufactured by irradiation of the light on the residues by the light irradiating unit,   wherein the container has a plurality of recesses, the residues are fixed on respective bottom surfaces of the recesses, and   the light irradiating unit irradiates the light on the residues fixed on the respective bottom surfaces of the recesses, and wherein   the respective bottom surfaces of the recesses of the container are composed of glass, the light is irradiated by the light irradiating unit from outside the respective bottom surfaces of the recesses of the container, and the irradiated light is made to propagate in the order of the bottom surfaces, the residues, and the water.   
     
     
         11 . A microparticle dispersion liquid manufacturing apparatus comprising:
 a container, in which a poorly soluble drug and a dispersion stabilizer are dissolved in a volatile organic solvent, a residue, obtained by removal by evaporation of the organic solvent contained in the solution, is fixed on each of a plurality of locations of an inner wall, and water is injected into an interior; and   a light irradiating unit, irradiating light on the residues fixed on the respective locations of the inner wall of the container; and   wherein a liquid, having microparticles, containing the poorly soluble drug and the dispersion stabilizer, dispersed in water, is manufactured by irradiation of the light on the residues by the light irradiating unit,   wherein the container has a plurality of recesses, the residues are fixed on respective bottom surfaces of the recesses, and   the light irradiating unit irradiates the light on the residues fixed on the respective bottom surfaces of the recesses, and wherein   the respective bottom surfaces of the recesses of the container are flat surfaces, the light is irradiated by the light irradiating unit from outside the respective bottom surfaces of the recesses of the container, and the irradiated light is made to propagate in the order of the bottom surfaces, the residues, and the water.   
     
     
         12 . The microparticle dispersion liquid manufacturing apparatus according to  claim 10 , wherein the light irradiating unit comprises: a light source, outputting light; and a branching unit, branching the light output from the light source and irradiating the light simultaneously on the residues fixed on the respective locations of the inner wall of the container. 
     
     
         13 . The microparticle dispersion liquid manufacturing apparatus according to  claim 10 , wherein the light irradiating unit comprises: a light source, outputting light; and a diffracting unit, diffracting the light output from the light source and irradiating the light simultaneously on the residues fixed on the respective locations of the inner wall of the container. 
     
     
         14 . The microparticle dispersion liquid manufacturing apparatus according to  claim 10 , wherein the light irradiating unit comprises: a light source, outputting light; and a scanning unit, scanning the light output from the light source and irradiating the light successively on the residues fixed on the respective locations of the inner wall of the container. 
     
     
         15 - 28 . (canceled) 
     
     
         29 . The microparticle dispersion liquid manufacturing apparatus according to  claim 11 , wherein the light irradiating unit comprises: a light source, outputting light; and a branching unit, branching the light output from the light source and irradiating the light simultaneously on the residues fixed on the respective locations of the inner wall of the container. 
     
     
         30 . The microparticle dispersion liquid manufacturing apparatus according to  claim 11 , wherein the light irradiating unit comprises: a light source, outputting light; and a diffracting unit, diffracting the light output from the light source and irradiating the light simultaneously on the residues fixed on the respective locations of the inner wall of the container. 
     
     
         31 . The microparticle dispersion liquid manufacturing apparatus according to  claim 11 , wherein the light irradiating unit comprises: a light source, outputting light; and a scanning unit, scanning the light output from the light source and irradiating the light successively on the residues fixed on the respective locations of the inner wall of the container.