METHODS OF ADMINISTERING ANTI-TNFalpha ANTIBODIES

Abstract

Methods of treating disorders in which TFNα activity is detrimental via biweekly, subcutaneous administration of human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor α (hTNFα) are disclosed. The antibody may be administered with or without methotrexate. These antibodies have high affinity for hTNFα (e.g., K d =10 −8 M or less), a slow off rate for hTNFα dissociation (e.g., K off =10 −3 sec −1 or less) and neutralize hTNFα activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Kits containing a pharmaceutical composition and instructions for dosing, and preloaded syringes containing pharmaceutical compositions are also encompassed by the invention.

1 . A method for treating a disorder in a human subject in which the disease is treatable with a TNFα antibody, comprising administering a composition to the human subject in need thereof, on a biweekly dosing regimen such that the disorder is treated, said composition containing an anti-TNFα antibody or an antigen binding portion thereof. 
     
     
         2 . A kit containing a formulation comprising:
 a) a pharmaceutical composition comprising an anti-TNFα antibody and a pharmaceutically acceptable carrier; and   b) instructions for biweekly dosing of the pharmaceutical composition for the treatment of a disorder in which an anti-TNFα antibody or a binding portion thereof is effective in treating the disorder.