Polymer Nanofilm Coatings

Abstract

Disclosed herein are nanofilm coatings for implantable medical devices comprising a diblock or triblock copolymer (PEO-PMMA or PMOXA-PDMS-PMOXA, respectively). Such nanofilms, may be used, for example, as amphiphilic supports for therapeutic agents. These materials are conducive towards the formation of active substrates for a suite of biological and medical applications.

1 . A membrane comprising:
 a) a first layer comprising parylene, and   b) a second layer comprising a copolymer selected from the group consisting of polyethylene oxidepolymethylmethacrylate, polymethyloxazoline-polydimethylsiloxiane-polymthoxazoline, and a mixture thereof,   wherein the membrane has a thickness between 0.1 nm and 20 nm.   
     
     
         2 . The membrane of  claim 1 , wherein said membrane comprises a third layer, wherein the third layer comprises parylene. 
     
     
         3 . The membrane of  claim 2 , wherein said second layer is between the first and second layers. 
     
     
         4 . The membrane of  claim 1 , further comprising at least one therapeutic agent. 
     
     
         5 . The membrane of  claim 4 , wherein the at least one therapeutic agent is within the second layer. 
     
     
         6 . The membrane of  claim 1 , wherein the first layer comprises nonoporous parylene. 
     
     
         7 . The membrane of  claim 2 , wherein the third layer comprises rough parylene C. 
     
     
         8 . The membrane of  claim 1 , wherein the copolymer comprises a single layer having a thickness from about 1 nm to about 10 nm.