US2013005707A1PendingUtilityA1
Aminotriazolopyridines, compositions thereof, and methods of treatment therewith
Est. expirySep 8, 2028(~2.2 yrs left)· nominal 20-yr term from priority
Inventors:Sogole BahmanyarR.J. BatesKate BleaseAndrew Antony CalabreseThomas Oran DanielMercedes DelgadoJan ElsnerPaul E. ErdmanBruce FahrGregory D. FergusonBranden LeeLisa NadolnyGarrick PackardPatrick PapaVeronique Plantevin-KrenitskyJennifer RiggsPatricia RohaneSabita SankarJohn SapienzaYoshitaka SatohVictor SloanRandall StevensLida TehraniJayashree TikheEduardo TorresAndrew WallaceBrandon W. WhitefieldJingjing Zhao
A61P 37/08A61P 3/10A61P 9/00A61P 35/00A61P 7/02A61P 7/06A61P 43/00A61P 35/02A61P 37/02A61P 37/00A61P 5/00A61P 37/06A61P 9/10A61P 7/04A61P 31/12A61P 27/14A61P 25/28A61P 31/04A61P 3/00A61P 29/00A61P 25/14A61P 3/04A61P 31/00A61P 25/02A61P 25/00A61P 17/00A61P 11/00A61P 19/06A61P 11/06A61P 19/02A61P 17/10A61P 21/04A61P 1/00A61P 1/16A61P 21/00A61P 1/04A61P 17/06A61P 11/02A61P 19/08A61P 17/02A61P 19/00C07D 471/04A61K 31/437C07D 519/00C07D 519/06C07D 519/04
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Claims
Abstract
Provided herein are Heteroaryl Compounds of formula (I): wherein R 1 and R 2 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing inflammatory conditions or cancer, and conditions treatable or preventable by inhibition of a kinase or a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a subject in need thereof.
Claims
exact text as granted — not AI-modified1 . A method of inhibiting a kinase in a cell expressing said kinase, comprising contacting said cell with an effective amount of a compound of formula (I):
or a pharmaceutically acceptable salt, tautomer, stereoisomer, solvate or prodrug thereof, wherein:
R 1 is a substituted or unsubstituted aryl, or a substituted or unsubstituted heterocyclyl;
R 2 is a substituted or unsubstituted C 1-8 alkyl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted heterocyclylalkyl, a substituted or unsubstituted aralkyl, —NR 3 R 4 , —OR 3 , —C(═O)R 5 , —C(═O)NR 3 R 4 , —NHC(═O)R 3 , —(CH 2 ) 0-2 CR 6 (OR 3 )R 4 , or a substituted or unsubstituted heterocyclyl selected from azetidinyl, pyrrolidyl, piperidyl, morpholinyl, piperazin-2-onyl, 1,2,3,6-tetrahydropyridyl, isoxazolyl, imidazolyl, indazolyl, benzimidazolyl, 1H-benzo[d][1,2,3]triazolyl, benzisoxazolyl, benzo[d]oxazolyl, isoindolin-1-onyl, 1H-imidazo[4,5-b]pyridyl, isoquinolinyl, or quinolyl; or R 2 is pyridyl, provided R 1 is not (2-(pyrrolidin-1-yl)ethoxy)phenyl-4-yl;
R 3 and R 4 are at each occurrence independently —H, a substituted or unsubstituted C 1-8 alkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted heteroaryl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted heterocyclyl, a substituted or unsubstituted aralkyl, or a substituted or unsubstituted heterocyclylalkyl;
R 5 is substituted or unsubstituted C 1-8 alkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted heteroaryl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted heterocyclyl, a substituted or unsubstituted aralkyl, or a substituted or unsubstituted heterocyclylalkyl; and
R 6 is —H, or a substituted or unsubstituted C 1-8 alkyl, or together with R 4 and the atoms to which they are attached form a substituted or unsubstituted heterocyclyl;
provided the compound is not N 5 -cyclopentyl-N 2 -(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine.
2 . The method of claim 1 , wherein the kinase is one or more of Syk, FLT3, JAK1 or JAK2.
3 . The method of claim 1 , wherein the compound is
1-methyl-N 3 -(tetrahydro-2H-pyran-4-yl)-N 6 -(5-((tetrahydro-2H-pyran-4-yl)methyl)-[ 1,2,4]triazolo[1,5-a]pyridin-2-yl)-1H-indazole-3,6-diamine; N 3 -(tetrahydro-2H-pyran-4-yl)-N 6 -(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-1H-indazole-3,6-diamine; 1-methyl-N 3 -(piperidin-4-yl)-N 6 -(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-1H-indazole-3,6-diamine; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one; cis-6-(5-(4-hydroxy-4-methylcyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1,3,3-trimethylindolin-2-one; N-(3-(methoxymethyl)-1H-indazol-6-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; cis-4-(2-(5-methyl-6-morpholinopyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; N-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-1H-pyrazolo[4,3-b]pyridin-6-amine; cis-4-(2-(1H-pyrazolo[4,3-b]pyridin-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; N 2 -(3,4-dimethyl-1H-indazol-6-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3,4-trimethylindolin-2-one; trans-6-(5-(4-hydroxy-4-methylcyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1,3,3-trimethylindolin-2-one; N 2 -(1H-pyrazolo[4,3-b]pyridin-6-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; cis-4-(2-(imidazo[1,2-a]pyridin-7-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 3,3-dimethyl-6-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one; 6-(5-(4-hydroxypiperidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; (R)—N 2 -(3-methyl-1H-indazol-5-yl)-N 5 -(tetrahydrofuran-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; N-(3-methyl-1H-indazol-5-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N 2 -(3-methyl-1H-indazol-5-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 1-methyl-6-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 1-methyl-6-(5-(tetrahydro-2H-pyran-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylisoindolin-1-one; (S)-3,3-dimethyl-6-(5-(methyl(tetrahydrofuran-3-yl)amino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; (R)-3,3-dimethyl-6-(5-(methyl(tetrahydrofuran-3-yl)amino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; (R)-1,3,3-trimethyl-6-(5-(tetrahydrofuran-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 4-((2-(4-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyridine-2-ol; 3,3,4-trimethyl-6-(5-(tetrahydro-2H-pyran-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 3,3,4-trimethyl-6-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; trans-4-(2-(3-methyl-1H-indazol-5-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 3,3-dimethyl-6-(5-(tetrahydro-2H-pyran-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one; N 5 -(tetrahydro-2H-pyran-4-yl)-N 2 -(3-(trifluoromethyl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 4-((2-(2-(methoxymethyl)-1H-benzo[d]imidazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyridine-2-ol; (R)-3,3-dimethyl-6-(5-(piperidin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; N-(2-(methoxymethyl)-1H-benzo[d]imidazol-6-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (S)-3,3-dimethyl-6-(5-(tetrahydrofuran-3-yloxy)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; (R)-3,3-dimethyl-6-(5-(tetrahydrofuran-3-yloxy)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-2-methylisoindolin-1-one; 1,3,3-trimethyl-6-(5-((3-oxopiperazin-1-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; trans-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylisoindolin-1-one; 3,3-dimethyl-6-(5-(piperidin-4-ylmethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; cis-4-(2-(1-methyl-1H-pyrazolo[3,4-b]pyridin-5-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-6-(5-((4-hydroxy-4-methylcyclohexyl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; trans-6-(5-((4-hydroxy-4-methylcyclohexyl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; N 2 -(2-(methoxymethyl)-1H-benzo[d]imidazol-6-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 1,3,3-trimethyl-6-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 2-methyl-5-(5-(tetrahydro-2H-pyran-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one; 2-methyl-5-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one; trans-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1,3,3-trimethylindolin-2-one; N-(1,4-dimethyl-1H-indazol-6-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N 2 -(1,4-dimethyl-1H-indazol-6-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; cis-4-(2-(4-fluoro-1,3-dimethyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (R)-3,3-dimethyl-6-(5-(tetrahydrofuran-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 1,3,3-trimethyl-6-(5-(tetrahydro-2H-pyran-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1,3,3-trimethylindolin-2-one; 6-(5-((2-hydroxyethyl)(methyl)amino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; (S)-3,3-dimethyl-6-(5-(piperidin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 4-((2-(3-(trifluoromethyl)-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; 3,3-dimethyl-6-(5-((2-oxo-1,2-dihydropyridin-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 5-(5-((2-hydroxypyridin-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one; 3,3-dimethyl-6-(5-(methyl(tetrahydro-2H-pyran-4-yl)amino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 3,3-dimethyl-6-(5-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; N-(1-methyl-1H-indazol-6-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N 2 -(1-methyl-1H-indazol-6-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; trans-6-(5-(4-hydroxy-4-methylcyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; cis-6-(5-(4-hydroxy-4-methylcyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; cis-4-(2-(4-fluoro-3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (±)-cis-4-(2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yloxy)tetrahydrofuran-3-ol; (±)-trans-4-(2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)tetrahydrofuran-3-ol; (R)—N 2 -(3-methyl-1H-indazol-6-yl)-N 5 -(tetrahydrofuran-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 3,3-dimethyl-6-(5-(tetrahydro-2H-pyran-4-yloxy)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 3-methyl-1-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)azetidin-3-ol; 6-(5-(3-hydroxyazetidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; 6-(5-(3-hydroxy-3-methylazetidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; 3,3-dimethyl-6-(5-((3-oxopiperazin-1-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 6-(5-(hydroxy(tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-2-(2-methoxyethyl)isoindolin-1-one; trans-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; 3,3-dimethyl-6-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 3,3-dimethyl-6-(5-(tetrahydro-2H-pyran-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; (1S,3R)-3-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)methyl)cyclopentanol; (1S,3R)-3-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)methyl)cyclopentanol; (1R,3S)-3-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)methyl)cyclopentanol; (1R,3S)-3-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)methyl)cyclopentanol; (S)—N 2 -(3-methyl-1H-indazol-6-yl)-N 5 -(tetrahydrofuran-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 4-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyridin-2(1H)-one; 5-((3,3-difluoropiperidin-1-yl)methyl)-N-(3-methyl-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1-(2-hydroxyethyl)indolin-2-one; 2-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methylamino)acetamide; cis-1-(methoxymethyl)-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)cyclohexanol; 4-((2-(1-isopropyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; N 5 -methyl-N 2 -(3-methyl-1H-indazol-6-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 2-(methyl(2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)amino)ethanol; cis-4-(2-(1-(2-hydroxyethyl)-3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1-methylindolin-2-one; 6-(hydroxy(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyrimidin-4(3H)-one; cis-4-(2-(1-(2-methoxyethyl)-3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(2-(hydroxymethyl)-1H-benzo[d]imidazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(2-(methoxymethyl)-1H-benzo[d]imidazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(1-ethyl-3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-2-(2-hydroxyethyl)isoindolin-1-one; N-(3-methyl-1H-indazol-6-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)(tetrahydro-2H-pyran-4-yl)methanol; trans-4-(2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,4-dihydroisoquinolin-1(2H)-one; cis-4-(2-(4-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (R)-3-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methylamino)pyrrolidin-2-one; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-2-(2-hydroxyethyl)isoindolin-1-one; (±)-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methylamino)pyrrolidin-2-one; 4-((2-(3-amino-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)cyclohexanol; N 2 -(3-methyl-1H-indazol-6-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; cis-4-(2-(4-fluoro-3-(2-methoxyethoxy)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 4-(1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)ethyl)pyridin-2(1H)-one; (1S,2S)-2-(2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol; N-methyl-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methylamino)acetamide; 4-(5-((3-hydroxycyclopentyl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide (diastereomer 2); 1-(2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)azetidin-3-ol; cis-4-(2-(3-amino-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(2,3-dimethyl-2H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(1,3-dimethyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 4-((2-(4-fluoro-3-methylphenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyridin-2-ol; N 2 -(3-methyl-1H-indazol-6-yl)-N 5 -((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 4-((2-(6-(4-hydroxypiperidin-1-yl)pyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; (S)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methylamino)propanamide; cis-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol (enantiomer 1); cis-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol (enantiomer 2); trans-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol (enantiomer 1); trans-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol (enantiomer 2); cis-1-(hydroxymethyl)-4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 4-((2-(4-fluoro-3-methylphenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; 4-((2-(1H-pyrrolo[2,3-b]pyridin-5-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; (±)-5-isopropyl-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; cis-4-(2-(3-(methoxymethyl)-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 4-(5-((3-hydroxycyclopentyl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide (diastereomer 1); (±)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methylamino)propanamide; 1-(3-methyl-1H-indazol-6-yl)-4-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; 4-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; cis-4-(2-(1-methyl-1H-indazol-5-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(1H-benzo[d][1,2,3]triazol-5-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; cis-4-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)cyclohexanol; trans-4-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)cyclohexanol; 4-(5-(1H-imidazol-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-(5-(4-hydroxypiperidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; cis-4-(2-(1-isopropyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; N-methyl-4-(5-(2-methyl-1H-benzo[d]imidazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; cis-4-(2-(3-ethyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (1R,2R)-2-(4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyridin-2-ylamino)cyclopentanol; N-methyl-4-(5-(piperidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; (±)-trans-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (S)-4-(5-(3-hydroxypyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; (R)-4-(5-(3-hydroxypyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; N-methyl-4-(5-(pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; 1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)imidazolidine-2,4-dione; cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one; N-methyl-4-(5-(2-(piperidin-4-yl)ethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; cis-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)picolinamide; cis-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)picolinonitrile; 1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperidine-3-carboxamide; 5-methyl-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; (1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)azetidin-3-yl)methanol; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one; cis-4-(2-(2,6-dimethylpyridin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 4-(5-((4-aminocyclohexyl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-(1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)ethyl)piperazin-2-one; 4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazine-2,6-dione; cis-N 5 -(4-methoxycyclohexyl)-N 5 -methyl-N 2 -(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; cis-4-(methyl(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)amino)cyclohexanol; N-methyl-4-(5-(pyrrolidin-3-ylmethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; 5-(5-(2-(hydroxymethyl)-1H-benzo[d]imidazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)pyridin-2-ol; 1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)-1,4-diazepan-5-one; (1S,2R)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (S)-(1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyrrolidin-2-yl)methanol; (R)-(1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyrrolidin-2-yl)methanol; (1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperidin-3-yl)methanol; (1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperidin-4-yl)methanol; (S)-3-methyl-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; N-methyl-4-(5-(piperidin-4-ylmethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; cis-4-(2-(2-(2-hydroxyethoxy)pyridin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(2-(2-(pyrrolidin-1-yl)ethylamino)pyridin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(4-fluoro-3,5-dimethylphenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (6-(2-(6-methoxypyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1H-benzo[d]imidazol-2-yl)methanol; 3-methyl-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; 6-methyl-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; cis-4-(5-(4-aminocyclohexyloxy)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; N-methyl-4-(5-(piperidin-4-yloxy)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; (6-(2-(6-methylpyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1H-benzo[d]imidazol-2-yl)methanol; 1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)tetrahydropyrimidin-2(1H)-one; 1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)azetidin-3-ol; (R)-(1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyrrolidin-2-yl)methanol; (S)-(1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyrrolidin-2-yl)methanol; 2-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methylamino)acetamide; trans-4-(5-(4-aminocyclohexyloxy)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-((5-(3-hydroxybenzyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; cis-4-(2-(2-(2-(pyrrolidin-1-yl)ethoxy)pyridin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-1-(5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)pyridin-2-yl)piperidin-4-ol; cis-4-(2-(6-(methylamino)pyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 5-(2-aminoethoxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; cis-4-(2-(1H-pyrrolo[2,3-b]pyridin-5-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (6-(2-(6-(dimethylamino)pyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1H-benzo[d]imidazol-2-yl)methanol; (R)-1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperidin-3-ol; (S)-1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperidin-3-ol; 1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)imidazolidin-4-one; (R)-5-(pyrrolidin-2-ylmethoxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (S)-5-(pyrrolidin-2-ylmethoxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yloxy)propan-1-ol; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)pyridin-2-ol; 4-(5-(2-hydroxy-2-(piperidin-4-yl)ethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 5-(pyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(morpholinomethyl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (R)-1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)piperidin-3-ol; (S)-1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)piperidin-3-ol; cis-4-(2-(3,4-difluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 2-(4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyridin-2-ylamino)ethanol; cis-4-(2-(6-morpholinopyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(3,5-dimethylphenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yloxy)ethanol; cis-3-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyridin-2(1H)-one; cis-2-fluoro-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; cis-4-(2-(4-fluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(4-fluoro-3-methylphenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 5-(3-aminopropoxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; cis-4-(2-(2-fluoropyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (R)-(1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyrrolidin-3-yl)methanol; (S)-(1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyrrolidin-3-yl)methanol; N-methyl-4-(5-(pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; (R)-(1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyrrolidin-3-yl)methanol; (S)-(1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyrrolidin-3-yl)methanol; (R)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)propan-1-ol; (S)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)propan-1-ol; N 5 -isopropyl-N 2 -(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; cis-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)pyridin-2-ol; (R)-1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyrrolidin-3-ol; (S)-1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyrrolidin-3-ol; (1S,2S)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (R)-1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyrrolidin-3-ol; (S)-1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyrrolidin-3-ol; cis-3-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; cis-4-(2-(3-methoxyphenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(2-methoxyphenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-3-fluoro-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; cis-3-fluoro-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzonitrile; cis-4-(2-(6-methoxypyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(p-tolylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yloxy)cyclohexanecarboxamide; 1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)piperidin-4-ol; (1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)piperidin-4-yl)methanol; cis-2-fluoro-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; cis-3-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzonitrile; cis-4-(2-(pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(m-tolylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 5-(piperidin-4-yloxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; cis-4-(2-(4-chlorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(3-chlorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(3-fluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (1S,2R)-(2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexyl)methanol; cis-4-(2-(2-fluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 2-methyl-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)propan-1-ol; cis-4-(2-(6-(2-hydroxypropan-2-yl)pyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 4-(5-(cis-4-aminocyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; (R)-5-(piperidin-3-yloxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (S)-5-(piperidin-3-yloxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 4-(5-(cis-4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzonitrile; cis-4-(2-(1-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(2-(methylamino)pyridin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(2-methylpyridin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(5-methoxypyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)nicotinamide; cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)picolinamide; cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)pyridin-2-ol; 5-(pyridin-4-ylmethyl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (±)-trans-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (1S,2S)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol; trans-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)methyl)cyclohexanol; (1S,2R)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol; (1R,2R)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol; cis-4-(2-(2-methoxypyridin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 2-(6-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1H-benzo[d]imidazol-2-yl)propan-2-ol; 5-(1H-imidazo[4,5-b]pyridin-6-yl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)picolinonitrile; cis-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)methyl)cyclohexanol; trans-1-methyl-4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-1-methyl-4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-2-(4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexyl)propan-2-ol; cis-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; trans-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; cis-4-(2-(pyridin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(5-methylpyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(6-methoxypyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(6-(dimethylamino)pyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 5-(piperazin-1-ylmethyl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; trans-4-(5-(4-aminocyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 5-(piperidin-4-ylmethyl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperidin-4-ol; trans-2-(4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexyl)propan-2-ol; trans-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)cyclohexanol; cis-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)cyclohexanol; 4-(5-(cyclopentylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 5-(2-(methoxymethyl)-1H-benzo[d]imidazol-6-yl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 1-(6-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1H-benzo[d]imidazol-2-yl)ethanol; cis-4-(2-(6-methylpyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (S)—N 2 -(2-(2-aminoethoxy)pyridin-4-yl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; trans-4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yloxy)cyclohexanecarboxamide; (1R,2S)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol; 5-((1-ethylpiperidin-4-yl)methyl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 6-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1H-benzo[d]imidazole-2-carboxamide; (6-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1H-benzo[d]imidazol-2-yl)methanol; cis-(4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexyl)methanol; (S)—N 2 -(6-morpholinopyridin-3-yl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (R)-2-phenyl-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)ethanol; (S)-2-phenyl-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)ethanol; trans-(4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexyl)methanol; 4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)pyridin-2-ol; 4-(2-(4-fluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)picolinamide; cis-4-(2-(4-fluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yloxy)cyclohexanol; (1S,3R)-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol; (1S,3S)-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol; (1R,3R)-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol; (1R,3S)-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol; trans-5-(4-aminocyclohexyloxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; cis-5-(4-aminocyclohexyloxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(2-((methylamino)methyl)benzo[d]oxazol-6-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 2-(2-(4-fluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1-(piperidin-4-yl)ethanol; 4-(5-(1H-indazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; N 5 -(azepan-3-yl)-N 2 -(4-fluorophenyl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; N-phenyl-5-(2-(pyrrolidin-1-ylmethyl)-1H-benzo[d]imidazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; cis-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; 4-((2-(4-fluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperidin-4-ol; 2-(2-(4-fluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1-phenylethanol; 4-(5-(1H-benzo[d][1,2,3]triazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; (S)—N 5 -(piperidin-3-yl)-N 2 -(pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (R)—N 5 -(piperidin-3-yl)-N 2 -(pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 5-(4-methylisoxazol-3-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-(4-fluorophenyl)-5-(1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-(4-fluorophenyl)-5-(2-((methylamino)methyl)-1H-benzo[d]imidazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N 2 -phenyl-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 5-(3-amino-1H-indazol-6-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(2-((methylamino)methyl)-1H-benzo[d]imidazol-6-yl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-methyl-4-(5-(tetrahydrofuran-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; 3-((2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)benzamide; 2-(4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyridin-2-ylamino)ethanol; 5-(2-(2-aminoethoxy)pyridin-4-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(2-aminopyridin-4-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(2-(dimethylamino)pyridin-4-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N 1 -(4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyridin-2-yl)ethane-1,2-diamine; (R)—N 2 -(isoindolin-5-yl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (S)—N 2 -(isoindolin-5-yl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (R)—N 2 -(3-amino-1H-indazol-6-yl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (S)—N 2 -(3-amino-1H-indazol-6-yl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 4-((2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)benzamide; cis-4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (S)—N 2 -(1H-benzo[d][1,2,3]triazol-6-yl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (R)—N 2 -(1H-benzo[d][1,2,3]triazol-6-yl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; N-methyl-4-(5-(tetrahydro-2H-pyran-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; 5-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzo[d]isoxazol-3-amine; (R)-5-(3-amino-2-methylpropyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (S)-5-(3-amino-2-methylpropyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (R)-2-methyl-3-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)propanamide; (S)-2-methyl-3-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)propanamide; (R)—N 2 -(4-fluorophenyl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (R)—N 2 -(1-methyl-1H-indazol-6-yl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (S)—N 2 -(1H-indazol-6-yl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (S)—N 2 -(4-fluorophenyl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (S)—N 2 -(1-methyl-1H-indazol-6-yl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (R)—N 2 -(1H-indazol-6-yl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (R)—N 5 -(piperidin-3-yl)-N 2 -(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (S)—N 5 -(piperidin-3-yl)-N 2 -(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; trans-4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; N 5 -methyl-N 2 , N 5 -diphenyl-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 5-(5-methylisoxazol-3-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (R)—N 2 -phenyl-N 5 -(pyrrolidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (S)—N 2 -phenyl-N 5 -(pyrrolidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (R)-4-(5-(piperidin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; N 5 , N 5 -dimethyl-N 2 -phenyl-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; N-phenyl-5-(piperidin-3-ylmethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (R)-2-methyl-3-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)propan-1-ol; (S)-2-methyl-3-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)propan-1-ol; 5-(2-(methylamino)-1H-benzo[d]imidazol-5-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-phenyl-5-(piperidin-4-ylmethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (S)-4-(5-(piperidin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; N 2 -phenyl-N 5 -(pyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 5-(1H-indazol-6-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(2-((dimethylamino)methyl)-1H-benzo[d]imidazol-5-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(2-((methylamino)methyl)-1H-benzo[d]imidazol-5-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-phenyl-5-(pyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 7-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)isoquinolin-1-amine; 5-(1-(2-aminoethyl)-1H-benzo[d]imidazol-5-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (1-benzylpiperidin-4-yl)(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methanol; trans-4-(5-(4-aminocyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; cis-4-(5-(4-aminocyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; 2-(2-aminoethyl)-5-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)isoindolin-1-one; 2-(2-aminoethyl)-6-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)isoindolin-1-one; 5-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)isoindolin-1-one; (R)—N 2 -phenyl-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 5-(3-aminopropyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)isoindolin-1-one; 6-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)isoindolin-1-one; (2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)(pyridin-3-yl)methanol; (2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)(piperidin-4-yl)methanol; 5-phenoxy-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (S)-2-(phenylamino)-N-(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-5-carboxamide; 5-(4-aminobutyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-benzyl-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (S)—N 2 -phenyl-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; cis-N 5 -(4-aminocyclohexyl)-N 2 -phenyl-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; phenyl(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methanone; 5-(cyclohexyloxy)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(3-amino-1H-indazol-5-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-phenyl-5-(piperidin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-phenyl-5-(1,2,3,6-tetrahydropyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(1H-benzo[d]imidazol-6-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(1-(2-aminoethyl)-1H-benzo[d]imidazol-6-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 4-(5-(piperidin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; 4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyridin-2-ol; trans-N 5 -(4-aminocyclohexyl)-N 2 -phenyl-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; cis-4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanecarboxamide; N-phenyl-5-(2-(piperazin-1-yl)pyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(2-methoxypyridin-4-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(1H-indazol-5-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N 2 -phenyl-N 5 -(piperidin-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; N-phenyl-5-(pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-cyclohexyl-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)isobutyramide; N-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)acetamide; N-phenyl-5-(pyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N 2 , N 5 -diphenyl-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; N 5 -isopropyl-N 2 -phenyl-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; N 2 -(3-methylbenzo[d]isoxazol-6-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 1-methyl-5-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1H-benzo[d]imidazol-2(3H)-one; 4-((2-(3-(methoxymethyl)-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; N 2 -(3-methyl-[1,2,4]triazolo[4,3-a]pyridin-7-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; N-(5-methyl-6-morpholinopyridin-3-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 6-(5-(difluoro(tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; 3-methyl-N-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzo[d]isoxazol-6-amine; 3-methyl-N-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-7-amine; N 2 -(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 5-((tetrahydro-2H-pyran-4-yl)methyl)-N-(3-(trifluoromethyl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; cis-4-(2-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; N 5 -methyl-N 2 -(1-methyl-1H-indazol-5-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; cis-4-(2-(3-methylbenzo[d]isoxazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 3-methyl-N-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-amine; cis-tert-butyl 6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethyl-2-oxoindoline-1-carboxylate; 3,3,4-trimethyl-6-(5-((3-oxopiperazin-1-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; N 2 -(5-methyl-6-morpholinopyridin-3-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; N-(3,4-dimethyl-1H-indazol-6-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 6-(5-(isopropylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; N-(1-methyl-1H-indazol-5-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N 2 -(1-methyl-1H-indazol-5-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; N-(3-(methoxymethyl)-1H-indazol-6-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; cis-4-(2-(1H-pyrazolo[4,3-b]pyridin-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1,6-dimethylindolin-2-one; (S)-2-methyl-3-(2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)propan-1-ol; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1,4-dimethylindolin-2-one; N-(4-(1H-1,2,4-triazol-3-yl)phenyl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 3,3-dimethyl-6-(5-((tetrahydrofuran-3-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 6-(5-(2-methoxypyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; 4-(5-(cyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide 3,3-dimethyl-6-(5-((tetrahydrofuran-3-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 5-(difluoro(tetrahydro-2H-pyran-4-yl)methyl)-N-(3-methyl-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-((1,4-dioxan-2-yl)difluoromethyl)-N-(3-methyl-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 3,3-dimethyl-6-(5-methyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one N 2 -(4-(1H-1,2,4-triazol-3-yl)phenyl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 6-(5-(dimethylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one cis-4-(2-(4-(1H-1,2,4-triazol-3-yl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(3-methyl-[1,2,4]triazolo[4,3-a]pyridin-7-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 1-methyl-5-(5-(tetrahydro-2H-pyran-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1H-benzo[d]imidazol-2(3H)-one; cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1-methyl-1H-benzo[d]imidazol-2(3H)-one; or 3,3-dimethyl-6-(5-morpholino-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one.
4 . A method for the treatment or prevention of an inflammatory condition, an immunological condition, an autoimmune condition, an allergic condition, a rheumatic condition, a thrombotic condition, a cancer, an infection, a neurodegenerative disease, a neuroinflammatory disease, a cardiovascular disease or a metabolic condition, the method comprising administering to a subject in need thereof an effective amount of compound of formula (I):
or a pharmaceutically acceptable salt, tautomer, stereoisomer, solvate or prodrug thereof, wherein:
R 1 is a substituted or unsubstituted aryl, or a substituted or unsubstituted heterocyclyl;
R 2 is a substituted or unsubstituted C 1-8 alkyl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted heterocyclylalkyl, a substituted or unsubstituted aralkyl, —NR 3 R 4 , —OR 3 , —C(═O)R 5 , —C(═O)NR 3 R 4 , —NHC(═O)R 3 , —(CH 2 ) 0-2 CR 6 (OR 3 )R 4 , or a substituted or unsubstituted heterocyclyl selected from azetidinyl, pyrrolidyl, piperidyl, morpholinyl, piperazin-2-onyl, 1,2,3,6-tetrahydropyridyl, isoxazolyl, imidazolyl, indazolyl, benzimidazolyl, 1H-benzo[d][1,2,3]triazolyl, benzisoxazolyl, benzo[d]oxazolyl, isoindolin-1-onyl, 1H-imidazo[4,5-b]pyridyl, isoquinolinyl, or quinolyl; or R 2 is pyridyl, provided R 1 is not (2-(pyrrolidin-1-yl)ethoxy)phenyl-4-yl;
R 3 and R 4 are at each occurrence independently —H, a substituted or unsubstituted C 1-8 alkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted heteroaryl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted heterocyclyl, a substituted or unsubstituted aralkyl, or a substituted or unsubstituted heterocyclylalkyl;
R 5 is substituted or unsubstituted C 1-8 alkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted heteroaryl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted heterocyclyl, a substituted or unsubstituted aralkyl, or a substituted or unsubstituted heterocyclylalkyl; and
R 6 is —H, or a substituted or unsubstituted C 1-8 alkyl, or together with R 4 and the atoms to which they are attached form a substituted or unsubstituted heterocyclyl;
provided the compound is not N 5 -cyclopentyl-N 2 -(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine.
5 . The method of claim 4 , wherein the compound is
1-methyl-N 3 -(tetrahydro-2H-pyran-4-yl)-N 6 -(5-((tetrahydro-2H-pyran-4-yl)methyl)-[ 1,2,4]triazolo[1,5-a]pyridin-2-yl)-1H-indazole-3,6-diamine; N 3 -(tetrahydro-2H-pyran-4-yl)-N 6 -(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-1H-indazole-3,6-diamine; 1-methyl-N 3 -(piperidin-4-yl)-N 6 -(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-1H-indazole-3,6-diamine; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one; cis-6-(5-(4-hydroxy-4-methylcyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1,3,3-trimethylindolin-2-one; N-(3-(methoxymethyl)-1H-indazol-6-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; cis-4-(2-(5-methyl-6-morpholinopyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; N-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-1H-pyrazolo[4,3-b]pyridin-6-amine; cis-4-(2-(1H-pyrazolo[4,3-b]pyridin-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; N 2 -(3,4-dimethyl-1H-indazol-6-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3,4-trimethylindolin-2-one; trans-6-(5-(4-hydroxy-4-methylcyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1,3,3-trimethylindolin-2-one; N 2 -(1H-pyrazolo[4,3-b]pyridin-6-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; cis-4-(2-(imidazo[1,2-a]pyridin-7-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 3,3-dimethyl-6-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one; 6-(5-(4-hydroxypiperidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; (R)—N 2 -(3-methyl-1H-indazol-5-yl)-N 5 -(tetrahydrofuran-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; N-(3-methyl-1H-indazol-5-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N 2 -(3-methyl-1H-indazol-5-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 1-methyl-6-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 1-methyl-6-(5-(tetrahydro-2H-pyran-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylisoindolin-1-one; (S)-3,3-dimethyl-6-(5-(methyl(tetrahydrofuran-3-yl)amino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; (R)-3,3-dimethyl-6-(5-(methyl(tetrahydrofuran-3-yl)amino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; (R)-1,3,3-trimethyl-6-(5-(tetrahydrofuran-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 4-((2-(4-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyridine-2-ol; 3,3,4-trimethyl-6-(5-(tetrahydro-2H-pyran-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 3,3,4-trimethyl-6-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; trans-4-(2-(3-methyl-1H-indazol-5-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 3,3-dimethyl-6-(5-(tetrahydro-2H-pyran-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one; N 5 -(tetrahydro-2H-pyran-4-yl)-N 2 -(3-(trifluoromethyl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 4-((2-(2-(methoxymethyl)-1H-benzo[d]imidazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyridine-2-ol; (R)-3,3-dimethyl-6-(5-(piperidin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; N-(2-(methoxymethyl)-1H-benzo[d]imidazol-6-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (S)-3,3-dimethyl-6-(5-(tetrahydrofuran-3-yloxy)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; (R)-3,3-dimethyl-6-(5-(tetrahydrofuran-3-yloxy)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-2-methylisoindolin-1-one; 1,3,3-trimethyl-6-(5-((3-oxopiperazin-1-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; trans-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylisoindolin-1-one; 3,3-dimethyl-6-(5-(piperidin-4-ylmethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; cis-4-(2-(1-methyl-1H-pyrazolo[3,4-b]pyridin-5-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-6-(5-((4-hydroxy-4-methylcyclohexyl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; trans-6-(5-((4-hydroxy-4-methylcyclohexyl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; N 2 -(2-(methoxymethyl)-1H-benzo[d]imidazol-6-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 1,3,3-trimethyl-6-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 2-methyl-5-(5-(tetrahydro-2H-pyran-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one; 2-methyl-5-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one; trans-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1,3,3-trimethylindolin-2-one; N-(1,4-dimethyl-1H-indazol-6-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N 2 -(1,4-dimethyl-1H-indazol-6-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; cis-4-(2-(4-fluoro-1,3-dimethyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (R)-3,3-dimethyl-6-(5-(tetrahydrofuran-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 1,3,3-trimethyl-6-(5-(tetrahydro-2H-pyran-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1,3,3-trimethylindolin-2-one; 6-(5-((2-hydroxyethyl)(methyl)amino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; (S)-3,3-dimethyl-6-(5-(piperidin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 4-((2-(3-(trifluoromethyl)-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; 3,3-dimethyl-6-(5-((2-oxo-1,2-dihydropyridin-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 5-(5-((2-hydroxypyridin-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one; 3,3-dimethyl-6-(5-(methyl(tetrahydro-2H-pyran-4-yl)amino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 3,3-dimethyl-6-(5-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; N-(1-methyl-1H-indazol-6-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N 2 -(1-methyl-1H-indazol-6-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; trans-6-(5-(4-hydroxy-4-methylcyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; cis-6-(5-(4-hydroxy-4-methylcyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; cis-4-(2-(4-fluoro-3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (±)-cis-4-(2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yloxy)tetrahydrofuran-3-ol; (±)-trans-4-(2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)tetrahydrofuran-3-ol; (R)—N 2 -(3-methyl-1H-indazol-6-yl)-N 5 -(tetrahydrofuran-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 3,3-dimethyl-6-(5-(tetrahydro-2H-pyran-4-yloxy)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 3-methyl-1-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)azetidin-3-ol; 6-(5-(3-hydroxyazetidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; 6-(5-(3-hydroxy-3-methylazetidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; 3,3-dimethyl-6-(5((3-oxopiperazin-1-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 6-(5-(hydroxy(tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-2-(2-methoxyethyl)isoindolin-1-one; trans-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; 3,3-dimethyl-6-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 3,3-dimethyl-6-(5-(tetrahydro-2H-pyran-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; (1S,3R)-3-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)methyl)cyclopentanol; (1S,3R)-3-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)methyl)cyclopentanol; (1R,3S)-3-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)methyl)cyclopentanol; (1R,3S)-3-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)methyl)cyclopentanol; (S)—N 2 -(3-methyl-1H-indazol-6-yl)-N 5 -(tetrahydrofuran-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 4-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyridin-2(1H)-one; 5-((3,3-difluoropiperidin-1-yl)methyl)-N-(3-methyl-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1-(2-hydroxyethyl)indolin-2-one; 2-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methylamino)acetamide; cis-1-(methoxymethyl)-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)cyclohexanol; 4-((2-(1-isopropyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; N 5 -methyl-N 2 -(3-methyl-1H-indazol-6-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 2-(methyl(2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)amino)ethanol; cis-4-(2-(1-(2-hydroxyethyl)-3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1-methylindolin-2-one; 6-(hydroxy(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyrimidin-4(3H)-one; cis-4-(2-(1-(2-methoxyethyl)-3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(2-(hydroxymethyl)-1H-benzo[d]imidazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(2-(methoxymethyl)-1H-benzo[d]imidazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(1-ethyl-3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-2-(2-hydroxyethyl)isoindolin-1-one; N-(3-methyl-1H-indazol-6-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)(tetrahydro-2H-pyran-4-yl)methanol; trans-4-(2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,4-dihydroisoquinolin-1(2H)-one; cis-4-(2-(4-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (R)-3-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methylamino)pyrrolidin-2-one; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-2-(2-hydroxyethyl)isoindolin-1-one; (±)-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methylamino)pyrrolidin-2-one; 4-((2-(3-amino-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)cyclohexanol; N 2 -(3-methyl-1H-indazol-6-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; cis-4-(2-(4-fluoro-3-(2-methoxyethoxy)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 4-(1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)ethyl)pyridin-2(1H)-one; (1S,2S)-2-(2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol; N-methyl-2-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methylamino)acetamide; 4-(5-((3-hydroxycyclopentyl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide (diastereomer 2); 1-(2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)azetidin-3-ol; cis-4-(2-(3-amino-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(2,3-dimethyl-2H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(1,3-dimethyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 4-((2-(4-fluoro-3-methylphenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyridin-2-ol; N 2 -(3-methyl-1H-indazol-6-yl)-N 5 -((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 4-((2-(6-(4-hydroxypiperidin-1-yl)pyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; (S)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methylamino)propanamide; cis-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol (enantiomer 1); cis-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol (enantiomer 2); trans-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol (enantiomer 1); trans-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol (enantiomer 2); cis-1-(hydroxymethyl)-4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 4-((2-(4-fluoro-3-methylphenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; 4-((2-(1H-pyrrolo[2,3-b]pyridin-5-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; (±)-5-isopropyl-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; cis-4-(2-(3-(methoxymethyl)-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 4-(5-((3-hydroxycyclopentyl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide (diastereomer 1); (±)-2-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methylamino)propanamide; 1-(3-methyl-1H-indazol-6-yl)-4-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; 4-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; cis-4-(2-(1-methyl-1H-indazol-5-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(1H-benzo[d][1,2,3]triazol-5-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; cis-4-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)cyclohexanol; trans-4-((2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)cyclohexanol; 4-(5-(1H-imidazol-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-(5-(4-hydroxypiperidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; cis-4-(2-(1-isopropyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; N-methyl-4-(5-(2-methyl-1H-benzo[d]imidazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; cis-4-(2-(3-ethyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (1R,2R)-2-(4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyridin-2-ylamino)cyclopentanol; N-methyl-4-(5-(piperidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; (±)-trans-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (S)-4-(5-(3-hydroxypyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; (R)-4-(5-(3-hydroxypyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; N-methyl-4-(5-(pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; 1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)imidazolidine-2,4-dione; cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one; N-methyl-4-(5-(2-(piperidin-4-yl)ethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; cis-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)picolinamide; cis-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)picolinonitrile; 1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperidine-3-carboxamide; 5-methyl-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; (1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)azetidin-3-yl)methanol; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one; cis-4-(2-(2,6-dimethylpyridin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 4-(5-((4-aminocyclohexyl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-(1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)ethyl)piperazin-2-one; 4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazine-2,6-dione; cis-N 5 -(4-methoxycyclohexyl)-N 5 -methyl-N 2 -(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; cis-4-(methyl(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)amino)cyclohexanol; N-methyl-4-(5-(pyrrolidin-3-ylmethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; 5-(5-(2-(hydroxymethyl)-1H-benzo[d]imidazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)pyridin-2-ol; 1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)-1,4-diazepan-5-one; (1S,2R)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (S)-(1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyrrolidin-2-yl)methanol; (R)-(1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyrrolidin-2-yl)methanol; (1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperidin-3-yl)methanol; (1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperidin-4-yl)methanol; (S)-3-methyl-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; N-methyl-4-(5-(piperidin-4-ylmethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; cis-4-(2-(2-(2-hydroxyethoxy)pyridin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(2-(2-(pyrrolidin-1-yl)ethylamino)pyridin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(4-fluoro-3,5-dimethylphenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (6-(2-(6-methoxypyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1H-benzo[d]imidazol-2-yl)methanol; 3-methyl-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; 6-methyl-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; cis-4-(5-(4-aminocyclohexyloxy)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; N-methyl-4-(5-(piperidin-4-yloxy)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; (6-(2-(6-methylpyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1H-benzo[d]imidazol-2-yl)methanol; 1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)tetrahydropyrimidin-2(1H)-one; 1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)azetidin-3-ol; (R)-(1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyrrolidin-2-yl)methanol; (S)-(1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyrrolidin-2-yl)methanol; 2-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methylamino)acetamide; trans-4-(5-(4-aminocyclohexyloxy)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-((5-(3-hydroxybenzyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; cis-4-(2-(2-(2-(pyrrolidin-1-yl)ethoxy)pyridin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-1-(5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)pyridin-2-yl)piperidin-4-ol; cis-4-(2-(6-(methylamino)pyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 5-(2-aminoethoxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; cis-4-(2-(1H-pyrrolo[2,3-b]pyridin-5-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (6-(2-(6-(dimethylamino)pyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1H-benzo[d]imidazol-2-yl)methanol; (R)-1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperidin-3-ol; (S)-1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperidin-3-ol; 1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)imidazolidin-4-one; (R)-5-(pyrrolidin-2-ylmethoxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (S)-5-(pyrrolidin-2-ylmethoxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yloxy)propan-1-ol; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)pyridin-2-ol; 4-(5-(2-hydroxy-2-(piperidin-4-yl)ethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 5-(pyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(morpholinomethyl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (R)-1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)piperidin-3-ol; (S)-1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)piperidin-3-ol; cis-4-(2-(3,4-difluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 2-(4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyridin-2-ylamino)ethanol; cis-4-(2-(6-morpholinopyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(3,5-dimethylphenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yloxy)ethanol; cis-3-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyridin-2(1H)-one; cis-2-fluoro-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; cis-4-(2-(4-fluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(4-fluoro-3-methylphenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 5-(3-aminopropoxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; cis-4-(2-(2-fluoropyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (R)-(1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyrrolidin-3-yl)methanol; (S)-(1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyrrolidin-3-yl)methanol; N-methyl-4-(5-(pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; (R)-(1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyrrolidin-3-yl)methanol; (S)-(1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyrrolidin-3-yl)methanol; (R)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)propan-1-ol; (S)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)propan-1-ol; N 5 -isopropyl-N 2 -(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; cis-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)pyridin-2-ol; (R)-1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyrrolidin-3-ol; (S)-1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyrrolidin-3-ol; (1S,2S)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (R)-1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyrrolidin-3-ol; (S)-1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)pyrrolidin-3-ol; cis-3-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; cis-4-(2-(3-methoxyphenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(2-methoxyphenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-3-fluoro-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; cis-3-fluoro-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzonitrile; cis-4-(2-(6-methoxypyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(p-tolylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yloxy)cyclohexanecarboxamide; 1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)piperidin-4-ol; (1-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)piperidin-4-yl)methanol; cis-2-fluoro-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; cis-3-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzonitrile; cis-4-(2-(pyridin-2-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(m-tolylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 5-(piperidin-4-yloxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; cis-4-(2-(4-chlorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(3-chlorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(3-fluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (1S,2R)-(2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexyl)methanol; cis-4-(2-(2-fluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 2-methyl-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)propan-1-ol; cis-4-(2-(6-(2-hydroxypropan-2-yl)pyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 4-(5-(cis-4-aminocyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; (R)-5-(piperidin-3-yloxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (S)-5-(piperidin-3-yloxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 4-(5-(cis-4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzonitrile; cis-4-(2-(1-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(2-(methylamino)pyridin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(2-methylpyridin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(5-methoxypyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)nicotinamide; cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)picolinamide; cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)pyridin-2-ol; 5-(pyridin-4-ylmethyl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (±)-trans-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (1S,2S)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol; trans-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)methyl)cyclohexanol; (1S,2R)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol; (1R,2R)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol; cis-4-(2-(2-methoxypyridin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 2-(6-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1H-benzo[d]imidazol-2-yl)propan-2-ol; 5-(1H-imidazo[4,5-b]pyridin-6-yl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)picolinonitrile; cis-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)methyl)cyclohexanol; trans-1-methyl-4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-1-methyl-4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-2-(4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexyl)propan-2-ol; cis-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; trans-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; cis-4-(2-(pyridin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(5-methylpyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(6-methoxypyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(6-(dimethylamino)pyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 5-(piperazin-1-ylmethyl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; trans-4-(5-(4-aminocyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 5-(piperidin-4-ylmethyl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 1-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperidin-4-ol; trans-2-(4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexyl)propan-2-ol; trans-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)cyclohexanol; cis-4-((2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)cyclohexanol; 4-(5-(cyclopentylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 5-(2-(methoxymethyl)-1H-benzo[d]imidazol-6-yl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 1-(6-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1H-benzo[d]imidazol-2-yl)ethanol; cis-4-(2-(6-methylpyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (S)—N 2 -(2-(2-aminoethoxy)pyridin-4-yl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; trans-4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yloxy)cyclohexanecarboxamide; (1R,2S)-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol; 5-((1-ethylpiperidin-4-yl)methyl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 6-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1H-benzo[d]imidazole-2-carboxamide; (6-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1H-benzo[d]imidazol-2-yl)methanol; cis-(4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexyl)methanol; (S)—N 2 -(6-morpholinopyridin-3-yl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (R)-2-phenyl-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)ethanol; (S)-2-phenyl-2-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)ethanol; trans-(4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexyl)methanol; 4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)pyridin-2-ol; 4-(2-(4-fluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)picolinamide; cis-4-(2-(4-fluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yloxy)cyclohexanol; (1S,3R)-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol; (1S,3S)-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol; (1S,3R)-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol; (1R,3S)-3-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclopentanol; trans-5-(4-aminocyclohexyloxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; cis-5-(4-aminocyclohexyloxy)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(2-((methylamino)methyl)benzo[d]oxazol-6-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 2-(2-(4-fluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1-(piperidin-4-yl)ethanol; 4-(5-(1H-indazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; N 5 -(azepan-3-yl)-N 2 -(4-fluorophenyl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; N-phenyl-5-(2-(pyrrolidin-1-ylmethyl)-1H-benzo[d]imidazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; cis-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; 4-((2-(4-fluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperidin-4-ol; 2-(2-(4-fluorophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1-phenylethanol; 4-(5-(1H-benzo[d][1,2,3]triazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; (S)—N 5 -(piperidin-3-yl)-N 2 -(pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (R)—N 5 -(piperidin-3-yl)-N 2 -(pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 5-(4-methylisoxazol-3-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-(4-fluorophenyl)-5-(1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-(4-fluorophenyl)-5-(2-((methylamino)methyl)-1H-benzo[d]imidazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N 2 -phenyl-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 5-(3-amino-1H-indazol-6-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(2-((methylamino)methyl)-1H-benzo[d]imidazol-6-yl)-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-methyl-4-(5-(tetrahydrofuran-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; 3-((2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)benzamide; 2-(4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyridin-2-ylamino)ethanol; 5-(2-(2-aminoethoxy)pyridin-4-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(2-aminopyridin-4-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(2-(dimethylamino)pyridin-4-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N 1 -(4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyridin-2-yl)ethane-1,2-diamine; (R)—N 2 -(isoindolin-5-yl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (S)—N 2 -(isoindolin-5-yl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (R)—N 2 -(3-amino-1H-indazol-6-yl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (S)—N 2 -(3-amino-1H-indazol-6-yl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 4-((2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)benzamide; cis-4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; (S)—N 2 -(1H-benzo[d][1,2,3]triazol-6-yl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (R)—N 2 -(1H-benzo[d][1,2,3]triazol-6-yl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; N-methyl-4-(5-(tetrahydro-2H-pyran-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; 5-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzo[d]isoxazol-3-amine; (R)-5-(3-amino-2-methylpropyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (S)-5-(3-amino-2-methylpropyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (R)-2-methyl-3-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)propanamide; (S)-2-methyl-3-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)propanamide; (R)—N 2 -(4-fluorophenyl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (R)—N 2 -(1-methyl-1H-indazol-6-yl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (S)—N 2 -(1H-indazol-6-yl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (S)—N 2 -(4-fluorophenyl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (S)—N 2 -(1-methyl-1H-indazol-6-yl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (R)—N 2 -(1H-indazol-6-yl)-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (R)—N 5 -(piperidin-3-yl)-N 2 -(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (S)—N 5 -(piperidin-3-yl)-N 2 -(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; trans-4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; N 5 -methyl-N 2 , N 5 -diphenyl-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 5-(5-methylisoxazol-3-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (R)—N 2 -phenyl-N 5 -(pyrrolidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (S)—N 2 -phenyl-N 5 -(pyrrolidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; (R)-4-(5-(piperidin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; N 5 , N 5 -dimethyl-N 2 -phenyl-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; N-phenyl-5-(piperidin-3-ylmethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (R)-2-methyl-3-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)propan-1-ol; (S)-2-methyl-3-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)propan-1-ol; 5-(2-(methylamino)-1H-benzo[d]imidazol-5-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-phenyl-5-(piperidin-4-ylmethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (S)-4-(5-(piperidin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; N 2 -phenyl-N 5 -(pyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 5-(1H-indazol-6-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(2-((dimethylamino)methyl)-1H-benzo[d]imidazol-5-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(2-((methylamino)methyl)-1H-benzo[d]imidazol-5-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-phenyl-5-(pyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 7-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)isoquinolin-1-amine; 5-(1-(2-aminoethyl)-1H-benzo[d]imidazol-5-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (1-benzylpiperidin-4-yl)(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methanol; trans-4-(5-(4-aminocyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; cis-4-(5-(4-aminocyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; 2-(2-aminoethyl)-5-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)isoindolin-1-one; 2-(2-aminoethyl)-6-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)isoindolin-1-one; 5-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)isoindolin-1-one; (R)—N 2 -phenyl-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 5-(3-aminopropyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)isoindolin-1-one; 6-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)isoindolin-1-one; (2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)(pyridin-3-yl)methanol; (2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)(piperidin-4-yl)methanol; 5-phenoxy-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (S)-2-(phenylamino)-N-(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-5-carboxamide; 5-(4-aminobutyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-benzyl-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (S)—N 2 -phenyl-N 5 -(piperidin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; cis-N 5 -(4-aminocyclohexyl)-N 2 -phenyl-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; phenyl(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methanone; 5-(cyclohexyloxy)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(3-amino-1H-indazol-5-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-phenyl-5-(piperidin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-phenyl-5-(1,2,3,6-tetrahydropyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(1H-benzo[d]imidazol-6-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(1-(2-aminoethyl)-1H-benzo[d]imidazol-6-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 4-(5-(piperidin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; 4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)pyridin-2-ol; trans-N 5 -(4-aminocyclohexyl)-N 2 -phenyl-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; cis-4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanecarboxamide; N-phenyl-5-(2-(piperazin-1-yl)pyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(2-methoxypyridin-4-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(1H-indazol-5-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N 2 -phenyl-N 5 -(piperidin-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; N-phenyl-5-(pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-cyclohexyl-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)isobutyramide; N-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)acetamide; N-phenyl-5-(pyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N 2 , N 5 -diphenyl-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; N 5 -isopropyl-N 2 -phenyl-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; N 2 -(3-methylbenzo[d]isoxazol-6-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 1-methyl-5-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1H-benzo[d]imidazol-2(3H)-one; 4-((2-(3-(methoxymethyl)-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)methyl)piperazin-2-one; N 2 -(3-methyl-[1,2,4]triazolo[4,3-a]pyridin-7-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; N-(5-methyl-6-morpholinopyridin-3-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 6-(5-(difluoro(tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; 3-methyl-N-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzo[d]isoxazol-6-amine; 3-methyl-N-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-7-amine; N 2 -(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 5-((tetrahydro-2H-pyran-4-yl)methyl)-N-(3-(trifluoromethyl)-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; cis-4-(2-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; N 5 -methyl-N 2 -(1-methyl-1H-indazol-5-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; cis-4-(2-(3-methylbenzo[d]isoxazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 3-methyl-N-(5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-amine; cis-tert-butyl 6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethyl-2-oxoindoline-1-carboxylate; 3,3,4-trimethyl-6-(5-((3-oxopiperazin-1-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; N 2 -(5-methyl-6-morpholinopyridin-3-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; N-(3,4-dimethyl-1H-indazol-6-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 6-(5-(isopropylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; N-(1-methyl-1H-indazol-5-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N 2 -(1-methyl-1H-indazol-5-yl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; N-(3-(methoxymethyl)-1H-indazol-6-yl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; cis-4-(2-(1H-pyrazolo[4,3-b]pyridin-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1,6-dimethylindolin-2-one; (S)-2-methyl-3-(2-(3-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)propan-1-ol; cis-6-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1,4-dimethylindolin-2-one; N-(4-(1H-1,2,4-triazol-3-yl)phenyl)-5-((tetrahydro-2H-pyran-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 3,3-dimethyl-6-(5-((tetrahydrofuran-3-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 6-(5-(2-methoxypyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one; 4-(5-(cyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide 3,3-dimethyl-6-(5-((tetrahydrofuran-3-yl)methyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one; 5-(difluoro(tetrahydro-2H-pyran-4-yl)methyl)-N-(3-methyl-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-((1,4-dioxan-2-yl)difluoromethyl)-N-(3-methyl-1H-indazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 3,3-dimethyl-6-(5-methyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one N 2 -(4-(1H-1,2,4-triazol-3-yl)phenyl)-N 5 -(tetrahydro-2H-pyran-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine; 6-(5-(dimethylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3,3-dimethylindolin-2-one cis-4-(2-(4-(1H-1,2,4-triazol-3-yl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; cis-4-(2-(3-methyl-[1,2,4]triazolo[4,3-a]pyridin-7-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol; 1-methyl-5-(5-(tetrahydro-2H-pyran-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1H-benzo[d]imidazol-2(3H)-one; cis-5-(5-(4-hydroxycyclohexylamino)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1-methyl-1H-benzo[d]imidazol-2(3H)-one; or 3,3-dimethyl-6-(5-morpholino-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-2-one.
6 . The method of claim 4 , wherein the cancer is cancer of the head, neck, eye, mouth, throat, esophagus, bronchus, larynx, pharynx, chest, bone, lung, colon, rectum, stomach, prostate, urinary bladder, uterine, cervix, breast, ovaries, testicles or other reproductive organs, skin, thyroid, blood, lymph nodes, kidney, liver, pancreas, brain, central nervous system, solid tumors or blood-borne tumors.
7 . The method of claim 4 , wherein the immunological condition is Behcet's syndrome, a non-allergy mast cell disease, ankylosing spondylitis, osteoarthritis, rheumatoid arthritis, multiple sclerosis, lupus, inflammatory bowel disease, ulcerative colitis, Crohn's disease, myasthenia gravis, Grave's disease, transplant rejection, humoral transplant rejection, non-humoral transplant rejection, cellular transplant rejection, immune thrombocytopenic purpura, idiopathic thrombocytopenic purpura, diabetes, immunological response to bacterial, parasitic, helminth infestation or viral infection, eczema, dermatitis, graft versus host disease, Goodpasture's disease, hemolytic disease of the newborn, autoimmune hemolytic anemia, anti-phospholipid syndrome, ANCA-associated vasculitis, Churg-Strauss syndrome, Wegeners granulomatosus, pemphigus vulgaris, serum sickness, mixed cryoglobulinemia, peripheral neuropathy associated with IgM antibody, microscopic polyangiitis, Hashimoto's thyroiditis, Sjogrens syndrome, a fibrosing condition or primary biliary cirrhosis.
8 . The method of claim 4 , wherein the inflammatory condition is non-ANCA vasculitis, psoriasis, asthma, allergic rhinitis, allergic conjunctivitis, chronic urticaria, hives, anaphylaxis, bronchitis, chronic obstructive pulmonary disease, cystic fibrosis, inflammatory bowel disease, irritable bowel syndrome, gout, Crohn's disease, mucous colitis, ulcerative colitis, allergy to an intestinal antigen, diabetes or obesity.
9 . The method of claim 4 , wherein the cardiovascular disease is restenosis, atherosclerosis, stroke, myocardial infarction, ischemic damage to the heart, lung, gut, kidney, liver, pancreas, spleen or brain.
10 . The method of claim 4 , wherein the neurodegenerative or neuroinflammatory disease is Huntington's disease, Alzheimer's disease, or viral or bacterial-associated encephalitis or damage.
11 . A method of inhibiting a kinase in a cell expressing said kinase, comprising contacting said cell with an effective amount of a compound or pharmaceutically acceptable salt, tautomer, stereoisomer, solvate or prodrug thereof, wherein the compound is
N-(2-((dimethylamino)methyl)-1H-benzo[d]imidazol-6-yl)-5-(3-fluorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(3-fluorophenyl)-N-(1H-indazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (6-(5-(3-fluorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1H-benzo[d]imidazol-2-yl)methanol; 5-(3-fluorophenyl)-N-(1-methyl-1H-benzo[d]imidazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 3′-chloro-5′-(2-(4-(methylcarbamoyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)biphenyl-2-carboxamide; 4-(5-(3-(3-aminopropyl)-5-chlorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-(5-(3-(1H-imidazol-5-yl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-(5-(3-(3-aminopropyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-(5-(4-(1H-imidazol-4-yl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 3-(2-(2-methyl-1H-benzo[d]imidazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol; 4-(5-(3-(2-aminoethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-(5-(3-fluorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-(5-(3-chlorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 3-(2-(benzo[d]isoxazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol; 4-(5-(3-hydroxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3-methoxy-N-methylbenzamide; 3-(2-(4-(1H-imidazol-2-yl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol; N 6 -(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)quinoline-2,6-diamine; 4-(5-(3-carbamoylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 3-(2-(1-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol; 4-(5-(3-methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-(5-(2-fluorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-(5-(2-chlorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; N 6 -(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-N 3 -(piperidin-4-yl)-1H-indazole-3,6-diamine; 3-(2-(4-(aminomethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol; 4-(5-(3-hydroxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzoic acid; 6-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)quinolin-2-ol; 3-(2-(1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol; 3-(2-(1-methyl-1H-benzo[d][1,2,3]triazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol; 4-(2-(4-(methylcarbamoyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzoic acid; 3-(2-(4-(methylcarbamoyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzoic acid; N-(2-((dimethylamino)methyl)-1H-benzo[d]imidazol-6-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 3-(2-(4-morpholinophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol; 4-(5-(3-(aminomethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-(5-(3-hydroxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-(1-methylpiperidin-4-yl)benzamide; 1-methyl-N 6 -(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-1H-indazole-3,6-diamine; 4-(5-(3-hydroxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; N-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-2,3-dihydrobenzo[d]isothiazol-6-amine dione; N-(5-methoxypyridin-3-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N 2 -(2-aminoethyl)-N 4 -(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)pyridine-2,4-diamine; N 4 -(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)pyridine-2,4-diamine; N-(6-morpholinopyridin-3-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N 5 -(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzo[d]isoxazole-3,5-diamine; N-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzo[d]isoxazol-5-amine; N 6 -(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzo[d]isoxazole-3,6-diamine; 2-(2-aminoethyl)-5-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one; N-(2-methyl-1H-benzo[d]imidazol-5-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-(1-methyl-1H-benzo[d]imidazol-6-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzo[d]isoxazol-6-amine; N-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-1H-benzo[d][1,2,3]triazol-6-amine; 1-(4-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)phenyl)pyrrolidin-2-one; 4-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)picolinamide; 4-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)picolinonitrile; N-(isoindolin-5-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-(1-methyl-1H-indazol-6-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-(1-methyl-1H-benzo[d]imidazol-5-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-(4-(1H-1,2,4-triazol-5-yl)phenyl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N 6 -(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-1H-indazole-3,6-diamine; 5-phenyl-N-(pyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)quinolin-6-amine; 1-(5-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-1-yl)ethanone; N-(1H-indazol-5-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(3-(1H-1,2,4-triazol-5-yl)phenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 4-(5-(3-cyanophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; 4-(5-(3-hydroxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; 2-fluoro-5-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; 3-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzonitrile; 3-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; N-(1H-indazol-6-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one; 5-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)pyridine-2-ol; N-(6-methoxypyridin-3-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)picolinamide; 2-fluoro-4-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; 5-phenyl-N-(pyrimidin-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-phenyl-N-(pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile; 4-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-(piperidin-4-yl)benzamide; N-(3-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenyl)acetamide; N-(4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenyl)acetamide; 5-(2-fluorophenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(3-fluorophenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(4-aminophenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 3-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile; 5-(3-(aminomethyl)phenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzamide; 3-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzamide; 5-(3-aminophenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 4-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; 5-(4-fluorophenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol; 2-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol; 3-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol; N-(4-morpholinophenyl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N 1 ,N 1 -dimethyl-N 4 -(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzene-1,4-diamine; N-(3,4-dimethoxyphenyl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(furan-3-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(3-chlorophenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; or N,5-diphenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine.
12 . The method of claim 11 , wherein the kinase is one or more of Syk, FLT3, JAK1 or JAK2.
13 . A method for the treatment or prevention of an inflammatory condition, an immunological condition, an autoimmune condition, an allergic condition, a rheumatic condition, a thrombotic condition, a cancer, an infection, a neurodegenerative disease, a neuroinflammatory disease, a cardiovascular disease or a metabolic condition, the method comprising administering to a subject in need thereof an effective amount of compound or pharmaceutically acceptable salt, tautomer, stereoisomer, solvate or prodrug thereof, wherein the compound is
N-(2-((dimethylamino)methyl)-1H-benzo[d]imidazol-6-yl)-5-(3-fluorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(3-fluorophenyl)-N-(1H-indazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; (6-(5-(3-fluorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1H-benzo[d]imidazol-2-yl)methanol; 5-(3-fluorophenyl)-N-(1-methyl-1H-benzo[d]imidazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 3′-chloro-5′-(2-(4-(methylcarbamoyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)biphenyl-2-carboxamide; 4-(5-(3-(3-aminopropyl)-5-chlorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-(5-(3-(1H-imidazol-5-yl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-(5-(3-(3-aminopropyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-(5-(4-(1H-imidazol-4-yl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 3-(2-(2-methyl-1H-benzo[d]imidazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol; 4-(5-(3-(2-aminoethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-(5-(3-fluorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-(5-(3-chlorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 3-(2-(benzo[d]isoxazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol; 4-(5-(3-hydroxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3-methoxy-N-methylbenzamide; 3-(2-(4-(1H-imidazol-2-yl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol; N 6 -(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)quinoline-2,6-diamine; 4-(5-(3-carbamoylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 3-(2-(1-methyl-1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol; 4-(5-(3-methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-(5-(2-fluorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-(5-(2-chlorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; N 6 -(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-N 3 -(piperidin-4-yl)-1H-indazole-3,6-diamine; 3-(2-(4-(aminomethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol; 4-(5-(3-hydroxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzoic acid; 6-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)quinolin-2-ol; 3-(2-(1H-indazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol; 3-(2-(1-methyl-1H-benzo[d][1,2,3]triazol-6-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol; 4-(2-(4-(methylcarbamoyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzoic acid; 3-(2-(4-(methylcarbamoyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzoic acid; N-(2-((dimethylamino)methyl)-1H-benzo[d]imidazol-6-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 3-(2-(4-morpholinophenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol; 4-(5-(3-(aminomethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; 4-(5-(3-hydroxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-(1-methylpiperidin-4-yl)benzamide; 1-methyl-N 6 -(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-1H-indazole-3,6-diamine; 4-(5-(3-hydroxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-methylbenzamide; N-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-2,3-dihydrobenzo[d]isothiazol-6-amine dione; N-(5-methoxypyridin-3-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N 2 -(2-aminoethyl)-N 4 -(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)pyridine-2,4-diamine; N 4 -(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)pyridine-2,4-diamine; N-(6-morpholinopyridin-3-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N 5 -(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzo[d]isoxazole-3,5-diamine; N-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzo[d]isoxazol-5-amine; N 6 -(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzo[d]isoxazole-3,6-diamine; 2-(2-aminoethyl)-5-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one; N-(2-methyl-1H-benzo[d]imidazol-5-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-(1-methyl-1H-benzo[d]imidazol-6-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzo[d]isoxazol-6-amine; N-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-1H-benzo[d][1,2,3]triazol-6-amine; 1-(4-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)phenyl)pyrrolidin-2-one; 4-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)picolinamide; 4-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)picolinonitrile; N-(isoindolin-5-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-(1-methyl-1H-indazol-6-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-(1-methyl-1H-benzo[d]imidazol-5-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-(4-(1H-1,2,4-triazol-5-yl)phenyl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N 6 -(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-1H-indazole-3,6-diamine; 5-phenyl-N-(pyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)quinolin-6-amine; 1-(5-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)indolin-1-yl)ethanone; N-(1H-indazol-5-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(3-(1H-1,2,4-triazol-5-yl)phenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 4-(5-(3-cyanophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; 4-(5-(3-hydroxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; 2-fluoro-5-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; 3-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzonitrile; 3-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; N-(1H-indazol-6-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)isoindolin-1-one; 5-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)pyridine-2-ol; N-(6-methoxypyridin-3-yl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)picolinamide; 2-fluoro-4-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; 5-phenyl-N-(pyrimidin-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-phenyl-N-(pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile; 4-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-N-(piperidin-4-yl)benzamide; N-(3-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenyl)acetamide; N-(4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenyl)acetamide; 5-(2-fluorophenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(3-fluorophenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(4-aminophenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 3-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile; 5-(3-(aminomethyl)phenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzamide; 3-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzamide; 5-(3-aminophenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 4-(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)benzamide; 5-(4-fluorophenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 4-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol; 2-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol; 3-(2-(phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenol; N-(4-morpholinophenyl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; N 1 ,N 1 -dimethyl-N 4 -(5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzene-1,4-diamine; N-(3,4-dimethoxyphenyl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(furan-3-yl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 5-(3-chlorophenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine; or N,5-diphenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine.
14 . The method of claim 13 , wherein the cancer is cancer of the head, neck, eye, mouth, throat, esophagus, bronchus, larynx, pharynx, chest, bone, lung, colon, rectum, stomach, prostate, urinary bladder, uterine, cervix, breast, ovaries, testicles or other reproductive organs, skin, thyroid, blood, lymph nodes, kidney, liver, pancreas, brain, central nervous system, solid tumors or blood-borne tumors.
15 . The method of claim 13 , wherein the immunological condition is Behcet's syndrome, a non-allergy mast cell disease, ankylosing spondylitis, osteoarthritis, rheumatoid arthritis, multiple sclerosis, lupus, inflammatory bowel disease, ulcerative colitis, Crohn's disease, myasthenia gravis, Grave's disease, transplant rejection, humoral transplant rejection, non-humoral transplant rejection, cellular transplant rejection, immune thrombocytopenic purpura, idiopathic thrombocytopenic purpura, diabetes, immunological response to bacterial, parasitic, helminth infestation or viral infection, eczema, dermatitis, graft versus host disease, Goodpasture's disease, hemolytic disease of the newborn, autoimmune hemolytic anemia, anti-phospholipid syndrome, ANCA-associated vasculitis, Churg-Strauss syndrome, Wegeners granulomatosus, pemphigus vulgaris, serum sickness, mixed cryoglobulinemia, peripheral neuropathy associated with IgM antibody, microscopic polyangiitis, Hashimoto's thyroiditis, Sjogrens syndrome, a fibrosing condition or primary biliary cirrhosis.
16 . The method of claim 13 , wherein the inflammatory condition is non-ANCA vasculitis, psoriasis, asthma, allergic rhinitis, allergic conjunctivitis, chronic urticaria, hives, anaphylaxis, bronchitis, chronic obstructive pulmonary disease, cystic fibrosis, inflammatory bowel disease, irritable bowel syndrome, gout, Crohn's disease, mucous colitis, ulcerative colitis, allergy to an intestinal antigen, diabetes or obesity.
17 . The method of claim 13 , wherein the cardiovascular disease is restenosis, atherosclerosis, stroke, myocardial infarction, ischemic damage to the heart, lung, gut, kidney, liver, pancreas, spleen or brain.
18 . The method of claim 13 , wherein the neurodegenerative or neuroinflammatory disease is Huntington's disease, Alzheimer's disease, or viral or bacterial-associated encephalitis or damage.Cited by (0)
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