US2013011447A1PendingUtilityA1

Controlled release nanoparticulate compositions

Assignee: ALKERMES PHARMA IRELAND LTDPriority: Oct 1, 1998Filed: Sep 14, 2012Published: Jan 10, 2013

Est. expiryOct 1, 2018(expired)· nominal 20-yr term from priority

Inventors:Jon Swanson Rajeev Jain Robert Hontz John Devane Kenneth Iain Cumming Maurice Joseph Anthony Clancy Janet Elizabeth Codd Gary Liversidge

A61P 3/06A61P 9/00A61K 9/2077A61K 9/2054A61P 25/28A61K 9/146

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Claims

Abstract

Described are controlled release nanoparticulate formulations comprising a nanoparticulate agent to be administered and a rate-controlling polymer which functions to prolong the release of the agent following administration. The novel compositions release the agent following administration for a time period ranging from about 2 to about 24 hours or longer.

Claims

exact text as granted — not AI-modified

1 . A controlled release nanoparticulate composition comprising:
 (a) a poorly soluble agent to be administered having an effective average particle size of less than about 1000 nm;   (b) at least one surface stabilizer associated with the surface of the agent, and   (c) at least one pharmaceutically acceptable rate-controlling polymer,   wherein the composition provides controlled release of the agent for a time period ranging from about 2 to about 24 hours or longer.   
     
     
         2 .- 35 . (canceled)

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