Phosphorus-containing compounds with polymeric chains, and methods of making and using the same

Abstract

The present invention relates to novel phosphorus-containing compounds with polymeric chains, and methods of making and using the same. In part, subject compositions containing phosphorus-containing compounds with polymeric chains and a therapeutic agent, and methods of making and using the same, are described. Certain of the subject compositions exhibit reverse thermal gelation.

1 - 42 . (canceled) 
     
     
         43 . A method of making a phosphorus-containing compound as shown in the following scheme: 
       
         
           
           
               
               
           
         
         wherein R1 represents a polymeric chain; 
         R2 represents a chemical moiety other than R1 and does not interfere with the biocompatability of the compound; and 
         X 2  is a halogen.