Combination for the treatment of radiation- or chemotherapy-induced mucositis

Abstract

The present invention relates to the use of a combination of glycine, proline, and optionally a natural or synthetic film-forming polymer, and/or lysine and/or leucine, to prepare a composition for the treatment of mucositis induced by radiation or chemotherapy.

1 . An oral formulation comprising:
 a) glycine,   b) proline,   
       and optionally
 c) a natural or synthetic film-forming polymer, and/or 
 d) lysine, and/or 
 e) leucine, 
 
       for the treatment of mucositis induced by radiation or chemotherapeutics. 
     
     
         2 . The formulation as claimed in  claim 1 , wherein the natural or synthetic film-forming polymer is selected from hyaluronic acid or a salt thereof, polyvinylpyrrolidone and cellulose derivatives. 
     
     
         3 . The formulation as claimed in  claim 2 , wherein the natural or synthetic film-forming polymer is hyaluronic acid or a salt thereof. 
     
     
         4 . The formulation as claimed in  claim 1 , wherein the amino acids are in the L form. 
     
     
         5 . The formulation as claimed in  claims 1  and  2 , wherein the various components of the combination are present in the following composition ranges by weight:
 a) 0.5 to 20% of glycine, 
 b) 0.2 to 15% of proline, 
 c) 0.5 to 5% of hyaluronic acid or a salt thereof, and/or 
 
       and optionally
 d) 0.05 to 10% of lysine, and/or 
 e) 0.05% to 3% of leucine. 
 
     
     
         6 . The formulation as claimed in  claims 1  and  2 , wherein the composition is in the form of a spray, aerosol, mouthwash or gel.