US2013040383A1PendingUtilityA1
Nucleic acid molecules encoding anti-inflammatory domain antibodies
Assignee: CEPHALON AUSTRALIA PTY LTDPriority: Dec 20, 2005Filed: Aug 14, 2012Published: Feb 14, 2013
Est. expiryDec 20, 2025(expired)· nominal 20-yr term from priority
A61P 9/10A61P 37/06A61P 9/00A61P 37/00A61P 35/04A61P 31/04A61P 29/00A61P 35/00A61P 3/10A61P 25/00A61P 31/00A61P 21/00A61P 19/00A61P 19/10C07K 16/241A61P 17/02A61P 19/02A61P 11/00A61P 1/16A61P 1/04A61P 17/00C07K 2317/569A61P 1/00C07K 2317/24C07K 2317/565C07K 16/24C07K 16/00A61K 39/395
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Claims
Abstract
The present invention provides a recombinant domain antibody (dAb) which binds to human TNF-α, the dAb comprising an immunoglobulin heavy or light chain variable domain, comprising at least one complementarity determining region (CDR) having a sequence derived from a New World primate.
Claims
exact text as granted — not AI-modified1 . (canceled)
2 . An isolated nucleic acid molecule encoding a domain antibody (dAb) which binds to human TNF-α, wherein the dAb comprises an amino acid sequence selected from the group consisting of:
(SEQ ID NO: 8)
DIQMTQSPSSLSASVGDRVTITCRASQAIDSYLHWYQQKPGKAPKLLIYS
ASNLETGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQVVWRPFTFGQ
GTKVEIKR;
(SEQ ID NO: 9)
DIQMTQSPSSLSASVGDRVTITCRASQSIDSYLHWYQQKPGKAPKLLIYS
ASNLETGVPSRFSGSGSGTDFTLTISSLLPEDFATYYCQQVVWRPFTFGQ
GTKVEIKR;
(SEQ ID NO: 10)
DIQMTQSPSSLSASVGDRVTITCRASQAIDSYLHWYQQKPGKAPKLLIYS
ASNLETGVPSRFSGSGSGTDFTLTISSLLPEDFATYYCQQVVWRPFTFGQ
GTKVEIKR;
(SEQ ID NO: 50)
DIQMTQSPSSLSASVGDRVTITCRASQSIDSYLHWYQQKPGKPPKLLIYS
ASNLETGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQVVWRPFTFGQ
GTKVEIKR;
(SEQ ID NO: 51)
DIQMTQSPSSLSASVGDRVTITCRASQSIDSYLHWYQQKPGKAPKLLIYS
ASNLETGVPSRFSGRGSGTDFTLTISSLQPEDFATYYCQQVVWRPFTFGQ
GTKVEIKR;
and
(SEQ ID NO: 52)
DIQMTQSPSSLSASVGDRVTITCRASQSIDSYLHWYQQKPGKAPKLLIYS
ASNLETGVPSRFSGSGSGTDFTLTISSLLPEDFATYYCQQVVWRPFTFGQ
GTKVEIKR.
3 . The isolated nucleic acid molecule of claim 2 , wherein the dAb comprises the amino acid sequence:
(SEQ ID NO: 10)
DIQMTQSPSSLSASVGDRVTITCRASQAIDSYLHWYQQKPGKAPKLLIYS
ASNLETGVPSRFSGSGSGTDFTLTISSLLPEDFATYYCQQVVWRPFTFGQ
GTKVEIKR.
4 . An expression vector comprising the nucleic acid molecule of claim 2 .
5 . An expression vector comprising the nucleic acid molecule of claim 3 .
6 . An isolated nucleic acid molecule encoding a domain antibody (dAb) which binds to human TNF-α, wherein the dAb consists of an amino acid sequence selected from the group consisting of:
(SEQ ID NO: 8)
DIQMTQSPSSLSASVGDRVTITCRASQAIDSYLHWYQQKPGKAPKLLIYS
ASNLETGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQVVWRPFTFGQ
GTKVEIKR;
(SEQ ID NO: 9)
DIQMTQSPSSLSASVGDRVTITCRASQSIDSYLHWYQQKPGKAPKLLIYS
ASNLETGVPSRFSGSGSGTDFTLTISSLLPEDFATYYCQQVVWRPFTFGQ
GTKVEIKR;
(SEQ ID NO: 10)
DIQMTQSPSSLSASVGDRVTITCRASQAIDSYLHWYQQKPGKAPKLLIYS
ASNLETGVPSRFSGSGSGTDFTLTISSLLPEDFATYYCQQVVWRPFTFGQ
GTKVEIKR;
(SEQ ID NO: 50)
DIQMTQSPSSLSASVGDRVTITCRASQSIDSYLHWYQQKPGKPPKLLIYS
ASNLETGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQVVWRPFTFGQ
GTKVEIKR;
(SEQ ID NO: 51)
DIQMTQSPSSLSASVGDRVTITCRASQSIDSYLHWYQQKPGKAPKLLIYS
ASNLETGVPSRFSGRGSGTDFTLTISSLQPEDFATYYCQQVVWRPFTFGQ
GTKVEIKR;
and
(SEQ ID NO: 52)
DIQMTQSPSSLSASVGDRVTITCRASQSIDSYLHWYQQKPGKAPKLLIYS
ASNLETGVPSRFSGSGSGTDFTLTISSLLPEDFATYYCQQVVWRPFTFGQ
GTKVEIKR.
7 . The isolated nucleic acid molecule of claim 6 , wherein the dAb consists of the amino acid sequence:
(SEQ ID NO: 10)
DIQMTQSPSSLSASVGDRVTITCRASQAIDSYLHWYQQKPGKAPKLLIYS
ASNLETGVPSRFSGSGSGTDFTLTISSLLPEDFATYYCQQVVWRPFTFGQ
GTKVEIKR.
8 . An expression vector comprising the nucleic acid molecule of claim 6 .
9 . An expression vector comprising the nucleic acid molecule of claim 7 .Join the waitlist — get patent alerts
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