US2013059361A1PendingUtilityA1

Compositions and Methods for Effecting the Levels of High Density Lipoprotein (HDL) Cholesterol and Apolipoprotein AI, Very Low Density Lipoprotein (VLDL) Cholesterol and Low Density Lipoprotein (LDL) Cholesterol

Assignee: JAYE MICHAELPriority: Dec 6, 1996Filed: Dec 12, 2011Published: Mar 7, 2013

Est. expiryDec 6, 2016(expired)· nominal 20-yr term from priority

Inventors:Michael C. Jaye Kim-Anh Thi Doan John A. Krawiec Kevin J. Lynch Dilip V. Amin Victoria J. South Dawn Marchadier Cyrille Maugeais Daniel J. Rader

G01N 2333/918C12N 9/20C12N 9/18G01N 33/573

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Claims

Abstract

Compositions and methods for raising the level of HDL cholesterol and apolipoprotein AI in a patient and for lowering the levels of VLDL cholesterol and LDL cholesterol in a patient, including compositions and methods which effect the expression of a gene, LIPG, which encodes a lipase enzyme that is a member of the triacylglycerol lipase family or which effect the enzymatic activity of the enzyme.

Claims

exact text as granted — not AI-modified

1 - 65 . (canceled) 
     
     
         66 . A composition for modulating the activity of LIPG comprising an enhancer or inhibitor of LIPG expression. 
     
     
         67 . A composition for modulating the activity of LIPG comprising an enhancer or inhibitor of LIPG enzymatic activity.

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