Nutritional compositions containing human milk oligosaccharides and methods for using the same

Abstract

This disclosure features human milk permeates and compositions containing the same obtained from fractionated whole human milk. The oligosaccharide rich permeate and permeate compositions of the present invention are useful as nutritional supplements for pre-term and full term infants, for establishing or maintaining gut flora and for treating the symptoms of inflammatory bowel disease.

1 - 63 . (canceled) 
     
     
         64 . A nutritional supplement comprising human milk oligosaccharides. 
     
     
         65 . The nutritional supplement of  claim 64 , wherein said nutritional supplement is administered as a part of a non-human milk baby formula. 
     
     
         66 . The nutritional supplement of  claim 64  wherein said nutritional supplement comprises neutral and/or anionic human milk oligosaccharides. 
     
     
         67 . The nutritional supplement of  claim 66  wherein the neutral and/or anionic human milk oligosaccharides contain galactose, N-acetylglucosamine, lactose and/or fucose. 
     
     
         68 . The nutritional supplement of  claim 64  wherein said human milk oligosaccharides are fucosilated and/or sialilated. 
     
     
         69 . The nutritional supplement of  claim 64  further comprising vitamins and/or minerals. 
     
     
         70 . The nutritional supplement of  claim 64  further comprising a probiotic. 
     
     
         71 . The nutritional supplement of  claim 70  wherein the probiotic is a lactobacilli and/or a bifidobacteria. 
     
     
         72 . The nutritional supplement of  claim 71  wherein the probiotic is a bifidobacteria. 
     
     
         73 . A method for promoting the development of beneficial gut flora in preterm infants or neonates or maintaining proper gut flora in children and adults comprising administering a nutritional supplement comprising human milk oligosaccharides. 
     
     
         74 . The method of  claim 73  wherein said nutritional supplement is added to a human milk formulation or a non-human milk formulation prior to administration. 
     
     
         75 . The method of  claim 74 , wherein said nutritional supplement is added to a non-human milk formulation prior to administration. 
     
     
         76 . The method of  claim 73  wherein said nutritional supplement comprises neutral and/or anionic human milk oligosaccharides. 
     
     
         77 . The method of  claim 76  wherein the neutral and/or anionic human milk oligosaccharides contain galactose, N-acetylglucosamine, lactose and/or fucose. 
     
     
         78 . The method of  claim 73  wherein said human milk oligosaccharides are fucosilated and/or sialilated. 
     
     
         79 . The method of  claim 73  further comprising vitamins and/or minerals. 
     
     
         80 . The method of  claim 73  further comprising a probiotic. 
     
     
         81 . The method of  claim 80  wherein the probiotic is a lactobacilli and/or a bifidobacteria. 
     
     
         82 . The method of  claim 81  wherein the probiotic is a bifidobacteria. 
     
     
         83 . A method for treating an inflammatory bowel disease comprising administering a nutritional supplement comprising human milk oligosaccharides. 
     
     
         84 . The method of  claim 83  wherein the inflammatory bowel disease is selected from the group consisting of ulcerative colitis, indeterminate colitis, microscopic colitis, collagenous colitis, Crohn's disease, and irritable bowel disease. 
     
     
         85 . The method of  claim 83  wherein the nutritional supplement is administered to a preterm infant, infant, child or adult. 
     
     
         86 . The method of  claim 83  wherein said nutritional supplement is added to a human milk formulation or a non-human milk formulation prior to administration. 
     
     
         87 . The method of  claim 86 , wherein said nutritional supplement is added to a non-human milk formulation prior to administration. 
     
     
         88 . The method of  claim 87  wherein said nutritional supplement comprises neutral and/or anionic human milk oligosaccharides. 
     
     
         89 . The method of  claim 88  wherein the neutral and/or anionic human milk oligosaccharides contain galactose, N-acetylglucosamine, lactose and/or fucose. 
     
     
         90 . The nutritional supplement of  claim 83  wherein said human milk oligosaccharides are fucosilated and/or sialilated. 
     
     
         91 . A method of treating or preventing necrotizing Enterocolitis comprising administering a nutritional composition comprising human milk oligosaccharides. 
     
     
         92 . The method of  claim 91  wherein said nutritional supplement is added to a human milk formulation or a non-human milk formulation prior to administration. 
     
     
         93 . The method of  claim 92 , wherein said nutritional supplement is added to a non-human milk formulation prior to administration. 
     
     
         94 . The method of  claim 91  wherein said nutritional supplement comprises neutral and/or anionic human milk oligosaccharides. 
     
     
         95 . The method of  claim 94  wherein the neutral and/or anionic human milk oligosaccharides contain galactose, N-acetylglucosamine, lactose and/or fucose. 
     
     
         96 . The method of  claim 91  wherein said human milk oligosaccharides are fucosilated and/or sialilated. 
     
     
         97 . The nutritional supplement of  claim 64 , wherein the human milk oligosaccharides are derived from human milk. 
     
     
         98 . The method of  claim 73 , wherein the human milk oligosaccharides are derived from human milk. 
     
     
         99 . The method of  claim 83 , wherein the human milk oligosaccharides are derived from human milk. 
     
     
         100 . The method of  claim 91 , wherein the human milk oligosaccharides are derived from human milk.