Neisserial antigens

Abstract

The invention provides proteins from Neisseria meningitidis (strains A & B) and from Neisseria gonorrhoeae , including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.

1 : An isolated protein comprising:
 (a) the amino acid sequence of SEQ ID NO: 654; or   (b) an amino acid sequence having 80% or greater sequence identity to the amino acid sequence of SEQ ID NO: 654; or   (b) a fragment of SEQ ID NO: 654 of at least 10 contiguous amino acids in length.   
     
     
         2 : The isolated protein of  claim 1  comprising (b). 
     
     
         3 : The isolated protein of  claim 2 , wherein the amino acid sequence has 90% or greater sequence identity to the amino acid sequence of SEQ ID NO: 654. 
     
     
         4 : The isolated protein of  claim 2 , wherein the amino acid sequence has 95% or greater sequence identity to the amino acid sequence of SEQ ID NO: 654. 
     
     
         5 : The isolated protein of  claim 1  comprising (c). 
     
     
         6 : A composition comprising the protein of any one of  claims 1 - 5  and an adjuvant. 
     
     
         7 : The composition of  claim 6  further comprising a pharmaceutically acceptable carrier.