Medical fluid, a method of treatment and use of the fluid

Abstract

A medical fluid for a harvested organ, tissue or parts thereof, for evaluation and/or preservation. The fluid includes cocaine or a stimulating analogue thereof; nor-adrenalin; and/or adrenaline. In addition, the fluid includes an oncotic agent, such as dextran; hormones, such as thyroxin; triiodotyronine; cortisone, insulin; and electrolytes and optionally nutrients in substantially physiological concentrations in a physiologically acceptable medium. In addition, the medical fluid further includes albumin in a concentration not exceeding 5.0%, and an oxygen carrier, such as erythrocytes. Further components may be dopamine; hydrocortisone; methylprednisolone; and a vasopressor agent, such as desmopressin. The cocaine; adrenalin; and noradrenaline are present in concentrations of each about 0.010 μM to 0.100 μM, for example in a ratio of 1:1:1.

1 . A medical fluid for a harvested organ, tissue or parts thereof, for evaluation and/or preservation, comprising:
 cocaine or a stimulating analogue thereof; adrenalin and/or noradrenalin; an oncotic agent; hormones; and   electrolytes and optionally nutrients in substantially physiological concentrations in a physiologically acceptable medium.   
     
     
         2 . The fluid according to  claim 1 , in which noradrenaline is present in a concentration of about 0.010 μM to 0.100 μM. 
     
     
         3 . The fluid according to  claim 1 , in which adrenaline is present in a concentration of about 0.010 μM to 0.100 μM. 
     
     
         4 . The fluid according to  claim 1 , in which cocaine or a stimulating analogue thereof is present in a concentration of about 0.010 μM to 0.100 μM. 
     
     
         5 . The fluid according to  claim 1 , wherein said oncotic agent is albumin or dextran or a combination thereof. 
     
     
         6 . The fluid according to  claim 1 , wherein said hormones are any one of thyroxin; triiodotyronine; or cortisone or a combination thereof. 
     
     
         7 . The fluid according to  claim 1 , further comprising an oxygen carrier, such as erythrocytes. 
     
     
         8 . The fluid according to  claim 1 , further comprising at least one of glucose; insulin; dopamine; hydrocortisone; methylprednisolone; and a vasopressor agent, such as desmopressin. 
     
     
         9 . The fluid according to  claim 1 , wherein cocaine or a stimulating analogue thereof; adrenalin; and noradrenaline are present in concentrations of each about 0.010 μM to 0.100 μM. 
     
     
         10 . The fluid according to  claim 1 , wherein cocaine or a stimulating analogue thereof; adrenalin; and noradrenaline are present in concentration ratios of 1:1:1. 
     
     
         11 . A method for treatment of a harvested organ for evaluation and/or preservation, comprising:
 circulating a first fluid in the vascular system of the organ, and optionally partly or completely immersing said organ in a second fluid;   said first fluid comprising cocaine or a stimulating analogue thereof; adrenalin and/or noradrenalin; an oncotic agent; hormones; and   electrolytes and optionally nutrients in substantially physiological concentrations in a physiologically acceptable medium.   
     
     
         12 . The method according to  claim 11 , in which noradrenaline is present in a concentration of about 0.010 μM to 0.100 μM. 
     
     
         13 . The method according to  claim 11 , in which adrenaline is present in a concentration of about 0.010 μM to 0.100 μM. 
     
     
         14 . The method according to  claim 11 , in which cocaine or a stimulating analogue thereof is present in a concentration of about 0.010 μM to 0.100 μM. 
     
     
         15 . The method according to  claim 11 , in which said first fluid further comprises:
 at least one of glucose; albumin; insulin; dopamine; hydrocortisone; methylprednisolone; a vasopressor agent; and an oxygen carrier.   
     
     
         16 . The method according to  claim 11 , in which said second fluid further comprises:
 at least one of glucose; albumin; insulin; dopamine; hydrocortisone; methylprednisolone; and a vasopressor agent, such as desmopressin; and an oxygen carrier, such as erythrocytes.   
     
     
         17 . The method according to  claim 11 , wherein said first fluid is the same as said second fluid. 
     
     
         18 . Use of a fluid for a harvested organ, tissue or part thereof for evaluation and/or preservation, wherein the fluid comprises:
 cocine or a stimulating analogue thereof; adrenalin; and/or nor-adrenalin;   an oncotic agent;   hormones; triiodotyronine; cortisone;   electrolytes and optionally nutrients in substantially physiological concentrations in a physiologically acceptable medium.   
     
     
         19 . The use according to  claim 18 , wherein the fluid further comprises at least one of:
 glucose; albumin; insulin; dopamine; hydrocortisone; methylprednisolone; a vasopressor agent; and an oxygen carrier.