Chlamydomonas intraflagellar transport 88 (ift-88)

Abstract

The invention relates to various intraflagellar transport (IFT) polypeptides and the nucleic acids that encode them. The new IFT particle polypeptides and nucleic acids can be used in a variety of diagnostic, screening, and therapeutic methods.

1 . An isolated polypeptide encoded by a nucleic acid comprising SEQ ID NO:15. 
     
     
         2 . The polypeptide of  claim 1 , wherein the polypeptide is encoded by a nucleic acid consisting of SEQ ID NO:15. 
     
     
         3 . An isolated polypeptide comprising an amino acid sequence that has at least 90% identity to the full length amino acid sequence of SEQ ID NO:16. 
     
     
         4 . The polypeptide of  claim 3 , wherein the polypeptide has at least 95% identity to the full length amino acid sequence of SEQ ID NO:16. 
     
     
         5 . The polypeptide of  claim 3 , wherein the polypeptide has at least 99% identity to the full length amino acid sequence of SEQ ID NO:16. 
     
     
         6 . The polypeptide of  claim 3 , wherein the polypeptide consists of the amino acid sequence of SEQ ID NO:16.