Hydraulic cement compositions with low ph methods, articles and kits

Abstract

A non-aqueous hydraulic cement composition comprises a non-aqueous mixture of (a) β-tricalcium phosphate powder, (b) monocalcium phosphate comprising monocalcium phosphate anhydrous (MCPA), monocalcium phosphate monohydrate (MCPM), or a combination thereof, and (c) non-aqueous water-miscible liquid, wherein a 0.1 g/ml saturated aqueous solution of the monocalcium phosphate has a pH less than 3.0. Methods of producing a hardened cement, hardened cements, kits, and articles of manufacture employ such compositions.

1 . A non-aqueous hydraulic cement composition, comprising a non-aqueous mixture of (a) β-tricalcium phosphate powder, (b) monocalcium phosphate comprising monocalcium phosphate anhydrous (MCPA), monocalcium phosphate monohydrate (MCPM), or a combination thereof, and (c) non-aqueous water-miscible liquid, wherein a 0.1 g/ml saturated aqueous solution of the monocalcium phosphate has a pH less than 3.0. 
     
     
         2 . The non-aqueous hydraulic cement composition of  claim 1 , wherein a 0.1 g/ml saturated aqueous solution of the monocalcium phosphate has a pH less than 3.0 and greater than 2.0. 
     
     
         3 . The non-aqueous hydraulic cement composition of  claim 1 , wherein a 0.1 g/ml saturated aqueous solution of the monocalcium phosphate has a pH of about 2.5-2.8. 
     
     
         4 . The non-aqueous hydraulic cement composition of  claim 1 , wherein the monocalcium phosphate comprises monocalcium phosphate anhydrous (MCPA). 
     
     
         5 . The non-aqueous hydraulic cement composition of  claim 4 , wherein the monocalcium phosphate consists essentially of monocalcium phosphate anhydrous (MCPA). 
     
     
         6 . The non-aqueous hydraulic cement composition of  claim 4 , wherein at least 75% of the monocalcium phosphate has a particle size in a range of about 200-600 μm. 
     
     
         7 . The non-aqueous hydraulic cement composition of  claim 6 , wherein the composition has a powder (weight) to liquid (volume) ratio of about 2-5. 
     
     
         8 . The non-aqueous hydraulic cement composition of  claim 4 , wherein at least 75% of the monocalcium phosphate has a particle size in a range of about 1-100 μm. 
     
     
         9 . The non-aqueous hydraulic cement composition of  claim 8 , wherein the composition has a powder (weight) to liquid (volume) ratio of about 3-4.5. 
     
     
         10 . The non-aqueous hydraulic cement composition of  claim 1 , further comprising porous β-tricalcium phosphate granules. 
     
     
         11 . The non-aqueous hydraulic cement composition of  claim 1 , wherein the composition has a powder (weight) to liquid (volume) ratio of about 0.5-10. 
     
     
         12 . The non-aqueous hydraulic cement composition of  claim 1 , further comprising one or more of a surfactant, a porogen and a gelling agent. 
     
     
         13 . A method of preparing a hardened cement, comprising contacting the hydraulic cement composition of  claim 1  with a hydrating liquid. 
     
     
         14 . The method of  claim 13 , wherein the hydrating liquid comprises water. 
     
     
         15 . A hardened cement formed according to the method of  claim 13 . 
     
     
         16 . The method of  claim 13 , wherein the non-aqueous hydraulic cement composition is injected in vivo and the hydrating liquid comprises a body fluid. 
     
     
         17 . An article of manufacture comprising a container filled with the non-aqueous hydraulic cement composition of  claim 1 . 
     
     
         18 . The article of manufacture of  claim 17 , wherein the container is a syringe. 
     
     
         19 . The article of manufacture of  claim 17 , wherein the container is a vacuum package. 
     
     
         20 . A kit comprising an article of manufacture according to  claim 17  and a separately-contained quantity of hydrating liquid.