Water-Soluble and Water-Insoluble, Ring Opening Metathesis Polymerization Products, Monomers and Related Methods

Abstract

The invention provides certain novel water-soluble and water-insoluble monomers for ring opening metathesis polymerization and novel polymers, compositions and products, and related methods thereof.

1 - 25 . (canceled) 
     
     
         26 . A polymer comprising a monomer of Formula Ia: 
       
         
           
           
               
               
           
         
         wherein 
         X is O, CH 2  or substituted CH 2 ; 
         Y 1 , Y 2  each is independently carbonyl, (C 1 -C 4 ) alkylene, substituted (C 1 -C 4 ) alkylene; and 
         Z 1 , Z 2  each is independently —OH, —OR z , alkyl, —NR z , substituted alkyl, aryl, substituted aryl, wherein 
         R z  is an alkyl, substituted alkyl, aryl, substituted aryl, poly(ethylene oxide), 
         wherein the polymer is cross-linked. 
       
     
     
         27 . The cross-linked polymer of  claim 26  having a monomer selected from: 
       
         
           
           
               
               
           
         
       
     
     
         28 . The cross-linked polymer of  claim 26 , wherein the polymer is a co-polymer. 
     
     
         29 . The cross-linked polymer of  claim 26 , wherein the co-polymer is a statistical co-polymer or a gradient co-polymer. 
     
     
         30 . The co-polymer of  claim 28 , wherein the co-polymer comprises co-monomer selected from: 
       
         
           
           
               
               
           
         
       
     
     
         31 . The cross-linked polymer of  claim 30 , wherein the copolymer is cross-linked with 
       
         
           
           
               
               
           
         
         wherein 
         R is a di-, tri- or tetra-valent radical of alkyl, substituted alkyl, aryl, or substituted aryl, or a peptide having from 3 to 25 amino acids; 
         n and p are each an integer selected from 0 to 200. 
       
     
     
         32 . The cross-linked polymer of  claim 26 , wherein the cross-linking agent is selected from: 
       
         
           
           
               
               
           
         
         wherein R is —(CH 2 ) m —, —(CH 2 CH 2 O) n —, or a peptide of 3 to 25 amino acids, m is from 0 to 10, and 
         n is from 1 to 3000. 
       
     
     
         33 . The polymer of  claim 26 , having a swelling ratio of from about 0.1 to about 3,000. 
     
     
         34 - 39 . (canceled) 
     
     
         40 . An article of manufacture comprising a polymer, the polymer comprises a monomer of Formula Ia: 
       
         
           
           
               
               
           
         
         wherein 
         X is O, CH 2  or substituted CH 2 ; 
         Y 1 , Y 2  each is independently carbonyl, (C 1 -C 4 ) alkylene, substituted (C 1 -C 4 ) alkylene; and 
         Z 1 , Z 2  each is independently —OH, —OR z , alkyl, —NR z , substituted alkyl, aryl, substituted aryl, wherein 
         R z  is an alkyl, substituted alkyl, aryl, substituted aryl, poly(ethylene oxide), 
         wherein the polymer is cross-linked. 
       
     
     
         41 . The article of manufacture of  claim 40 , wherein the polymer has a swelling ratio of from about 30 to about 150. 
     
     
         42 . The article of manufacture of  claim 40 , wherein the polymer has a swelling ratio of less than about 1.0. 
     
     
         43 . The article of manufacture of  claim 42 , wherein the article is a contact lens or material thereof.