US2013079501A1PendingUtilityA1

Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)

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Assignee: JACKSON SIMON MARKPriority: Aug 23, 2007Filed: Mar 16, 2012Published: Mar 28, 2013
Est. expiryAug 23, 2027(~1.1 yrs left)· nominal 20-yr term from priority
Inventors:Simon Mark JacksonNigel Pelham Clinton WalkerDerek E. PiperBei ShanWenyan ShenJoyce Chi Yee ChanChadwick Terence KingRandal R. KetchemChristopher MehlinTeresa Arazas CarabeoQiong Cao
A61P 43/00A61P 9/10A61P 7/00A61P 3/06A61P 9/00A61P 25/28A61P 3/00A61K 31/405C07K 2317/76A61K 31/366A61K 31/505C07K 2317/92A61K 31/40A61K 31/22C07K 16/40C07K 2299/00A61K 2039/505C07K 2317/14A61K 45/06C07K 2317/34C12N 15/1137A61K 39/395A61K 31/44A61K 31/66A61K 39/3955A61K 31/47A61K 2300/00C07K 2317/24
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Claims

Abstract

Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

Claims

exact text as granted — not AI-modified
1 - 36 . (canceled) 
     
     
         37 . A antigen binding protein variant comprising:
 a heavy chain variable region that is at least 85% identical to the amino acid sequence of SEQ ID NO: 459; and   a light chain variable region that is at least 85% identical to the amino acid sequence of SEQ ID NO: 461.   
     
     
         38 . The antigen binding protein variant of  claim 37 , wherein the heavy chain variable region is at least 90% identical to the amino acid sequence of SEQ ID NO: 459, and wherein the light chain variable region is at least 90% identical to the amino acid sequence of SEQ ID NO: 461. 
     
     
         39 . The antigen binding protein variant of  claim 37 , wherein the heavy chain variable region is at least 95% identical to the amino acid sequence of SEQ ID NO: 459, and wherein the light chain variable region is at least 95% identical to the amino acid sequence of SEQ ID NO: 461. 
     
     
         40 . The antigen binding protein variant of  claim 37 , wherein the antigen binding protein specifically binds to PCSK9. 
     
     
         41 . The antigen binding protein variant of  claim 37 , wherein the antigen binding protein is an antibody or a binding part thereof. 
     
     
         42 . A antigen binding protein variant comprising:
 a heavy chain variable region that is at least 85% identical to the amino acid sequence of SEQ ID NO: 463; and   a light chain variable region that is at least 85% identical to the amino acid sequence of SEQ ID NO: 465.   
     
     
         43 . The antigen binding protein variant of  claim 42 , wherein the heavy chain variable region is at least 90% identical to the amino acid sequence of SEQ ID NO: 463, and wherein the light chain variable region is at least 90% identical to the amino acid sequence of SEQ ID NO: 465. 
     
     
         44 . The antigen binding protein variant of  claim 42 , wherein the heavy chain variable region is at least 95% identical to the amino acid sequence of SEQ ID NO: 463, and wherein the light chain variable region is at least 95% identical to the amino acid sequence of SEQ ID NO: 465. 
     
     
         45 . The antigen binding protein variant of  claim 42 , wherein the antigen binding protein specifically binds to PCSK9. 
     
     
         46 . The antigen binding protein variant of  claim 42 , wherein the antigen binding protein is an antibody or a binding part thereof. 
     
     
         47 . A antigen binding protein variant comprising:
 a heavy chain variable region that is at least 85% identical to the amino acid sequence of SEQ ID NO: 483; and   a light chain variable region that is at least 85% identical to the amino acid sequence of SEQ ID NO: 485.   
     
     
         48 . The antigen binding protein variant of  claim 47 , wherein the heavy chain variable region is at least 90% identical to the amino acid sequence of SEQ ID NO: 483, and wherein the light chain variable region is at least 90% identical to the amino acid sequence of SEQ ID NO: 485. 
     
     
         49 . The antigen binding protein variant of  claim 47 , wherein the heavy chain variable region is at least 95% identical to the amino acid sequence of SEQ ID NO: 483, and wherein the light chain variable region is at least 95% identical to the amino acid sequence of SEQ ID NO: 485. 
     
     
         50 . The antigen binding protein variant of  claim 47 , wherein the antigen binding protein specifically binds to PCSK9. 
     
     
         51 . The antigen binding protein variant of  claim 47 , wherein the antigen binding protein is an antibody or a binding part thereof.

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