US2013085569A1PendingUtilityA1

Crosslinker enhanced repair of knee meniscus

45
Assignee: HEDMAN THOMAS PPriority: May 27, 2010Filed: May 26, 2011Published: Apr 4, 2013
Est. expiryMay 27, 2030(~3.9 yrs left)· nominal 20-yr term from priority
Inventors:Thomas P. HedmanPaul Slusarewicz
A61F 2/0063A61F 2250/0067A61F 2/3872A61L 31/043A61L 31/14A61L 27/54A61L 27/58A61L 2300/412A61L 27/505A61L 27/34A61L 27/18A61F 2/30756A61L 2430/06
45
PatentIndex Score
0
Cited by
0
References
0
Claims

Abstract

A method of treating a tear in a knee meniscus of a patient. The method includes exposing the torn knee meniscus to a protein crosslinker during surgery to repair the tear. Also provided is a fixation device for the surgical repair of tears of the meniscus of the knee, where the device contains one or more protein crosslinking reagents.

Claims

exact text as granted — not AI-modified
1 . A method of treating a tear in a knee meniscus of a patient, comprising contacting a torn knee meniscus with a delivery device comprising a protein crosslinking agent during surgery to repair the tear, wherein the crosslinking agent increases the number of covalent crosslink bonds in native tissue in the knee meniscus. 
     
     
         2 . The method of  claim 1 , wherein the delivery device comprises a patch or fixation device comprising the crosslinking agent. 
     
     
         3 . The method of  claim 2 , wherein the fixation device is an arrow, dart, tack or suture. 
     
     
         4 . The method of  claim 2 , wherein the patch or fixation device is biodegradable. 
     
     
         5 . The method of  claim 2 , wherein the patch or fixation device further comprises a basic salt. 
     
     
         6 . The method of  claim 5 , wherein the basic salt is calcium carbonate, calcium hydroxyapatite, sodium bicarbonate, 2-Amino-2-hydroxymethyl-propane-1,3-diol (Tris) or 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES). 
     
     
         7 . The method of  claim 2 , wherein the patch is non-biodegradable. 
     
     
         8 . The method of  claim 2 , wherein the patch is porous and the crosslinking agent is embedded within the pores. 
     
     
         9 . The method of  claim 2 , wherein the crosslinking agent is adhered to one side of the patch as part of a semi-solid formulation. 
     
     
         10 . The method of  claim 2 , wherein the patch or fixation device is coated with one or more layers of crosslinking agent-containing biodegradable polymer. 
     
     
         11 . The method of  claim 10 , wherein each layer comprises a basic salt. 
     
     
         12 . The method of  claim 11 , wherein the salt is calcium carbonate, calcium hydroxyapatite, sodium bicarbonate, 2-Amino-2-hydroxymethyl-propane-1,3-diol (Tris) or 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES). 
     
     
         13 . The method of  claim 10 , wherein the patch or fixation device is coated with multiple layers of crosslinking agent-containing biodegradable polymer, and the crosslinking agent varies from layer to layer. 
     
     
         14 . The method of  claim 2 , wherein the patch is affixed to the meniscus with a bio-compatible adhesive. 
     
     
         15 . The method of  claim 14 , wherein the adhesive is poly(glycerol-co-sebacate acrylate), an oleic methyl ester or an alkyl ester cyanoacrylate. 
     
     
         16 . The method of  claim 2 , wherein the patch is affixed to the meniscus by an associated fixation device. 
     
     
         17 . The method of  claim 16 , wherein the associated fixation device is an arrow, dart, tack or suture. 
     
     
         18 . The method of  claim 16 , wherein the associated fixation device comprises a crosslinking agent. 
     
     
         19 . A delivery device for contacting the knee meniscus of a patient, the device comprising a patch or fixation device comprising a protein crosslinking agent. 
     
     
         20 . The delivery device of  claim 19 , wherein the fixation device is an arrow, dart, tack or suture. 
     
     
         21 . The delivery device of  claim 19 , wherein the patch or fixation device is biodegradable. 
     
     
         22 . The delivery device of  claim 19 , wherein the patch or fixation device further comprises a basic salt. 
     
     
         23 . The delivery device of  claim 22 , wherein the basic salt is calcium carbonate, calcium hydroxyapatite, sodium bicarbonate, 2-Amino-2-hydroxymethyl-propane-1,3-diol (Tris) or 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES). 
     
     
         24 . The delivery device of  claim 19 , wherein the patch is porous and the crosslinking agent is embedded within the pores. 
     
     
         25 . The delivery device of  claim 19 , wherein the crosslinking agent is adhered to one side of the patch as part of a semi-solid formulation 
     
     
         26 . The delivery device of  claim 19 , wherein the patch or fixation device is coated with one or more layers of crosslinking agent-containing biodegradable polymer. 
     
     
         27 . The delivery device of  claim 26 , wherein each layer comprises a basic salt. 
     
     
         28 . The delivery device of  claim 27 , wherein the salt is calcium carbonate, calcium hydroxyapatite, sodium bicarbonate, 2-Amino-2-hydroxymethyl-propane-1,3-diol (Tris) or 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES). 
     
     
         29 . The delivery device of  claim 26 , wherein the patch or fixation device is coated with multiple layers of crosslinking agent-containing biodegradable polymer, and the crosslinking agent varies from layer to layer. 
     
     
         30 . The delivery device of  claim 19 , wherein the patch is affixed to the meniscus with a bio-compatible adhesive. 
     
     
         31 . The delivery device of  claim 30 , wherein the adhesive is poly(glycerol-co-sebacate acrylate), an oleic methyl ester or an alkyl ester cyanoacrylate. 
     
     
         32 . The delivery device of  claim 19 , wherein the patch is affixed to the meniscus by an associated fixation device. 
     
     
         33 . The delivery device of  claim 32 , wherein the associated fixation device is an arrow, dart, tack or suture. 
     
     
         34 . The delivery device of  claim 33 , wherein the associated fixation device comprises a crosslinking agent.

Cited by (0)

No later patents cite this yet.

References (0)

No backward citations on record.