Heteroaryl imidazolone derivatives as jak inhibitors

Abstract

New heteroaryl imidazolone derivatives having the chemical structure of formula (I) are disclosed, as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

1 . A compound of formula (I) 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt, solvate, N-oxide, stereoisomer or deuterated derivative thereof, 
       
       wherein
 m is 0, 1, 2 or 3; 
 p is 0, 1, 2 or 3; 
 Z and V are independently chosen from a nitrogen atom and a carbon atom, wherein at least one of Z and V is a nitrogen atom and the other is a carbon atom; 
 W is chosen from a nitrogen atom and a —CR 3  group; 
 W′ is chosen from a nitrogen atom and a —CR 2  group; 
 W″ is chosen from a nitrogen atom and a —CR 4  group; 
 X and Y are independently chosen from a nitrogen atom and a —CR 5  group, wherein at least one of X and Y is a —CR 5  group; 
 Y′ is chosen from a nitrogen atom and a —CR 5′  group; 
 R 1 , R 2 , R 3 , R 4  and R 5  are independently chosen from a hydrogen atom, a halogen atom, a hydroxyl group, a cyano group, a linear or branched C 1 -C 6  alkyl group, a C 2 -C 4  alkenyl group, a C 2 -C 4  alkynyl group, a C 1 -C 4  haloalkyl group, a C 1 -C 4  hydroxyalkyl group, a C 3 -C 10  cycloalkyl group, a C 3 -C 10  cycloalkenyl group, a monocyclic or polycyclic C 5 -C 14  aryl group, a 5- to 14-membered heteroaryl group containing at least one heteroatom chosen from O, S and N, a 5- to 14-membered heterocyclyl group containing at least one heteroatom chosen from O, S and N, a bicyclyl group containing a monocyclic C 5 -C 9 aryl or heteroaryl group bonded directly to a 5- to 9-membered cycloalkyl or heterocyclyl group, said heteroaryl or heterocyclyl group containing at least one heteroatom seleeted chosen from O, S and N, an aza-bicycloalkyl group having up to 12 carbon atoms, an aza-bicycloalkenyl group having up to 12 carbon atoms, a —(CH 2 ) q SR 15  group, a —(CH 2 ) q SOR 15  group, a —(CH 2 ) q S(O) 2 R 15  group, a —(CH 2 ) q S(O) 2 NR 15 R 16  group, a —(CH 2 ) q NR 15 S(O) 2 R 16  group, a —(CH 2 ) q NR 15 S(O) 2 NR 16  group, a —(CH 2 ) q OR 15  group, a —(CH 2 ) q C(O)OR 15  group, a —(CH 2 ) q O—C(O)R 15  group, a —(CH 2 ) q .C(O)—(CH 2 ) q —R 15  group, a —(CH 2 ) q NR 15 R 16  group, a —(CH 2 ) q CH(R 15 )NR 16 R 17  group, a —(CH 2 ) q .C(O)—(CH 2 ) q —NR 15 R 16  group, a —(CH 2 ) q .NR 15 C(O)—(CH 2 ) q —R 16  group and a —(CH 2 ) q .NR 15 C(O)—(CH 2 ) q —NR 16 R 17  group, wherein each q and q′ are independently 0, 1 or 2, wherein the alkenyl, alkynyl, haloalkyl, hydroxyalkyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocyclyl, bicyclyl, aza-bicycloalkyl and aza-bicycloalkenyl groups are unsubstituted or substituted by one or more Ra substituents, and the alkyl groups are unsubstituted or substituted by one or more Rb substituents; 
 R 5′  is chosen from a hydrogen atom, a halogen atom, a hydroxyl group, a cyano group, a linear or branched C 1 -C 6  alkyl group, a C 2 -C 4  alkenyl group, a C 2 -C 4  alkynyl group, a C 1 -C 4  haloalkyl group, a C 1 -C 4  hydroxyalkyl group and a C 3 -C 10  cycloalkyl group; 
 R 6 , R 7 , R 9  and R 10  are independently chosen from a hydrogen atom, a hydroxyl group, a C 1 -C 4  hydroxyalkyl group, a —(C 1 -C 4  alkyl)-O—(C 1 -C 4  alkyl) group and a linear or branched C 1 -C 6  alkyl group, wherein the alkyl groups are unsubstituted or substituted by one or more substituents chosen from a cyano group, a C 1 -C 4  haloalkyl group, a C 1 -C 4  hydroxyalkyl group, a C 1 -C 4  alkoxycarbonyl group, a C 3 -C 7  cycloalkyl group, a phenyl group and a 6 membered, saturated N-containing heterocyclyl ring; 
 R 8  and R 11  are independently chosen from a hydrogen atom, a halogen atom, a cyano group, a linear or branched C 1 -C 6  alkyl group, a C 2 -C 4  alkenyl group, a C 2 -C 4  alkynyl group, a C 1 -C 4  haloalkyl group, a C 1 -C 4  hydroxyalkyl group, a C 3 -C 10  cycloalkyl group, a C 3 -C 10  cycloalkenyl group, a monocyclic or polycyclic C 5 -C 14  aryl group, a 5- to 14-membered heteroaryl group containing at least one heteroatom chosen from O, S and N, a 5- to 14-membered heterocyclyl group containing at least one heteroatom chosen from O, S and N, a bicyclyl group containing a monocyclic C 5 -C 9  aryl or heteroaryl group fused to a 5- to 9-membered cycloalkyl or heterocyclyl group, said heteroaryl or heterocyclyl group containing at least one heteroatom chosen from O, S and N, a bicyclyl group containing a C 3 -C 10  cycloalkyl group fused to a 5- to 9-membered heterocyclyl group containing at least one heteroatom chosen from O, S and N, an aza-bicycloalkyl group having up to 12 carbon atoms, a aza-bicycloalkenyl group having up to 12 carbon atoms, a —(CH 2 ) n SR 15  group, a —(CH 2 ) n SOR 15  group, a —(CH 2 ) n S(O) 2 R 15  group, a —(CH 2 ) n S(O) 2 NR 15 R 16  group, a —(CH 2 ) n NR 15 S(O) 2 R 16  group, a —(CH 2 ) n NR 15 S(O) 2 NR 16  group, a —(CH 2 ) n OR 15  group, a —(CH 2 ) n C(O)OR 15  group, a —(CH 2 ) n O—C(O)R 15  group, a —(CH 2 ) n .C(O)—(CH 2 ) n —R 15  group, a —(CH 2 ) n .C(OH)(J)-(CH 2 ) n K group, a —(CH 2 ) n NR 15 R 15  group, a —(CH 2 ) n CH(R 15 )NR 16 R 17  group, a —(CH 2 ) n .C(O)—(CH 2 ) n —NR 15 R 16  group, a —(CH 2 ) n .NR 15 C(O)—(CH 2 ) n —R 16  group and a —(CH 2 ) n .NR 15 C(O)—(CH 2 ) n —NR 16 R 17  group, wherein each n and n′ are independently 0 or 1 and wherein J is chosen from a hydrogen atom and a methyl group, K is chosen from a hydroxyl group, a methyl group and a —NR′R″ group, and R′ and R″ are independently chosen from a hydrogen atom, a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  haloalkyl group and a C 1 -C 4  hydroxyalkyl group, wherein the alkenyl, alkynyl, haloalkyl, hydroxyalkyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocyclyl, bicyclyl, aza-bicycloalkyl and aza-bicycloalkenyl groups are unsubstituted or substituted by one or more substituents chosen from Ra substituents, —(C 1 -C 4 alkyl)-CN groups, and —(C 1 -C 4 alkyl)-C(O)NR′R″ groups, wherein R′ and R″ are independently chosen from a hydrogen atom and a linear or branched C 1 -C 4  alkyl group; and the alkyl groups are unsubstituted or substituted by one or more Rb substituents: 
 Ra is chosen from a halogen atom, a cyano group, a hydroxyl group, an oxo group, a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  haloalkyl group, C 1 -C 4  alkoxy group, a C 1 -C 4  hydroxyalkyl group, a C 3 -C 7  cycloalkyl unsubstituted or substituted by one or more Re substituents, a C 3 -C 7  cycloalkenyl group unsubstituted or substituted by one or more Re substituents, a monocyclic or polycyclic C 5 -C 14  aryl group unsubstituted or substituted by one or more Re substituents, a 5- to 14-membered heteroaryl group containing at least one heteroatom chosen from O, S and N unsubstituted or substituted by one or more Re substituents, a 5- to 14-membered heterocyclyl group containing at least one heteroatom chosen from O, S and N unsubstituted or substituted by one or more Re substituents, a —(CH 2 ) q SR 12  group, a —(CH 2 ) q SOR 12  group, a —(CH 2 ) q S(O) 2 R 12  group, a —(CH 2 ) q S(O) 2 NR 12 R 13  group, a —(CH 2 ) q NR 12 S(O) 2 R 13  group, a —(CH 2 ) q NR 12 S(O) 2 NR 13  group, a —(CH 2 ) q OR 12  group, a —(CH 2 ) q C(O)OR 12  group, a —(CH 2 ) q O—C(O)R 12  group, a —(CH 2 ) q C(O)—(CH 2 ) q —R 12  group, a —(CH 2 ) q NR 12 R 13  group, a —(CH 2 ) q CH(R 12 )NR 13 R 14  group, a —(CH 2 ) q .C(O)—(CH 2 ) q —NR 12 R 13  group, a —(CH 2 ) q .NR 12 C(O)—(CH 2 ) q —R 13  group and a —NR 12 C(O)—(CH 2 ) q —NR 13 R 14  group, wherein each q and q′ are independently 0, 1 or 2; 
 Rb is chosen from a cyano group, a C 1 -C 4  haloalkyl group, C 1 -C 4  alkoxy group, a C 1 -C 4  hydroxyalkyl group, a C 3 -C 7  cycloalkyl unsubstituted or substituted by one or more Re substituents, a C 3 -C 7  cycloalkenyl group unsubstituted or substituted by one or more Re substituents, a monocyclic or polycyclic C 5 -C 14  aryl group unsubstituted or substituted by one or more Re substituents, a 5- to 14-membered heteroaryl group containing at least one heteroatom chosen from O, S and N unsubstituted or substituted by one or more Re substituents, a 5- to 14-membered heterocyclyl group containing at least one heteroatom chosen from O, S and N unsubstituted or substituted by one or more Re substituents, a —(CH 2 ) q SR 12  group, a —(CH 2 ) q SOR 12  group, a —(CH 2 ) q S(O) 2 R 12  group, a —(CH 2 ) q S(O) 2 NR 12 R 13  group, a —(CH 2 ) q NR 12 S(O) 2 R 13  group, a —(CH 2 ) q NR 12 S(O) 2 NR 13  group, a —(CH 2 ) q OR 12  group, a —(CH 2 ) q C(O)OR 12  group, a —(CH 2 ) q O—C(O)R 12  group, a —(CH 2 ) q .C(O)—(CH 2 ) q —R 12  group, a —(CH 2 ) q NR 12 R 13  group, a —(CH 2 ) q CH(R 12 )NR 13 R 14  group, a —(CH 2 ) q .C(O)—(CH 2 ) q —NR 12 R 13  group, a —(CH 2 ) q .NR 12 C(O)—(CH 2 ) q —R 13  group and a —NR 12 C(O)—(CH 2 ) q —NR 13 R 14  group, wherein each q and q′ are independently 0, 1 or 2; 
 R 12 , R 13  and R 14  are independently chosen from a hydrogen atom, a cyano group, a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  haloalkyl group, a C 1 -C 4  hydroxyalkyl group, a C 1 -C 4  alkoxycarbonyl group, a C 3 -C 7  cycloalkyl group, a phenyl group, a 5- to 6-membered monocyclic heteroaryl group containing 1, 2 or 3 heteroatoms chosen from N, O and S, a 5- to 6-membered heterocyclyl group containing 1, 2 or 3 nitrogen atoms, and a bicyclyl group containing a monocyclic C 6 -C 6  aryl or heteroaryl group bonded directly to a 5- to 6-membered cycloalkyl or heterocyclyl group said heteroaryl or heterocyclyl group contains 1, 2 or 3 nitrogen atoms, wherein the haloalkyl, hydroxyalkyl, alkoxycarbonyl, cycloalkyl, phenyl, heteroaryl, heterocyclyl and bicyclyl groups are unsubstituted or substituted by one or more Rc substituents, and the alkyl groups are unsubstituted or substituted by one or more Rd substituents; 
 Rc is chosen from a halogen atom, a hydroxyl group, a cyano group, a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  haloalkyl group, a C 1 -C 4  alkoxy group, a C 1 -C 4  hydroxyalkyl group, a C 3 -C 7  cycloalkyl group, a phenyl group, a 5- to 6-membered monocyclic heteroaryl group containing 1, 2 or 3 nitrogen atoms, a 5- to 6-membered heterocyclyl group containing 1, 2 or 3 nitrogen atoms, and a C 3 -C 7  heterocycloalkyl ketone group containing 1, 2 or 3 nitrogen atoms, wherein the phenyl group is unsubstituted or substituted by one or more halogen atoms and wherein the heteroaryl, heterocyclyl and heterocycloalkyl ketone groups are unsubstituted or substituted by one or more linear or branched C 1 -C 3  alkyl groups; 
 Rd is chosen from a cyano group, a C 1 -C 4  haloalkyl group, a C 1 -C 4  alkoxy group, a C 1 -C 4  hydroxyalkyl group, a C 3 -C 7  cycloalkyl group, a phenyl group, a 5- to 6-membered monocyclic heteroaryl group containing 1, 2 or 3 nitrogen atoms, a 5- to 6-membered heterocyclyl group containing 1, 2 or 3 nitrogen atoms, and a C 3 -C 7  heterocycloalkyl ketone group containing 1, 2 or 3 nitrogen atoms, wherein the phenyl group is unsubstituted or substituted by one or more halogen atoms and wherein the heteroaryl, heterocyclyl and heterocycloalkyl ketone groups are unsubstituted or substituted by one or more linear or branched C 1 -C 3  alkyl groups; 
 Re is chosen from a halogen atom, a hydroxyl group, a cyano group, a linear or branched C 1 -C 6  alkyl group and a C 1 -C 4  haloalkyl group; 
 R 15 , R 16 , and R 17  are independently chosen from a hydrogen atom, a cyano group, a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  haloalkyl group, a C 1 -C 4  hydroxyalkyl group, a C 1 -C 4  alkoxycarbonyl group, a C 3 -C 7  cycloalkyl group, a monocyclic or polycyclic C 5 -C 14  aryl group, a 5- to 14-membered heteroaryl group containing at least one heteroatom chosen from O, S and N, and a 5- to 14-membered heterocyclyl group containing at least one heteroatom chosen from O, S and N, wherein the haloalkyl, hydroxyalkyl, alkoxycarbonyl, cycloalkyl, aryl, heteroaryl and heterocyclyl groups are unsubstituted or substituted by one or more Ra substituents and the alkyl groups are unsubstituted or substituted by one or more Rb substituents; 
 with the proviso that the compound of formula (I) does not bear a —(CH 2 ) n SR 15  group, a —(CH 2 ) n SOR 15  group, a —(CH 2 ) n S(O) 2 R 15 , group, a —(CH 2 ) n  S(O) 2 NR 15 R 16  group, a —(CH 2 ) n NR 15 S(O) 2 R 16  group, a —(CH 2 ) n NR 15 S(O) 2 NR 16  group, a —(CH 2 ) n OR 15  group, a —(CH 2 ) n C(O)OR 15  group, a —(CH 2 ) n O—C(O)R 15  group, a —(CH 2 ) n .C(O)—(CH 2 ) n —R 15  group, a —(CH 2 ) n NR 15 R 16  group, a —(CH 2 ) n CH(R 15 )NR 16 R 17  group, a —(CH 2 ) n .C(O)—(CH 2 ) n —NR 15 R 16  group, a —(CH 2 ) n .NR 15 C(O)—(CH 2 ) n —R 16  group or a —(CH 2 ) n .NR 15 C(O)—(CH 2 ) n —NR 16 R 17  group bonded directly to an imidazolone nitrogen atom. 
 
     
     
         2 . The compound according to  claim 1 , wherein
 R 1  is chosen from a hydrogen atom, a halogen atom, a hydroxyl group, a cyano group, a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  haloalkyl group, a C 1 -C 4  hydroxyalkyl group, a C 3 -C 10  cycloalkyl group and a —(CH 2 ) n NR′R″ group, wherein n is 0 or 1 and R′ and R″ are independently chosen from a hydrogen atom, a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  haloalkyl group and a C 1 -C 4  hydroxyalkyl group;   R 2  and R 4  are independently chosen from a hydrogen atom, a halogen atom, a hydroxyl group, a cyano group, a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  haloalkyl group, a C 1 -C 4  hydroxyalkyl group and a C 3 -C 14  cycloalkyl group;   R 3  is chosen from a hydrogen atom, a halogen atom, a hydroxyl group, a cyano group, a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  haloalkyl group, a C 1 -C 4  hydroxyalkyl group, a C 3 -C 10  cycloalkyl group, a —(CH 2 ) q C(O)—(CH 2 ) q —R group and a —(CH 2 ) g .C(O)—(CH 2 ) q —NR′R″ group, wherein each q and q′ are independently 0, 1 or 2, R is chosen from a hydrogen atom, OF a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  haloalkyl group, a C 1 -C 4  hydroxyalkyl group and a cyano group, and R′ and R″ are independently chosen from a hydrogen atom, a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  haloalkyl group and a C 1 -C 4  hydroxyalkyl group;   R 5  is chosen from a hydrogen atom, a halogen atom, a hydroxyl group, a cyano group, a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  haloalkyl group, a C 1 -C 4  hydroxyalkyl group, a C 1 -C 6  alkoxy group, an O—(C 1 -C 4  alkyl)-O—(C 1 -C 6  alkyl) group, a C 3 -C 10  cycloalkyl group, a 5- to 10-membered heterocyclyl group, a C 6 -C 10  aryl group and a 5- to 10-membered heteroaryl group, wherein said heterocyclyl, aryl and heteroaryl groups are unsubstituted or substituted by one or more substituents chosen from a halogen atom, a linear or branched C 1 -C 6  alkyl group, a cyano group, a hydroxyl group and a C 1 -C 4  alkoxy group;   R 5 ′ is chosen from a hydrogen atom, a halogen atom, a hydroxyl group, a cyano group, a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  haloalkyl group, a C 1 -C 4  hydroxyalkyl group and a C 3 -C 7  cycloalkyl group;   R 6 , R 7 , R 9  and R 10  are independently chosen from a hydrogen atom, a C 1 -C 4  haloalkyl group, a C 1 -C 4  hydroxyalkyl group, a —(C 1 -C 4  alkyl)-O—(C 1 -C 4  alkyl) group and a linear or branched C 1 -C 6  alkyl group;   R 8  and R 11  are independently chosen from a hydrogen atom, a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  haloalkyl group, a C 1 -C 4  hydroxyalkyl group, a C 3 -C 10  cycloalkyl group, a C 3 -C 10  cycloalkenyl group, a C 6 -C 10  aryl group, a 5-to 10-membered heteroaryl group containing 1, 2 or 3 heteroatoms chosen from N, O and S, a 5- to 10-membered heterocyclyl group containing 1, 2 or 3 heteroatoms chosen from N, O and S, -L-Het-R′″, -L-NR′R″, -L-A, -A-SO—R′″, -A-A′, -A-L′-C(O)NR′R″, -A-(C 1 -C 4  alkyl)-CN, -A-L′-NR′R″, -A-L′-OR′, -A-NR′R″, -A-C(O)—Het′-L-CN, -A-C(O)—NR′R′, -A-C(O)—(O) Z -A″, -A-C(O)—(O) Z —R′, -A-C(O)—(O) Z -L-A′″, -A-C(O)—(O) Z R′″, -A-C(O)—(O) Z -L-CN, -A-C(O)-L′-Het-R′ group and a —(CH 2 ) n .C(OH)(J)-(CH 2 ) n K group, wherein z is 0 or 1, n and n′ are independently 0 or 1, J is chosen from a hydrogen atom and a methyl group, K is chosen from a hydroxyl group, a methyl group and a —NR′R″ group and wherein R′ and R″ are independently chosen from a hydrogen atom, a linear or a branched C 1 -C 6  alkyl group, a C 1 -C 4  haloalkyl group and a C 1 -C 4  hydroxyalkyl group, and R′″ is chosen from a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  haloalkyl group and a C 1 -C 4  hydroxyalkyl group, wherein the heterocyclyl and heteroaryl groups are optionally fused to a phenyl group or to a pyridyl group; the cycloalkyl group are optionally fused to a 1,3-dioxolane group; and the cycloalkyl, cycloalkenyl, heterocyclyl, aryl and heteroaryl groups are unsubstituted or substituted by one or more substituents chosen from a halogen atom, a hydroxyl group, a cyano group, a linear or branched C 1 -C 6  alkyl group and a C 1 -C 4  alkoxy group, and wherein L is a linear or branched C 1 -C 6  alkylene group, and L′ is a linear C 1 -C 2  alkylene group;   Het is chosen from O and NR IV , and Het′ is NR IV , wherein R IV  is chosen from a hydrogen atom, a linear or branched C 1 -C 4  alkyl group, a C 1 -C 4  haloalkyl group and C 1 -C 4  hydroxyalkyl group;   A is chosen from a C 3 -C 10  cycloalkyl group, C 3 -C 10  cycloalkenyl group, a 5- to 10-membered heterocyclyl group, a C 6 -C 10  aryl group and a 5- to 10-membered heteroaryl group, wherein the cycloalkyl, cycloalkenyl, heterocyclyl, aryl and heteroaryl groups are unsubstituted or substituted by one or more substituents selected chosen from a halogen atom, a hydroxyl group, a cyano group, a linear or branched C 1 -C 6  alkyl group and a C 1 -C 4  alkoxy group;   A′ is chosen from a C 3 -C 7  cycloalkyl group, a C 3 -C 7  cycloalkenyl group, a 5- to 10-membered heterocyclyl group, a C 6 -C 16  aryl group and a 5- to 10-membered heteroaryl group, wherein the cycloalkyl, cycloalkenyl, heterocyclyl, aryl and heteroaryl groups are unsubstituted or substituted by one or more substituents chosen from a halogen atom, a hydroxyl group, a cyano group, a linear or branched C 1 -C 6  alkyl group and a C 1 -C 4  alkoxy group;   A″ is chosen from a C 3 -C 7  cycloalkyl group, a phenyl group, a 5- to 6-membered monocyclic heteroaryl group containing 1, 2 or 3 heteroatoms chosen from N, O and S and a 5- to 6-membered heterocyclyl group containing 1, 2 or 3 nitrogen atoms, wherein the cycloalkyl, phenyl, heteroaryl and heterocyclyl groups are unsubstituted or substituted by one or more substituents chosen from a halogen atom, a hydroxyl group, a cyano group, a linear or branched C 1 -C 6  alkyl group, and a C 1 -C 4  alkoxy group; and   A′″ is chosen from a C 3 -C 7  cycloalkyl group, a phenyl group, a 5- to 6-membered monocyclic heteroaryl group containing 1, 2 or 3 nitrogen atoms and a 5-to 6-membered heterocyclyl group containing 1, 2 or 3 nitrogen atoms, wherein said phenyl group is unsubstituted or substituted by one or more halogen atoms and wherein said heteroaryl and heterocyclyl groups are unsubstituted or substituted by one or more linear or branched C 1 -C 3  alkyl groups.   
     
     
         3 . The compound according to  claim 1 , wherein R 8  or R 11  are independently chosen from a hydrogen atom, a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  haloalkyl group, a C 1 -C 4  hydroxyalkyl group, a C 3 -C 10  cycloalkyl group, a C 6 -C 10  aryl group, a 5- to 10-membered heteroaryl group containing 1, 2 or 3 heteroatoms chosen from N, O and S, a 5- to 10-membered heterocyclyl group containing 1, 2 or 3 heteroatoms selected chosen from N, O and S, -L-Het-R′″, -L-A, -A-SO 2 -R′, -A-A′, -A-L-CN, -A-L′-NR′R″, -A-L′-OR′, -A-NR′R″, -A-C(O)—NR′R″, -A-C(O)—(O) Z —R′, -A-C(O)-L-Het-R′ group and a —(CH 2 ) n .C(OH)(J)-(CH 2 ) n K group, wherein z is 0 or 1, n and n′ are independently 0 or 1, J is chosen from a hydrogen atom and a methyl group, K is chosen from a hydroxyl group, a methyl group and a —NR′R″ group; and wherein R′ and R″ are independently chosen from a hydrogen atom, a linear or a branched C 1 -C 3  alkyl group, a C 1 -C 3  haloalkyl group and a C 1 -C 3  hydroxyalkyl group and R″ is chosen from a linear or branched C 1 -C 3  alkyl group, a C 1 -C 3  haloalkyl group and a C 1 -C 3  hydroxyalkyl group; wherein the heterocyclyl and heteroaryl groups are optionally fused to a phenyl group or to a pyridyl group and the cycloalkyl group is optionally fused to a 1,3-dioxolane group; and wherein the cycloalkyl, heterocyclyl, aryl and heteroaryl groups are unsubstituted or substituted by one or more substituents chosen from a halogen atom, a hydroxyl group, a cyano group, a linear or branched C 1 -C 6  alkyl group and a C 1 -C 4  alkoxy group, and wherein L is a linear or branched C 1 -C 3  alkylene group and L′ is a linear C 1 -C 2  alkylene group;
 Het is chosen from O and NR IV , wherein R IV  is chosen from a hydrogen atom, a linear or branched C 1 -C 4  alkyl group, a C 1 -C 4  haloalkyl group and C 1 -C 4  hydroxyalkyl group, 
 A is chosen from a C 3 -C 10  cycloalkyl group, a 5- to 10-membered heterocyclyl group, a C 6 -C 10  aryl group and a 5- to 10-membered heteroaryl group, wherein the cycloalkyl, heterocyclyl, aryl and heteroaryl groups are unsubstituted or substituted by one or more substituents chosen from a halogen atom, a hydroxyl group, a cyano group, a linear or branched C 1 -C 6  alkyl group and a C 1 -C 4  alkoxy group; 
 A′ is chosen from a C 3 -C 7  cycloalkyl group, a 5- to 10-membered heterocyclyl group, a C 6 -C 10  aryl group and a 5- to 10-membered heteroaryl group, wherein the cycloalkyl, heterocyclyl, aryl and heteroaryl groups are unsubstituted or substituted by one or more substituents chosen from a halogen atom, a hydroxyl group, a cyano group, a linear or branched C 1 -C 6  alkyl group and a C 1 -C 4  alkoxy group. 
 
     
     
         4 . The compound according to  claim 1 , wherein Z is a nitrogen atom and V is a carbon atom. 
     
     
         5 . The compound according to  claim 1 , wherein Z is a carbon atom and V is a nitrogen atom. 
     
     
         6 . The compound according to  claim 1 , wherein R 1  is chosen from a hydrogen atom, a halogen atom, a cyano group, a linear or branched C 1 -C 6  alkyl group, a C 3 -C 7  cycloalkyl group and a —(CH 2 )—NR′R″ group, wherein n is 0 or 1, and R′ and R″ are independently chosen from a hydrogen atom, a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  haloalkyl group and a C 1 -C 4  hydroxyalkyl group. 
     
     
         7 . The compound according to  claim 1 , wherein R 2  is chosen from a hydrogen atom, a halogen atom, a cyano group, a linear or branched C 1 -C 6  alkyl group and a C 3 -C 7  cycloalkyl group. 
     
     
         8 . The compound according to  claim 1 , wherein R 3  is chosen from a hydrogen atom, a halogen atom, a cyano group, a linear or branched C 1 -C 6  alkyl group, a C 3 -C 7  cycloalkyl group and a —(CH 2 ) q .C(O)—(CH 2 ) q —NR′R″ group, wherein q and q′ are independently 0 or 1, and R′ and R″ are independently chosen from a hydrogen atom, a linear or branched C 1 -C 6  alkyl group and a C 1 -C 4  haloalkyl group. 
     
     
         9 . The compound according to  claim 1 , wherein R 4  is chosen from a hydrogen atom, a halogen atom, a hydroxyl group, a cyano group, a linear or branched C 1 -C 6  alkyl group and a C 3 -C 7  cycloalkyl group. 
     
     
         10 . The compound according to  claim 1 , wherein R 5  and R 5 ′ are independently chosen from a hydrogen atom, a halogen atom, a hydroxyl group, a cyano group, a linear or branched C 1 -C 6  alkyl group, a 5- to 7-membered heterocyclyl group containing at least one heteroatom chosen from O, S and N and a —(CH 2 ) n OR′″ group, wherein n is 0 or 1 and R′″ is chosen from a linear or branched C 1 -C 6  alkyl group and a —(C 1 -C 4 alkyl)-O—(C 1 -C 4  alkyl) group. 
     
     
         11 . The compound according to  claim 1 , wherein R 5  and R 5 ′ are independently chosen from a hydrogen atom, a halogen atom, a hydroxyl group, a cyano group and a linear or branched C 1 -C 6  alkyl group. 
     
     
         12 . The compound according to  claim 1 , wherein R 6  and R 7  are independently chosen from a hydrogen atom, a hydroxyl group, a C 1 -C 4  hydroxyalkyl group, a —(C 1 -C 4  alkyl)-O—(C 1 -C 4  alkyl) group and a linear or branched C 1 -C 4  alkyl group. 
     
     
         13 . The compound according to  claim 1 , wherein R 9  and R 10  are independently chosen from a hydrogen atom, a hydroxyl group, a C 1 -C 4  hydroxyalkyl group, a —(C 1 -C 4  alkyl)-O—(C 1 -C 4  alkyl) group and a linear or branched C 1 -C 4  alkyl group. 
     
     
         14 . The compound according to  claim 1 , wherein R 8  and R 11  are each independently chosen from a hydrogen atom, a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  hydroxyalkyl group, a C 3 -C 7  cycloalkyl group, a C 3 -C 7  cycloalkenyl group, a phenyl group, a 5- to 6-membered monocyclic heteroaryl group containing 1, 2 or 3 heteroatoms chosen from N, O and S, a 5- to 7-membered heterocyclyl group containing 1, 2 or 3 heteroatoms chosen from N, O and S, a bicyclyl group containing a phenyl group or a pyridyl group fused to a 5- to 7-membered heterocyclyl group containing at least one heteroatom selected chosen from O, S and N, a bicyclyl group containing a phenyl group or a pyridyl group fused to a C 5 -C 7  cycloalkyl group, a bicyclyl group containing a C 5 -C 7  cycloalkyl group fused to a 1,3 dioxolane group, a —S(O)R′ group, a —S(O) 2 R′ group, a —(CH 2 ) n OR′″ group, a —(CH 2 ) n C(O)OR′ group, a —(CH 2 ) n .C(O)—(CH 2 ) n —R′ group, a —(CH 2 ) n .C(OH)(J)-(CH 2 ) n K group, a —(CH 2 ) n CH(R′″)NR′R″ group and a —(CH 2 ) n .C(O)(CH 2 ) n NR′R″ group; wherein n and n′ are independently 0 or 1, J is chosen from a hydrogen atom and a methyl group, K is chosen from a hydroxyl group, a methyl group and a —NR′R″ group, R′ and R″ are independently chosen from a hydrogen atom, a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  haloalkyl group and a C 1 -C 4  hydroxyalkyl group and R′″ is chosen from a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  haloalkyl group and a C 1 -C 4  hydroxyalkyl group; and wherein the cycloalkyl, cycloalkenyl, phenyl, heteroaryl, heterocyclyl and bicyclyl groups are unsubstituted or substituted by one or more substituents chosen from a halogen atom, a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  haloalkyl group, a C 3 -C 7  cycloalkyl group, a phenyl group, a 5- to 6-membered monocyclic heteroaryl group containing 1, 2 or 3 heteroatoms chosen from N, O and S, a 4- to 5-membered heterocyclyl group containing 1, 2 or 3 heteroatoms chosen from N, O and S, a —S(O)R′ group, a —S(O) 2 R′ group, a —(CH 2 ) n OR′ group, a —(CH 2 ) n C(O)OR′ group, a —(CH 2 ) n .C(O)—(CH 2 ) n —R′ group, a —(CH 2 ) n NR′R″ group, a —(CH 2 ) n CH(R′″)NR′R″ group, a —(CH 2 ) n .C(O)(CH 2 ) n NR′R″ group and a —(CH 2 ) n CN group, wherein n and n′ are independently 0 or 1, and R′ and R″ are independently chosen from a hydrogen atom, a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  haloalkyl group and a C 1 -C 4  hydroxyalkyl group, and R′″ is chosen from a linear or branched C r  C 8  alkyl group, C 1 -C 4  haloalkyl group and a C 1 -C 4  hydroxyalkyl group. 
     
     
         15 . The compound for according to  claim 14 , wherein
 R 8  and R 11  are independently chosen from a hydrogen atom, a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  hydroxyalkyl group, a C 3 -C 7  cycloalkyl group, a C 3 -C 7  cycloalkenyl group, a phenyl group, a pyridyl group, a 5- to 7-membered heterocyclyl group containing 1, 2 or 3 heteroatoms chosen from N, O and S, a bicyclyl group containing a phenyl group or a pyridyl group bonded directly to a 5- to 7-membered heterocyclyl group containing at least one heteroatom chosen from O, S and N, a bicyclyl group containing a phenyl group or a pyridyl group fused to a C 5 -C 7  cycloalkyl group, a bicyclyl group containing a C 5 -C 7 cycloalkyl group fused to a 1,3 dioxolane group, a —(CH 2 ) n OR′″ group, a —(CH 2 ) n C(O)OR′ group, a —(CH 2 ) n .C(O)—(CH 2 ) n —R′ group, a —(CH 2 ) n .C(OH)(J)-(CH 2 ) n K group, a —(CH 2 ) n NR′R″ group, a —(CH 2 ) n CH(R′″)NR′R″ group and a —(CH 2 ) n .C(O)(CH 2 ) n NR′R″ group; wherein n and n′ are independently 0 or 1, J is chosen from a hydrogen atom and a methyl group, K is chosen from a hydroxyl group, a methyl group and a —NR′R″ group, and R′ and R″ are independently chosen from a hydrogen atom, a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  haloalkyl group and a C 1 -C 4  hydroxyalkyl group, and R″ is chosen from a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  haloalkyl group and a C 1 -C 4  hydroxyalkyl group; and wherein the cycloalkyl, cycloalkenyl, phenyl, pyridyl, heterocyclyl and bicyclyl groups are unsubstituted or substituted by one or more substituents chosen from a halogen atom, a linear or branched C 1 -C 3  alkyl group, a C 1 -C 4  haloalkyl group, a C 3 -C 7  cycloalkyl group, a phenyl group, a 5- to 6-membered monocyclic heteroaryl group containing 1, 2 or 3 heteroatoms chosen from N, O and S, a 4- to 5-membered heterocyclyl group containing 1, 2 or 3 heteroatoms chosen from N, O and S, a —S(O)R′ group, a —S(O) 2 R′ group, a —(CH 2 ) n OR′ group, a —C(O)OR′ group, a —(CH 2 ) n .C(O)—(CH 2 ) n —R′ group, a —(CH 2 ) n NR′R″ group, a —(CH 2 ) n .C(O)(CH 2 ) n NR′R″ group and a —(CH 2 ) n CN group, wherein n and n′ are independently 0 or 1, and R′ and R″ are independently chosen from a hydrogen atom, a linear or branched C 1 -C 6  alkyl group, a C 1 -C 4  haloalkyl group and a C 1 -C 4  hydroxyalkyl group.   
     
     
         16 . The compound according to  claim 1   
       wherein
 m is 0, 1 or 2; 
 p is 0, 1 or 2; 
 one of Z and V is a nitrogen atom, and the other is a carbon atom; 
 R 1  is chosen from a hydrogen atom and a —NH 2  group; 
 R 2  is chosen from a hydrogen atom and a halogen atom; 
 R 3  is chosen from a hydrogen atom, a halogen atom, a cyano group and a —C(O)—NH 2  group; 
 R 4  is chosen from a hydrogen atom and a halogen atom 
 R 5  is chosen from a hydrogen atom, a halogen atom, a morpholinyl group, a piperazinyl group, a —O—CH 3  group and a —O—(CH 2 ) 2 —O—CH 3  group; 
 R 5  is a hydrogen atom; 
 R 6  and R 7  are independently chosen from a hydrogen atom, a methyl group, a C 1 -C 2  hydroxyalkyl group and a —(C 1 -C 2  alkyl)-O—(C 1 -C 2  alkyl) group; 
 R 3  and R 10  are independently chosen from a hydrogen atom, a methyl group, a C 1 -C 2  hydroxyalkyl group and a —(C 1 -C 2  alkyl)-O—(C 1 -C 2  alkyl) group; 
 R 8  and R 11  are independently chosen from a hydrogen atom, a linear or branched C 1 -C 3  alkyl group, a C 1 -C 4  hydroxyalkyl group, a C 3 -C 7  cycloalkyl group, a C 3 -C 7  cycloalkenyl group, a phenyl group, a pyridyl group, a pyrimidinyl group, a morpholinyl group, a piperidyl group, a tetrahydropyranyl group, a chromanyl group, a 3,4-dihydro-2H-pyrano[2,3-b]pyridyl group, a 1,2,3,4-tetrahydronaphthalenyl group, a 5,6,7,8-tetrahydroquinolinyl group, a 1,4-dioxaspiro[4.5]decanyl group, a —(CH 2 ) n OR′″ group, a —(CH 2 )C(O)OR′ group, a —(CH 2 ) n .C(O)—(CH 2 ) n —R′ group, a —(CH 2 ) n .C(OH)(J)—(CH 2 ) n K group, a —(CH 2 ) n NR′R″ group, a —(CH 2 ) n CH(R′″)NR′R″ group and a —(CH 2 ) n .C(O)(CH 2 ) n NR′R″ group; wherein n and n′ are independently 0 or 1, J is chosen from a hydrogen atom and a methyl group, K is chosen from a hydroxyl group, a methyl group and a —NR′R″ group, and R′ and R″ are independently chosen from a hydrogen atom, a linear or branched C 1 -C 4  alkyl group and a C 1 -C 4  haloalkyl group, and R′″ is chosen from a linear or branched C 1 -C 3  alkyl group and a C 1 -C 4  haloalkyl group; and wherein the cycloalkyl, cycloalkenyl, phenyl, pyridyl, pyrimidinyl, morpholinyl, piperidyl, tetrahydropyranyl, chromanyl, 3,4-dihydro-2H-pyrano[2,3-b]pyridyl 1,2,3,4-tetrahydronaphthalenyl, 5,6,7,8-tetrahydroquinolinyl and 1,4-dioxaspiro[4.5]decanyl groups are unsubstituted or substituted by one or two substituents chosen from a halogen atom, a linear or branched C 1 -C 3  alkyl group, a linear or branched C 1 -C 3  haloalkyl group, an oxo group, a —S(O) 2 R′ group, a —(CH 2 ) n OR′ group, a —(CH 2 )C(O)OR′ group, a —(CH 2 ) n .C(O)—(CH 2 ) n —R′ group, a —(CH 2 ) n C(O)(CH 2 ) n NR′R″ group, a —(CH 2 ) n NR′R″ group and a —(CH 2 ) n CN group, wherein n and n′ are independently 0 or 1, and R′ and R″ are independently chosen from a hydrogen atom, a linear or branched C 1 -C 4  alkyl group and a C 1 -C 4  haloalkyl group. 
 
     
     
         17 . The compound according to  claim 1   
       wherein
 m is 0, 1 or 2; 
 p is 0, 1 or 2; 
 one of Z and V is a nitrogen atom, and the other is a carbon atom; 
 R 1  is chosen from a hydrogen atom and a —NH 2  group; 
 R 2  is chosen from a hydrogen atom and a halogen atom; 
 R 3  is chosen from a hydrogen atom, a halogen atom, a cyano group and a —C(O)—NH 2  group; 
 R 4  is chosen from a hydrogen atom and a halogen atom; 
 R 5  is chosen from a hydrogen atom and a halogen atom; 
 R 5′  is a hydrogen atom; 
 R 3  and R 7  independently is chosen from a hydrogen atom, a methyl group, a C 1 -C 2  hydroxyalkyl group and a —(C 1 -C 2  alkyl)-O—(C 1 -C 2  alkyl) group; 
 R 9  and R 10  are independently chosen from a hydrogen atom, a methyl group, a C 1 -C 2  hydroxyalkyl group and a —(C 1 -C 2  alkyl)-O—(C 1 -C 2  alkyl) group; and 
 R 8  and R 11  are independently chosen from a hydrogen atom, a linear or branched C 1 -C 3  alkyl group, a C 1 -C 4  hydroxyalkyl group, a C 3 -C 7  cycloalkyl group, a C 3 -C 7  cycloalkenyl group, a phenyl group, a pyridyl group, a pyrimidinyl group, a morpholinyl group, a piperidyl group, a tetrahydropyranyl group, a chromanyl group, a 3,4-dihydro-2H-pyrano[2,3-b]pyridyl group, a 1,2,3,4-tetrahydronaphthalenyl group, a 5,6,7,8-tetrahydroquinolinyl group, a 1,4-dioxaspiro[4.5]decanyl group, a —(CH 2 ) n OR′″ group, a —(CH 2 ) n C(O)OR′ group, a —(CH 2 ) n .C(O)—(CH 2 ) n —R′ group, a —(CH 2 ) n .C(OH)(J)—(CH 2 ) n K group, a —(CH 2 ) n NR′R″ group, a —(CH 2 ) n CH(R′″) NR′R″ group and a —(CH 2 ) n .C(O)(CH 2 ) n NR′R″ group; wherein n and n′ are independently 0 or 1, J is chosen from a hydrogen atom and a methyl group, K is chosen from a hydroxyl group, a methyl group and a —NR′R″ group, R′ and R″ are independently chosen from a hydrogen atom, a linear or branched C 1 -C 4  alkyl group and a C 1 -C 4  haloalkyl group, and R′″ is chosen from a linear or branched C 1 -C 3  alkyl group and a C 1 -C 4  haloalkyl group; and wherein the cycloalkyl, cycloalkenyl, phenyl, pyridyl, pyrimidinyl, morpholinyl, piperidyl, tetrahydropyranyl, chromanyl, 3,4-dihydro-2H-pyrano[2,3-b]pyridyl 1,2,3,4-tetrahydronaphthalenyl, 5,6,7,8-tetrahydroquinolinyl and 1,4-dioxaspiro[4.5]decanyl groups are unsubstituted or substituted by one or two substituents chosen from a halogen atom, a linear or branched C 1 -C 3  alkyl group, a linear or branched C 1 -C 3  haloalkyl group, an oxo group, a —S(O) 2 R′ group, a —(CH 2 ) n OR′ group, a —(CH 2 ) n C(O)OR′ group, a —(CH 2 ) n .C(O)—(CH 2 )—R′ group, a —(CH 2 ) n .C(O)(CH 2 ) r ,NR′R″ group, a —(CH 2 ) n NR′R″ group and a —(CH 2 ) n CN group, wherein n and n′ are independently 0 or 1, and R′ and R″ are independently chosen from a hydrogen atom, a linear or branched C 1 -C 4  alkyl group and a C 1 -C 4  haloalkyl group. 
 
     
     
         18 . The compound according to  claim 16 , wherein the compound is of Formula (I-a): 
       
         
           
           
               
               
           
         
       
       and wherein
 m is 0, 1 or 2; 
 p is 0, 1 or 2; 
 W″ is chosen from a nitrogen atom and a —CR 4  group 
 X and Y are independently chosen from a nitrogen atom and a —CR 5  group, wherein at least one of X and Y is a —CR 5  group; 
 R 1  is chosen from a hydrogen atom and a —NH 2  group; 
 R 2  is chosen from a hydrogen atom and a halogen atom; 
 R 3  is chosen from a hydrogen atom, a halogen atom, a cyano group and a —C(O)—NH 2  group; 
 R 4  is a hydrogen atom; 
 R 5  is chosen from a hydrogen atom, a halogen atom, a morpholinyl group and a piperazinyl group; 
 R 6  and R 7  are independently chosen from a hydrogen atom, a methyl group, a C 1 -C 2  hydroxyalkyl group and a —(C 1 -C 2  alkyl)-O—(C 1 -C 2  alkyl) group; 
 R 9  and R 10  are independently chosen from a hydrogen atom, a methyl group, a C 1 -C 2  hydroxyalkyl group and a —(C 1 -C 2  alkyl)-O—(C 1 -C 2  alkyl) group; 
 R 8  is chosen from a linear or branched C 1 -C 3  alkyl group, a C 1 -C 4  hydroxyalkyl group, a C 3 -C 7  cycloalkyl group, a C 3 -C 7  cycloalkenyl group, a phenyl group, a pyridyl group, a pyrimidinyl group, a morpholinyl group, a piperidyl group, a tetrahydropyranyl group, a chromanyl group, a 3,4-dihydro-2H-pyrano[2,3-b]pyridyl group, a 1,2,3,4-tetrahydronaphthalenyl group, a 5,6,7,8-tetrahydroquinolinyl group, a 1,4-dioxaspiro[4.5]decanyl group, a —(CH 2 ) n OR′″ group, a —(CH 2 ) n C(O)OR′ group, a —(CH 2 ) n .C(O)—(CH 2 ), —R′ group, a —(CH 2 ) n .C(OH)(J)-(CH 2 ) n K group, a —(CH 2 )NR′R″ group, a —(CH 2 ) n CH(R′″)NR′R″ group and a —(CH 2 ) n .C(O)(CH 2 ) n NR′R″ group; wherein n and n′ are independently 0 or 1, J is chosen from a hydrogen atom and a methyl group, K is chosen from a hydroxyl group, a methyl group and a —NR′R″ group, R′ and R″ are independently chosen from a hydrogen atom, a linear or branched C 1 -C 3  alkyl group and a C 1 -C 4  haloalkyl group, and R′″ is chosen from a linear or branched C 1 -C 3  alkyl group and a C 1 -C 4  haloalkyl group; and wherein the cycloalkyl, cycloalkenyl, phenyl, pyridyl, pyrimidinyl, morpholinyl, piperidyl, tetrahydropyranyl, chromanyl and 3,4-dihydro-2H-pyrano[2,3-b]pyridyl 1,2,3,4-tetrahydronaphthalenyl, 5,6,7,8-tetrahydroquinolinyl and 1,4-dioxaspiro[4.5]decanyl groups are unsubstituted or substituted by one or more substituents chosen from a halogen atom, a linear or branched C 1 -C 3  alkyl group, a —S(O) 2 R′ group, a —(CH 2 ) n OR′ group, a —(CH 2 ) n C(O)OR′ group, a —(CH 2 ) n .C(O)—(CH 2 )—R′ group, a —(CH 2 ) n .C(O)(CH 2 ) n NR′R″ group, a —(CH 2 ) n NR′R″ group and a —(CH 2 ) n CN group, wherein n and n′ are independently 0 or 1, and R′ and R″ are independently chosen from a hydrogen atom, a linear or branched C 1 -C 3  alkyl group and a C 1 -C 4  haloalkyl group; and 
 R 11  is chosen from a hydrogen atom, a linear or branched C 1 -C 3  alkyl group, a C 1 -C 4  hydroxyalkyl group, a phenyl group, a morpholinyl group, a tetrahydropyranyl group, a —(CH 2 ) n OR″ group, a —(CH 2 ) n .C(OH)(J)-(CH 2 ) n K group, a —(CH 2 ) n NR′R″ group and a —(CH 2 ) n CH(R′″)NR′R″ group; wherein n and n′ are independently 0 or 1, J is chosen from a hydrogen atom and a methyl group, and K is chosen from a hydroxyl group, a methyl group and a —NR′R″ group, R′ and R″ are independently chosen from a hydrogen atom, a linear or branched C 1 -C 3  alkyl group and a C 1 -C 4  haloalkyl group, and R′″ is chosen from a linear or branched C 1 -C 3  alkyl group and a C 1 -C 4  haloalkyl group; and wherein the phenyl, morpholinyl and tetrahydropyranyl groups are unsubstituted or substituted by one or more substituents chosen from a halogen atom, a linear or branched C 1 -C 3  alkyl group and a —(CH 2 ) n OR′ group wherein n is 0 or 1, and R′ is chosen from a hydrogen atom, a linear or branched C 1 -C 3  alkyl group and a C 1 -C 4  haloalkyl group. 
 
     
     
         19 . The compound according to  claim 16 , wherein the compound is of Formula (I-a): 
       
         
           
           
               
               
           
         
       
       and wherein
 m is 0, 1 or 2; 
 p is 0, 1 or 2; 
 W″ is chosen from a nitrogen atom and a —CR 4  group; 
 X and Y are independently chosen from a nitrogen atom and a —CR 5  group, wherein at least one of X and Y is a —CR 5  group; 
 R 1  is chosen from a hydrogen atom and a —NH 2  group; 
 R 2  is chosen from a hydrogen atom and a halogen atom; 
 R 3  is chosen from a hydrogen atom, a halogen atom, a cyano group and a —C(O)—NH 2  group; 
 R 4  is a hydrogen atom; 
 R 5  is chosen from a hydrogen atom and a halogen atom; 
 R 6  and R 7  are independently chosen from a hydrogen atom, a methyl group, a C 1 -C 2  hydroxyalkyl group and a —(C 1 -C 2  alkyl)-O—(C 1 -C 2  alkyl) group; 
 R 9  and R 10  are independently chosen from a hydrogen atom, a methyl group, a C 1 -C 2  hydroxyalkyl group and a —(C 1 -C 2  alkyl)-O—(C 1 -C 2  alkyl) group; 
 R 8  is chosen from a linear or branched C 1 -C 3  alkyl group, a C 1 -C 4  hydroxyalkyl group, a C 3 -C 7  cycloalkyl group, a C 3 -C 7  cycloalkenyl group, a phenyl group, a pyridyl group, a pyrimidinyl group, a morpholinyl group, a piperidyl group, a tetrahydropyranyl group, a chromanyl group, a 3,4-dihydro-2H-pyrano[2,3-b]pyridyl group, a 1,2,3,4-tetrahydronaphthalenyl group, a 5,6,7,8-tetrahydroquinolinyl group, a 1,4-dioxaspiro[4,5]decanyl group, a —(CH 2 ) n OR″ group, a —(CH 2 ) n C(O)OR′ group, a —(CH 2 ) n .C(O)—(CH 2 ) n —R′ group, a —(CH 2 ) n . C(OH)(J)-(CH 2 ) n K group, a —(CH 2 ) n NR′R″ group, a —(CH 2 ) n CH(R′″)NR′R″ group and a —(CH 2 ) n .C(O)(CH 2 ) n NR′R″ group; wherein n and n′ are independently 0 or 1, J is chosen from, a hydrogen atom and a methyl group, and K is chosen from a hydroxyl group, a methyl group and a —NR′R″ group, and R′ and R″ are independently chosen from a hydrogen atom, a linear or branched C 1 -C 3  alkyl group and a C 1 -C 4  haloalkyl group, and R′″ is chosen from a linear or branched C 1 -C 3  alkyl group and a C 1 -C 4  haloalkyl group; and wherein the cycloalkyl, cycloalkenyl, phenyl, pyridyl, pyrimidinyl, morpholinyl, piperidyl, tetrahydropyranyl, chromanyl, and 3,4-dihydro-2H-pyrano[2,3-b]pyridyl, 1,2,3,4-tetrahydronaphthalenyl, 5,6,7,8-tetrahydroquinolinyl and 1,4-dioxaspiro[4.5]decanyl groups are unsubstituted or substituted by one or more substituents chosen from a halogen atom, a linear or branched C 1 -C 3  alkyl group, a —S(O) 2 R′ group, a —(CH 2 ) n OR′ group, a —(CH 2 ) n C(O)OR′ group, a —(CH 2 ) n .C(O)—(CH 2 ) n —R′ group, a —(CH 2 ) n .C(O)(CH 2 ) n NR′R″ group, a —(CH 2 ) n NR′R″ group and a —(CH 2 ) n CN group, wherein n and n′ are independently 0 or 1, and R′ and R″ are independently chosen from a hydrogen atom, a linear or branched C 1 -C 3  alkyl group and a C 1 -C 4  haloalkyl group; and 
 R 11  is chosen from a hydrogen atom, a linear or branched C 1 -C 3  alkyl group, a C 1 -C 4  hydroxyalkyl group, a phenyl group, a morpholinyl group, a tetrahydropyranyl group, a —(CH 2 ) n OR′″ group, a —(CH 2 ) n .C(OH)(J)-(CH 2 ) n K group, a —(CH 2 ) n NR′R″ group and a —(CH 2 ) n CH(R′″)NR′R″ group; wherein n and n′ are independently 0 or 1, J is chosen from a hydrogen atom and a methyl group, and K is chosen from a hydroxyl group, a methyl group and a —NR′R″ group, R′ and R″ are independently chosen from a hydrogen atom, a linear or branched C 1 -C 3  alkyl group and a C 1 -C 4  haloalkyl group, and R′″ is chosen from a linear or branched C 1 -C 3  alkyl group and a C 1 -C 4  haloalkyl group; and wherein the phenyl, morpholinyl and tetrahydropyranyl groups are unsubstituted or substituted by one or more substituents chosen from a halogen atom, a linear or branched C 1 -C 3  alkyl group and a —(CH 2 ) n OR′ group, wherein n is 0 or 1, and R′ is chosen from a hydrogen atom, a linear or branched C 1 -C 3  alkyl group and a C 1 -C 4  haloalkyl group. 
 
     
     
         20 . The compound according to  claim 16 , wherein the compound is of formula (I-b): 
       
         
           
           
               
               
           
         
       
       and wherein
 m is 0; 
 p is 0 or 1; 
 W is chosen from a nitrogen atom and a —CR 3  group; 
 W′ is chosen from a nitrogen atom and a CR 2  group; 
 X is chosen from a nitrogen atom and a —CR 5  group; 
 Y is a —CR 5  group; 
 Y′ is chosen from a nitrogen atom and a —CR 5′  group; 
 R 1  is a hydrogen atom; 
 R 2  is chosen from a hydrogen atom and a halogen atom; 
 R 3  is a hydrogen atom; 
 R 4  is chosen from a hydrogen atom and a halogen atom; 
 R 5  is chosen from a hydrogen atom, a halogen atom, a morpholinyl group, a —O—CH 3  group and a —O—(CH 2 ) 2 —O—CH 3  group; 
 R 5′  is a hydrogen atom; 
 R 6  and R 7  are independently chosen from a hydrogen atom and a methyl group; 
 R 8  is chosen from a cyclohexyl group, a phenyl group, a pyridyl group, a chromanyl group, a tetrahydropyranyl group, wherein the cyclohexyl, phenyl, pyridyl, chromanyl and tetrahydropyranyl groups are unsubstituted or substituted by one or more substituents chosen from a halogen atom, a linear or branched C 1 -C 3  alkyl group and a —(CH 2 ) n CN group, wherein n is 0 or 1; and 
 R 11  is chosen from a hydrogen atom and a C 1 -C 4  hydroxyalkyl group. 
 
     
     
         21 . The compound according to  claim 16 , wherein the compound is of formula (I-b): 
       
         
           
           
               
               
           
         
       
       and wherein
 m is 0; 
 p is 0 or 1; 
 W is chosen from a nitrogen atom and a —CR 3  group; 
 W′ is chosen from a nitrogen atom and a —CR 2  group; 
 X is chosen from a nitrogen atom and a —CR 5  group; 
 Y is a —CR 5  group; 
 Y′ is chosen from a nitrogen atom and a —CR 5′  group; 
 R 1  is a hydrogen atom; 
 R 2  is chosen from a hydrogen atom and a halogen atom; 
 R 3  is a hydrogen atom; 
 R 4  is chosen from a hydrogen atom and a halogen atom; 
 R 5  is chosen from a hydrogen atom and a halogen atom; 
 R 5′  is a hydrogen atom; 
 R 6  and R 7  are independently chosen from a hydrogen atom and a methyl group; 
 R 8  is chosen from a cyclohexyl group, a phenyl group, a pyridyl group, a chromanyl group, a tetrahydropyranyl group, wherein the cyclohexyl, phenyl, pyridyl, chromanyl and tetrahydropyranyl groups are unsubstituted or substituted by one or more substituents chosen from a halogen atom, a linear or branched C 1 -C 3  alkyl group and a —(CH 2 ) n —,CN group, wherein n is 0 or 1; and 
 R 11  is chosen from a hydrogen atom and a C 1 -C 4  hydroxyalkyl group. 
 
     
     
         22 . The compound according to  claim 1  chosen from:
 3-[8-Oxo-9-(tetrahydro-2H-pyran-4-yl)-8,9-dihydro-7H-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile; 
 3-(9-Cyclohexyl-8-oxo-8,9-dihydro-7H-purin-2-yl)imidazo[1,2-a]pyridine-6-carbonitrile; 
 3-[3-(2-Methylcyclohexyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]imidazo[1,2-a]pyridine-6-carbonitrile; 
 3-{9-[(4R)-8-Fluoro-3,4-dihydro-2H-chromen-4-yl]-8-oxo-8,9-dihydro-7H-purin-2-yl}imidazo[1,2-a]pyridine-6-carbonitrile; 
 3-[7-Methyl-8-oxo-9-(tetrahydro-2H-pyran-4-yl)-8,9-dihydro-7H-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile; 
 3-(9-Benzyl-7-methyl-8-oxo-8,9-dihydro-7H-purin-2-yl)imidazo[1,2-a]pyridine-6-carbonitrile; 
 3-[7-(2-Morpholin-4-ylethyl)-8-oxo-9-(tetrahydro-2H-pyran-4-yl)-8,9-dihydro-7H-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile; 
 3-[7-(2-(Dimethylamino)ethyl]-8-oxo-9-(tetrahydro-2H-pyran-4-yl)-8,9-dihydro-7H-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile; 
 3-[7-(2-Hydroxyethyl)-8-oxo-9-(tetrahydro-2H-pyran-4-yl)-8,9-dihydro-7H-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile; 
 3-[7-(2-Hydroxy-2-methylpropyl)-8-oxo-9-(tetrahydro-2H-pyran-4-yl)-8,9-dihydro-7H-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile; 
 3-[7-[(2R)-2,3-Dihydroxypropyl]-8-oxo-9-(tetrahydro-2H-pyran-4-yl)-8,9-dihydro-7H-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile; 
 3-[7-[(2S)-2,3-Dihydroxypropyl]-8-oxo-9-(tetrahydro-2H-pyran-4-yl)-8,9-dihydro-7H-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile; 
 3-[7-[(2S)-3-(Dimethylamino)-2-hydroxypropyl]-8-oxo-9-(tetrahydro-2H-pyran-4-yl)-8,9-dihydro-7H-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile; 
 3-[7-(2-Methoxyethyl)-8-oxo-9-(tetrahydro-2H-pyran-4-yl)-8,9-dihydro-7H-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile; 
 3-[7-(2-Aminoethyl)-8-oxo-9-(tetrahydro-2H-pyran-4-yl)-8,9-dihydro-7H-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile; 
 3-(8-Oxo-9-(tetrahydro-2H-pyran-4-yl)-7-{2-[(2,2,2-trifluoroethyl)amino]ethyl}-8,9-dihydro-7H-purin-2-yl)imidazo[1,2-a]pyridine-6-carbonitrile; 
 2-(2-(6-Cyanoimidazo[1,2-a]pyridin-3-0)-8-oxo-9-(tetrahydro-2H-pyran-4-yl)-8,9-dihydro-7H-purin-7-yl)acetic acid; 
 3-[7-(2,4-Dimethoxybenzyl)-8-oxo-9-(tetrahydro-2H-pyran-4-0)-8,9-dihydro-7H-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile; 
 2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one; 
 3-[8-Oxo-9-(tetrahydro-2H-pyran-4-yl)-8,9-dihydro-7H-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile; 
 9-Cyclohexyl-2-(6-fluoroimidazo[1,2-a]pyridin-3-yl)-7H-purin-8(9H)-one; 
 9-[(4R)-8-Fluoro-3,4-dihydro-2H-chromen-4-yl]-2-(6-fluoroimidazo[1,2-a]pyridin-3-yl)-7,9-dihydro-8H-purin-8-one; 
 2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-9-[(1S)-1-phenylethyl]-7,9-dihydro-8H -purin-8-one; 
 2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-9-[(1R)-1-phenylethyl]-7,9-dihydro-8H-purin-8-one; 
 2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-9-(pyridin-3-ylmethyl)-7,9-dihydro-8H-purin-8-one; 
 2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-9-(5,6,7,8-tetrahydroquinolin-5-yl)-7H-purin-8(9H)-one; 
 2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-9-(pyridin-2-ylmethyl)-7H-purin-8(9H)-one; 
 2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-9-((5-fluoropyridin-2-yl)methyl)-7H-purin-8(9H)-one; 
 (R)-2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-9-(1-(5-fluoropyridin-2-y)ethyl)-7H-purin-8(9H)-one; 
 (R)-2-(6-Fluoroimidazo[1,2-a]pyridin-1-yl)-9-(1-(5-fluoropyridin-2-yl)ethyl)-7-(2-hydroxyethyl)-7H-purin-8(9H)-one; 
 2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-9-(1-(5-fluoropyridin-2-yl)-2-methoxyethyl)-7H-purin-8(9H)-one; 
 (R)-2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-9-(1-(pyridin-2-y)ethyl)-7H-purin-8(9H)-one; 
 (R)-2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-9-(1-(5-fluoropyrimidin-2-yl)ethyl)-7H-purin-8(9H)-one; 
 (S)-2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-9-(1-(5-fluoropyridin-2-yl)ethyl)-7H-purin-8(9H)-one; 
 (S)-2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-9-(1-(5-fluoropyridin-2-yl)-2-hydroxyethyl)-7H-purin-8(9H)-one; 
 1-(2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-8-oxo-7H-purin-9(8H)-yl)cyclohexanecarbonitrile; 
 (1s,4s)-Ethyl 4-(2-(6-fluoroimidazo[1,2-a]pyridin-3-yl)-8-oxo-7H-purin-9(8H)-yl)cyclohexanecarboxylate; 
 (1r,4r)-Ethyl 4-(2-(6-fluoroimidazo[1,2-a]pyridin-3-yl)-8-oxo-7H-purin-9(8H)-yl)cyclohexanecarboxylate; 
 (1r,4r)-4-(2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-8-oxo-7H-purin-9(8H)-yl)cyclohexanecarboxylic acid; 
 (1r,4r)-4-(2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-8-oxo-7H-purin-9(8H)-yl)-N-methylcyclohexanecarboxamide; 
 9-(2,2-Dimethyltetrahydro-2H-pyran-4-yl)-2-(6-fluoroimidazo[1,2-a]pyridin-3-yl)-7,9-dihydro-8H-purin-8-one; 
 9-(2,2-Dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl)-2-(6-fluoroimidazo[1,2-a]pyridin-3-yl)-7H-purin-8(9H)-one; 
 2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-9-(1,4-dioxaspiro[4.5]decan-8-yl)-7H-purin-8(9H)-one; 
 2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-9-(4-oxocyclohexyl)-7H-purin-8(9H)-one; 
 2-((1r,4r)-4-(2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-8-oxo-7H-purin-9(8H)-yl)cyclohexyl)acetonitrile; 
 2-((1r,4r)-4-(2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-7-(2-hydroxyethyl)-8-oxo-7H-purin-9(8H)-yl)cyclohexyl)acetonitrile; 
 2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-9-((1r,4r)-4-(hydroxymethyl)cyclohexyl)-7H-purin-8(9H)-one; 
 2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-9-((1r,4r)-4-hydroxycyclohexyl)-7H-purin-8(9H)-one; 
 2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-9-((1R,4R)-4-hydroxy-1,2,3,4-tetrahydronaphthalen-1-yl)-7H-purin-8(9H)-one; 
 2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-9-(1r,4r)-4-hydroxy-4-methylcyclohexyl)-7H-purin-8(9H)-one; 
 9-((1r,4r)-4-(Aminomethyl)cyclohexyl)-2-(6-fluoroimidazo[1,2-a]pyridin-3-yl)-7H-purin-8(9H)-one; 
 9-((1r,4r)-4-Aminocyclohexyl)-2-(6-fluoroimidazo[1,2-a]pyridin-3-yl)-7H-purin-8(9H)-one; 
 9-Cyclobutyl-2-(6-fluoroimidazo[1,2-a]pyridin-3-yl)-7H-purin-8(9H)-one; 
 (R)-2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-9-(3-methylbutan-2-yl)-7H-pu one; 
 2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-9-(1-methoxypropan-2-yl)-7H-purin-8(9H)-one; 
 (R)-tert-Butyl-3-(2-(6-fluoroimidazo[1,2-a]pyridin-3-yl)-8-oxo-7H-purin-9(8H)-yl)butanoate; 
 (R)-3-(2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-8-oxo-7H-purin-9(8H)-yl)butanoic acid; 
 (R)-3-(2-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-8-oxo-7H-purin-9(8H)-yl)butanamide; 
 9-(1-(2,2-Difluoroethyl)piperidin-4-yl)-2-(6-fluoroimidazo[1,2-a]pyridin-3-yl)-7H-purin-8(9H)-one; 
 9-(4,4-Difluorocyclohexyl)-2-(6-fluoroimidazo[1,2-a]pyridin-3-yl)-7,9-dihydro-8H-purin-8-one; 
 2-(6-Fluoroimidazo[1,2-a]pyridin-1-yl)-9-[(3R)-piperidin-3-yl]-7,9-dihydro-8H-purin-8-one; 
 2-(6-Fluorolmidazo[1,2-a]pyridin-3-yl)-9-((3R)-1-(methylsulfonyl)piperidin-3-yl]-7,9-dihydro-8H-purin-8-one; 
 (R)-9-(1-acetylpiperidin-3-yl)-2-(6-fluoroimidazo[1,2-a]pyridin-3-yl)-7H-purin-8(9H)-one; 
 3-[2-Oxo-3-(tetrahydro-2H-pyran-4-yl)-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]imidazo[1,2-a]pyridine-6-carbonitrile; 
 3-[1-Methyl-2-oxo-3-(tetrahydro-2H-pyran-4-yl)-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]imidazo[1,2-a]pyridine-6-carbonitrile; 
 5-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-3-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one; 
 5-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-1-methyl-3-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one; 
 5-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-1-(2-hydroxyethyl)-3-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one; 
 tert-Butyl-4-[5-(6-fluoroimidazo[1,2-a]pyridin-3-yl)-2-oxo-1,2-dihydro-3H-imidazo[4,5-b]pyridin-3-yl]piperidine-1-carboxylate; 
 5-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-3-piperidin-4-yl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one; 
 5-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-3-[1-(methylsulfonyl)piperidin-4-yl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one; 
 3-(1-Acetylpiperidin-4-yl)-5-(6-fluoroimidazo[1,2-a]pyridin-3-yl)-1,3-dihydro-2H -imidazo[4,5-b]pyridin-2-one; 
 6-Fluoro-5-(6-fluoroimidazo[1,2-a]pyridin-3-yl)-3-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one; 
 6-(6-Fluoroimidazo[1,2-a]pyridin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one; 
 2-(2-Amino-6-fluoroimidazo[1,2-a]pyridin-3-yl)-9-(tetrahydro-2H-pyran-4-yl)-7H-purin-8(9H)-one; 
 2-(Imidazo[1,2-a]pyrazin-3-yl)-9-(tetrahydro-2H-pyran-4-yl)-7H-purin-8(9H)-one; 
 2-Pyrazolo[1,5-a]pyrazin-3-yl-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one; 
 9-[(1R)-1-Phenylethyl]-2-pyrazolo[1,5-a]pyrazin-3-yl-7,9-dihydro-8H-purin-8-one; 
 (R)-9-(1-(5-Fluoropyridin-2-yl)ethyl)-2-(pyrazolo[1,5-a]pyrazin-3-yl)-7H-purin-8(9H)-one; 
 2-(Pyrazolo[1,5-a]pyrazin-3-yl)-9-((tetrahydro-2H-pyran-4-yl)methyl)-7H-purin-8(9H)-one; 
 9-(4,4-Difluorocyclohexyl)-2-(pyrazolo[1,5-a]pyrazin-3-yl)-7H-purin-8(9H)-one; 
 9-(2,2-Dimethyltetrahydro-2H-pyran-4-yl)-2-(pyrazolo[1,5-a]pyrazin-3-yl)-7H-purin-8(9H)-one; 
 (R)-9-(8-Fluorochroman-4-O-2-(pyrazolo[1,5-a]pyrazin-3-yl)-7H-purin-8(9H)-one; 
 2-((1r,4r)-4-(8-Oxo-2-(pyrazolo[1,5-a]pyrazin-3-yl)-7H-purin-9(8H)-yl)cyclohexyl)acetonitrile; 
 2-((1r,4r)-4-(7-(2-Hydroxyethyl)-8-oxo-2-(pyrazolo[1,5-a]pyrazin-3-yl)-7H-purin-9(8H)-yl)cyclohexyl)acetonitrile; 
 5-(Pyrazolo[1,5-a]pyrazin-3-0)-3-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one; 
 6-Fluoro-5-pyrazolo[1,5-a]pyrazin-3-O-3-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4, 5-b]pyridin-2-one; 
 2-(Pyrazolo[1,5-a]pyridin-3-yl)-9-(tetrahydro-2H-pyran-4-yl)-7H-purin-8(9H)-one; 
 2-(6-Fluoropyrazolo[1,5-a]pyridin-3-yl)-9-(tetrahydro-2H-pyran-4-yl)-7H-purin-8(9H)-one; 
 2-(4-Fluoropyrazolo[1,5-a]pyridin-3-yl)-9-(tetrahydro-2H-pyran-4-yl)-7H-purin-8(9H)-one; 
 2-(Pyrazolo[1,5-a]pyrimidin-3-yl)- 9 -(tetrahydro-2H-pyran-4-yl)-7H-purin-8(9H)-one; 
 6-(Pyrazolo[1,5-a]pyrimidin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]pyridin-2(3H)-one; 
 3-[8-Oxo-9-(tetrahydro-2H-pyran-4-yl)-8,9-dihydro-7H-purin-2-yl]imidazo[1,2-a]pyridine-6-carboxamide; 
 (R)-2-(6-fluoroimidazo[1,2-a]pyridin-3-yl)-9-(piperidin-3-ylmethyl)-7H-purin-8(9H)-one; 
 (S)-2-(6-fluoroimidazo[1,2-a]pyridin-3-yl)-9-(piperidin-3-ylmethyl)-7H-purin-8(9H)-one; 
 (1r,4r)-4-(2-(6-fluoroimidazo[1,2-a]pyridin-3-yl)-8-oxo-7H-purin-9(8H)-yl)cyclonexanecarboxamide; 
 2-(6-fluoroimidazo[1,2-a]pyridin-3-yl)-6-morpholino-9-(tetrahydro-2H -pyran-4-yl)-7H-purin-8(9H)-one; 
 2-(6-fluoroimidazo[1,2-a]pyridin-1-yl)-6-(piperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-7H-purin-8(9H)-one; 
 6-morpholino-2-(pyrazolo[1,5-a]pyrazin-3-yl)-9-(tetrahydro-2H-pyran-4-yl)-7H-purin-8(9H)-one; 
 6-(2-methoxyethoxy)-2-(pyrazolo[1,5-a]pyrazin-3-yl)-9-(tetrahydro-2H-pyran-4-yl)-7H-purin-8(9H)-one, 
 6-methoxy-2-(pyrazolo[1,5-a]pyrazin-3-yl)-9-(tetrahydro-2H-pyran-4-yl)-7H-purin-8(9H)-one; 
 and pharmaceutically acceptable salts, of solvates, of N-oxides, stereoisomers or deuterated derivatives thereof. 
 
     
     
         23 . A pharmaceutical composition comprising a compound according to  claim 1  and a pharmaceutically acceptable diluent or carrier. 
     
     
         24 . (canceled) 
     
     
         25 . A method for simultaneously inhibiting JAK1, JAK2 and JAK3, which comprises administering a therapeutically effective amount of a compound according to  claim 1  to a subject in need thereof. 
     
     
         26 . (canceled) 
     
     
         27 . A combination product or simultaneous, separate or sequential use to treat a human or animal comprising (i) a compound according to  claim 1 ; and (ii) at least one additional compound chosen from:
 a) Dyhydrofolate reductase inhibitors,   b) DHODH inhibitors;   c) Immunomodulators;   d) Inhibitors of DNA synthesis and repair;   e) Anti-alpha 4 integrin antibodies;   f) Alpha 4 integrin antagonists;   g) Corticoids and glucocorticoids;   h) Fumaric acid esters;   i) Anti-TNF alpha antibodies;   j) Soluble TNF alpha receptors;   k) Anti-CD20 monoclonal antibodies;   l) Anti-CD52 antibodies;   m) Anti-CD25 antibodies   n) Anti-CD88 antibodies   o) Anti-IL12R/IL23R antibodies,   p) Calcineurin inhibitors;   q) IMPDH inhibitors;   r) Cannabinoid receptor agonists;   s) Chemokine CCR1 antagonists;   t) Chemokine CCR2 antagonists;   u) NF-kappaB activation inhibitors;   v) S1P receptor agonists;   w) S1P liase inhibitors;   x) Syk inhibitors;   y) PKC inhibitors;   z) M3 antagonists;   aa) Long-acting beta adrenergic agonists;   bb) Vitamin-D derivatives;   cc) Phosphosdiesterase IV inhibitors   dd) p38 Inhibitors;   ee) MEK inhibitors;   ff) PI3Kδγ inhibitors;   gg) Interferons comprising Interferon beta 1a and/or Interferon beta 1b; and   hh) Interferons alpha.   
     
     
         28 . The compound according to  claim 6 , wherein R 1  is chosen from a hydrogen atom, a linear or branched C 1 -C 3  alkyl group and a —NR′R″ group, wherein R′ and R″ are independently chosen from a hydrogen atom and a linear or branched C 1 -C 3  alkyl group. 
     
     
         29 . The compound according to  claim 7 , wherein R 2  is chosen from a hydrogen atom and a halogen atom. 
     
     
         30 . The compound according to  claim 8 , wherein R 3  is chosen from a hydrogen atom, a halogen atom, a cyano group and a —C(O)—NH 2  group. 
     
     
         31 . The compound according to  claim 9 , wherein R 4  is chosen from a hydrogen atom, a halogen atom and a hydroxyl group. 
     
     
         32 . The compound according to  claim 10 , wherein R 5  and R 5 ′ are independently chosen from a hydrogen atom, a halogen atom, a linear or branched C 1 -C 3  alkyl group, a morpholinyl group, a piperazinyl group, a —O—CH 3  group and a —O —(CH 2 ) 2 —O—CH 3  group. 
     
     
         33 . The compound according to  claim 11 , wherein R 5  and R 5 ′ are independently chosen from a hydrogen atom, a halogen atom and a linear or branched C 1 -C 3  alkyl group. 
     
     
         34 . The compound according to  claim 12 , wherein R 6  and R 7  are independently chosen from a hydrogen atom, a hydroxyl group, a C 1 -C 3  hydroxyalkyl group, a —(C 1 -C 3  alkyl)-O—(C 1 -C 3  alkyl) group and a linear or branched C 1 -C 3  alkyl group. 
     
     
         35 . The compound according to  claim 13 , wherein R 9  and R 10  are independently chosen a hydrogen atom, a hydroxyl group, a C 1 -C 3  hydroxyalkyl group, a —(C 1 -C 3  alkyl)-O—(C 1 -C 3  alkyl) group and a linear or branched C 1 -C 3  alkyl group. 
     
     
         36 . The compound according to  claim 18 , wherein W″ is a —CR 4  group, X is chosen from a nitrogen atom and a —CR 5  group, Y is a —CR 5  group, R 5  is a hydrogen atom, R 6  and R 7  are independently chosen from a hydrogen atom and a methyl group and R 9  and R 10  are independently chosen from a hydrogen atom and a methyl group. 
     
     
         37 . The compound according to  claim 19 , wherein W″ is a —CR 4  group, X is chosen from a nitrogen atom or a —CR 5  group, Y is a —CR 5  group, R 5  is a hydrogen atom, R 6  and R 7  are independently chosen from a hydrogen atom and a methyl group and R 9  and R 10  are independently chosen from a hydrogen atom and a methyl group. 
     
     
         38 . The compound according to  claim 20 , wherein W′ is a —CR 2  group. 
     
     
         39 . The compound according to  claim 21 , wherein W′ is a —CR 2  group. 
     
     
         40 . The combination product according to  claim 27 , wherein the (ii) at least one additional compound is chosen from: Methotrexate; CH-1504; leflunomide; teriflunomide; Glatiramer acetate; Laquinimod; Mitoxantrone; Cladribine; Natalizumab; R-1295; TBC-4746; CDP-323; ELND-002; Firategrast; TMC-2003; prednisone; methylprednisolone; fluticasone; mometasone; beta-metasone; BG-12; lnfliximab; Adalimumab; Certolizumab pegol; Ethanercept; Rituximab; Ocrelizumab; Ofatumumab; TRU-015; alemtuzumab; daclizumab; eculizumab; pexilizumab; ustekinumab; cyclosporine A; tacrolimus; mycophenolate mophetyl; Sativex; MLN-3897; PS-031291; INCB-8696; MLN-0415; fingolimod; BAF-312; ACT128800; LX2931; R-112; NVP-AEB071; tiotropium; aclidinium; formoterol; calcipotriol; roflumilast; GRC-4039; ARRY-797; ARRY-142886; ARRY-438162; Avonex; CinnoVex; Rebif; Betaferon; Betaseron; and Sumiferon MP.